A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210 · see citing works

Oxidative Damage Is the Earliest Event in Alzheimer Disease

Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885 · see citing works

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works

Mitochondrial abnormalities in Alzheimer's disease

Hirai, K., Aliev, G., Nunomura, A., Fujioka, H., Russell, R. L., Atwood, C. S., Johnson, A. B., Kress, Y., Vinters, H. V., Tabaton, M., et al. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-09-03017.2001 · Cited by 1,367 · see citing works

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S., & Perry, G. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02653.1997 · Cited by 1,239 · see citing works

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224 · see citing works

A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

Cao, X., & Südhof, T. C. (2001) · Science · doi:10.1126/science.1058783 · Cited by 1,202 · see citing works

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104 · see citing works

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

Cho, D.-H., Nakamura, T., Fang, J., Cieplak, P., Godzik, A., Gu, Z., & Lipton, S. A. (2009) · Science · doi:10.1126/science.1171091 · Cited by 1,092 · see citing works

Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

Blalock, E. M., Geddes, J. W., Chen, K. C., Porter, N. M., Markesbery, W. R., & Landfield, P. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308512100 · Cited by 1,025 · see citing works

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia

Reiman, E. M., Chen, K., Alexander, G. E., Caselli, R. J., Bandy, D., Osborne, D., Saunders, A. M., & Hardy, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2635903100 · Cited by 977 · see citing works

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

Yao, J., Irwin, R. W., Zhao, L., Nilsen, J., Hamilton, R. T., & Brinton, R. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903563106 · Cited by 940 · see citing works

Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Wang, X., Su, B., Siedlak, S. L., Moreira, P. I., Fujioka, H., Wang, Y., Casadesus, G., & Zhu, X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804871105 · Cited by 835 · see citing works

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

Praticò, D., Uryu, K., Leight, S., Trojanoswki, J. Q., & Lee, V. M.-Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04183.2001 · Cited by 777 · see citing works

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

Nunomura, A., Perry, G., Pappolla, M., Wade, R., Hirai, K., Chiba, S., & Smith, M. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-06-01959.1999 · Cited by 768 · see citing works

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

Turner, P. R., O’Connor, K., Tate, W. P., & Abraham, W. C. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00089-3 · Cited by 751 · see citing works

Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

Kruman, I. I., Bruce‐Keller, A. J., Bredesen, D. E., Waeg, G., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05089.1997 · Cited by 719 · see citing works

The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

Hansson Petersen, C. A., Alikhani, N., Behbahani, H., Wiehager, B., Pavlov, P. F., Alafuzoff, I., Leinonen, V., Ito, A., Winblad, B., Glaser, E., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806192105 · Cited by 693 · see citing works

Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species

Starkov, A. A., Fiskum, G. M., Chinopoulos, C., Lorenzo, B. J., Browne, S. E., Patel, M. S., & Beal, M. F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1899-04.2004 · Cited by 692 · see citing works

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

Rhein, V., Song, X., Wiesner, A., Ittner, L. M., Baysang, G., Meier, F., Ozmen, L., Bluethmann, H., Dröse, S., Brandt, U., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905529106 · Cited by 655 · see citing works

Prediction of cognitive decline in normal elderly subjects with 2-[ ¹⁸ F]fluoro-2-deoxy- <scp>d</scp> -glucose/positron-emission tomography (FDG/PET)

de Leon, M. J., Convit, A., Wolf, O. T., Tarshish, C. Y., DeSanti, S., Rusinek, H., Tsui, W., Kandil, E., Scherer, A. J., Roche, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191044198 · Cited by 629 · see citing works

Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications

Bubber, P., Haroutunian, V., Fisch, G., Blass, J. P., & Gibson, G. E. (2005) · Annals of Neurology · doi:10.1002/ana.20474 · Cited by 622 · see citing works

Mild cognitive impairment

Chételat, G., Desgranges, B., Sayette, V. D. L., Viader, F., Eustache, F., & Baron, J. (2003) · Neurology · doi:10.1212/01.wnl.0000055847.17752.e6 · Cited by 604 · see citing works

Increase of Brain Oxidative Stress in Mild Cognitive Impairment

Praticò, D., Clark, C. M., Liun, F., Lee, V., & Trojanowski, J. Q. (2002) · Archives of Neurology · doi:10.1001/archneur.59.6.972 · Cited by 587 · see citing works

