Retrosplenial amnesia

VALENSTEIN, EDWARD; BOWERS, DAWN; VERFAELLIE, MIEKE; HEILMAN, KENNETH M.; DAY, ARTHUR; WATSON, ROBERT T.

doi:10.1093/brain/110.6.1631

Cited by 487Memory and Neural MechanismsMemory Processes and InfluencesCognitive Functions and Memory

Retrosplenial amnesia

VALENSTEIN, EDWARD, BOWERS, DAWN, VERFAELLIE, MIEKE, HEILMAN, KENNETH M., DAY, ARTHUR, WATSON, ROBERT T.·1987·Brain

DOI 10.1093/brain/110.6.1631

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Abstract

A 39-year-old man developed retrograde and anterograde amnesia following haemorrhage from an arteriovenous malformation situated near the splenium of the corpus callosum. MRI studies demonstrated damage to the splenium, and to a region containing the retrosplenial cortex and the cingulate bundle. The fornix was anterior and inferior to the site of maximal damage, but may have been involved; the stria terminalis was probably spared. Structures known to be important in memory but spared by the lesion included the hippocampus, thalamus, and basal forebrain. The retrosplenial cortex receives input from the subiculum and projects to the anterior thalamus, thus providing an alternative route between hippocampus and thalamus. Perhaps more importantly, medial temporal structures involved in memory receive anterior thalamic input directly via the cingulate bundle and indirectly through a relay in the retrosplenial cortex. We suggest that this thalamocortical portion of Papez' circuit may be important in memory, and that lesions of the cingulum and retrosplenial cortex may cause amnesia by disrupting this pathway.

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Both retrosplenial damage and hippocampal damage can cause anterograde amnesia.
“This outcome is to be expected as both retrosplenial damage and hippocampal damage can cause anterograde amnesia (Spiers et al., 2001; Valenstein et al., 1987; Vann et al., 2009)”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Valenstein et al., 1987

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Authors: VALENSTEIN, E., BOWERS, D., VERFAELLIE, M., HEILMAN, K. M., DAY, A., & WATSON, R. T.
Affiliations: University of Florida Health (US)
University of Florida (US)
Corresponding author: VALENSTEIN, EDWARD
ORCID: BOWERS, DAWN
VERFAELLIE, MIEKE
HEILMAN, KENNETH M.
DAY, ARTHUR
Venue: Brain
Publisher: Oxford University Press (OUP)
Published: 1987
Volume: 110
Issue: 6
Pages: 1631-1646
ISSN: 0006-8950 (ISSN-L)
1460-2156
DOI: 10.1093/brain/110.6.1631
OpenAlex: W4233322041
Cited by: 487
References: 0
Citations by year: 2026: 4 · 2025: 10 · 2024: 13 · 2023: 4 · 2022: 14 · 2021: 15 · 2020: 11 · 2019: 16 · 2018: 17 · 2017: 12 · 2016: 10 · 2015: 7 · 2014: 14 · 2013: 19 · 2012: 16
FWCI: 3.80
Type: journal article
Language: en
Open access: closed
Locations: Brain (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords: retrograde amnesia, anterograde amnesia, arteriovenous malformation, splenium of corpus callosum, retrosplenial cortex, Papez circuit, thalamocortical circuits, memory, fornix, stria terminalis, hippocampus, anterior thalamic nuclei
MeSH terms: Adult, Amnesia, Brain, Cerebral Angiography, Intracranial Arteriovenous Malformations, Cerebral Hemorrhage, Corpus Callosum, Follow-Up Studies, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Tomography, X-Ray Computed

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Retrosplenial amnesia

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