REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus

Davis, Christopher J.; Harding, Joseph W.; Wright, John W.

doi:10.1016/s0006-8993(03)02508-3

Cited by 115Sleep and Wakefulness ResearchMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus

Davis, Christopher J., Harding, Joseph W., Wright, John W.·2003·Brain Research

DOI 10.1016/s0006-8993(03)02508-3

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Abstract

Sleep loss adversely affects certain types of cognitive processing, particularly associative memory. Given that long-term potentiation (LTP) represents a putative cellular basis of learning and memory consolidation, the influence of sleep deprivation on LTP was examined. Rats were REM sleep deprived for 24, 48, or 72 h using the inverted flowerpot method in temperature-regulated chambers. Hippocampal slices taken from sleep-deprived rats were compared with home cage and pedestal control animals at 5, 15 and 60 min post-tetanization. The results indicated that at 5 min post-tetanization there were no differences in field potentials in any of the sleep-deprived or control groups, suggesting comparable levels of induction. However, analysis of latency-to-peak slope indicated that members of the 48 and 72 h sleep-deprived groups required approximately twice as long to achieve maximum slope as the 24 h group, home cage or 24, 48, 72 h pedestal controls (means 8.17, 7.50, 2.67, 4.67 and 3.17 min, respectively). At 15 min post-tetanization there were no group differences, however at 60 min post-tetanization the slopes of the field excitatory postsynaptic potentials were significantly diminished for the 24, 48 and 72 h sleep-deprived groups (means 30.44, -1.89, 1.47, respectively) as compared with home cage and pedestal controls (means 59.54, 58.42, respectively). This delay in maximal induction, and the degradation of the maintenance phase of LTP, may represent sleep deprivation-induced impairment of the underlying neurochemical mechanisms normally responsible for memory acquisition.

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Selective deprivation of REM sleep appears to be sufficient for producing an impairment in LTP induction.
“Selective deprivation of REM sleep appears to be sufficient for producing an impairment in LTP induction (269,270,596,636,743,970,1010).”
From About Sleep's Role in Memory (2013) · cites this paper as [269]

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,460 · see citing works
Synaptic Plasticity and Memory: An Evaluation of the Hypothesis
Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works
Sleep, learning, and dreams: off-line memory reprocessing
Stickgold, R., Hobson, J. A., Fosse, R., & Fosse, M. (2001) · Science · doi:10.1126/science.1063530 · Cited by 762 · see citing works
Visual discrimination learning requires sleep after training
Stickgold, R., James, L., & Hobson, J. A. (2000) · Nature Neuroscience · doi:10.1038/81756 · Cited by 715 · see citing works
Postsynaptic protein phosphorylation and LTP
Soderling, T. R., & Derkach, V. A. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01490-3 · Cited by 551 · see citing works
Sleep Enhances Plasticity in the Developing Visual Cortex
Frank, M. G., Issa, N. P., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00279-3 · Cited by 523 · see citing works
Behavioural stress facilitates the induction of long-term depression in the hippocampus
Xu, L., Anwyl, R., & Rowan, M. J. (1997) · Nature · doi:10.1038/387497a0 · Cited by 509 · see citing works
Sleep states and memory processes
Smith, C. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00024-n · Cited by 473 · see citing works
Behavioral stress impairs long-term potentiation in rodent hippocampus
Foy, M. R., Stanton, M. E., Levine, S., & Thompson, R. F. (1987) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(87)90664-9 · Cited by 436 · see citing works
Stress: metaplastic effects in the hippocampus
Kim, J. J., & Yoon, K. S. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01322-8 · Cited by 403 · see citing works
Sleeping brain, learning brain. The role of sleep for memory systems
Peigneux, P., Laureys, S., Delbeuck, X., & Maquet, P. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00001 · Cited by 347 · see citing works
Psychological stress impairs spatial working memory: Relevance to electrophysiological studies of hippocampal function.
Diamond, D. M., Fleshner, M., Ingersoll, N., & Rose, G. M. (1996) · Behavioral Neuroscience · doi:10.1037//0735-7044.110.4.661 · Cited by 340 · see citing works
Molecular genetic analysis of synaptic plasticity, activity-dependent neural development, learning, and memory in the mammalian brain
Chen, C., & Tonegawa, S. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.157 · Cited by 300 · see citing works
Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus<i>In Vitro</i>
Mesches, M. H., Fleshner, M., Heman, K. L., Rose, G. M., & Diamond, D. M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-j0004.1999 · Cited by 276 · see citing works
Memory: Organization and Locus of Change
(1992) · doi:10.1093/oso/9780195069211.001.0001 · Cited by 272 · see citing works
Hippocampal synaptic plasticity and NMDA receptors: a role in information storage?
