Effects of orexin-A on memory processing

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501 · see citing works

The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · see citing works

Neurons containing hypocretin (orexin) project to multiple neuronal systems

Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466 · see citing works

Narcolepsy in orexin Knockout Mice

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095 · see citing works

Differential expression of orexin receptors 1 and 2 in the rat brain

Marcus, J. N., Aschkenasi, C. J., Lee, C. E., Chemelli, R. M., Saper, C. B., Yanagisawa, M., & Elmquist, J. K. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1190 · Cited by 1,659 · see citing works

Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity

Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., Sugiyama, F., Yagami, K.-I., Goto, K., Yanagisawa, M., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00293-8 · Cited by 1,401 · see citing works

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268 · see citing works

Distribution of orexin neurons in the adult rat brain

Nambu, T., Sakurai, T., Mizukami, K., Hosoya, Y., Yanagisawa, M., & Goto, K. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01336-0 · Cited by 1,070 · see citing works

Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M., & Nakazato, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.2.748 · Cited by 1,050 · see citing works

Arousal effect of orexin A depends on activation of the histaminergic system

Huang, Z., Qu, W., Li, W., Mochizuki, T., Eguchi, N., Watanabe, T., Urade, Y., & Hayaishi, O. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181330998 · Cited by 555 · see citing works

Neurotransmitter receptors involved in post-training memory processing by the amygdala, medial septum, and hippocampus of the rat

Izquierdo, I., Cunha, C. D., Rosat, R. M., Jerusalinsky, D. A., Ferreira, M. B. C., & Medina, J. H. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90847-w · Cited by 395 · see citing works

The novel brain neuropeptide, orexin‐A, modulates the sleep–wake cycle of rats

Piper, D. C., Upton, N., Smith, M. I., & Hunter, A. J. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00919.x · Cited by 351 · see citing works

Cardiovascular regulatory actions of the hypocretins in brain

Samson, W. K., Gosnell, B. A., Chang, J.-K., Resch, Z. T., & Murphy, T. C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01457-2 · Cited by 294 · see citing works

Mushroom bodies of the cockroach: Their participation in place memory

Mizunami, M., Weibrecht, J. M., & Strausfeld, N. J. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981228)402:4 · Cited by 284 · see citing works

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

Brown, R. E., Sergeeva, O. A., Eriksson, K. S., & Haas, H. L. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00178-7 · Cited by 269 · see citing works

β-Amyloid precursor polypeptide in SAMP8 mice affects learning and memory

Morley, J. E., Kumar, V. B., Bernardo, A. E., Farr, S. A., Uezu, K., Tumosa, N., & Flood, J. F. (2000) · Peptides · doi:10.1016/s0196-9781(00)00342-9 · Cited by 219 · see citing works

Site-directed antisense oligonucleotide decreases the expression of amyloid precursor protein and reverses deficits in learning and memory in aged SAMP8 mice

Kumar, V. B., Farr, S. A., Flood, J. F., Kamlesh, V., Franko, M. W., Banks, W. A., & Morley, J. E. (2000) · Peptides · doi:10.1016/s0196-9781(00)00339-9 · Cited by 193 · see citing works

The molecular and genetic basis of AD: The end of the beginning

Rosenberg, R. N. (2000) · Neurology · doi:10.1212/wnl.54.11.2045 · Cited by 157 · see citing works

Modulation of memory processing by neuropeptide Y varies with brain injection site

Flood, J. F., Baker, M. L., Hernandez, E. N., & Morley, J. E. (1989) · Brain Research · doi:10.1016/0006-8993(89)91706-x · Cited by 149 · see citing works

Nicotine Up-Regulates Expression of Orexin and Its Receptors in Rat Brain

Kane, J. K., Parker, S. L., Matta, S. G., Fu, Y., Sharp, B. M., & Li, M. D. (2000) · Endocrinology · doi:10.1210/endo.141.10.7707 · Cited by 123 · see citing works

Neuropeptide Y in Central Control

Niimi, M., Sato, M., & Taminato, T. (2001) · Endocrine · doi:10.1385/endo:14:2:269 · Cited by 96 · see citing works

