Alpha-lipoic acid as a new treatment option for Azheimer type dementia
Abstract
Oxidative stress and energy depletion are characteristic biochemical hallmarks of Alzheimer's disease (AD), thus antioxidants with positive effects on glucose metabolism such as thioctic (alpha-lipoic) acid should exert positive effects in these patients. Therefore, 600 mg alpha-lipoic acid was given daily to nine patients with AD and related dementias (receiving a standard treatment with acetylcholinesterase inhibitors) in an open study over an observation period of, on avarage, 337+/-80 days. The treatment led to a stabilization of cognitive functions in the study group, demonstrated by constant scores in two neuropsychological tests (mini-mental state examination: MMSE and AD assessment scale, cognitive subscale: ADAScog). Despite the fact that this study was small and not randomized, this is the first indication that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD and related dementias.
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In a small clinical pilot study, probable AD patients given alpha-lipoic acid and two choline acetyltransferase (CAT) inhibitors had slower cognitive decline than probable AD patients given only the two CAT inhibitors.
“In a small clinical pilot study, probable AD patients given alpha-lipoic acid and two choline acetyltransferase (CAT) inhibitors had slower cognitive decline than probable AD patients given only the two CAT inhibitors [151].”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [151]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
A new rating scale for Alzheimer's disease
(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1356 · Cited by 4,175 · see citing works
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380 · see citing works
Diabetes mellitus and the risk of dementia: The Rotterdam Study
Ott, A., Stolk, R. P., van Harskamp, F., Pols, H. A. P., Hofman, A., & Breteler, M. M. B. (1999) · Neurology · doi:10.1212/wnl.53.9.1937 · Cited by 2,175 · see citing works
Alpha-lipoic acid as a biological antioxidant
Packer, L., Witt, E. H., & Tritschler, H. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00017-r · Cited by 1,995 · see citing works
Clinical trial of indomethacin in Alzheimer's disease
Rogers, J., Kirby, L., Hempelman, S. R., Berry, D. A., McGeer, P. L., Kaszniak, A. W., Zalinski, J., Cofield, M., Mansukhani, L., Willson, P., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1609 · Cited by 991 · see citing works
Neuroprotection by the Metabolic Antioxidant α-Lipoic Acid
Packer, L., Tritschler, H. J., & Wessel, K. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00269-9 · Cited by 639 · see citing works
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.3.390 · Cited by 408 · see citing works
Bierhaus, A., Chevion, S., Chevion, M., Hofmann, M. A., Quehenberger, P., Illmer, T., Luther, T., Berentshtein, E., Tritschler, H., Müller, M., et al. (1997) · Diabetes · doi:10.2337/diab.46.9.1481 · Cited by 371 · see citing works
Münch, G. W., Schinzel, R., Loske, C., Wong, A. O., Durany, N., Li, J. J., Vlassara, H., Smith, M. A., Perry, G. L., & Riederer, P. F. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050069 · Cited by 302 · see citing works
Self-citationRogers, S. L., & Friedhoff, L. T. (1998) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(97)00079-5 · Cited by 293 · see citing works
Advanced glycation endproducts in ageing and Alzheimer's disease
Münch, G. W., Thome, J., Foley, P. B., Schinzel, R., & Riederer, P. F. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00016-1 · Cited by 275 · see citing works
Self-citationStern, Y., Albert, M., Brandt, J., Jacobs, D. M., Tang, M.-X., Marder, K. S., Bell, K. L., Sano, M. E. B., Devanand, D. P., Bylsma, F., et al. (1994) · Neurology · doi:10.1212/wnl.44.12.2300 · Cited by 235 · see citing works
Longitudinal association of vascular and Alzheimer’s dementias, diabetes, and glucose tolerance
Curb, J. D., Rodríguez, B. L., Abbott, R. D., Petrovitch, H., Ross, G. W., Masaki, K., Foley, D. J., Blanchette, P. L., Harris, T. B., Chen, R., et al. (1999) · Neurology · doi:10.1212/wnl.52.5.971 · Cited by 231 · see citing works
ESTRADA, D. E., Ewart, H. S., Tsakiridis, T. K., Volchuk, A., Ramlal, T., Tritschler, H., & Klip, A. (1996) · Diabetes · doi:10.2337/diab.45.12.1798 · Cited by 199 · see citing works
Brain Inflammation in Alzheimer Disease and the Therapeutic Implications
McGeer, E. G., & McGeer, P. L. (1999) · Current Pharmaceutical Design · doi:10.2174/1381612805666230111212056 · Cited by 198 · see citing works