Morris, R., Davis, S., & Butcher, S. P. (1990) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1990.0164 · Cited by 265 · see citing works
Opposing roles of type I and type II adrenal steroid receptors in hippocampal long-term potentiation
Pavlides, C., Watanabe, Y., Magarin˜os, A. M., & McEwen, B. S. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00151-8 · Cited by 261 · see citing works
Sleep deprivation in the rat by the disk-over-water method
Rechtschaffen, A., & Bergmann, B. M. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00020-t · Cited by 253 · see citing works
Sleep states, memory processes and synaptic plasticity
Smith, C. T. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00218-9 · Cited by 230 · see citing works
LONG-TERM POTENTIATION AND LEARNING
Martinez, J. L., & Derrick, B. E. (1996) · Annual Review of Psychology · doi:10.1146/annurev.psych.47.1.173 · Cited by 215 · see citing works
Evidence for a paradoxical sleep window for place learning in the Morris water maze
Smith, C., & Rose, G. M. (1996) · Physiology & Behavior · doi:10.1016/0031-9384(95)02054-3 · Cited by 211 · see citing works
Increased ACTH and corticosterone secretion induced by different methods of paradoxical sleep deprivation
Suchecki, D., Lobo, L. L., Hipólide, D. C., & Tufik, S. (1998) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1998.00122.x · Cited by 180 · see citing works
Sleep Deprivation Impairs Long-Term Potentiation in Rat Hippocampal Slices
Campbell, I. G., Guinan, M. J., & Horowitz, J. M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.2.1073 · Cited by 169 · see citing works
Synaptic plasticity in the hippocampus is modulated by behavioral state
Bramham, C. R., & Srebro, B. (1989) · Brain Research · doi:10.1016/0006-8993(89)91001-9 · Cited by 154 · see citing works
Functional consequences of sustained sleep deprivation in the rat
Everson, C. A. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00009-i · Cited by 151 · see citing works
Memory and the Brain: Unexpected Chemistries and a New Pharmacology
LYNCH, G. S. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3840 · Cited by 125 · see citing works
Rapid eye movement sleep deprivation modifies expression of long-term potentiation in visual cortex of immature rats.
Shaffery, J. P., Sinton, C. M., Bissette, G., Roffwarg, H. P., & Marks, G. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00589-9 · Cited by 114 · see citing works
The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro
Kramár, E. A., Armstrong, D. L., Ikeda, S., Wayner, M. J., Harding, J. W., & Wright, J. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02100-x · Cited by 103 · see citing works
Self-citation
Early handling increases hippocampal long-term potentiation in young rats
Wilson, D. A., Willner, J., Kurz, E. M., & Nadel, L. (1986) · Behavioural Brain Research · doi:10.1016/0166-4328(86)90240-8 · Cited by 101 · see citing works
Suppression of hippocampal synaptic plasticity during slow-wave sleep
Leonard, B. W., McNaughton, B. L., & Barnes, C. A. (1987) · Brain Research · doi:10.1016/0006-8993(87)90496-3 · Cited by 94 · see citing works
Time-dependent blockade of STP and LTP in hippocampal slices following acute stress in mice
Garcia, R., Musleh, W., Tocco, G., Thompson, R. F., & Baudry, M. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00621-6 · Cited by 83 · see citing works
STRESS-INDUCED SLEEP DEPRIVATION MODIFIES CORTICOTROPIN RELEASING FACTOR (CRF) LEVELS AND CRF BINDING IN RAT BRAIN AND PITUITARY
FADDA, P., & FRATTA, W. (1997) · Pharmacological Research · doi:10.1006/phrs.1997.0155 · Cited by 72 · see citing works
Parallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in water-deprived rats.
