The DOI matches its Crossref record; 36 of the 42 references it cites were found in a registry or an index.
β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans
Abstract
While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28, 31, and 36 years. We encountered sparse beta-amyloid (A beta)-immunoreactive, silver-negative plaque-like structures in the brains of the three older apes. The 36-year-old orangutan also evidenced small A beta-positive deposits in subcortical white matter and sparse vascular amyloid deposition, primarily in meningeal vessels. Neurofibrillary tangles were not detected on silver stains or on tau or ubiquitin immunohistochemistry. Many of the A beta-positive plaque-like deposits in the orangutans were apolipoprotein E-immunoreactive, as we have previously reported in aged rhesus monkeys and an aged chimpanzee. Also, paralleling our earlier findings in these nonhuman primates, A beta 40 in plaques was more prominent in the orangutan than is typically seen in human aging, AD, and Down syndrome. These intriguing species differences may provide clues to the mechanisms of amyloid deposition and the development of neuropathologic changes in AD.
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“Great apes accumulate Aβ in the brain, resulting in the development of amyloid plaques and CAA in aged animals [43, 44, 78, 112, 113, 124].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [44]
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Cites
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Alzheimer's disease: experimental models and reality
Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810
The Marmoset as a Model of Aging and Age-Related Diseases
Tardif, S. D., Mansfield, K. G., Ratnam, R., Ross, C. N., & Ziegler, T. E. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.54 · Cited by 249
Sequencing the chimpanzee genome: insights into human evolution and disease
Olson, M. V., & Varki, A. P. (2002) · Nature Reviews Genetics · doi:10.1038/nrg981 · Cited by 240
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Animal models in the drug discovery pipeline for Alzheimer's disease
Dam, D. V., & Deyn, P. P. D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01299.x · Cited by 239
Metadata
- Authors
- Gearing, M., Tigges, J., Mori, H., & Mirra, S. S.
- Affiliations
- Emory University (US)
- Tokyo Institute of Psychiatry (JP)
- Corresponding author
- Mirra, S.S
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1997-03
- Volume
- 18
- Issue
- 2
- Pages
- 139-146
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2088004915
- Cited by
- 130
- References
- 42
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 11 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 3
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institutes of Health
- National Institute on Aging (P30AG010130, AG-10130, 2 P01-AG 00001, P01AG000001)
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta deposition, orangutans, aging, Alzheimer's disease, apolipoprotein E, Aβ40, vascular amyloid, neurofibrillary tangles, great apes, species differences, non-human primates, meningeal vessels
- MeSH terms
- Aging, Animals, Brain, Brain Chemistry, Cerebral Cortex, Coloring Agents, Female, Immunohistochemistry, Male, Pongo pygmaeus, Amyloid beta-Peptides, Neurofibrillary Tangles
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