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

Liang, W. S., Reiman, E. M., Valla, J., Dunckley, T., Beach, T. G., Grover, A., Niedzielko, T. L., Schneider, L. E., Mastroeni, D., Caselli, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709259105 · Cited by 585 · see citing works

Caspase activation precedes and leads to tangles

de Calignon, A., Fox, L. M., Pitstick, R., Carlson, G. A., Bacskai, B. J., Spires-Jones, T. L., & Hyman, B. T. (2010) · Nature · doi:10.1038/nature08890 · Cited by 517 · see citing works

Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease

Karuppagounder, S. S., Pinto, J. T., Xu, H., Chen, H., Beal, M. F., & Gibson, G. E. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.10.008 · Cited by 488 · see citing works

β‐Amyloid inhibits integrated mitochondrial respiration and key enzyme activities

Casley, C. S., Canevari, L., Land, J. M., Clark, J. B., & Sharpe, M. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00681.x · Cited by 485 · see citing works

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

Hauptmann, S., Scherping, I., Dröse, S., Brandt, U., Schulz, K. L., Jendrach, M., Leuner, K., Eckert, A., & Müller, W. E. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.005 · Cited by 469 · see citing works

Calcium signaling and neurodegenerative diseases

Борисович, Б. И. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.01.001 · Cited by 467 · see citing works

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

Liu, F., Shi, J., Tanimukai, H., Gu, J., Gu, J., Grundke-Iqbal, I., Iqbal, K., & Gong, C.-X. (2009) · Brain · doi:10.1093/brain/awp099 · Cited by 439 · see citing works

Differential Expression of Oxidative Phosphorylation Genes in Patients With Alzheimer's Disease: Implications for Early Mitochondrial Dysfunction and Oxidative Damage

Mańczak, M., Park, B. S., Jung, Y., & Reddy, P. H. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:2:147 · Cited by 432 · see citing works

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

Gibson, G. E., Sheu, K. ‐. R., Blass, J. P., Baker, A., Carlson, K., Harding, B. N., & Perrino, P. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520320022009 · Cited by 425 · see citing works

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

O’Connor, T., Sadleir, K. R., Maus, E., Velliquette, R. A., Zhao, J., Cole, S. L., Eimer, W. A., Hitt, B. D., Bembinster, L. A., Lammich, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.047 · Cited by 422 · see citing works

Inhibition of PC12 cell redox activity is a specific,early indicator of the mechanism of beta-amyloid-mediated celldeath.

Shearman, M. S., RAGAN, C. I., & Iversen, L. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1470 · Cited by 411 · see citing works

Protein‐Bound Acrolein

Calingasan, N. Y., Uchida, K., & Gibson, G. E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720751.x · Cited by 400 · see citing works

Cloning and Expression of a Novel Mammalian Thioredoxin

Spyrou, G., Enmark, E., Miranda‐Vizuete, A., & Gustafsson, J.-Α. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2936 · Cited by 397 · see citing works

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

Área-Gómez, E., de Groof, A. J. C., Boldogh, I. R., Bird, T. D., Gibson, G. E., Koehler, C. M., Yu, W. H., Duff, K., Yaffe, M. P., Pon, L. A., et al. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090219 · Cited by 397 · see citing works

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

Liu, Y. M., Liu, F., Iqbal, K., Grundke, I., & Gong, C. (2008) · FEBS Letters · doi:10.1016/j.febslet.2007.12.035 · Cited by 396 · see citing works

Calcium and the aging nervous system

Gibson, G. E., & Peterson, C. (1987) · Neurobiology of Aging · doi:10.1016/0197-4580(87)90072-8 · Cited by 386 · see citing works

Oxidative stress increases expression and activity of BACE in NT2 neurons

Tamagno, E., Bardini, P., Obbili, A., Vitali, A., Borghi, R., Zaccheo, D., Pronzato, M. A., Danni, O., Smith, M. A., Perry, G., et al. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0515 · Cited by 385 · see citing works

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., & Yankner, B. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36875-8 · Cited by 373 · see citing works

