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Cited by 240Schizophrenia research and treatmentSubstance Abuse Treatment and OutcomesMental Health and Psychiatry

Substance use disorders in schizophrenia: review, integration, and a proposed model

Blanchard, J·2000·Clinical Psychology Review
DOI 10.1016/s0272-7358(99)00033-1
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Abstract

Substance use disorders occur in approximately 40 to 50% of individuals with schizophrenia. Clinically, substance use disorders are associated with a variety of negative outcomes in schizophrenia, including incarceration, homelessness, violence, and suicide. An understanding of the reasons for such high rates of substance use disorders may yield insights into the treatment of this comorbidity in schizophrenia. This review summarizes methodological and conceptual issues concerning the study of substance use disorders in schizophrenia and provides a review of the prevalence of this co-occurrence. Prevailing theories regarding the co-occurrence of schizophrenia and substance use disorders are reviewed. Little empirical support is found for models suggesting that schizophrenic symptoms lead to substance use (self-medication), that substance use leads to schizophrenia, or that there is a genetic relationship between schizophrenia and substance use. An integrative affect-regulation model incorporating individual differences in traits and responses to stress is proposed for future study.

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Crossref · 10.1016/s0272-7358(99)00033-1

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173 of 173 references verified0 citation errors · 0 not checkable

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  • Blanchard et al.'s model suggests that individuals with negative affectivity/neuroticism and disinhibition/impulsivity who also have difficulties applying effective coping methods are more at risk of using substances to cope with negative emotion under stress.

    “In their model, Blanchard et al. (30) suggest that individuals with certain personality traits (i.e., negative affectivity/neuroticism and disinhibition/impulsivity) who also show difficulties in applying effective coping methods (e.g., interpersonal problem-solving) are more at risk of using substances to cope with negative emotion when encountering important stresses.”

    From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [30]

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Authors
Blanchard, J.
Affiliations
University of New Mexico (US)
Corresponding author
Blanchard, J
ORCID
Blanchard, J
Venue
Clinical Psychology Review
Publisher
Elsevier BV
Published
2000-03
Volume
20
Issue
2
Pages
207-234
ISSN
0272-7358 (ISSN-L)
DOI
10.1016/s0272-7358(99)00033-1
OpenAlex
W2040936438
Cited by
240
References
169
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 4 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 15 · 2013: 15 · 2012: 11
FWCI
5.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Psychology Review (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH51240)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
substance use disorders, schizophrenia, comorbidities, self-medication, stress response, individual differences, genetic relatedness, prevalence, adverse outcomes, suicide, homelessness, incarceration
MeSH terms
Affect, Emotions, Humans, Models, Psychological, Schizophrenia, Comorbidity, Diagnosis, Dual (Psychiatry), Substance-Related Disorders

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