The Effect of Cholinergic, GABAergic, Serotonergic, and Glutamatergic Receptor Modulation on Posttrial Memory Processing in the Hippocampus

Farr, S. A., Flood, J. F., & Morley, J. E. (2000) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1999.3927 · Cited by 96 · see citing works

Antibody to Amyloid β Protein Alleviates Impaired Acquisition, Retention, and Memory Processing in SAMP8 Mice

Morley, J. E., Farr, S. A., & Flood, J. F. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4047 · Cited by 86 · see citing works

CNQX infused into rat hippocampus or amygdala disrupts the expression of memory of two different tasks

Izquierdo, I., Bianchin, M. M., Silva, M. B. E., Zanatta, M. S., Walz, R., Ruschel, A. C., da Silva, R. C., Paczko, N., & Medina, J. H. (1993) · Behavioral and Neural Biology · doi:10.1016/0163-1047(93)91061-q · Cited by 67 · see citing works

Septo-hippocampal drug interactions in post-trial memory processing

Farr, S. A., Uezu, K., Flood, J. F., & Morley, J. E. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02049-1 · Cited by 52 · see citing works

Age-related changes in hippocampal drug facilitation of memory processing in SAMP 8 Mice

Flood, J. F., Harris, F. J., & Morley, J. E. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02007-1 · Cited by 49 · see citing works

Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention

Farr, S. A., Banks, W. A., Scola, M. E. L., Flood, J. F., & Morley, J. E. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02495-1 · Cited by 48 · see citing works

Age-related changes in septal serotonergic, GABAergic and glutamatergic facilitation of retention in SAMP8 mice

Flood, J. F., Farr, S. A., Uezu, K., & Morley, J. E. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00098-0 · Cited by 45 · see citing works

Japanese siblings with missense mutation (717Val right arrow Ile) in amyloid precursor protein of early-onset Alzheimer's disease

Matsumura, Y., Kitamura, E., Miyoshi, K., Yamamoto, Y., Furuyama, J., & Sugihara, T. (1996) · Neurology · doi:10.1212/wnl.46.6.1721 · Cited by 21 · see citing works

The Amyloid .BETA. Protein Precursor Mutations Linked to Familial Alzheimer's Disease Alter Processing in a Way That Fosters Amyloid Deposition.

Younkin, S. G. (1994) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.174.217 · Cited by 20 · see citing works

Untitled work

Horvath (1999) · doi:10.1002/(sici)1096-9861(19991213)415:2

Obesity and Hypertriglyceridemia Produce Cognitive Impairment

Farr, S. A., Yamada, K. A., Butterfield, D. A., Abdul, H. M., Xu, L., Miller, N. E., Banks, W. A., & Morley, J. E. (2008) · Endocrinology · doi:10.1210/en.2007-1722 · Cited by 382 · see citing works

Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice

Mieda, M., Willie, J. T., Hara, J., Sinton, C. M., Sakurai, T., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400590101 · Cited by 341 · see citing works

The hypocretins/orexins: integrators of multiple physiological functions

Li, J., Hu, Z., & de Lecea, L. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12415 · Cited by 246 · see citing works

Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo

Wayner, M. J., Armstrong, D. L., Phelix, C. F., & Oomura, Y. (2004) · Peptides · doi:10.1016/j.peptides.2004.03.018 · Cited by 190 · see citing works

Hypocretin/Orexin Neurons Contribute to Hippocampus-Dependent Social Memory and Synaptic Plasticity in Mice

Yang, L., Zou, B., Xiong, X., Pascual, C., Xie, J., Malik, A., Xie, J., Sakurai, T., & Xie, X. (. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3200-12.2013 · Cited by 153 · see citing works

Ghrelin-induced feeding is dependent on nitric oxide

Gaskin, F. S., Farr, S. A., Banks, W. A., Kumar, V. B., & Morley, J. E. (2003) · Peptides · doi:10.1016/s0196-9781(03)00160-8 · Cited by 151 · see citing works

