Cited by 87Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionDementia and Cognitive Impairment Research

Formulation of a Medical Food Cocktail for Alzheimer's Disease: Beneficial Effects on Cognition and Neuropathology in a Mouse Model of the Disease

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Parachikova, Anna, Green, Kim N., Hendrix, Curt, LaFerla, Frank M.·2010·PLoS ONE

Abstract

BACKGROUND: Dietary supplements have been extensively studied for their beneficial effects on cognition and AD neuropathology. The current study examines the effect of a medical food cocktail consisting of the dietary supplements curcumin, piperine, epigallocatechin gallate, α-lipoic acid, N-acetylcysteine, B vitamins, vitamin C, and folate on cognitive functioning and the AD hallmark features and amyloid-beta (Aβ) in the Tg2576 mouse model of the disease. PRINCIPAL FINDINGS: The study found that administering the medical food cocktail for 6 months improved cortical- and hippocampal- dependent learning in the transgenic mice, rendering their performance indistinguishable from non-transgenic controls. Coinciding with this improvement in learning and memory, we found that treatment resulted in decreased soluble Aβ, including Aβ oligomers, previously found to be linked to cognitive functioning. CONCLUSION: In conclusion, the current study demonstrates that combination diet consisting of natural dietary supplements improves cognitive functioning while decreasing AD neuropathology and may thus represent a safe, natural treatment for AD.

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  • Curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects.

    “Although research has demonstrated that curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects, further research is necessary to conclusively state curcumin’s ability at ameliorating cognitive function in humans [146,162,169].”

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Authors
Parachikova, A., Green, K. N., Hendrix, C., & LaFerla, F. M.
Affiliations
University of California, Irvine (US)
Corresponding author
LaFerla, Frank M.
Venue
PLoS ONE
Published
2010-11-17
Volume
5
Issue
11
Pages
e14015
ISSN
1932-6203 (ISSN-L)
OpenAlex
W1998037561
Cited by
87
References
38
Citations by year
2024: 3 · 2023: 3 · 2022: 2 · 2021: 3 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 14 · 2012: 14
FWCI
8.44
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
  • Small Business Innovation Research
  • National Institutes of Health
  • National Institute on Aging (AG-021982, R01AG021982)
  • National Center for Complementary and Integrative Health (R43AT003025)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, dietary supplements, curcumin, piperine, epigallocatechin gallate, alpha-lipoic acid, N-acetylcysteine, B vitamins, vitamin C, folic acid, Tg2576 mice, amyloid-beta, amyloid-beta oligomers, learning and memory, hippocampus, cortical learning, cognitive function, neuropathology
MeSH terms
Acetylcysteine, Alkaloids, Alzheimer Disease, Animals, Ascorbic Acid, Brain, Catechin, Cerebral Cortex, Cognition, Curcumin, Folic Acid, Hippocampus, Humans, Thioctic Acid, Memory, Mice, Inbred C57BL, Mice, Inbred Strains, Mice, Transgenic, Piperidines, Vitamin B Complex, Vitamins, Immunoblotting, Amyloid beta-Protein Precursor, Maze Learning, Dietary Supplements, Mice, Benzodioxoles, Polyunsaturated Alkamides

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