CoChat
Sign Up
Cited by 319Memory and Neural MechanismsSpatial Cognition and NavigationVestibular and auditory disorders

Pure topographic disorientation due to right retrosplenial lesion

Takahashi, N., Kawamura, M., Shiota, J., Kasahata, N., Hirayama, K.·1997·Neurology
DOI 10.1212/wnl.49.2.464
Open this paper in CoChat — free account

Abstract

Correlated spiking activity prevails in immature cortical networks and is believed to contribute to neuronal circuit maturation; however, its spatiotemporal organization is not fully understood. Using wide-field calcium imaging from acute whole-brain slices of rat pups on postnatal days 1–6, we found that correlated spikes were initiated in the anterior part of the lateral entorhinal cortex and propagated anteriorly to the frontal cortex and posteriorly to the medial entorhinal cortex, forming traveling waves that engaged almost the entire cortex. The waves were blocked by ionotropic glutamatergic receptor antagonists but not by GABAergic receptor antagonists. During wave events, glutamatergic and GABAergic synaptic inputs were balanced and induced UP state-like depolarization. Magnified monitoring with cellular resolution revealed that the layer III neurons were first activated when the waves were initiated. Consistent with this finding, layer III contained a larger number of neurons that were autonomously active, even under a blockade of synaptic transmission. During wave propagation, the layer III neurons constituted a leading front of the wave. The waves did not enter the parasubiculum; however, in some cases, they were reflected at the parasubicular border and propagated back in the opposite direction. During this reflection process, the layer III neurons in the medial entorhinal cortex maintained persistent activity. Thus, our data emphasize the role of layer III in early network behaviors and provide insight into the circuit mechanisms through which cerebral cortical networks maturate.

Integrity signals

Registry

Crossref · 10.1212/wnl.49.2.464

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Unilateral retrosplenial damage can cause topographic disorientation.

    “Meanwhile, unilateral retrosplenial damage, which presumably involves the cingulum, can cause topographic disorientation (Maguire, 2001; Takahashi et al., 1997)”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Takahashi et al., 1997

  • Candidate neocortical regions for coding such information include the retrosplenial cortex, parahippocampal cortex, and anterior cingulate cortex.

    “Candidate neocortical regions include the retrosplenial cortex (Takahashi et al. 1997; Epstein et al. 2007), parahippocampal cortex (Rosenbaum et al. 2004; Bohbot et al. (2015), for extensive reviews see Spiers and Maguire 2007b; Epstein 2008; Ranganath and Ritchey 2012; Miller et al. 2014), and the anterior cingulate cortex (Teixeira et al. 2006).”

    From Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment (2019) · cites this paper as Takahashi et al. 1997

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Takahashi, N., Kawamura, M., Shiota, J., Kasahata, N., & Hirayama, K.
Affiliations
SHOWA Medical University (JP)
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-08
Volume
49
Issue
2
Pages
464-469
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.49.2.464
OpenAlex
W2131730569
Cited by
319
References
9
Citations by year
2026: 5 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 13 · 2021: 15 · 2020: 15 · 2019: 19 · 2018: 17 · 2017: 15 · 2016: 16 · 2015: 12 · 2014: 19 · 2013: 10 · 2012: 8
FWCI
4.07
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
retrosplenial cortex, spatial disorientation, traveling waves, glutamatergic neurotransmission, GABAergic neurotransmission, up states, medial entorhinal cortex, persistent activity
MeSH terms
Cerebral Hemorrhage, Corpus Callosum, Humans, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Orientation, Parietal Lobe, Pattern Recognition, Visual, Mental Recall, Space Perception, Tomography, X-Ray Computed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review