Orexin-A Infusion in the Locus Ceruleus Triggers Norepinephrine (NE) Release and NE-Induced Long-Term Potentiation in the Dentate Gyrus

Walling, S. G., Nutt, D. J., Lalies, M. D., & Harley, C. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1587-04.2004 · Cited by 134 · see citing works

Testing the Neurovascular Hypothesis of Alzheimer’s Disease: LRP-1 Antisense Reduces Blood-Brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

Jaeger, L. B., Dohgu, S., Hwang, M. C., Farr, S., Murphy, M. P., Fleegal-DeMotta, M. A., Lynch, J. L., Robinson, S., Niehoff, M., Johnson, S. N., et al. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1074 · Cited by 135 · see citing works

The waking brain: an update

Lin, J., Anaclet, C., Sergeeva, O. A., & Haas, H. L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0631-8 · Cited by 130 · see citing works

Neuropeptides Exert Neuroprotective Effects in Alzheimer's Disease

Chen, X., Du, Y., & Chen, L. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00493 · Cited by 131 · see citing works

Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task

Akbari, E., Naghdi, N., & Motamedi, F. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.028 · Cited by 123 · see citing works

Orexins/hypocretins cause sharp wave- and θ-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling

Selbach, O., Doreulee, N., Bohla, C., Eriksson, K. S., Sergeeva, O. A., Poelchen, W., Brown, R. E., & Haas, H. L. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.012 · Cited by 112 · see citing works

Lipids and Cognition

Morley, J. E., & Banks, W. A. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091576 · Cited by 108 · see citing works

Orexin Signaling Via the Orexin 1 Receptor Mediates Operant Responding for Food Reinforcement

Sharf, R., Sarhan, M., Brayton, C. E., Guarnieri, D. J., Taylor, J. R., & Dileone, R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.035 · Cited by 100 · see citing works

The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze

Akbari, E., Naghdi, N., & Motamedi, F. (2006) · Peptides · doi:10.1016/j.peptides.2006.11.002 · Cited by 99 · see citing works

Inflammation-sleep interface in brain disease: TNF, insulin, orexin

Clark, I. A., & Vissel, B. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-51 · Cited by 94 · see citing works

The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task

Akbari, E., Motamedi, F., Naghdi, N., & Noorbakhshnia, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.09.019 · Cited by 90 · see citing works

Orexins/hypocretins control bistability of hippocampal long‐term synaptic plasticity through co‐activation of multiple kinases

Selbach, O., Bohla, C., Barbara, A. B., Doreulee, N., Eriksson, K. S., Sergeeva, O. A., & Haas, H. L. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02021.x · Cited by 87 · see citing works

Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory

Beck, B., & Pourié, G. (2013) · Nutrition Reviews · doi:10.1111/nure.12045 · Cited by 86 · see citing works

Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention

Fadel, J. R., & Burk, J. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.046 · Cited by 84 · see citing works

The Hypocretin/Orexin System: An Increasingly Important Role in Neuropsychiatry

Chen, Q., de Lecea, L., Hu, Z., & Gao, D. (2014) · Medicinal Research Reviews · doi:10.1002/med.21326 · Cited by 84 · see citing works

High normal plasma triglycerides are associated with preserved cognitive function in Chinese oldest-old

Yin, Z., Shi, X., Kraus, V. B., Fitzgerald, S. M., Qian, H., Xu, J., Zhai, Y., Brasher, M. S., & Zeng, Y. (2012) · Age and Ageing · doi:10.1093/ageing/afs033 · Cited by 84 · see citing works

Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice

Mavanji, V., Butterick, T. A., Duffy, C. M., Nixon, J. P., Billington, C. J., & Kotz, C. M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.10.014 · Cited by 77 · see citing works

Orexin and Alzheimer’s Disease

Liguori, C. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_50 · Cited by 73 · see citing works

Orexin-A-induced ERK1/2 activation reverses impaired spatial learning and memory in pentylenetetrazol-kindled rats via OX1R-mediated hippocampal neurogenesis