Maren, S., DeCola, J. P., Swain, R. A., Fanselow, M. S., & Thompson, R. F. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.1.44 · Cited by 63 · see citing works
Acute cold stress leading to elevated corticosterone neither enhances synaptic efficacy nor impairs LTP in the dentate gyrus of freely moving rats
Bramham, C. R., Southard, T. L., Ahlers, S. T., & Sarvey, J. M. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01265-1 · Cited by 54 · see citing works
Leitmotifs in the biochemistry of LTP induction: amplification, integration and coordination
Dineley, K. T., Weeber, E. J., Atkins, C. M., Adams, J. P., Anderson, A. E., & Sweatt, J. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00321.x · Cited by 50 · see citing works
Parallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in water-deprived rats
Maren, S., Decola, J., Swain, R. A., Fanselow, M., & Thompson, R. F. (1994) · Behavioral Neuroscience · doi:10.1037//0735-7044.108.1.44 · Cited by 45 · see citing works
Use of Brain Slices to Study Long-Term Potentiation and Depression as Examples of Synaptic Plasticity
Teyler, T. J. (1999) · Methods · doi:10.1006/meth.1999.0764 · Cited by 27 · see citing works
Untitled work
(1997) · doi:10.1002/(sici)1098-2396(199707)26:3

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About Sleep's Role in Memory
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783 · see citing works
“Selective deprivation of REM sleep appears to be sufficient for producing an impairment in LTP induction (269, 270, 596, 636, 743, 970, 1010).”
Background
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Sleep, memory, and plasticity
Walker, M. P., & Stickgold, R. (2006) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070307 · Cited by 1,075 · see citing works
Overnight therapy? The role of sleep in emotional brain processing
Walker, M. P., & van der Helm, E. (2009) · Psychological Bulletin · doi:10.1037/a0016570 · Cited by 1,087 · see citing works
A deficit in the ability to form new human memories without sleep
Yoo, S.-S., Hu, P. T., Gujar, N., Jolesz, F. A., & Walker, M. P. (2007) · Nature Neuroscience · doi:10.1038/nn1851 · Cited by 597 · see citing works
Sleep, Plasticity and Memory from Molecules to Whole-Brain Networks
Abel, T. G., Havekes, R., Saletin, J., & Walker, M. P. (2013) · Current Biology · doi:10.1016/j.cub.2013.07.025 · Cited by 551 · see citing works
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 549 · see citing works
The cognitive cost of sleep lost
McCoy, J. G., & Strecker, R. E. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.07.004 · Cited by 284 · see citing works
The role of protein synthesis in memory consolidation: Progress amid decades of debate
Hernandez, P. J., & Abel, T. G. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.09.010 · Cited by 264 · see citing works
Circadian regulation of hippocampal long-term potentiation
Chaudhury, D., Wang, L. M., & Colwell, C. S. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405276352 · Cited by 231 · see citing works
Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning
Hairston, I. S., Little, M. T. M., Scanlon, M. D., Barakat, M. T., Palmer, T. D., Sapolsky, R. M., & Heller, H. C. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00218.2005 · Cited by 223 · see citing works
Astrocyte-derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice
Florian, C., Vecsey, C. G., Halassa, M. M., Haydon, P., & Abel, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5761-10.2011 · Cited by 202 · see citing works
Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation
Tartar, J. L., Ward, C. P., McKenna, J. T., Thakkar, M., Arrigoni, E., McCarley, R. W., Brown, R. E., & Strecker, R. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04808.x · Cited by 206 · see citing works
Insufficient Sleep Reversibly Alters Bidirectional Synaptic Plasticity and NMDA Receptor Function
Kopp, C., Longordo, F., Nicholson, J. R., & Lüthi, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2702-06.2006 · Cited by 192 · see citing works
The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity
Havekes, R., Vecsey, C. G., & Abel, T. G. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.02.010 · Cited by 188 · see citing works
Sleep deprivation‐induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus
McDermott, C. M., Hardy, M. N., Bazan, N. G., & Magee, J. C. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093781 · Cited by 178 · see citing works
Cognitive neuroscience of sleep
Poe, G. R., Walsh, C. M., & Bjorness, T. E. (2010) · Progress in brain research · doi:10.1016/b978-0-444-53702-7.00001-4 · Cited by 174 · see citing works
Long-Term Potentiation at CA3–CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress
Kumar, A. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00007 · Cited by 169 · see citing works
Napping to renew learning capacity: enhanced encoding after stimulation of sleep slow oscillations
Antonenko, D., Diekelmann, S., Olsen, C., Jan Born, A., & Mölle, M. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12118 · Cited by 164 · see citing works
REM sleep and memory
Boyce, R., Williams, S., & Adamantidis, A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.05.001 · Cited by 161 · see citing works
Measures of Cortical Plasticity after Transcranial Paired Associative Stimulation Predict Changes in Electroencephalogram Slow-Wave Activity during Subsequent Sleep
Huber, R., Määttä, S., Esser, S. K., Sarasso, S., Ferrarelli, F., Watson, A., Ferreri, F., Peterson, M. J., & Tononi, G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1636-08.2008 · Cited by 147 · see citing works
The Role of Sleep in Memory Consolidation and Brain Plasticity: Dream or Reality?
