Formulation of a Medical Food Cocktail for Alzheimer's Disease: Beneficial Effects on Cognition and Neuropathology in a Mouse Model of the Disease
Open accessAbstract
BACKGROUND: Dietary supplements have been extensively studied for their beneficial effects on cognition and AD neuropathology. The current study examines the effect of a medical food cocktail consisting of the dietary supplements curcumin, piperine, epigallocatechin gallate, α-lipoic acid, N-acetylcysteine, B vitamins, vitamin C, and folate on cognitive functioning and the AD hallmark features and amyloid-beta (Aβ) in the Tg2576 mouse model of the disease. PRINCIPAL FINDINGS: The study found that administering the medical food cocktail for 6 months improved cortical- and hippocampal- dependent learning in the transgenic mice, rendering their performance indistinguishable from non-transgenic controls. Coinciding with this improvement in learning and memory, we found that treatment resulted in decreased soluble Aβ, including Aβ oligomers, previously found to be linked to cognitive functioning. CONCLUSION: In conclusion, the current study demonstrates that combination diet consisting of natural dietary supplements improves cognitive functioning while decreasing AD neuropathology and may thus represent a safe, natural treatment for AD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects.
“Although research has demonstrated that curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects, further research is necessary to conclusively state curcumin’s ability at ameliorating cognitive function in humans [146,162,169].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [169]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
Lesné, S., Koh, M. T., Kotilinek, L., Kayed, R., Glabe, C. G., Yang, A., Gallagher, M., & Ashe, K. H. (2006) · Nature · doi:10.1038/nature04533 · Cited by 2,769 · cited 1× · see citing works
“. Recent studies have highlighted the importance of soluble oligomeric species of Aβ, in particular the 56 kD molecule Aβ*56, in learning and memory”
BackgroundRetractedStrittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268 · see citing works
Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice
Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works
A new one-trial test for neurobiological studies of memory in rats. 1: behavioral data
Ennaceur, A., & Delacour, J. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90157-x · Cited by 3,223 · see citing works
Applications of the Morris water maze in the study of learning and memory
D’Hooge, R., & Deyn, P. P. D. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00067-4 · Cited by 2,035 · see citing works
Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers
Guido, S., Joy, D. C., Joseph, T., Majeed, M. A., Rajendran, R., & Srinivas, P. (1998) · Planta Medica · doi:10.1055/s-2006-957450 · Cited by 1,976 · see citing works
Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530 · see citing works
Activation of microglial cells by β-amyloid protein and interferon-γ
Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314 · see citing works
Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294 · see citing works
Self-citationCurcumin has potent anti‐amyloidogenic effects for Alzheimer's β‐amyloid fibrils in vitro
Ono, K., Hasegawa, K., Naiki, H., & Yamada, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20025 · Cited by 1,254 · see citing works
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
Oddo, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.012 · Cited by 980 · see citing works
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
Dodart, J.-C., Bales, K. R., Gannon, K. S., Greene, S. J., DeMattos, R. B., Mathis, C., DeLong, C. A., Wu, S., Wu, X., Holtzman, D. M., et al. (2002) · Nature Neuroscience · doi:10.1038/nn842 · Cited by 858 · see citing works
Hensley, K., Hall, N., Subramaniam, R., Cole, P., Harris, M., Aksenov, M., Aksenova, M., Gabbita, S. P., Wu, J. F., Carney, J. M., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052146.x · Cited by 779 · cited 1× · see citing works
“Strong genetic evidence suggests that it is the aberrant accumulation of Ab which lies upstream, and that it is this accumulation which leads to downstream pathologies such as tangle formation [2], extensive inflammation [3], oxidative damage to lipids, proteins and DNA [4], and glycation of proteins [5].”
BackgroundKayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., et al. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-18 · Cited by 773 · see citing works
Glucocorticoids increase amyloid-β and tau pathology in a mouse model of alzheimer’s disease
Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., & LaFerla, F. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2797-06.2006 · Cited by 623 · see citing works
Self-citationImmunomodulatory and antitumor activity of Piper longum Linn. and piperine
Sunila, E. S., & Kuttan, G. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.10.016 · Cited by 534 · see citing works
Phenolic anti-inflammatory antioxidant reversal of Aβ-induced cognitive deficits and neuropathology
Frautschy, S. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00300-1 · Cited by 514 · see citing works
Different Contributions of the Hippocampus and Perirhinal Cortex to Recognition Memory
Wan, H., Aggleton, J. P., & Brown, M. W. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-03-01142.1999 · Cited by 449 · see citing works
Green, K. N., Steffan, J. S., Martinez-Coria, H., Sun, X., Schreiber, S. S., Thompson, L. M., & LaFerla, F. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3203-08.2008 · Cited by 404 · see citing works
Self-citationMandel, S. A., Weinreb, O., Amit, T., & Youdim, M. B. H. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02291.x · Cited by 379 · see citing works
Green, K. N., Martínez‐Coria, H., Khashwji, H., Hall, E. B., Yurko‐Mauro, K., Ellis, L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0055-07.2007 · Cited by 326 · see citing works
Self-citationCausative and susceptibility genes for Alzheimer’s disease: a review
Rocchi, A., Pellegrini, S., Siciliano, G., & Murri, L. (2003) · Brain Research Bulletin · doi:10.1016/s0361-9230(03)00067-4 · Cited by 319 · see citing works
Vijayakumar, R. S., Surya, D., & Nalini, N. (2004) · Redox Report · doi:10.1179/135100004225004742 · Cited by 286 · see citing works
Hippocampus, amygdala, and memory deficits in rats
Sutherland, R. J., & McDonald, R. J. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90072-m · Cited by 279 · see citing works
Piperine Enhances the Bioavailability of the Tea Polyphenol (−)-Epigallocatechin-3-gallate in Mice
Lambert, J. D., Hong, J., Kim, D. H., Mishin, V. M., & Yang, C. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.8.1948 · Cited by 245 · see citing works
Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months
King, D. L., & Arendash, G. W. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00639-x · Cited by 240 · see citing works
Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease
Adair, J. C., Knoefel, J. E., & Morgan, N. (2001) · Neurology · doi:10.1212/wnl.57.8.1515 · Cited by 240 · see citing works
Oddo, S., Caccamo, A., Green, K. N., Liang, K., Tran, L., Chen, Y., Leslie, F. M., & LaFerla, F. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408500102 · Cited by 211 · see citing works
Self-citationAlpha-lipoic acid as a new treatment option for Azheimer type dementia
Hager, K., Marahrens, A., Kenklies, M., Riederer, P., & Münch, G. (2001) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00104-2 · Cited by 188 · see citing works
Aggleton, J. P., Keen, S., Warburton, E. C., & Bussey, T. J. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00007-5 · Cited by 168 · see citing works
Learning Decreases Aβ*56 and Tau Pathology and Ameliorates Behavioral Decline in 3xTg-AD Mice
Billings, L. M., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4800-06.2007 · Cited by 138 · see citing works
Self-citationHorie, K., Miyata, T., Yasuda, T., Takeda, A., Yasuda, Y., Maeda, K., Sobue, G., & Kurokawa, K. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6944 · Cited by 137 · see citing works
Mumby, D. G., Wood, E. R., Duva, C. A., Kornecook, T. J., Pinel, J. P. J., & Phillips, A. G. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.2.266 · Cited by 94 · see citing works
Selvendiran, K., & Sakthisekaran, D. (2004) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2003.08.027 · Cited by 82 · see citing works
Myhrer, T. (1988) · Behavioral Neuroscience · doi:10.1037//0735-7044.102.3.356 · Cited by 79 · see citing works
Mumby, D. G., Wood, E. R., Duva, C. A., et al. (1996) · Behavioral Neuroscience · doi:10.1037/0735-7044.110.2.266 · Cited by 71 · see citing works
Myhrer, T. (1988) · Behavioral Neuroscience · doi:10.1037/0735-7044.102.3.356 · Cited by 69 · see citing works
Phillips, R. R., Malamut, B. L., Bachevalier, J., & Mishkin, M. (1988) · Behavioural Brain Research · doi:10.1016/0166-4328(88)90035-6 · Cited by 68 · see citing works
Vaucher, E., Fluit, P., Chishti, M. A., Westaway, D. A., Mount, H. T. J., & Kar, S. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7915 · Cited by 33 · see citing works
From prion diseases to Alzheimer’s disease
Hsiao, K. (1997) · Springer eBooks · doi:10.1007/978-3-7091-6844-8_15 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Therapeutics of Alzheimer's disease: Past, present and future
