Cited by 733Memory and Neural MechanismsMemory Processes and InfluencesNeural and Behavioral Psychology Studies

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The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain

Maddock, Richard J.·1999·Trends in Neurosciences

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Abstract

Little is known about the function of the retrosplenial cortex and until recently, there was no evidence that it had any involvement in emotional processes. Surprisingly, recent functional neuroimaging studies show that the retrosplenial cortex is consistently activated by emotionally salient words. A review of the functional neuroimaging literature reveals a previously overlooked pattern of observations: the retrosplenial cortex is the cortical region most consistently activated by emotionally salient stimuli. Evidence that this region is also involved in episodic memory suggests that it might have a role in the interaction between emotion and episodic memory. Recognition that the retrosplenial cortex has a prominent role in the processing of emotionally salient stimuli invites further studies to define its specific functions and its interactions with other emotion-related brain regions.

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Authors: Maddock, R. J.
Affiliations: University of California, Davis (US)
Corresponding author: Maddock, Richard J.
ORCID: Maddock, Richard J.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1999-07
Volume: 22
Issue: 7
Pages: 310-316
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/s0166-2236(98)01374-5
OpenAlex: W2020995685
Cited by: 733
References: 64
Citations by year: 2026: 3 · 2025: 8 · 2024: 2 · 2023: 11 · 2022: 15 · 2021: 21 · 2020: 14 · 2019: 23 · 2018: 13 · 2017: 32 · 2016: 24 · 2015: 23 · 2014: 25 · 2013: 43 · 2012: 31
FWCI: 2.74
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: retrosplenial cortex, emotions, emotional salience, episodic memory, emotional processing, brain regions
MeSH terms: Mental Disorders, Brain Mapping, Cerebral Cortex, Corpus Callosum, Emotions, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Neural Pathways, Tomography, Emission-Computed

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The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain

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