Time-dependent blockade of STP and LTP in hippocampal slices following acute stress in mice
Abstract
The characteristics of short-term potentiation (STP) and long-term potentiation (LTP) in the CA1 region of hippocampal slices were determined at various times following exposure to acute stress produced by restraint and tail-shock in mice. In slices prepared from control animals, theta-burst stimulation resulted in a large increase in evoked field excitatory postsynaptic potentials (EPSPs) amplitude and slope that remained stable at least up to 30 min after stimulation. Slices prepared 1 h after stress exhibited a marked decrease in the extent of both STP and LTP. STP and LTP magnitude were still significantly decreased 24 h after stress exposure and were completely restored to control levels by 48 h. These results provide evidence for a reversible impairment of STP and LTP in CA1 following an acute episode of stress, and suggest that stress activates processes different from those activated by LTP-inducing stimuli.
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Phase 2 can develop within minutes of the onset of a strong emotional experience, and may last from hours to days.
“In theory, phase 2 can develop within minutes of the onset of a strong emotional experience, and may last from hours to days (Garcia et al. [146]; Shors et al. [264]).”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Garcia et al. [146]
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- Authors
- Garcia, R., Musleh, W., Tocco, G., Thompson, R. F., & Baudry, M.
- Affiliations
- University of Southern California (US)
- ORCID
- Baudry, Michel
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 233
- Issue
- 1
- Pages
- 41-44
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2114385628
- Cited by
- 83
- References
- 2
- Citations by year
- 2025: 2 · 2023: 2 · 2021: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 52194)
- National Institute of Neurological Disorders and Stroke (NS18427, R01NS018427)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- short-term potentiation, long-term potentiation, acute stress, hippocampal CA1, theta burst stimulation, field excitatory postsynaptic potentials, restraint stress, tail shock
- MeSH terms
- Animals, Hippocampus, Male, Mice, Inbred C57BL, Synaptic Transmission, Stress, Physiological, Time Factors, Long-Term Potentiation, Mice
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