Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

Boveris, A., & Chance, B. (1973) · Biochemical Journal · doi:10.1042/bj1340707 · Cited by 2,626 · see citing works

Aging, energy, and oxidative stress in neurodegenerative diseases

Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434 · see citing works

Brain cytochrome oxidase in Alzheimer's disease

Kish, S. J., Bergeron, C., Rajput, A., Dozic, S., Mastrogiacomo, F., Chang, L., Wilson, J. M., DiStefano, L. M., & Nobrega, J. N. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09439.x · Cited by 537 · see citing works

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

Mutisya, E. M., Bowling, A. C., & Beal, M. F. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63062179.x · Cited by 531 · see citing works

Electron transport chain defects in Alzheimer's disease brain

Parker, W. D., Parks, J. K., Filley, C. M., & Kleinschmidt-DeMasters, B. K. (1994) · Neurology · doi:10.1212/wnl.44.6.1090 · Cited by 495 · see citing works

Correlation of the kinetics of electron transfer activity of various eukaryotic cytochromes c with binding to mitochondrial cytochrome c oxidase.

Ferguson-Miller, S. M., Brautigan, D. L., & Margoliash, E. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33807-3 · Cited by 446 · see citing works

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., & Yankner, B. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36875-8 · Cited by 373 · see citing works

Are reactive oxygen species involved in Alzheimer's disease?

Benzi, G. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00066-n · Cited by 365 · see citing works

Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors.

Peterson, C., & Goldman, J. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2758 · Cited by 221 · see citing works

Impairment in mitochondrial cytochrome oxidase gene expression in Alzheimer disease.

Chandrasekaran, K., Giordano, T., Brady, D., Stoll, J., Martin, L. J., & Rapoport, S. (1994) · Brain Research. Molecular Brain Research · doi:10.1016/0169-328x(94)90147-3 · Cited by 221 · see citing works

Reduced platelet cytochrome c oxidase activity in Alzheimer's disease

Parker, W. D., Mahr, N., Filley, C. M., Parks, J. K., Hughes, D., Young, D. A., & Cullum, C. M. (1994) · Neurology · doi:10.1212/wnl.44.6.1086 · Cited by 199 · see citing works

The mitochondrial electron transfer alteration as a factor involved in the brain aging

Benzi, G. M., Pastoris, O., Marzatico, F., Villa, R. F., Dagani, F., & Curti, D. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90109-b · Cited by 135 · see citing works

Amyotrophic lateral sclerosis

Curti, D., Malaspina, A., Facchetti, G., Camana, C., Mazzini, L., Tosca, P., Zerbi, F., & Ceroni, M. (1996) · Neurology · doi:10.1212/wnl.47.4.1060 · Cited by 135 · see citing works

Altered metabolic properties of cultured skin fibroblasts in Alzheimer's disease

Sims, N. R., Finegan, J. M., & Blass, J. P. (1987) · Annals of Neurology · doi:10.1002/ana.410210507 · Cited by 123 · see citing works

Cytosol protein kinase C downregulation in fibroblasts from Alzheimer's disease patients

Govoni, S. M., Bergamaschi, S., Racchi, M., Battaini, F., Binetti, G. G., Bianchetti, A., & Trabucchi, M. (1993) · Neurology · doi:10.1212/wnl.43.12.2581 · Cited by 105 · see citing works

Mitochondrial involvement in schizophrenia and other functional psychoses

Whatley, S. A., Curti, D., & Marchbanks, R. M. (1996) · Neurochemical Research · doi:10.1007/bf02532409 · Cited by 103 · see citing works

Functional Alterations in Alzheimerʼs Disease

Simonian, N. A., & Hyman, B. T. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199311000-00004 · Cited by 89 · see citing works

PET correlates of normal and impaired memory functions.

Heiss, W. D., Pawlik, G., Holthoff‐Detto, V., Kessler, J., & Szelies, B. (1992) · PubMed · Cited by 68 · see citing works

Spin Trapping of Azidyl and Hydroxyl Radicals in Azide-Inhibited Rat Brain Submitochondrial Particles

Partridge, R. S., Monroe, S., Parks, J. K., Johnson, K. L., Parker, W. D., Eaton, G. R., & Eaton, S. S. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1159 · Cited by 66 · see citing works

Defective phorbol ester-stimulated secretion of β-amyloid precursor protein from Alzheimer's disease fibroblasts

Bergamaschi, S., Binetti, G. G., Govoni, S. M., Wetsel, W. C., Battaini, F., Trabucchi, M., Bianchetti, A., & Racchi, M. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12168-4 · Cited by 62 · see citing works

A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease

Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758 · see citing works

Estrogen: A master regulator of bioenergetic systems in the brain and body

Rettberg, J. R., Yao, J., & Brinton, R. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.08.001 · Cited by 534 · see citing works

Mitochondrial Diseases of the Brain

Chaturvedi, R. K., & Beal, M. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.03.018 · Cited by 416 · see citing works

The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease

Miranda, S., Opazo, C., Larrondo, L. F., Muñoz, F. J., Ruiz, F., Leighton, F., & Inestrosa, N. C. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00015-0 · Cited by 369 · see citing works

Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer’s disease

Bosetti, F. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00314-1 · Cited by 348 · see citing works

Brain aging, Alzheimer's disease, and mitochondria

Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.012 · Cited by 306 · see citing works

A Long Journey into Aging, Brain Aging, and Alzheimer’s Disease Following the Oxidative Stress Tracks

Mecocci, P., Boccardi, V., Cecchetti, R., Bastiani, P., Scamosci, M., Ruggiero, C., & Baroni, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170732 · Cited by 256 · see citing works

Energy Hypometabolism in Posterior Cingulate Cortex of Alzheimer's Patients: Superficial Laminar Cytochrome Oxidase Associated with Disease Duration

Valla, J. E., Berndt, J. D., & Gonzalez-Lima, F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04923.2001 · Cited by 237 · see citing works

Mitochondrial abnormalities in Parkinson's disease and Alzheimer's disease: can mitochondria be targeted therapeutically?