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Melov, S., Adlard, P. A., Morten, K., Johnson, F., Golden, T. R., Hinerfeld, D., Schilling, B., Mavros, C., Masters, C. L., Volitakis, I., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000536 · Cited by 363 · see citing works

Hippocampal hypometabolism predicts cognitive decline from normal aging

Mosconi, L., De Santi, S., Li, J., Tsui, W. H., Li, Y., Boppana, M., Laska, E., Rusinek, H., & de Leon, M. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.12.008 · Cited by 360 · see citing works

Selective Inactivation of α-Ketoglutarate Dehydrogenase and Pyruvate Dehydrogenase: Reaction of Lipoic Acid with 4-Hydroxy-2-nonenal

Humphries, K. M., & Szweda, L. I. (1998) · Biochemistry · doi:10.1021/bi981512h · Cited by 357 · see citing works

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

Wang, X., Su, B., Fujioka, H., & Zhu, X. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.071208 · Cited by 341 · see citing works

Oxidative stress activates a positive feedback between the γ‐ and β‐secretase cleavages of the β‐amyloid precursor protein

Tamagno, E., Guglielmotto, M., Aragno, M., Borghi, R., Autelli, R., Giliberto, L., Muraca, G., Danni, O., Zhu, X., Smith, M. A., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05072.x · Cited by 338 · see citing works

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

Harris‐White, M. E., Hensley, K., Butterfield, D. A., Leedle, R. A., & Carney, J. M. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90041-1 · Cited by 331 · see citing works

Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease

Reddy, P. H., McWeeney, S. K., Park, B. S., Mańczak, M., Gutala, R. V., Partovi, D., Jung, Y., Yau, V., Searles, R. P., Mori, M., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh140 · Cited by 327 · see citing works

Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.

Ito, E., Oka, K., Etcheberrigaray, R., Nelson, T. J., McPhie, D. L., Tofel-Grehl, B., Gibson, G. E., & Alkon, D. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.534 · Cited by 317 · see citing works

What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?

Jagust, W. J., Reed, B., Mungas, D., Ellis, W. G., & DeCarli, C. S. (2007) · Neurology · doi:10.1212/01.wnl.0000269790.05105.16 · Cited by 299 · see citing works

Mitochondrial Approaches for Neuroprotection

Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works

PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease

Landreth, G. E., Jiang, Q., Mandrekar, S., & Heneka, M. T. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.05.003 · Cited by 277 · see citing works

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

Li, F., Calingasan, N. Y., Yu, F., Mauck, W. M., Toidze, M., Almeida, C. G., Takahashi, R. H., Carlson, G. A., Beal, M. F., Lin, M. T. S., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02455.x · Cited by 276 · see citing works

The Effects and Mechanisms of Mitochondrial Nutrient α-Lipoic Acid on Improving Age-Associated Mitochondrial and Cognitive Dysfunction: An Overview

Liu, J. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9403-0 · Cited by 268 · see citing works

Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity

Calabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Stella, A. M. G., Schapira, T., Dinkova‐Kostova, A. T., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9775-9 · Cited by 267 · see citing works

Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease

Planel, E., Miyasaka, T., Launey, T., Chui, D.-H., Tanemura, K., Sato, S., Murayama, O., Ishiguro, K., Tatebayashi, Y., & Takashima, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.5561-03.2004 · Cited by 261 · see citing works

Energy Inhibition Elevates β-Secretase Levels and Activity and Is Potentially Amyloidogenic in APP Transgenic Mice: Possible Early Events in Alzheimer's Disease Pathogenesis

Velliquette, R. A., O'Connor, T., & Vassar, R. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2350-05.2005 · Cited by 254 · see citing works

Inhibition of NADH-Linked Mitochondrial Respiration by 4-Hydroxy-2-nonenal

Humphries, K. M., Yoo, Y., & Szweda, L. I. (1998) · Biochemistry · doi:10.1021/bi971958i · Cited by 231 · see citing works

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease

Dumont, M., Wille, E., Stack, C., Calingasan, N. Y., Beal, M. F., & Lin, M. T. (2009) · The FASEB Journal · doi:10.1096/fj.09-132928 · Cited by 221 · see citing works