Zhao, X., Zhang, R. X., Tang, S. H., Ren, Y. Y., Yang, W., Liu, X. M., & Tang, J. Y. (2013) · Peptides · doi:10.1016/j.peptides.2013.11.019 · Cited by 72 · see citing works

Orexin-A Exerts Neuroprotective Effects via OX1R in Parkinson’s Disease

Liu, M., Xue, Y., Liu, C., Liu, Y.-H., Diao, H., Wang, Y., Pan, Y.-P., & Chen, L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00835 · Cited by 72 · see citing works

Orexin‐A increases the firing activity of hippocampal CA1 neurons through orexin‐1 receptors

Chen, X., Chen, L., & Du, Y. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23975 · Cited by 59 · see citing works

Metabolic state signalling through central hypocretin/orexin neurons

Burdakov, D., & Alexopoulos, H. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00380.x · Cited by 57 · see citing works

Light as a modulator of emotion and cognition: Lessons learned from studying a diurnal rodent

Yan, L., Lonstein, J. S., & Núñez, A. A. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.09.003 · Cited by 55 · see citing works

Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant

Dietrich, H., & Jenck, F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1933-5 · Cited by 55 · see citing works

Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice

Banks, W. A., Morley, J. E., Farr, S. A., Price, T. O., Nuran Ercal, A., Vidaurre, I., & Schally, A. V. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016369107 · Cited by 56 · see citing works

The effect of orexin-A on motor and cognitive functions in a rat model of Parkinson’s disease

Hadadianpour, Z., Fatehi, F., Ayoobi, F., Kaeidi, A., Shamsizadeh, A., & Fatemi, I. (2017) · Neurological Research · doi:10.1080/01616412.2017.1352185 · Cited by 54 · see citing works

Synaptic plasticity modulation by circulating peptides and metaplasticity: Involvement in Alzheimer’s disease

Peineau, S., Rabiant, K., Pierrefiche, O., & Potier, B. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.018 · Cited by 53 · see citing works

Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems

Kaplan, G. B., Lakis, G. A., & Zhoba, H. B. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.05.006 · Cited by 54 · see citing works

Aging‐related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system

Stanley, E. M., & Fadel, J. R. (2011) · Synapse · doi:10.1002/syn.21533 · Cited by 49 · see citing works

Orexin-A-induced feeding is dependent on nitric oxide

Farr, S. A., Banks, W. A., Kumar, V. B., & Morley, J. E. (2005) · Peptides · doi:10.1016/j.peptides.2004.12.004 · Cited by 49 · see citing works

Nitric oxide is a central component in neuropeptide regulation of appetite

Morley, J. E., Farr, S. A., Sell, R. L., Hileman, S. M., & Banks, W. A. (2011) · Peptides · doi:10.1016/j.peptides.2010.12.015 · Cited by 49 · see citing works

Lesions of orexin neurons block conditioned place preference for sexual behavior in male rats

Sebastiano, A. R. D., Wilson, H., Lehman, M. N., & Coolen, L. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.09.006 · Cited by 47 · see citing works

The role of orexin in post-stroke inflammation, cognitive decline, and depression

Song, J., Kim, E., Kim, C. H., Song, H., & Lee, J. E. (2015) · Molecular Brain · doi:10.1186/s13041-015-0106-1 · Cited by 46 · see citing works

Role of the Orexin System on the Hypothalamus-Pituitary-Thyroid Axis

Messina, A., Fusco, C. D., Monda, V., Esposito, M., Moscatelli, F., Valenzano, A. A., Carotenuto, M., Viggiano, E., Chieffi, S., Luca, V. D., et al. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00066 · Cited by 44 · see citing works

Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice

Aitta‐aho, T., Pappa, E., Burdakov, D., & Apergis‐Schoute, J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.10.005 · Cited by 44 · see citing works

Orexins/hypocretins and aminergic systems

Eriksson, K. S., Sergeeva, O. A., Haas, H. L., & Selbach, O. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.02015.x · Cited by 41 · see citing works