Frank, M. G., & Benington, J. H. (2006) · The Neuroscientist · doi:10.1177/1073858406293552 · Cited by 143 · see citing works
Neurobiological Consequences of Sleep Deprivation
Alkadhi, K. A., Zagaar, M. A., Alhaider, I. A., Salim, S., & Aleisa, A. M. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311030001 · Cited by 121 · see citing works
REM sleep deprivation inhibits LTP in vivo in area CA1 of rat hippocampus
Kim, E. Y., Mahmoud, G. S., & Grover, L. M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.057 · Cited by 114 · see citing works
Sleep deprivation impairs hippocampus‐mediated contextual learning but not amygdala‐mediated cued learning in rats
Ruskin, D. N., Liu, C., Dunn, K. E., Bazan, N. G., & LaHoste, G. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03426.x · Cited by 107 · see citing works
The Function(s) of Sleep
Frank, M. G., & Heller, H. C. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_140 · Cited by 109 · see citing works
Selective rapid eye movement sleep deprivation impairs the maintenance of long‐term potentiation in the rat hippocampus
Ishikawa, A., Kanayama, Y., Matsumura, H., Tsuchimochi, H., Ishida, Y., & Nakamura, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04874.x · Cited by 100 · see citing works
Sleep: a synchrony of cell activity‐driven small network states
Krueger, J. M., Huang, Y. H., Rector, D. M., & Buysse, D. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12238 · Cited by 95 · see citing works
Distinct modulatory effects of sleep on the maintenance of hippocampal and medial prefrontal cortex LTP
Romcy‐Pereira, R., & Pavlides, C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03808.x · Cited by 95 · see citing works
Brain mechanisms that control sleep and waking
Siegel, J. (2004) · Die Naturwissenschaften · doi:10.1007/s00114-004-0541-9 · Cited by 81 · see citing works
Consolidative mechanisms of emotional processing in REM sleep and PTSD
Murkar, A., & Koninck, J. D. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.03.001 · Cited by 82 · see citing works
Paradoxical sleep deprivation impairs spatial learning and affects membrane excitability and mitochondrial protein in the hippocampus
Yang, R., Hu, S.-J., Wang, Y., Zhang, W., Luo, W., & Chen, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.033 · Cited by 80 · see citing works
Sleep and Synaptic Plasticity in the Developing and Adult Brain
Frank, M. G. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_305 · Cited by 78 · see citing works
Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress
Grønli, J., Soule, J. D., & Bramham, C. R. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00224 · Cited by 76 · see citing works
Memory processes during sleep: beyond the standard consolidation theory
Axmacher, N., Draguhn, A., Elger, C. E., & Fell, J. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0019-1 · Cited by 73 · see citing works
Sleep deprivation induces differential morphological changes in the hippocampus and prefrontal cortex in young and old rats
Acosta-Peña, E., Camacho‐Abrego, I., Melgarejo-Gutiérrez, M. A., Flores, G., Drucker-Colı́n, R., & García‐García, F. (2014) · Synapse · doi:10.1002/syn.21779 · Cited by 72 · see citing works
Rapid eye movement sleep deprivation decreases long-term potentiation stability and affects some glutamatergic signaling proteins during hippocampal development
Lopez, J., Roffwarg, H. P., Dreher, A., Bissette, G., Karolewicz, B., & Shaffery, J. P. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.072 · Cited by 71 · see citing works
Experience-dependent changes in NMDA receptor composition at mature central synapses
Kopp, C., Longordo, F., & Lüthi, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.03.014 · Cited by 69 · see citing works
Antidepressant Suppression of Non-REM Sleep Spindles and REM Sleep Impairs Hippocampus-Dependent Learning While Augmenting Striatum-Dependent Learning
Watts, A., Gritton, H. J., Sweigart, J., & Poe, G. R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0170-12.2012 · Cited by 68 · see citing works