Anand, R., Gill, K. D., & Mahdi, A. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.004 · Cited by 748 · see citing works
Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 671 · see citing works
Sabogal-Guáqueta, A. M., Muñoz‐Manco, J. I., Ramírez‐Pineda, J. R., Lamprea, M. R., Osorio, E., & Cardona‐Gómez, G. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.027 · Cited by 453 · see citing works
l ‐Cysteine metabolism and its nutritional implications
Yin, J., Ren, W., Yang, G., Duan, J., Huang, X., Fang, R., Li, C.-Y., Li, Y., Yin, Y., Hou, Y., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500031 · Cited by 355 · see citing works
Skvarc, D., Berk, M., Byrne, L. K., Dean, O. M., Dodd, S., Lewis, M., Marriott, A., Moore, E. M., Morris, G., Page, R. S., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.11.011 · Cited by 312 · see citing works
Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146476 · Cited by 243 · see citing works
Neuroprotective Herbs for the Management of Alzheimer’s Disease
Gregory, J., Vengalasetti, Y. V., Bredesen, D. E., & Rao, R. V. (2021) · Biomolecules · doi:10.3390/biom11040543 · Cited by 238 · see citing works
Reversal of cognitive decline: A novel therapeutic program
Bredesen, D. E. (2014) · Aging · doi:10.18632/aging.100690 · Cited by 231 · see citing works
Medical and Dietary Uses of N-Acetylcysteine
Šalamon, Š., Kramar, B., Marolt, T. P., Poljšak, B., & Milisav, I. (2019) · Antioxidants · doi:10.3390/antiox8050111 · Cited by 188 · see citing works
Recruiting adaptive cellular stress responses for successful brain ageing
Stranahan, A. M., & Mattson, M. P. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3151 · Cited by 169 · see citing works
Bayat, V., Thiffault, I., Jaiswal, M., Tétreault, M., Donti, T., Sasarman, F., Bernard, G., Demers-Lamarche, J., Dicaire, M., Mathieu, J., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001288 · Cited by 165 · see citing works
Dixit, S., Bernardo, A., Walker, J. M., Kennard, J. A., Kim, G. Y., Kessler, E. S., & Harrison, F. E. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500308h · Cited by 135 · see citing works
The Role of Nutrition and Diet in Alzheimer Disease: A Systematic Review
Shah, R. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.01.014 · Cited by 126 · see citing works
Jayasena, T., Poljak, A., Smythe, G. A., Braidy, N., Münch, G. W., & Sachdev, P. S. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.06.003 · Cited by 120 · see citing works
Curcumin in Alzheimer’s disease: Can we think to new strategies and perspectives for this molecule?
Serafini, M. M., Catanzaro, M., Rosini, M., Racchi, M., & Lanni, C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.08.004 · Cited by 119 · see citing works
Azzini, E., Peña-Corona, S. I., Hernández-Parra, H., Chandran, D., Saleena, L. A. K., Sawikr, Y., Peluso, I., DHUMAL, S. S., Kumar, M., Leyva-Gómez, G., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8200 · Cited by 103 · see citing works
The effect of N-acetylcysteine (NAC) on human cognition – A systematic review
Skvarc, D., Dean, O. M., Byrne, L. K., Gray, L. J., Lane, S. E., Lewis, M., Fernandes, B. S., Berk, M., & Marriott, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.013 · Cited by 108 · see citing works
The Essential Role of Soluble Aβ Oligomers in Alzheimer’s Disease
Wang, Z.-X., Tan, L., Liu, J., & Yu, J.-T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9143-0 · Cited by 110 · see citing works
Stewart, S., Cacucci, F., & Lever, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101827 · Cited by 94 · see citing works
Hriţcu, L., Noumedem, J. A. K., Cioancă, O., Hăncianu, M., Postu, P. A., & Mihăşan, M. (2015) · Behavioral and Brain Functions · doi:10.1186/s12993-015-0059-7 · Cited by 94 · see citing works
Foley, A. M., Ammar, Z., Lee, R. H., & Mitchell, C. S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142208 · Cited by 87 · see citing works
Dragicevic, N., Delic, V., Cao, C., Copes, N., Lin, X., Mamcarz, M., Wang, L., Arendash, G. W., & Bradshaw, P. C. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.018 · Cited by 85 · see citing works
Hsiao, Y., Kuo, J., Chen, S., & Gean, P. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.031 · Cited by 81 · see citing works
Kasote, D. M., Hegde, M. V., & Katyare, S. S. (2013) · BioFactors · doi:10.1002/biof.1093 · Cited by 71 · see citing works
Fernández-Fernández, L., Comes, G., Bolea, I., Valente, T., Ruiz, J., Murtra, P., Ramírez, B., Anglès, N., Reguant, J., Morelló, J. R., et al. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.014 · Cited by 67 · see citing works
Mitigating Alzheimer’s Disease with Natural Polyphenols: A Review
Gaudreault, R., & Mousseau, N. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190315093520 · Cited by 63 · see citing works
Chakrabarti, S., Sinha, M., Thakurta, I. G., Banerjee, P., & Chattopadhyay, M. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990152 · Cited by 63 · see citing works
Alzheimer’s Disease and Antioxidant Therapy: How Long How Far?