Oxidative stress potentiates BACE1 gene expression and A? generation

Tong, Y., Zhou, W., Fung, V., Christensen, M. A., Qing, H., Sun, X., & Song, W. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0255-3 · Cited by 219 · see citing works

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

Nathan, C., Calingasan, N., Nezezon, J., Ding, A., Lucia, M. S., La Perle, K., Fuortes, M., Lin, M., Ehrt, S., Kwon, N. S., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051529 · Cited by 214 · see citing works

Decreased thioredoxin and increased thioredoxin reductase levels in alzheimer’s disease brain

Lovell, M. A., Xie, C., Gabbita, S. P., & Markesbery, W. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00258-0 · Cited by 202 · see citing works

Alpha-lipoic acid as a new treatment option for Azheimer type dementia

Hager, K., Marahrens, A., Kenklies, M., Riederer, P., & Münch, G. (2001) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00104-2 · Cited by 188 · see citing works

Mitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype

Gibson, G. E., Haroutunian, V. H., Zhang, H., Park, L. C. H., Shi, Q., LESSER, M. L., Mohs, R. C., Sheu, R., & Blass, J. P. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200009)48:3 · Cited by 184 · see citing works

Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

Hinerfeld, D. A., Traini, M. D., Weinberger, R. P., Cochran, B. C., Doctrow, S. R., Harry, J. L., & Melov, S. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02195.x · Cited by 180 · see citing works

Presenilin-1 Mutation Increases Neuronal Vulnerability to Focal IschemiaIn Vivoand to Hypoxia and Glucose Deprivation in Cell Culture: Involvement of Perturbed Calcium Homeostasis

Mattson, M. P., Zhu, H., Yu, J., & Kindy, M. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01358.2000 · Cited by 172 · see citing works

A Novel Cell-permeable Antioxidant Peptide, SS31, Attenuates Ischemic Brain Injury by Down-regulating CD36

Cho, S., Szeto, H. H., Kim, E., Kim, H., Tolhurst, A. T., & Pinto, J. T. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609388200 · Cited by 170 · see citing works

Reversible Inactivation of α-Ketoglutarate Dehydrogenase in Response to Alterations in the Mitochondrial Glutathione Status

Nulton-Persson, A. C., Starke, D. W., Mieyal, J. J., & Szweda, L. I. (2003) · Biochemistry · doi:10.1021/bi027370f · Cited by 168 · see citing works

Enhanced caffeine‐induced Ca2+release in the 3xTg‐AD mouse model of Alzheimer's disease

Smith, I. F., Hitt, B. D., Green, K. N., Oddo, S., & LaFerla, F. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03332.x · Cited by 164 · see citing works

Altered Calcium Uptake in Cultured Skin Fibroblasts from Patients with Alzheimer's Disease

Peterson, C. M., Gibson, G. E., & Blass, J. P. (1985) · New England Journal of Medicine · doi:10.1056/nejm198504183121618 · Cited by 158 · see citing works

Oxidative Stress and Transcriptional Regulation in Alzheimer Disease

Shi, Q., & Gibson, G. E. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815721c3 · Cited by 156 · see citing works

Depolarization of In Situ Mitochondria Due to Hydrogen Peroxide‐Induced Oxidative Stress in Nerve Terminals

Chinopoulos, C., Tretter, L., & Ádám‐Vizi, V. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730220.x · Cited by 154 · see citing works

Lipid peroxidation in neurodegeneration: new insights into Alzheimerʼs disease

Arlt, S., Beisiegel†, U., & Kontush, A. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200206000-00009 · Cited by 151 · see citing works

Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease

Brooks, W. M., Lynch, P. J., Ingle, C. C., Hatton, A., Emson, P. C., Faull, R. L. M., & Starkey, M. (2006) · Brain Research · doi:10.1016/j.brainres.2006.09.106 · Cited by 148 · see citing works

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

Taylor, D. M., Maxwell, M. M., Luthi‐Carter, R., & Kazantsev, A. G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8357-y · Cited by 147 · see citing works

Calcium Responses in Fibroblasts from Asymptomatic Members of Alzheimer's Disease Families

Etcheberrigaray, R., Hirashima, N., Nee, L. E., Prince, J., Govoni, S. M., Racchi, M., Tanzi, R. E., & Alkon, D. L. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0176 · Cited by 142 · see citing works

Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model

Karuppagounder, S. S., Xu, H., Shi, Q., Chen, L. H., Pedrini, S., Pechman, D., Baker, H., Beal, M. F., Gandy, S., & Gibson, G. E. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.013 · Cited by 142 · see citing works

Metabolic Impairment Induces Oxidative Stress, Compromises Inflammatory Responses, and Inactivates a Key Mitochondrial Enzyme in Microglia

Park, L. C. H., Zhang, H., Sheu, K. R., Calingasan, N. Y., Kristal, B. S., LINDSAY, J. G., & Gibson, G. E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721948.x · Cited by 139 · see citing works

Mitochondrial targeting of quinones: Therapeutic implications

Cochemé, H. M., Kelso, G. F., James, A. M., Ross, M. F., Trnka, J., Mahendiran, T., Asin-Cayuela, J., Blaikie, F. H., Manas, A. B., Porteous, C. M., et al. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.02.007 · Cited by 138 · see citing works

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: Prevention by NGF and bFGF

Cheng, B., & Mattson, M. P. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90120-f · Cited by 137 · see citing works

Reversible Inhibition of α-Ketoglutarate Dehydrogenase by Hydrogen Peroxide: Glutathionylation and Protection of Lipoic Acid

Applegate, M. A. B., Humphries, K. M., & Szweda, L. I. (2007) · Biochemistry · doi:10.1021/bi7017464 · Cited by 137 · see citing works

Induction of Alzheimer Antigens by an Uncoupler of Oxidative Phosphorylation

Blass, J. P., Baker, A. C., Ko, L., & Black, R. S. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530080046009 · Cited by 137 · see citing works

Inactivation of the 2‐oxo acid dehydrogenase complexes upon generation of intrinsic radical species

Bunik, V. I., & Sievers, C. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03204.x · Cited by 134 · see citing works

Expression of β-Amyloid Induced Age-Dependent Presynaptic and Axonal Changes in Drosophila

Zhao, X.-L., Wang, W.-A., Tan, J.-X., Huang, J.-K., Zhang, X., Zhang, B.-Z., Wang, Y.-H., YangCheng, H.-Y., Zhu, H.-L., Sun, X.-J., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3699-09.2010 · Cited by 130 · see citing works

Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments

Fraser, S. P., Suh, Y.-H., & Djamgoz, M. B. A. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10079-5 · Cited by 123 · see citing works

Amyloid β-Peptide Promotes Permeability Transition Pore in Brain Mitochondria

Moreira, P. I., Santos, M. S., Moreno, A. J., & Oliveira, C. R. (2001) · Bioscience Reports · doi:10.1023/a:1015536808304 · Cited by 122 · see citing works

Oxidative α-Ketoglutarate Dehydrogenase Inhibition via Subtle Elevations in Monoamine Oxidase B Levels Results in Loss of Spare Respiratory Capacity

Kumar, M. J., Nicholls, D. G., & Andersen, J. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306378200 · Cited by 120 · see citing works

Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease

Iijima‐Ando, K., Hearn, S., Shenton, C., Gatt, A., Zhao, L., & Iijima, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008310 · Cited by 119 · see citing works

Evaluation of Dimebon in cellular model of Huntington's disease

Wu, J., Li, Q., & Борисович, Б. И. (2008) · Molecular Neurodegeneration · doi:10.1186/1750-1326-3-15 · Cited by 117 · see citing works

Acrolein inhibits NADH-linked mitochondrial enzyme activity: Implications for Alzheimer's disease

Pocernich, C. B., & Butterfield, D. A. (2003) · Neurotoxicity Research · doi:10.1007/bf03033161 · Cited by 113 · see citing works

Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3‐nitropropionic acid neurotoxicity

Klivènyi, P., Starkov, A. A., Calingasan, N. Y., Gardian, G., Browne, S. E., Yang, L., Bubber, P., Gibson, G. E., Patel, M. S., & Beal, M. F. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02263.x · Cited by 108 · see citing works

α-Ketoglutarate Dehydrogenase and Glutamate Dehydrogenase Work in Tandem To Modulate the Antioxidant α-Ketoglutarate during Oxidative Stress in Pseudomonas fluorescens

