Polyanhydrides: An overview
Abstract
Polyanhydrides have been considered to be useful biomaterials as carriers of drugs to various organs of the human body such as brain, bone, blood vessels, and eyes. They can be prepared easily from available, low cost resources and can be manipulated to meet desirable characteristics. Polyanhydrides are biocompatible and degrade in vivo into non-toxic diacid counterparts that are eliminated from the body as metabolites. Owing to their usefulness, this review focuses on the development, synthesis methods, structures and characterization of polyanhydrides, which will provide an overview for the researchers in the field. Their in vitro and in vivo degradability, toxicity, biocompatibility and applications are discussed in the subsequent chapters of this special issue on polyanhydrides and poly(ortho esters).
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Poly(amino acid)s have been reported to form nanovesicles after covalent conjugation with PEG and have demonstrated efficient biodegradability, biocompatibility, and pH sensitivity.
“These hydrophobic polymers have been reported to form nanovesicles after covalent conjugation with PEG. Moreover, they have demonstrated not only efficient biodegradability and biocompatibility [70] but also have pH sensitivity [71].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [70]
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- Authors
- Kumar, N., Langer, R. S., & Domb, A. J.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Domb, Abraham J
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2002-10
- Volume
- 54
- Issue
- 7
- Pages
- 889-910
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2124696441
- Cited by
- 394
- References
- 108
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 9 · 2023: 15 · 2022: 21 · 2021: 14 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 21 · 2015: 26 · 2014: 22 · 2013: 21 · 2012: 27
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- polyanhydrides, biodegradable polymers, drug delivery, biocompatibility, in vivo degradation, toxicity, polymer synthesis, poly(ortho esters), biomaterials
- MeSH terms
- Anhydrides, Animals, Drug Carriers, Humans, Polymers, Drug Delivery Systems
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