Hippocampal orexin receptors inactivation reduces PTZ induced seizures of male rats

Goudarzi, E., Salmani, M. E., Lashkarbolouki, T., & Goudarzi, I. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.01.006 · Cited by 41 · see citing works

Intranasal insulin and orexins to treat age-related cognitive decline

Erichsen, J. M., Calva, C. B., Reagan, L. P., & Fadel, J. R. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113370 · Cited by 37 · see citing works

Orexins increase penicillin-induced epileptic activity

Kortunay, S., Erken, H. A., Erken, G., Genç, O., Şahiner, M., Turgut, S., & Turgut, G. (2012) · Peptides · doi:10.1016/j.peptides.2012.02.013 · Cited by 37 · see citing works

Cognitive Impairment

Joshi, S., & Morley, J. E. (2006) · Medical Clinics of North America · doi:10.1016/j.mcna.2006.05.014 · Cited by 38 · see citing works

Somatostatin receptor subtype-4 agonist NNC 26–9100 decreases extracellular and intracellular Aβ1–42 trimers

Sandoval, K. E., Farr, S. A., Banks, W. A., Crider, A. M., Morley, J. E., & WITT, K. A. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.03.020 · Cited by 35 · see citing works

Changes in hippocampal orexin 1 receptor expression involved in tooth pain-induced learning and memory impairment in rats

Raoof, R., Esmaeili‐Mahani, S., Abbasnejad, M., Raoof, M., Sheibani, V., Kooshki, R., Amirkhosravi, L., & Rafie, F. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.03.002 · Cited by 35 · see citing works

Unexpected expression of orexin-B in basal conditions and increased levels in the adult rat hippocampus during pilocarpine-induced epileptogenesis

Morales, A., Bonnet, C., Bourgoin, N., Touvier, T., Nadam, J., Laglaine, A., Navarro, F. P., Moulin, C., Georges, B., Péquignot, J.-M., et al. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.075 · Cited by 35 · see citing works

Decreased serum orexin A levels in drug-naive children with attention deficit and hyperactivity disorder

Baykal, S., Albayrak, Y., Durankuş, F., Güzel, S., Abbak, Ö., Potas, N., Beyazyüz, M., Karabekiroğlu, K., & Donma, M. M. (2019) · Neurological Sciences · doi:10.1007/s10072-018-3692-8 · Cited by 34 · see citing works

Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits

Zoeram, S. B., Salmani, M. E., Lashkarbolouki, T., & Goudarzi, I. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.009 · Cited by 33 · see citing works

Alzheimer’s Disease: Future Treatments

Morley, J. E. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.10.008 · Cited by 31 · see citing works

Feeding behaviors and ORXR–β-GABAAR subunit interactions in Carassius auratus

Facciolo, R. M., Crudo, M., Zizza, M., Giusi, G., & Canonaco, M. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.09.008 · Cited by 31 · see citing works

Waking with the hypothalamus

Haas, H. L., & Lin, J. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0996-4 · Cited by 29 · see citing works

International Union of Basic and Clinical Pharmacology CXIV: Orexin Receptor Function, Nomenclature and Pharmacology

Kukkonen, J. P., Jacobson, L. H., Hoyer, D., Rinne, M. K., & Borgland, S. L. (2024) · Pharmacological Reviews · doi:10.1124/pharmrev.123.000953 · Cited by 28 · see citing works

The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders

Moorman, D. E. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4871-2 · Cited by 29 · see citing works

Orexin A-induced enhancement of attentional processing in rats: role of basal forebrain neurons

Zajo, K. N., Fadel, J. R., & Burk, J. A. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4139-z · Cited by 29 · see citing works

Cerebrospinal fluid substance P concentrations are elevated in patients with Alzheimer's disease

Johansson, P., Almqvist, E. G., Wallin, A., Johansson, J.-O., Andréasson, U., Blennow, K., Zetterberg, H., & Svensson, J. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.10.006 · Cited by 30 · see citing works

Orexins cause epileptic activity

Erken, H. A., Erken, G., Genç, O., Kortunay, S., Şahiner, M., Turgut, G., & Turgut, S. (2012) · Peptides · doi:10.1016/j.peptides.2012.06.012 · Cited by 28 · see citing works

Orexin A induces bidirectional modulation of synaptic plasticity: Inhibiting long-term potentiation and preventing depotentiation

Lu, G., Lee, C.-H., & Chiou, L. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.03.005 · Cited by 28 · see citing works

Peptides and aging: Their role in anorexia and memory.