The effects of long-term sleep deprivation on the long-term potentiation in the dentate gyrus and brain oxidation status in rats
Süer, C., Dolu, N., Artis, A. S., Sahin, L., Yilmaz, A., & Cetin, A. (2011) · Neuroscience Research · doi:10.1016/j.neures.2011.01.008 · Cited by 66 · see citing works
Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain
Lyons, L. C., Vanrobaeys, Y. S., & Abel, T. G. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15787 · Cited by 62 · see citing works
REM sleep enhancement induced by different procedures improves memory retention in rats
Wetzel, W., Wagner, T., & Balschun, D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02890.x · Cited by 58 · see citing works
Neurotoxic Saboteurs: Straws that Break the Hippo’s (Hippocampus) Back Drive Cognitive Impairment and Alzheimer’s Disease
Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9407-2 · Cited by 55 · see citing works
Eliminating the adrenal stress response does not affect sleep deprivation-induced acquisition deficits in the water maze
Ruskin, D. N., Dunn, K. E., Billiot, I., Bazan, N. G., & LaHoste, G. J. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.11.003 · Cited by 53 · see citing works
Spatial and reversal learning in the Morris water maze are largely resistant to six hours of REM sleep deprivation following trainingPreprint
Walsh, C. M., Booth, V., & Poe, G. R. (2011) · Learning & Memory · doi:10.1101/lm.2099011 · Cited by 53 · see citing works
Instantaneous acceleration and amplification of hippocampal theta wave coincident with phasic pontine activities during REM sleep
Karashima, A., Nakao, M., Katayama, N., & Honda, K. (2005) · Brain Research · doi:10.1016/j.brainres.2005.05.055 · Cited by 51 · see citing works
Effects of sleep disruption on rat dentate granule cell LTP in vivo
Marks, C. A., & Wayner, M. J. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.03.018 · Cited by 60 · see citing works
Dementia Risk in Posttraumatic Stress Disorder: the Relevance of Sleep-Related Abnormalities in Brain Structure, Amyloid, and Inflammation
Mohlenhoff, B. S., O’Donovan, A., Weiner, M. W., & Neylan, T. C. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0835-1 · Cited by 47 · see citing works
Effect of castration on the susceptibility of male rats to the sleep deprivation-induced impairment of behavioral and synaptic plasticity
Hajali, V., Sheibani, V., Ghazvini, H., Ghadiri, T., Valizadeh, T., Saadati, H., & Shabani, M. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.05.008 · Cited by 46 · see citing works
Sleep-Deprivation Induces Changes in GABAB and mGlu Receptor Expression and Has Consequences for Synaptic Long-Term Depression
Tadavarty, R., Rajput, P. S., Wong, J. M., Kumar, U., & Sastry, B. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024933 · Cited by 47 · see citing works
Fatigue reversibly reduced cortical and hippocampal dendritic spines concurrent with compromise of motor endurance and spatial memory
Chen, J., Wang, T., Huang, H., Chen, L.-J., Huang, Y.-S., Wang, Y.-J., & Tseng, G. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.022 · Cited by 45 · see citing works
Regular treadmill exercise prevents sleep deprivation-induced disruption of synaptic plasticity and associated signaling cascade in the dentate gyrus
Zagaar, M. A., Dao, A. T., Alhaider, I. A., & Alkadhi, K. A. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.07.011 · Cited by 45 · see citing works
Growth hormone rescues hippocampal synaptic function after sleep deprivation
Kim, E., Grover, L. M., Bertolotti, D., & Green, T. L. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00580.2009 · Cited by 44 · see citing works
Calcineurin contributes to spatial memory impairment induced by rapid eye movement sleep deprivation
Wang, G.-P., Huang, L., Wu, H., Zhang, L., You, Z.-D., & Zhao, Z. (2009) · Neuroreport · doi:10.1097/wnr.0b013e32832f0772 · Cited by 44 · see citing works
Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine
Tartar, J. L., McKenna, J. T., Ward, C. P., McCarley, R. W., Strecker, R. E., & Brown, R. E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.032 · Cited by 42 · see citing works
NR2A at CA1 Synapses Is Obligatory for the Susceptibility of Hippocampal Plasticity to Sleep Loss
Longordo, F., Kopp, C., Mishina, M., Luján, R., & Lüthi, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1215-09.2009 · Cited by 42 · see citing works
The compensatory effect of regular exercise on long-term memory impairment in sleep deprived female rats
Salari, M., Sheibani, V., Saadati, H., Pourrahimi, A. M., Khaksari, M., Esmaeelpour, K., & Khodamoradi, M. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.06.014 · Cited by 41 · see citing works
Prior regular exercise prevents synaptic plasticity impairment in sleep deprived female rats
Saadati, H., Sheibani, V., Esmaeili‐Mahani, S., Hajali, V., & Mazhari, S. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.09.009 · Cited by 37 · see citing works
Frontal cortical mitochondrial dysfunction and mitochondria-related β-amyloid accumulation by chronic sleep restriction in mice
Zhào, H., Wu, H., He, J., Zhuang, J., Liu, Z., Yang, Y., Huang, L., & Zhao, Z. (2016) · Neuroreport · doi:10.1097/wnr.0000000000000631 · Cited by 38 · see citing works
Long-term depression of excitatory synaptic transmission in rat hippocampal CA1 neurons following sleep-deprivation
Tadavarty, R., Kaan, T. K. Y., & Sastry, B. R. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.012 · Cited by 37 · see citing works
Pontine‐wave generator activation‐dependent memory processing of avoidance learning involves the dorsal hippocampus in the rat
Datta, S., Saha, S. G., Prutzman, S. L., Mullins, O. J., & Mavanji, V. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20501 · Cited by 37 · see citing works
REM sleep deprivation attenuates actin-binding protein cortactin: A link between sleep and hippocampal plasticity
Davis, C. J., Meighan, P. C., Taishi, P., Krueger, J. M., Harding, J. W., & Wright, J. W. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.02.046 · Cited by 36 · see citing works
Self-citation
The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models
Chen, P., Ban, W., Wang, W., You, Y., & Yang, Z. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5020022 · Cited by 35 · see citing works
Sleep‐deprivation and autobiographical memory: evidence from sleep‐deprived nurses
Khormizi, H. Z., Salehinejad, M. A., Nitsche, M. A., & Nejati, V. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12683 · Cited by 35 · see citing works
Experimental sleep fragmentation impairs spatial reference but not working memory in Fischer/Brown Norway rats
Ward, C. P., McCarley, R. W., & Strecker, R. E. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00714.x · Cited by 34 · see citing works
Sleep deprivation impairs spontaneous object-place but not novel-object recognition in rats
Ishikawa, H. A., Yamada, K., Pavlides, C., & Ichitani, Y. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.08.004 · Cited by 33 · see citing works
Intrahippocampal administration of anandamide increases REM sleep
Rueda‐Orozco, P. E., Gómez, E. S., Montes-Rodríguez, C. J., Pérez-Morales, M., & Prospero-Garcia, O. E. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.02.044 · Cited by 32 · see citing works
Reciprocal Interaction of Sleep and Synaptic Plasticity
Miyamoto, H. (2003) · Molecular Interventions · doi:10.1124/mi.3.7.404 · Cited by 30 · see citing works
Xylaria nigripes mitigates spatial memory impairment induced by rapid eye movement sleep deprivation.
Zhao, Z., Li, Y., Chen, H., Huang, L., Zhao, F., Yu, Q., Xiang, Z., & Zhao, Z. (2014) · Europe PMC (PubMed Central) · Cited by 28 · see citing works
Sleep deprivation impairs synaptic tagging in mouse hippocampal slices
Vecsey, C. G., Huang, T. T., & Abel, T. G. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.03.016 · Cited by 28 · see citing works
Effects of sleep deprivation on spatial learning and memory in juvenile and young adult rats.