Mailloux, R. J., Singh, R., Brewer, G., Auger, C., Lemire, J. A., & Appanna, V. D. (2009) · Journal of Bacteriology · doi:10.1128/jb.00046-09 · Cited by 105 · see citing works

Effect of DL-α-lipoic acid on mitochondrial enzymes in aged rats

Palaniyappan, A., Ramanathan, K., & Panneerselvam, C. (2001) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(01)00268-x · Cited by 95 · see citing works

Hypoxia Increases ROS Signaling and Cytosolic Ca 2+ in Pulmonary Artery Smooth Muscle Cells of Mouse Lungs Slices

Desireddi, J., Farrow, K. N., Marks, J. D., Waypa, G. B., & Schumacker, P. T. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2862 · Cited by 88 · see citing works

Enhanced brain levels of 8,12- <i>iso</i> -iPF _2α -VI differentiate AD from frontotemporal dementia

Yao, Y., Zhukareva, V., Sung, S., Clark, C. M., Rokach, J., Lee, V. M.-Y., Trojanowski, J. Q., & Praticò, D. (2003) · Neurology · doi:10.1212/01.wnl.0000070185.02546.5d · Cited by 86 · see citing works

Preliminary Findings of High-Dose Thiamine in Dementia of Alzheimer's Type

Meador, K. J., Loring, D. W., Nichols, M., ZAMRINI, E. Y., Rivner, M. H., Posas, H. N., Thompson, E. E., & Moore, E. (1993) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879300600408 · Cited by 82 · see citing works

Intraneuronal amyloid β accumulation and oxidative damage to nucleic acids in Alzheimer disease

Nunomura, A., Tamaoki, T., Tanaka, K., Motohashi, N., Nakamura, M., Hayashi, T., Yamaguchi, H., Shimohama, S., Lee, H., Zhu, X., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.12.012 · Cited by 80 · see citing works

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

Ke, Z., & Gibson, G. E. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2003.09.008 · Cited by 80 · see citing works

Chronic exposure to sub‐lethal beta‐amyloid (Aβ) inhibits the import of nuclear‐encoded proteins to mitochondria in differentiated PC12 cells*

Sirk, D. P., Zhu, Z., Wadia, J. S., Shulyakova, N., Phan, N., Fong, J. C., & Mills, L. R. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04907.x · Cited by 78 · see citing works

Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition

Dumont, M., Ho, D. J., Calingasan, N. Y., Xu, H., Gibson, G. E., & Beal, M. F. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.008 · Cited by 74 · see citing works

Pathophysiological Roles of Amyloidogenic Carboxy-Terminal Fragments of the β-Amyloid Precursor Protein in Alzheimer’s Disease

Chang, K., & Suh, Y. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.cr0050014 · Cited by 71 · see citing works

Thiamine and Alzheimer's Disease

Blass, J. P. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520320019008 · Cited by 71 · see citing works

Mitochondria from Alzheimer's fibroblasts show decreased uptake of calcium and increased sensitivity to free radicals

Kumar, U., Dunlop, D. M., & Richardson, J. S. (1994) · Life Sciences · doi:10.1016/0024-3205(94)90142-2 · Cited by 69 · see citing works

Selective vulnerability of brain regions to oxidative stress in a non-coma model of insulin-induced hypoglycemia

Haces, M. L., Montiel, T., & Massieu, L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.10.003 · Cited by 67 · see citing works

Novel functions of the α-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease

Shi, Q., Xu, H., Kleinman, W. A., & Gibson, G. E. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.12.008 · Cited by 62 · see citing works

Mitochondrial Enzymes and Endoplasmic Reticulum Calcium Stores as Targets of Oxidative Stress in Neurodegenerative Diseases

Gibson, G. E., & Huang, H. (2004) · Journal of Bioenergetics and Biomembranes · doi:10.1023/b:jobb.0000041764.45552.f3 · Cited by 62 · see citing works

Inhibition of α‐ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase‐3 activation, and necrotic cell death

Huang, H.-M., Ou, H., Xu, H., Chen, H.-L., Fowler, C., & Gibson, G. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10756 · Cited by 61 · see citing works

Drugs Used to Treat Parkinsons Disease, Present Status and Future Directions

Abdel‐Salam, O. M. E. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708786441867 · Cited by 50 · see citing works

