Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory
Abstract
The hippocampus is a brain region of primary importance for neurogenesis, which occurs during early developmental states as well as during adulthood. Increases in neuronal proliferation and in neuronal death with age have been associated with drastic changes in memory and learning. Numerous neurotransmitters are involved in these processes, and some neuropeptides that mediate neurogenesis also modulate feeding behavior. Concomitantly, feeding peptides, which act primarily in the hypothalamus, are also present in the hippocampus. This review aims to ascertain the role of several important feeding peptides in cognitive functions, either through their local synthesis in the hippocampus or through their actions via specific receptors in the hippocampus. A link between neurogenesis and the orexigenic or anorexigenic properties of feeding peptides is discussed.
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Corticotropin-releasing hormone, growth-hormone-releasing hormone, galanin, and ghrelin function in hunger and satiety signaling.
“corticotropin-releasing hormone, growth-hormone-releasing hormone, galanin and ghrelin, some of which are expressed in both the stomach and the brain, function in hunger and satiety signaling [39].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [39]
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Hypothalamic MCH Neurons: From Feeding to Cognitive Control
Concetti, C., Peleg-Raibstein, D., & Burdakov, D. (2023) · Function · doi:10.1093/function/zqad059 · Cited by 28 · see citing works
- Authors
- Beck, B., & Pourié, G.
- Affiliations
- Inserm (FR)
- ORCID
- Pourié, Grégory
- Venue
- Nutrition Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-06-25
- Volume
- 71
- Issue
- 8
- Pages
- 541-561
- ISSN
- 0029-6643 (ISSN-L)
- OpenAlex
- W2164325958
- Cited by
- 86
- References
- 420
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 1
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Reviews (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- ghrelin, neuropeptide Y, hippocampus, neurogenesis, learning and memory, neuronal proliferation, neuronal cell death, aging, orexigenic peptides, anorexigenic peptides, hypothalamus, neuropeptide receptors, cognitive function
- MeSH terms
- Diet, Hippocampus, Humans, Learning, Memory, Neuropeptide Y, Neuropeptides, Ghrelin
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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