Morley, J. (2015) · Peptides · doi:10.1016/j.peptides.2015.04.007 · Cited by 24 · see citing works

Aging-related alterations in orexin/hypocretin modulation of septo-hippocampal amino acid neurotransmission

Stanley, E. M., & Fadel, J. R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.033 · Cited by 27 · see citing works

Biology of Neuropeptides: Orexinergic Involvement in Primary Headache Disorders

Holland, P. R. (2017) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13078 · Cited by 26 · see citing works

Orexin receptor activity in the basal forebrain alters performance on an olfactory discrimination task

Piantadosi, P. T., Holmes, A., Roberts, B. M., & Bailey, A. M. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.041 · Cited by 25 · see citing works

Role of orexin-A in experimental autoimmune encephalomyelitis

Fatemi, I., Shamsizadeh, A., Ayoobi, F., Taghipour, Z., Sanati, M. H., Roohbakhsh, A., & Motevalian, M. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.01.001 · Cited by 25 · see citing works

Hippocampal orexin receptors: Localization and function

Salmani, M. E., Sarfi, M., & Goudarzi, I. (2022) · Vitamins and hormones · doi:10.1016/bs.vh.2021.12.004 · Cited by 24 · see citing works

Orexin/hypocretin receptor 1 signaling mediates Pavlovian cue-food conditioning and extinction

Keefer, S. E., Cole, S., & Petrovich, G. D. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.042 · Cited by 24 · see citing works

Orexin 1 receptors in the anterior cingulate and orbitofrontal cortex regulate cost and benefit decision-making

Karimi, S., Hamidi, G. A., Fatahi, Z., & Haghparast, A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.006 · Cited by 23 · see citing works

The action of orexin B on passive avoidance learning. Involvement of neurotransmitters

Palotai, M., Telegdy, G., Ekwerike, A., & Jászberényi, M. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.016 · Cited by 22 · see citing works

The Mechanism and Characterization of Learning and Memory Impairment in Sleep-Deprived Mice

Xu, Z., Gao, C., Fang, C., Zhou, H., & Jiang, X. (2010) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-010-9098-8 · Cited by 21 · see citing works

Role of dorsal hippocampal orexin-1 receptors in memory restoration induced by morphine sensitization phenomenon

Alijanpour, S., Tirgar, F., & Zarrindast, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.023 · Cited by 20 · see citing works

The Relationships Between Components of Metabolic Syndrome and Mild Cognitive Impairment Subtypes: A Cross-Sectional Study of Japanese Older Adults

Bae, S., Shimada, H., Lee, S., Makizako, H., Lee, S., Harada, K., Doi, T., Tsutsumimoto, K., Hotta, R., Nakakubo, S., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161230 · Cited by 19 · see citing works

Chemogenetic activation of orexin/hypocretin neurons ameliorates aging-induced changes in behavior and energy expenditure

Stanojlović, M., Pallais, J. P., Mavanji, V., & Kotz, C. M. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2018 · Cited by 19 · see citing works

Spatial memory requires hypocretins to elevate medial entorhinal gamma oscillations

Liao, Y., Wen, R., Fu, S., Cheng, X., Ren, S., Lu, M., Qian, L., Luo, F., Wang, Y., Xiao, Q., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.10.012 · Cited by 18 · see citing works

Diurnal inhibition of NMDA‐EPSCs at rat hippocampal mossy fibre synapses through orexin‐2 receptors

Perin, M., Longordo, F., Massonnet, C., Welker, E., & Lüthi, A. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.272757 · Cited by 18 · see citing works