Oxidative stress increases internal calcium stores and reduces a key mitochondrial enzyme

Gibson, G. E., Zhang, H., Xu, H., Park, L. C. H., & Jeitner, T. M. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00091-6 · Cited by 49 · see citing works

Abnormalities in Alzheimer’s Disease Fibroblasts Bearing the APP670/671 Mutation

Gibson, G. E., Vestling, M., Zhang, H., Szolosi, S., Alkon, D. L., Lannfelt, L., Gandy, S., & Cowburn, R. F. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00149-8 · Cited by 46 · see citing works

Acidic Fibroblast Growth Factor Enhances Peroxynitrite-Induced Apoptosis in Primary Murine Fibroblasts

Shin, J. T., Barbeito, L., MacMillan-Crow, L. A., Beckman, J. S., & Thompson, J. A. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0479 · Cited by 44 · see citing works

Differential alterations in antioxidant capacity in cells from Alzheimer patients

Gibson, G. E., Zhang, H., Sheu, K.-F. R., & Park, L. C. H. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00057-0 · Cited by 44 · see citing works

Reduction in the E2k Subunit of the α-Ketoglutarate Dehydrogenase Complex Has Effects Independent of Complex Activity

Shi, Q., Chen, H., Xu, H., & Gibson, G. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409064200 · Cited by 38 · see citing works

Inactivation of 2-Oxoglutarate Dehydrogenase in Rat Liver Mitochondria by Its Substrate and t-Butyl Hydroperoxide

ROKUTAN, K., Kawai, K., & Asada, K. (1987) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a121926 · Cited by 36 · see citing works

α-KETO-ß-METHYL-n-VALERIC ACID DIMINISHES REACTIVE OXYGEN SPECIES AND ALTERS ENDOPLASMIC RETICULUM Ca2+ STORES

Huang, H., Zhang, H., Ou, H., et al. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.001 · Cited by 24 · see citing works

Catecholamines Enhance Dihydrolipoamide Dehydrogenase Inactivation by the Copper Fenton System. Enzyme Protection by Copper Chelators

Correa, J. G., & Stoppani, A. O. M. (1996) · Free Radical Research · doi:10.3109/10715769609088028 · Cited by 20 · see citing works

APP knockout attenuates microglial activation and enhances neuron survival in substantia nigra compacta after axotomy

Giorgio, L. A. D., Shimizu, Y., Chun, H. S., Cho, B., Sugama, S., JOH, T. H., & Volpe, B. T. (2002) · Glia · doi:10.1002/glia.10052 · Cited by 19 · see citing works

Amyloid precursor protein gene disruption attenuates degeneration of substantia nigra compacta neurons following axotomy

DeGiorgio, L. A., Shimizu, Y., Chun, H. S., Kim, Y.-S., Sugama, S., Son, J. H., JOH, T. H., & Volpe, B. T. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02483-6 · Cited by 18 · see citing works

Modification of endoplasmic reticulum Ca2+ stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer disease

Huang, H., Chen, H., Xu, H., & Gibson, G. E. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.05.017 · Cited by 18 · see citing works

Translocation of Amyloid Precursor Protein C-terminal Fragment(s) to the Nucleus Precedes Neuronal Death due to Thiamine Deficiency-induced Mild Impairment of Oxidative Metabolism

Karuppagounder, S. S., Xu, H., Pechman, D., Chen, L. H., DeGiorgio, L. A., & Gibson, G. E. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9594-z · Cited by 18 · see citing works

Inactivation of Mitochondrial Metabolism by Hyperoxia‐Induced Oxidative Stressa

Pruijn, F. B., Schoonen, W. G. E. J., & Joenje, H. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb38699.x · Cited by 17 · see citing works

Characterization of oxygen-resistant Chinese hamster ovary cells. III. Relative resistance of succinate and α-ketoglutarate dehydrogenases to hyperoxic inactivation

Schoonen, W. G. E. J., Wanamarta, A. H., Moorsel, J. M. V. D. K., Jakobs, C., & Joenje, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90004-m · Cited by 15 · see citing works

A New Approach to Treating Alzheimer's Disease

Blass, J. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.022 · Cited by 14 · see citing works