Teixeira, J., Silva, T., Andrade, P. B., & Borges, F. (2013) · Current Medicinal Chemistry · doi:10.2174/1871523011320240001 · Cited by 59 · see citing works
Antioxidant therapy: Still in search of the ‘magic bullet’
Benfeito, S., Oliveira, C., Soares, P., Fernandes, C., Silva, T., Teixeira, J., & Borges, F. (2012) · Mitochondrion · doi:10.1016/j.mito.2012.12.002 · Cited by 55 · see citing works
Gauci, A. J., Caruana, M., Giese, A., Scerri, C., & Vassallo, N. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111061 · Cited by 54 · see citing works
Zhou, X., Li, Y., Shi, X., & Ma, C. (2016) · PubMed Central · Cited by 52 · see citing works
Curcumin: a natural substance with potential efficacy in Alzheimer’s disease
Potter, P. E. (2013) · Journal of Experimental Pharmacology · doi:10.2147/jep.s26803 · Cited by 51 · see citing works
Energetics, Thermodynamics, and Molecular Recognition of Piperine with DNA
Haris, P., Varughese, M., Haridas, M., & Sudarsanakumar, C. (2015) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5b00514 · Cited by 47 · see citing works
Sharman, M. J., Gyengési, E., Liang, H., Chatterjee, P., Karl, T., Li, Q.-X., Wenk, M. R., Halliwell, B. B., Martins, R. N., & Münch, G. W. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.11.026 · Cited by 46 · see citing works
Khalili-Fomeshi, M., Azizi, M. G., Esmaeili, M., Gol, M., Kazemi, S., Ashrafpour, M., Moghadamnia, A. A., & Hosseinzadeh, S. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.09.031 · Cited by 43 · see citing works
Durairajan, S. S. K., Iyaswamy, A., Shetty, S. G., Kammella, A. K., Malampati, S., Shang, W., Yang, C., Song, J., Chung, S. K., Huang, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06217-9 · Cited by 42 · see citing works
Zhang, Z.-H., Wu, Q., Chen, C., Zheng, R., Chen, Y., Ni, J., & Song, G.-L. (2018) · Food & Function · doi:10.1039/c7fo02063e · Cited by 42 · see citing works
McCarty, M. F., O’Keefe, J. H., & DiNicolantonio, J. J. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109356 · Cited by 42 · see citing works
D469del-COMP Retention in Chondrocytes Stimulates Caspase-Independent Necroptosis
Coustry, F., Posey, K. L., Liu, P., Alcorn, J. L., & Hecht, J. T. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.10.033 · Cited by 42 · see citing works
Synergistic effects of diet and exercise on hippocampal function in chronically stressed mice
Hutton, C. P., Déry, N., Rosa, E., Lemon, J. A., Rollo, C. D., Boreham, D. R., Fahnestock, M., deCatanzaro, D., Wojtowicz, J. M., & Becker, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.005 · Cited by 41 · see citing works
Coppedè, F., Grossi, E., Buscema, M., & Migliore, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074012 · Cited by 39 · see citing works
Chen, Y.-W., Lin, H., Ng, M.-C., Hsiao, Y., Wang, C.-C., Gean, P., & Chen, P. S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00219 · Cited by 38 · see citing works
Emerging pharmacotherapy for cancer patients with cognitive dysfunction
Davis, J., Ahlberg, F. M., Berk, M., Ashley, D. M., & Khasraw, M. (2013) · BMC Neurology · doi:10.1186/1471-2377-13-153 · Cited by 36 · see citing works
Evaluation of Traditional Medicines for Neurodegenerative Diseases Using Drosophila Models
Lee, S., Bang, S. M., Lee, J. W., & Cho, K. S. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/967462 · Cited by 36 · see citing works
Liu, Q. F., Jeong, H., Lee, J. H., Hong, Y. K., Oh, Y., Kim, Y., Suh, Y. S., Bang, S. M., Yun, H. S., Lee, K., et al. (2016) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x16500749 · Cited by 34 · see citing works
Head, E., Murphey, H. L., Dowling, A. L. S., McCarty, K. L., Bethel, S. R., Nitz, J. A., Pleiss, M. M., VanRooyen, J. L., Grossheim, M., Smiley, J. R., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120937 · Cited by 34 · see citing works
Self-citationThe Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment
Zieneldien, T., Kim, J., & Cao, C. (2022) · Geriatrics · doi:10.3390/geriatrics7020024 · Cited by 29 · see citing works
“Although research has demonstrated that curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects, further research is necessary to conclusively state curcumin’s ability at ameliorating cognitive function in humans [146,162,169].”
