β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Strittmatter, W. J., Saunders, A. M., Schmechel, D., Pericak-Vance, M., Enghild, J., Salvesen, G. S., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1977 · Cited by 4,268

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

Jarrett, J. T., & Lansbury, P. T. (1993) · Cell · doi:10.1016/0092-8674(93)90635-4 · Cited by 2,178

Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., & Ihara, Y. (1994) · Neuron · doi:10.1016/0896-6273(94)90458-8 · Cited by 1,774

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp 717 ) Mutants

Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., & Younkin, S. G. (1994) · Science · doi:10.1126/science.8191290 · Cited by 1,471

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

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Reduction of β‐amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease

Motter, R., Vigo‐Pelfrey, C., Kholodenko, D., Barbour, R., Johnson‐Wood, K., Galasko, D., Chang, L., Miller, B., Clark, C., Green, R., et al. (1995) · Annals of Neurology · doi:10.1002/ana.410380413 · Cited by 701

Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy

Greenberg, S. M., Rebeck, G. W., Vonsattel, J. P., Gómez‐Isla, T., & Hyman, B. T. (1995) · Annals of Neurology · doi:10.1002/ana.410380219 · Cited by 547

Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome

Iwatsubo, T., Mann, D. M. A., Odaka, A., Suzuki, N., & Ihara, Y. (1995) · Annals of Neurology · doi:10.1002/ana.410370305 · Cited by 386

Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.

Selkoe, D. J., Bell, D. S., Podlisny, M. B., Price, D. L., & Cork, L. C. (1987) · Science · doi:10.1126/science.3544219 · Cited by 377

Evidence that Aβ42 is the real culprit in alzheimer's disease

Younkin, S. G. (1995) · Annals of Neurology · doi:10.1002/ana.410370303 · Cited by 331

Genetics of the apolipoprotein E system in man.

Utermann, G., Langenbeck, U., Beisiegel†, U., & Weber, W. T. (1980) · Europe PMC (PubMed Central) · Cited by 264

Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide.

Maggio, J. E., Stimson, E. R., Ghilardi, J. R., Allen, C. J., Dahl, C. E., Whitcomb, D. C., Vigna, S. R., Vinters, H. V., Labenski, M. E., & Mantyh, P. W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5462 · Cited by 195

Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.

Gearing, M., Rebeck, G. W., Hyman, B. T., Tigges, J., & Mirra, S. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.20.9382 · Cited by 179

Gene trees and hominoid phylogeny.

Ruvolo, M., Pan, D., Zehr, S. M., Goldberg, T. L., Disotell, T. R., & von Dornum, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8900 · Cited by 172

APP717 missense mutation affects the ratio of amyloid beta protein species (A beta 1-42/43 and a beta 1-40) in familial Alzheimer's disease brain

Tamaoka, A., Odaka, A., Ishibashi, Y., Usami, M., Sahara, N., Suzuki, N., Nukina, N., Mizusawa, H., Shoji, S., & Kanazawa, I. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)30050-8 · Cited by 168

Diffuse Plaques Contain C-terminal Aβ42and not Aβ40: Evidence From Cats and Dogs

Cummings, B. J., Satou, T., Head, E., Milgram, N. W., Cole, G. M., Savage, M. J., Podlisny, M. B., Selkoe, D. J., Siman, R. G., Greenberg, B., et al. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00062-0 · Cited by 140

Molecular systematics of higher primates: genealogical relations and classification.

Miyamoto, M. M., Koop, B. F., Slightom, J. L., GOODMAN, M. H., & Tennant, M. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.20.7627 · Cited by 124

Aβ‐peptide length aid apolipoprotein E genotype in Alzheimer's disease

Gearing, M., Mori, H., & Mirra, S. S. (1996) · Annals of Neurology · doi:10.1002/ana.410390320 · Cited by 120

Aβ40 is a major form of β-amyloid in nonhuman primates

Gearing, M., Tigges, J., Mori, H., & Mirra, S. S. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)00164-9 · Cited by 115

Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.

Fukumoto, H., Asami-Odaka, A., Suzuki, N., Shimada, H., Ihara, Y., & Iwatsubo, T. (1996) · Europe PMC (PubMed Central) · Cited by 108

Biochemical Evidence for the Long-Tail Form (Aβ1-42/43) of Amyloid β Protein as a Seed Molecule in Cerebral Deposits of Alzheimer′s Disease

Tamaoka, A., Kondo, T., Odaka, A., Sahara, N., Sawamura, N., Ozawa, K., Suzuki, N., Shoji, S., & Mori, H. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2740 · Cited by 101

Aged Non‐Human Primates: An Animal Model of Age‐Associated Neurodegenerative Disease

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Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys.