Neumann, A., Schinzel, R., Palm, D., Riederer, P. F., & Münch, G. W. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00731-0 · Cited by 195 · see citing works
Self-citationInteractions among Antioxidants in Health and Disease: Vitamin E and Its Redox Cycle
Packer, L. (1992) · Experimental Biology and Medicine · doi:10.3181/00379727-200-43433 · Cited by 164 · see citing works
Cytotoxicity of advanced glycation endproducts is mediated by oxidative stress
Loske, C., Neumann, A., Cunningham, A. M., Nichol, K. A., Schinzel, R., Riederer, P. F., & Münch, G. W. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050108 · Cited by 144 · see citing works
Self-citationThe Dana Consortium on the Therapy of HIV Dementia and Related Cognitive Disorders* (1998) · Neurology · doi:10.1212/wnl.50.3.645 · Cited by 113 · see citing works
Abnormalities of Glucose Metabolism in Alzheimer's Disease
Hoyer, S. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb00190.x · Cited by 112 · see citing works
Bierhaus, A., Chevion, S., Chevion, M., Hofmann, M. A., Quehenberger, P., Illmer, T., Luther, T., Berentshtein, E., Tritschler, H., Muller, M., et al. (1997) · Diabetes · doi:10.2337/diabetes.46.9.1481 · Cited by 106 · see citing works
Neurodegenerative mechanisms in alzheimer disease
Sopher, B. L., Fukuchi, K., Kavanagh, T. J., Furlong, C. E., & Martin, G. M. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02814999 · Cited by 75 · see citing works
Estrada, D. E., Ewart, H. S., Tsakiridis, T., Volchuk, A., Ramlal, T., Tritschler, H., & Klip, A. (1996) · Diabetes · doi:10.2337/diabetes.45.12.1798 · Cited by 74 · see citing works
Altered regulation of brain glucose metabolism as a cause of neurodegenerative disorders?
Blum-Degen, D., Frölich, L., Hoyer, S., & Riederer, P. F. (1995) · PubMed · Cited by 55 · see citing works
Self-citationDiabetes and Dementia in Long‐Term Care
Tariot, P. N., Ogden, M. A., Cox, C., & Williams, T. F. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb07234.x · Cited by 50 · see citing works
Flynn, B. L., & Ranno, A. E. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.17172 · Cited by 35 · see citing works
Lockhart, B. P., Jones, C., Cuisinier, C., et al. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02372-0 · Cited by 24 · see citing works
Chang, N., EBELS, I., & Benson, B. (1979) · Journal of Neural Transmission · doi:10.1007/bf01250335 · Cited by 23 · see citing works
Chemie und Biochemie der α‐Liponsäure
Schmidt, U., Grafen, P., & Goedde, H. W. (1965) · Angewandte Chemie · doi:10.1002/ange.19650772004 · Cited by 13 · see citing works
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Shinto, L., Quinn, J., Montine, T., Dodge, H. H., Woodward, W., Baldauf-Wagner, S., Waichunas, D., Bumgarner, L., Bourdette, D., Silbert, L., et al. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-130722 · Cited by 288 · see citing works
Combination Therapy in Alzheimer???s Disease: A Review of Current Evidence
Schmitt, B., Bernhardt, T., Moeller, H.-J., Heuser, I., & Fr??lich, L. (2004) · CNS Drugs · doi:10.2165/00023210-200418130-00001 · Cited by 182 · see citing works
A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments
Gibson, G. E., & Shi, Q. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-100336 · Cited by 124 · see citing works
Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease
Butterfield, D. A., & Boyd-Kimball, D. (2020) · Antioxidants · doi:10.3390/antiox9090818 · Cited by 85 · see citing works
Parachikova, A., Green, K. N., Hendrix, C., & LaFerla, F. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014015 · Cited by 87 · see citing works
Soczynska, J. K., Kennedy, S. H., Chow, C. S., Woldeyohannes, H. O., Konarski, J. Z., & McIntyre, R. S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.6.827 · Cited by 23 · see citing works
- Authors
- Hager, K., Marahrens, A., Kenklies, M., Riederer, P., & Münch, G.
- Affiliations
- University of Würzburg (DE)
- Leipzig University (DE)
- Venue
- Archives of Gerontology and Geriatrics
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 32
- Issue
- 3
- Pages
- 275-282
- ISSN
- 0167-4943 (ISSN-L)
- OpenAlex
- W2055361714
- Cited by
- 188
- References
- 30
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 11 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 4 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Gerontology and Geriatrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- alpha-lipoic acid, Alzheimer's disease, dementia, antioxidants, oxidative stress, energy depletion, glucose metabolism, acetylcholinesterase inhibitors, cognitive function, neuroprotection
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