BackgroundLindheimer, J. B., Loy, B. D., & O’Connor, P. J. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0216 · Cited by 29 · see citing works
Park, S. H., Lee, S., Hong, Y. K., Hwang, S., Lee, J. H., Bang, S. M., Kim, Y., Koo, B., Lee, I., & Cho, K. S. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00792 · Cited by 29 · see citing works
Froestl, W., Pfeifer, A., & Muhs, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121729 · Cited by 27 · see citing works
Medical Foods for Alzheimerʼs Disease
Shah, R. C. (2011) · Drugs & Aging · doi:10.2165/11587380-000000000-00000 · Cited by 26 · see citing works
Hopeahainol A attenuates memory deficits by targeting β‐amyloid in APP / PS 1 transgenic mice
Zhu, X., Ye, L., Ge, H. M., Chen, L., Jiang, N., Qian, L., Li, L., Liu, R., Shen, J., Zhang, S., et al. (2012) · Aging Cell · doi:10.1111/acel.12022 · Cited by 24 · see citing works
Aβ-degrading proteases:therapeutic potential in Alzheimer disease
Leissring, M. (2016) · CNS Drugs · doi:10.1007/s40263-016-0364-1 · Cited by 25 · see citing works
Berry, A., Collacchi, B., Masella, R., Varı́, R., & Cirulli, F. (2021) · Nutrients · doi:10.3390/nu13051519 · Cited by 23 · see citing works
Role of Natural Plant Products Against Alzheimer’s Disease
Varshney, H., & Siddique, Y. H. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210420135437 · Cited by 22 · see citing works
Nature’s Derivative(s) as Alternative Anti-Alzheimer’s Disease Treatments
Sharma, A., & Kumar, Y. (2019) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-190137 · Cited by 20 · see citing works
Wolf, A. B., Braden, B. B., Bimonte‐Nelson, H. A., Kusne, Y. N., Young, N., Engler-Chiurazzi, E. B., Garcia, A. N., Walker, D. G., Moses, G. S. D., Tran, V.-H., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120478 · Cited by 16 · see citing works
Self-citationPandit, C., Latha, S. S., Rani, T. U., & Anilakumar, K. R. (2018) · International Journal of Hyperthermia · doi:10.1080/02656736.2018.1511835 · Cited by 14 · see citing works
Bolognesi, M. L., Bergamini, C., Fato, R., Oiry, J., Vasseur, J., & Smietana, M. (2014) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12282 · Cited by 14 · see citing works
Hutton, C. P., Lemon, J. A., Šakić, B., Rollo, C. D., Boreham, D. R., Fahnestock, M. L., Wojtowicz, J. M., & Becker, S. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170921 · Cited by 14 · see citing works
Mohanty, B., Suvitha, A., & Venkataramanan, N. S. (2018) · ChemistrySelect · doi:10.1002/slct.201702846 · Cited by 13 · see citing works
Oxidative Stress and Alzheimer’s Disease
Wu, Y., Xu, Q., & Song, W. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_197 · Cited by 14 · see citing works
Effect of Natural Plant Products on Alzheimer’s Disease
Varshney, H., & Siddique, Y. H. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230228102223 · Cited by 11 · see citing works
Kandasamy, S., Sivanandam, M., Hunday, G., Pavan, M. S., & Kumaradhas, P. (2019) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2019.07.019 · Cited by 11 · see citing works
Hart, M. J., Glicksman, M. A., Liu, M., Sharma, M., Cuny, G. D., & Galván, V. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.11.020 · Cited by 11 · see citing works
Redução dos níveis séricos de ácido fólico em pacientes com a doença de Alzheimer
de Almeida, C. C., Brentani, H., Forlenza, O. V., & Diniz, B. S. (2012) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/s0101-60832012000300004 · Cited by 11 · see citing works
Wu, M., Li, Y., Miao, Y., Qiao, H., & Wang, Y. (2023) · Journal of drug targeting · doi:10.1080/1061186x.2023.2245582 · Cited by 9 · see citing works
Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Tancheva, L. P., Kalfin, R. E., Minchev, B., Uzunova, D. N., Tasheva, K. N., Tsvetanova, E. R., Georgieva, A. P., Alexandrova, A., Stefanova, M. O., Solak, A., et al. (2023) · Antioxidants · doi:10.3390/antiox12122050 · Cited by 8 · see citing works