Hypocretin (Orexin) Replacement Therapies

Seigneur, E. M., & de Lecea, L. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100070 · Cited by 15 · see citing works

Research Paper: The Modulatory Role of Orexin 1 Receptor in CA1 on Orofacial Pain-induced Learning and Memory Deficits in Rats

Kooshki, R., Abbasnejad, M., Esmaeili‐Mahani, S., & Raoof, M. (2017) · Basic and Clinical Neuroscience Journal · doi:10.18869/nirp.bcn.8.3.213 · Cited by 15 · see citing works

Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism

Smagin, G. N., Song, D., Budac, D. P., Waller, J. A., Li, Y., Pehrson, A. L., & Sánchez, C. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.03.001 · Cited by 15 · see citing works

Orexin decreases mRNA expressions of NMDA and AMPA receptor subunits in rat primary neuron cultures

Yamada, N., Katsuura, G., Tatsuno, I., Asaki, T., Kawahara, S., Ebihara, K., Saitō, Y., & Nakao, K. (2008) · Peptides · doi:10.1016/j.peptides.2008.05.002 · Cited by 14 · see citing works

Sleep reduction: A link to other neurobiological diseases

Kumar, A., & Chanana, P. (2014) · Sleep and Biological Rhythms · doi:10.1111/sbr.12066 · Cited by 14 · see citing works

Involvement of orexin-2 receptors in the CA1 region of the hippocampus in the extinction and reinstatement of methamphetamine-induced conditioned place preference in the rats

Amirteymori, H., Veisi, A., Khaleghzadeh‐Ahangar, H., Mozafari, R., & Haghparast, A. (2022) · Peptides · doi:10.1016/j.peptides.2022.170926 · Cited by 13 · see citing works

The SAMP8 mouse as a model for Alzheimer disease: studies from Saint Louis University

Morley, J. E., Banks, W. A., Kumar, V. B., & Farr, S. A. (2003) · International Congress Series · doi:10.1016/s0531-5131(03)01562-0 · Cited by 13 · see citing works

K+ channels stimulated by glucose: a new energy-sensing pathway

Burdakov, D. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0189-8 · Cited by 13 · see citing works

Orexin A improves the cognitive impairment induced by chronic intermittent hypoxia in mice

Zhu, J., Tang, S., Zhao, D., Zeng, Z., Mo, H., & Hu, K. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.05.022 · Cited by 12 · see citing works

Effects of peptides, with emphasis on feeding, pain, and behavior

Yu, Y., Jawa, A., Pan, W., & Kastin, A. J. (2004) · Peptides · doi:10.1016/j.peptides.2004.09.015 · Cited by 12 · see citing works

The orexinergic system influences conditioned odor aversion learning in the rat: a theory on the processes and hypothesis on the circuit involved

Ferry, B. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00164 · Cited by 11 · see citing works

Orexin neuropeptides modulate the hippocampal-dependent memory through basolateral amygdala interconnections

Abounoori, M., Maddah, M. M., & Ardeshiri, M. R. (2021) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2021.100035 · Cited by 11 · see citing works

Increased training compensates for OX1R blockage-impairment of spatial memory and c-Fos expression in different cortical and subcortical areas

García‐Brito, S., Aldavert-Vera, L., Huguet, G., Álvarez-Monell, A., Kádár, E., & Segura-Torres, P. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.05.028 · Cited by 11 · see citing works

Orexin-1 receptor blockade differentially affects spatial and visual discrimination memory facilitation by intracranial self-stimulation

García‐Brito, S., Aldavert-Vera, L., Huguet, G., Kádár, E., & Segura-Torres, P. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107188 · Cited by 11 · see citing works

Orexin (hypocretin) mediates light‐dependent fluctuation of hippocampal function in a diurnal rodent

Soler, J. E., Xiong, H., Samad, F., Manfredsson, F. P., Robison, A. J., Núñez, A. A., & Yan, L. (2021) · Hippocampus · doi:10.1002/hipo.23376 · Cited by 9 · see citing works