Ward, C. P., Wooden, J. I., & Kieltyka, R. (2017) · Psychology & Neuroscience · doi:10.1037/pne0000075 · Cited by 25 · see citing works
Both Duration and Timing of Sleep are Important to Memory Consolidation
Poe, G. R., Walsh, C. M., & Bjorness, T. E. (2010) · SLEEP · doi:10.1093/sleep/33.10.1277 · Cited by 24 · see citing works
Effects of donepezil on cognitive performance after sleep deprivation
Dodds, C. M., Bullmore, E. T., Henson, R. N., Christensen, S. R., Miller, S. L., Smith, M. L., Dewit, O., Lawrence, P., & Nathan, P. J. (2011) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1248 · Cited by 24 · see citing works
Neuronal Models for Sleep-Wake Regulation and Synaptic Reorganization in the Sleeping Hippocampus
Best, J. A., Behn, C. D., Poe, G. R., & Booth, V. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407301239 · Cited by 24 · see citing works
Differential effects of duration of sleep fragmentation on spatial learning and synaptic plasticity in pubertal mice
Wallace, E. P., Kim, D. Y., Kim, K.-M., Chen, S., Braden, B. B., Williams, J. R., Jasso, K. R., Garcia, A., Rho, J. M., Bimonte‐Nelson, H. A., et al. (2015) · Brain Research · doi:10.1016/j.brainres.2015.04.037 · Cited by 23 · see citing works
The impact of sleep deprivation on hippocampal-mediated learning and memory in rats
Saygın, M., Özgüner, M., Onder, O. O., Doğuç, D. K., İlhan, İ., & Peker, Y. (2017) · Bratislavské lekárske listy/Bratislava medical journal · doi:10.4149/bll_2017_080 · Cited by 21 · see citing works
Long‐term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus
Arrigoni, E., Lu, J., Vetrivelan, R., & Saper, C. B. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07001.x · Cited by 21 · see citing works
Effects of sleep deprivation on cognitive functions
Zhang, N., & Liu, H.-T. (2008) · Neuroscience Bulletin · doi:10.1007/s12264-008-0910-z · Cited by 20 · see citing works
Anatomical correlates of rapid eye movement sleep-dependent plasticity in the developing cortex
Renouard, L., Bridi, M., Coleman, T., Arckens, L., & Frank, M. G. (2018) · SLEEP · doi:10.1093/sleep/zsy124 · Cited by 19 · see citing works
Synaptic plasticity along the sleep–wake cycle: Implications for epilepsy
Romcy-Pereira, R. N., Leite, J. P., & Garcia‐Cairasco, N. (2008) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2008.09.026 · Cited by 19 · see citing works
Low-frequency stimulation of the hippocampus following fear extinction impairs both restoration of rapid eye movement sleep and retrieval of extinction memory
Deschaux, O., Thevenet, A., Spennato, G., Arnaud, C., Moreau, J., & Garcia, R. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.067 · Cited by 16 · see citing works
Antidepressants that inhibit both serotonin and norepinephrine reuptake impair long-term potentiation in hippocampus
Cooke, J. D., Cavender, H. M., Lima, H. K., & Grover, L. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3587-1 · Cited by 17 · see citing works
Introduction to Pediatric Sleep Medicine
Sheldon, S. H. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9458-0.50006-4 · Cited by 16 · see citing works
Synapses tagged, memories kept: synaptic tagging and capture hypothesis in brain health and disease
Ibrahim, M. Z. B., Wang, Z., & Sajikumar, S. (2024) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2023.0237 · Cited by 16 · see citing works
Sleep and Cognition in Older Adults
Bruce, A. S., & Aloia, M. S. (2006) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2006.04.008 · Cited by 17 · see citing works
Sleep deprivation impairs recall of social transmission of food preference in rats
Ward, C. P., Wooden, J. I., Pido, J., Mathews, H. L., Kieltyka, R., & Montemayor, B. (2014) · Nature and Science of Sleep · doi:10.2147/nss.s68611 · Cited by 15 · see citing works
The beneficial effects of leptin on REM sleep deprivation-induced cognitive deficits in micePreprint
Chang, H.-F., Su, C.-L., Chang, C.-H., Chen, Y.-W., & Gean, P.-W. (2013) · Learning & Memory · doi:10.1101/lm.030775.113 · Cited by 12 · see citing works
REM Sleep Deprivation Alters Learning-Induced Cell Proliferation and Generation of Newborn Young Neurons in the Dentate Gyrus of the Dorsal Hippocampus
Tripathi, S., & Jha, S. K. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00465 · Cited by 10 · see citing works
The Involvement of PTEN in Sleep Deprivation-Induced Memory Impairment in Rats
Su, C.-L., Chen, C.-H., Lu, H.-Y., & Gean, P. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.001156 · Cited by 10 · see citing works
Declarative virtual water maze learning and emotional fear conditioning in primary insomnia
Kühn, M., Hertenstein, E., Feige, B., Landmann, N., Spiegelhalder, K., Baglioni, C., Hemmerling, J., Durand, D., Frase, L., Klöppel, S., et al. (2018) · Journal of Sleep Research · doi:10.1111/jsr.12693 · Cited by 9 · see citing works