Xiao, J., Sui, Y., Li, S., Wu, Q., Yang, T., Xie, B., & Sun, Z. (2013) · European Food Research and Technology · doi:10.1007/s00217-013-1922-0 · Cited by 8 · see citing works
Mohammadi, E., Nikbakht, F., Vazifekhah, S., Babaei, J. F., & Jogataei, M. T. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114263 · Cited by 7 · see citing works
Bosco, R. B. D., Christyraj, J. R. S. S., & Yesudhason, B. V. (2024) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823241307019 · Cited by 5 · see citing works
Curcumin Offers Potential Efficacy for Treating Alzheimer’s Disease
Potter, P. E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815461-8.00010-4 · Cited by 4 · see citing works
Beneficial Effects of Flavonoids on Neurological Disorders
Farooqui, A. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3804-5_4 · Cited by 2 · see citing works
Therapeutics of Alzheimer’s Disease
Herrera-Rivero, M., & Emiliano, G. (2011) · InTech eBooks · doi:10.5772/27990 · Cited by 3 · see citing works
Lee, J. M., Sancheti, S., Park, J. W., Noh, I. C., Cho, W. D., & Choi, J. H. (2013) · Cited by 2 · see citing works
Zhang, Y., Xu, D., Zhang, X., Zhou, W., Zhang, L., & Lin, Q. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250160 · Cited by 1 · see citing works
Neuroimmune Effects of Developmental TCE Exposure
Blossom, S. J. (2014) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6311-4_7 · Cited by 1 · see citing works
Frontiers in Clinical Drug Research - Alzheimer Disorders
Atta-ur-rahman, Mavoungou, C., Zimmerman, K. S., Wright, J., Harding, J., Cavallaro, R., Fuso, A., Yoshiyama, Y., Asija, Z., Clifford, A., et al. (2015) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/97816810806801150301 · Cited by 1 · see citing works
Nutraceuticals–Functional Foods for Improving Health and Preventing Disease
Zhao, J. H. (2012) · Pharmaceutical biotechnology · doi:10.1002/9783527632909.ch23 · Cited by 1 · see citing works
Concocting the Right Diet for Brain Health
Westmark, C. J. (2011) · Translational Medicine · doi:10.4172/2161-1025.1000106e
de Almeida, C. C., Brentani, H., & Forlenza, O. V. (2012)
Age Related Changes in Cognition and Brain: A Focus on Progestogens
Braden, B. B. (2012)
- Authors
- Parachikova, A., Green, K. N., Hendrix, C., & LaFerla, F. M.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- LaFerla, Frank M.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-11-17
- Volume
- 5
- Issue
- 11
- Pages
- e14015
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2984445
- OpenAlex
- W1998037561
- Cited by
- 87
- References
- 38
- Citations by year
- 2024: 3 · 2023: 3 · 2022: 2 · 2021: 3 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 14 · 2012: 14
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Small Business Innovation Research
- National Institutes of Health
- National Institute on Aging (AG-021982, R01AG021982)
- National Center for Complementary and Integrative Health (R43AT003025)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, dietary supplements, curcumin, piperine, epigallocatechin gallate, alpha-lipoic acid, N-acetylcysteine, B vitamins, vitamin C, folic acid, Tg2576 mice, amyloid-beta, amyloid-beta oligomers, learning and memory, hippocampus, cortical learning, cognitive function, neuropathology
- MeSH terms
- Acetylcysteine, Alkaloids, Alzheimer Disease, Animals, Ascorbic Acid, Brain, Catechin, Cerebral Cortex, Cognition, Curcumin, Folic Acid, Hippocampus, Humans, Thioctic Acid, Memory, Mice, Inbred C57BL, Mice, Inbred Strains, Mice, Transgenic, Piperidines, Vitamin B Complex, Vitamins, Immunoblotting, Amyloid beta-Protein Precursor, Maze Learning, Dietary Supplements, Mice, Benzodioxoles, Polyunsaturated Alkamides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review