Orexin-A aggravates the impairment of hippocampal neurons caused by intermittent hypoxemia by the OXR-PLCβ1-ERK1/2 pathway

Li, G., Tang, S. H., Chi, H., Huang, W., Lu, S., Lv, X., Liu, X., Li, Y., Wang, Y., & Tang, J. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000768 · Cited by 9 · see citing works

Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line

Koesema, E. J., & Kodadek, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188082 · Cited by 6 · see citing works

Hypothalamic orexins as possible therapeutic agents in threat and spatial memory disorders

Mazur, F., & Całka, J. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1228056 · Cited by 6 · see citing works

Blockade of dorsal hippocampal orexin-1 receptors impaired morphine-induced state-dependent learning

Farahmandfar, M., Kadivar, M., & Rastipisheh, S. (2016) · Neuropeptides · doi:10.1016/j.npep.2016.10.002 · Cited by 6 · see citing works

Orexin‐1 receptors in the rostral ventromedial medulla are involved in the modulation of capsaicin evoked pulpal nociception and impairment of learning and memory

Shahsavari, F., Abbasnejad, M., Esmaeili‐Mahani, S., & Raoof, M. (2018) · International Endodontic Journal · doi:10.1111/iej.12958 · Cited by 6 · see citing works

Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus

Loika, Y., Loiko, E., Feng, F., Stallard, E., Yashin, A. I., Arbeev, K. G., Kuipers, A. L., Feitosa, M. F., Province, M. A., & Kulminski, A. M. (2023) · Aging · doi:10.18632/aging.204665 · Cited by 5 · see citing works

Antiaging methods and medicines for the memory.

Banks, W., & Farr, S. (2004) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2004.02.007 · Cited by 5 · see citing works

Central hypocretin/orexin administration alleviates sleep/wake disturbances, anhedonia, and neuroinflammation in an animal model of seasonal affective disorder

Costello, A., Linning‐Duffy, K., Shi, J., Lonstein, J. S., & Yan, L. (2026) · Annals of Medicine · doi:10.1080/07853890.2025.2611202 · Cited by 4 · see citing works

Effects of Traumatic Brain Injury on the Orexin/Hypocretin System

Somach, R. T., Lim, M. M., & Cohen, A. S. (2025) · Neurotrauma Reports · doi:10.1089/neur.2024.0111 · Cited by 2 · see citing works

Effects of pre-training injection of orexin A into dorsal raphe nucleus in passive avoidance acquisition on male rats

Aghdam, A. S., Piri, E., Sarihi, A., Komaki‬, A., Shahidi, ‬., Hosseinipanah, S. M., Ghaderi, A., Rahimian, N., & Falah, N. (2012) · Procedia - Social and Behavioral Sciences · doi:10.1016/j.sbspro.2012.01.066 · Cited by 2 · see citing works

Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice

Mavanji, V., Butterick, T. A., Duffy, C. M., Nixon, J. P., Billington, C. J., & Kotz, C. M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.10.014 · Cited by 77 · see citing works

Multiple dose pharmacokinetics of sertraline in subjects with varying degrees of hepatic impairment

Wilner, K. D., Everson, G. T., Foulds, G. H., Hansen, R. A., Shrestra, R., Mckinley, C. R., & McClain, C. J. (1996) · European Neuropsychopharmacology · doi:10.1016/0924-977x(96)87485-2 · Cited by 4 · see citing works

Hypothalamic orexins as possible therapeutic agents in threat and spatial memory disorders

Mazur, F., & Całka, J. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1228056 · Cited by 6 · see citing works

The effect of orexin 1 and orexin 2 receptors antagonisms in the basolateral amygdala on memory processing in a passive avoidance task

Ardeshiri, M. R., Hosseinmardi, N., & Akbari, E. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.004 · Cited by 20 · see citing works

Antibody to Amyloid β Protein Alleviates Impaired Acquisition, Retention, and Memory Processing in SAMP8 Mice

Morley, J. E., Farr, S. A., & Flood, J. F. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2001.4047 · Cited by 86 · see citing works