Protective Effect of α‐Keto‐β‐Methyl‐n‐Valeric Acid on BV‐2 Microglia under Hypoxia or Oxidative Stress

Huang, H., Ou, H., CHEN, H., Hou, R. C., & Jeng, K. C. G. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.049 · Cited by 9 · see citing works

5.2 Nitric Oxide in Regulation of Mitochondrial Function, Respiration, and Glycolysis

Bolaños, J. P., & Almeida, Á. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_18 · Cited by 8 · see citing works

5.3 Mitochondrial Production of Oxidants and Their Role in the Regulation of Cellular Processes

Brookes, P. S. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_19 · Cited by 7 · see citing works

4.3 Coupling of Neuronal Function to Oxygen and Glucose Metabolism Through Changes in Neurotransmitter Dynamics as Revealed with Aging, Hypoglycemia, and Hypoxia

Joseph, J. A., & Gibson, G. E. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_12 · Cited by 7 · see citing works

Mitochondrial dysfunction in neurodegenerative diseases and stroke: Neuroprotective strategies

Beal, M. F. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.008 · Cited by 5 · see citing works

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

Ke, Z. (2004) · Neurochemistry International · doi:10.1016/s0197-0186(03)00298-5 · Cited by 5 · see citing works

6.2 Mitochondrial-Endoplasmic Reticulum Interactions

Szabadkai, G., & Rizzuto, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_23 · Cited by 2 · see citing works

P4‐165: 3xTg‐AD mouse neurons show early oxidized redox state

Brewer, G. J., Kunz, E. A., Parihar, M. S., et al. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.2232 · Cited by 1 · see citing works

Treatment strategies for the cognitive deficits of Alzheimer's disease.

Kj, M. (1994) · PubMed · Cited by 1 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432 · see citing works

Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer’s Disease Risk Factors in Yeast

Treusch, S., Hamamichi, S., Goodman, J. L., Matlack, K. E. S., Chung, C. Y., Baru, V., Shulman, J. M., Parrado, A., Bevis, B. J., Valastyan, J. S., et al. (2011) · Science · doi:10.1126/science.1213210 · Cited by 379 · see citing works

Mitochondrial Dysfunction, Oxidative Stress, Neuroinflammation, and Metabolic Alterations in the Progression of Alzheimer's Disease: A Meta-Analysis of In Vivo Magnetic Resonance Spectroscopy Studies

Song, T., Song, X., Zhu, C., Patrick, R., Skurla, M., Santangelo, I., Green, M., Harper, D., Ren, B., Forester, B. P., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101503 · Cited by 346 · see citing works

VDAC1, mitochondrial dysfunction, and Alzheimer’s disease

Shoshan-Barmatz, V., Nahon-Crystal, E., Shteinfer-Kuzmine, A., & Gupta, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.03.010 · Cited by 286 · see citing works

Osteoblast-Derived Lipocalin-2 Regulated by miRNA-96-5p/Foxo1 Advances the Progression of Alzheimer’s Disease

Wu, B.-W., Guo, J.-D., Wu, M.-S., Liu, Y., Lu, M., Zhou, Y.-H., & Han, H.-W. (2020) · Epigenomics · doi:10.2217/epi-2019-0215 · Cited by 20 · see citing works

[Alzheimer's disease: cellular and molecular aspects].

Octave, J., & Pierrot, N. (2008) · PubMed · Cited by 8 · see citing works

Laboratory diagnostic tests for Alzheimer's disease.

Iqbal, K., Wang, G. P., Grundke, I., et al. (1989) · PubMed · Cited by 5 · see citing works

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.

Dickson, D. W., Farlo, J., Davies, P., Crystal, H., Fuld, P. A., & Yen, S. H. (1988) · PubMed Central · Cited by 383 · see citing works

Amyloid Beta Protein as a Marker or Risk Factor of Alzheimers Disease

Mehta, P. D. (2007) · Current Alzheimer Research · doi:10.2174/156720507781788891 · Cited by 30 · see citing works

Fibrous astrocytes in Alzheimer's disease and senile dementia of Alzheimer's type

Mancardi, G., Liwnicz, B. H., & Mandybur, T. I. (1983) · Acta Neuropathologica · doi:10.1007/bf00688390 · Cited by 88 · see citing works