Cited by 212Xenotransplantation and immune responseGlycosylation and Glycoproteins ResearchOrgan and Tissue Transplantation Research

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The α-gal epitope (Galα1-3Galβ1-4GlcNAc-R) in xenotransplantation

Galili, Uri·2001·Biochimie

DOI 10.1016/s0300-9084(01)01294-9

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Abstract

Many patients with failing organs (e.g., heart, liver or kidneys), do not receive the needed organ because of an insufficient number of organ donors. Pig xenografts have been considered as an alternative source of organs for transplantation. The major obstacle currently known to prevent pig to human xenotransplantation is the interaction between the human natural anti-Gal antibody and the α-gal epitope (Galα1-3Galβ1-4GlcNAc-R), abundantly expressed on pig cells. This short review describes the characteristics of anti-Gal and of the alpha-gal epitope, their role in inducing xenograft rejection and some experimental approaches for preventing this rejection.

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Authors: Galili, U.
Affiliations: Rush University (US)
Corresponding author: Galili, Uri
ORCID: Galili, Uri
Venue: Biochimie
Publisher: Elsevier BV
Published: 2001-07
Volume: 83
Issue: 7
Pages: 557-563
ISSN: 0037-9042 (ISSN-L)
0300-9084
DOI: 10.1016/s0300-9084(01)01294-9
OpenAlex: W1987909360
Cited by: 212
References: 69
Citations by year: 2026: 5 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 5 · 2020: 15 · 2019: 8 · 2018: 5 · 2017: 8 · 2016: 9 · 2015: 4 · 2014: 14 · 2013: 9 · 2012: 9
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimie (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Xenotransplantation and immune response
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
Keywords: alpha-gal epitope, xenotransplantation, anti-Gal antibodies, xenograft rejection, organ shortage, rejection prevention, glycosylphosphatidylinositol
MeSH terms: Animals, Antibody-Dependent Cell Cytotoxicity, Carbohydrate Sequence, Galactosyltransferases, Graft Rejection, Humans, Immune Tolerance, Swine, T-Lymphocytes, Transplantation, Heterologous, Trisaccharides

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The α-gal epitope (Galα1-3Galβ1-4GlcNAc-R) in xenotransplantation

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