Poduri, A., Gearing, M., Rebeck, G. W., Mirra, S. S., Tigges, J., & Hyman, B. T. (1994) · PubMed Central · Cited by 97

Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

Mak, K., Yang, F., Vinters, H. V., Frautschy, S. A., & Cole, G. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)91725-6 · Cited by 80

Amyloid β 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs

Wısnıewskı, T., Lalowski, M. M., Bobik, M., RUSSELL, M., Strosznajder, J. B., & Frangione, B. (1996) · Biochemical Journal · doi:10.1042/bj3130575 · Cited by 66

Carboxy terminal of β-amyloid deposits in aged human, canine, and polar bear brains

Tekirian, T. L., Cole, G. M., Russell, M. J., Yang, F., Weikstein, D. R., Patel, E., Snowdon, D. A., Markesbery, W. R., & Geddes, J. W. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02062-4 · Cited by 62

Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: Colocalization with amyloid plaques

Mufson, E. J., Benzing, W. C., Cole, G. M., Wang, H., Emerich, D. F., Sladek, J. R., Morrison, J. H., & Kordower, J. H. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00064-6 · Cited by 58

Elevated Aβ levels in Alzheimer's disease brain are associated with selective accumulation of Aβ42 in parenchymal amyloid plaques and both Aβ40 and Aβ42 in cerebrovascular deposits

Savage, M. J., Kawooya, J. K., Pinsker, L. R., Emmons, T. L., Mistretta, S., Siman, R. G., & Greenberg, B. (1995) · Amyloid · doi:10.3109/13506129508999005 · Cited by 33

Aging

Bowden, D. M., & Williams, D. D. (1984) · Advances in veterinary science and comparative medicine · doi:10.1016/b978-0-12-039228-5.50015-2 · Cited by 28

Plasma and hepatic apoE isoproteins of nonhuman primates. Differences in apoE among humans, apes, and New and Old World monkeys.

Zannis, V. I., Nicolosi, R. J., Jensen, E., Breslow, J. L., & Hayes, K. C. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34247-4 · Cited by 23

Nonhuman Primates I

(1993) · Monographs on pathology of laboratory animals · doi:10.1007/978-3-642-84906-0 · Cited by 23

530 Amyloid β protein (Aβ) deposition in normal aging has the same characteristics as that in Alzheimer's disease: Predominance of Aβ42(43) and association of Aβ40 with cored plaques and microglial cells

Fukumoto, H., Asami-Odaka, A., Suzuki, N., Shimada, H., Ihara, Y., & Iwatsubos, T. (1996) · Neurobiology of Aging · doi:10.1016/s0197-4580(96)80532-x · Cited by 19

Age-Related Lesions, Nervous System

Cork, L. C., & Walker, L. C. (1993) · Monographs on pathology of laboratory animals · doi:10.1007/978-3-642-84924-4_37 · Cited by 16

Alzheimer's disease: experimental models and reality

Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810

The Marmoset as a Model of Aging and Age-Related Diseases

Tardif, S. D., Mansfield, K. G., Ratnam, R., Ross, C. N., & Ziegler, T. E. (2011) · ILAR Journal · doi:10.1093/ilar.52.1.54 · Cited by 249

Sequencing the chimpanzee genome: insights into human evolution and disease

Olson, M. V., & Varki, A. P. (2002) · Nature Reviews Genetics · doi:10.1038/nrg981 · Cited by 240

Alzheimer's Disease Aβ Vaccine Reduces Central Nervous System Aβ Levels in a Non-Human Primate, the Caribbean Vervet

Lemere, C. A., Beierschmitt, A., Iglesias, M., Spooner, E. T., Bloom, J. K., Leverone, J. F., Zheng, J. B., Seabrook, T. J., Louard, D., Li, D., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63296-8 · Cited by 230

Animal models in the drug discovery pipeline for Alzheimer's disease

Dam, D. V., & Deyn, P. P. D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01299.x · Cited by 239

Aging brain lesions of a 60-year-old Bornean orangutan (Pongo pygmaeus)

Nakayama, Y., CHAMBERS, J. K., Kaori, O. T. A., Yamaguchi, A., Kosuke, T. O. D. A., Sato, S., Akane, K. A. T. O., KAMAKURA, Y., & UCHIDA, K. (2026) · Journal of Veterinary Medical Science · doi:10.1292/jvms.26-0270

Apolipoprotein E and beta amyloid (βA4) immunoreactive plaques in the aged monkey cortex

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Cerebral amyloid beta(42) deposits and microvascular pathology in ageing baboons

Ndung'u, M., Haertig, W., Wegner, F., Mwenda, J. M., Low, R. W. C., Akinyemi, R. O., & Kalaria, R. N. (2012) · Newcastle University ePrints (Newcastle Univesity) · doi:10.25405/ncl.34188591

Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: Colocalization with amyloid plaques

Mufson, E. J., Benzing, W. C., Cole, G. M., Wang, H., Emerich, D. F., Sladek, J. R., Morrison, J. H., & Kordower, J. H. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)00064-6 · Cited by 58

The Morphologic Features of βAmyloid Protein in the Rhesus Monkey Brains

Wang, J. (2010) · Zhongguo bijiao yixue zazhi