Identification of a rapid eye movement sleep window for learning of the win-shift radial arm maze task for male Sprague-Dawley rats: Sleep duration and psychiatric disorders
LEGAULT, G., DELAY, S., & MADORE, A. (2010) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00842.x · Cited by 9 · see citing works
Functions and Circuits of REM Sleep
Gazea, M., Rio‐Bermudez, C. D., Nissen, C., & Adamantidis, A. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00017-7 · Cited by 5 · see citing works
Exogenous growth hormone administration during total sleep deprivation changed the microRNA-9 and dopamine D2 receptor expressions followed by improvement in the hippocampal synaptic potential, spatial cognition, and inflammation in rats
Arvin, P., Ghafouri, S., Bavarsad, K., Hajipour, S., Khoshnam, S. E., Mansouri, E., Sarkaki, A., & Farbood, Y. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06369-9 · Cited by 4 · see citing works
Sleep Impact on Perception, Memory, and Emotion in Adults and the Effects of Early-Life Experience
Lewin, M. P., Sullivan, R. M., & Wilson, D. A. (2019) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-813743-7.00039-6 · Cited by 4 · see citing works
Sleep and Brain Plasticity
Frank, M. G. (2019) · Springer eBooks · doi:10.1007/978-981-13-2814-5_5 · Cited by 4 · see citing works
Transcranial near-infrared therapy restores synaptic resilience by reshaping signaling landscapes in sleep-deprived tauopathy
Dong, Y., Wang, S., Liu, X., Song, Y., Song, Y., & Wang, Y. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00780 · Cited by 3 · see citing works
Rapid eye movements associated with REM sleep is involved in consolidation of visuospatial learning in rats
Mishra, Y., & Mallick, B. N. (2023) · Physiology & Behavior · doi:10.1016/j.physbeh.2023.114352 · Cited by 3 · see citing works
Sleep and memory: Elucidating the effects of sleep deprivation on different types of memory
Sarma, A., & Havekes, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00048-1 · Cited by 4 · see citing works
Long-term observation of absence of REM sleep caused by pontine cavernous hemangioma
Kagitani‐Shimono, K., Kato-Nishimura, K., Okinaga, T., Mohri, I., Tachibana, N., Ozono, K., & Taniike, M. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2011.09.002 · Cited by 3 · see citing works
SLEEP DEPRIVATION RESULTS IN DEPHOSPHORYLATION OF HIPPOCAMPAL AMPA RECEPTORS
Havekes, R., Novati, A., van der Zee, E. A., & Meerlo, P. (2007) · Cited by 3 · see citing works

Effect of sleep deprivation on space learning and memory and its mechanism of long-term potentiation in rats
Liu, G. (2006) · Di-san junyi daxue xuebao
Selective rapid eye movement sleep deprivation impairs the maintenance of long‐term potentiation in the rat hippocampus
Ishikawa, A., Kanayama, Y., Matsumura, H., Tsuchimochi, H., Ishida, Y., & Nakamura, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04874.x · Cited by 100 · see citing works
REM sleep deprivation inhibits LTP in vivo in area CA1 of rat hippocampus
Kim, E. Y., Mahmoud, G. S., & Grover, L. M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.057 · Cited by 114 · see citing works
Effects of sleep-deprivation on long-term depression of excitatory synaptic transmission in the ca1 region of the hippocampus
Tadavarty, R. (2012) · cIRcle (University of British Columbia) · doi:10.14288/1.0072600
Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory
Prince, T.-M., Wimmer, M., Choi, J., Havekes, R., Aton, S., & Abel, T. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.11.021 · Cited by 142 · see citing works

Authors: Davis, C. J., Harding, J. W., & Wright, J. W.
Affiliations: Washington State University (US)
Corresponding author: Wright, John W.
ORCID: Davis, Christopher J.
Wright, John W.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2003-05
Volume: 973
Issue: 2
Pages: 293-297
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/s0006-8993(03)02508-3
OpenAlex: W2001289346
Cited by: 115
References: 38
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2020: 1 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 1 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 4
FWCI: 3.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: REM sleep deprivation, long-term potentiation, hippocampal CA1, LTP maintenance, excitatory postsynaptic potentials, memory consolidation, sleep and memory
MeSH terms: Animals, Electric Stimulation, Electrophysiology, Female, Hippocampus, Sleep Deprivation, Time Factors, Rats, Sprague-Dawley, Long-Term Potentiation, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques

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REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus

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