Macdonald, R., Barnes, K., Hastings, C., & Mortiboys, H. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170501 · Cited by 216 · see citing works

Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease

Swerdlow, R. H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4149 · Cited by 203 · see citing works

Mitochondria in Neurodegeneration

Lezi, E., & Swerdlow, R. H. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_12 · Cited by 204 · see citing works

Inherent Abnormalities in Energy Metabolism in Alzheimer Disease: Interaction with Cerebrovascular Compromise

Blass, J. P., Sheu, R. K.-F., & Gibson, G. E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06370.x · Cited by 200 · see citing works

Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

Santos, R. X., Correia, S. C., Zhu, X., Smith, M. A., Moreira, P. I., Castellani, R. J., Nunomura, A., & Perry, G. L. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.5039 · Cited by 176 · see citing works

Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase‐dependent pathway

Solano, D. C., Sironi, M., Bonfini, C., Solerte, S. B., Govoni, S. M., & Racchi, M. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.1015 · Cited by 175 · see citing works

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

Selfridge, J. E., E, L., Lu, J., & Swerdlow, R. H. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.057 · Cited by 175 · see citing works

d ‐penicillamine reduces serum oxidative stress in Alzheimer’s disease patients

Squitti, R., Rossini, P. M., Cassetta, E., Moffa, F., Pasqualetti, P., Cortesi, M., Colloca, A., Rossi, L. C., & Finazzi‐Agrò, A. (2002) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2002.00933.x · Cited by 142 · see citing works

Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review

Berlanga‐Acosta, J., Guillén, G. E., Rodríguez-Rodríguez, N., Bringas-Vega, M. L., García-del-Barco-Herrera, D., Berlanga-Saez, J. O., Ojalvo, A. G., Valdés-Sosa, M. J., & Valdes-Sosa, P. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.560375 · Cited by 139 · see citing works

Metabolic Impairment Induces Oxidative Stress, Compromises Inflammatory Responses, and Inactivates a Key Mitochondrial Enzyme in Microglia

Park, L. C. H., Zhang, H., Sheu, K. R., Calingasan, N. Y., Kristal, B. S., LINDSAY, J. G., & Gibson, G. E. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721948.x · Cited by 139 · see citing works

Mitochondrial Dysfunction in Alzheimer’s Disease: A Biomarker of the Future?

Bell, S., Barnes, K., Marco, M. D., Shaw, P. J., Ferraiuolo, L., Blackburn, D. J., Venneri, A., & Mortiboys, H. (2021) · Biomedicines · doi:10.3390/biomedicines9010063 · Cited by 136 · see citing works

Mitochondria in Alzheimer's disease

Swerdlow, R. H., & Kish, S. J. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)53013-0 · Cited by 126 · see citing works

Glucose Metabolic Dysfunction in Neurodegenerative Diseases—New Mechanistic Insights and the Potential of Hypoxia as a Prospective Therapy Targeting Metabolic Reprogramming

Han, R., Liang, J., & Zhou, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115887 · Cited by 125 · see citing works

Vitamin E and Alzheimer’s disease: what do we know so far?

Browne, D., McGuinness, B., Woodside, J. V., & McKay, G. J. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s186760 · Cited by 116 · see citing works

Mitochondria, Cybrids, Aging, and Alzheimer's Disease

Swerdlow, R. H., Koppel, S., Weidling, I., Hayley, C., Ji, Y., & Wilkins, H. M. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.12.017 · Cited by 106 · see citing works

Elevated levels of oxidative DNA damage in lymphocytes from patients with Alzheimer’s disease11Abbreviations used: AD, Alzheimer’s disease; Endo III, Endonuclease III; 8OHA, 8-hydroxyadenine; 8OHG, 8-hydroxyguanine; 8OHdG, 8-hydroxy-2′-deoxyguanosine; Fapy-Ade, 4,6-diamino-5-formamidopyrimidine; Fapy-Gua, 2,6,-diamino-4-hydroxy-5-formamidopyrimidine; Fpg, formamidopyrimidine glycosilase; H2O2, hydrogen-peroxide; .OH, hydroxyl radical; PBS, phosphate-buffered saline; ROS, reactive oxygen species; RT, room temperature; SSB, single strand break

Mórocz, M., Kalman, J. L., Juhász, A., Sinkó, I., McGlynn, A. P., Downes, C. S., Janka, Z., & Raskó, I. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00257-3 · Cited by 105 · see citing works

Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration

Wilkins, H. M., Weidling, I. W., Ji, Y., & Swerdlow, R. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00508 · Cited by 102 · see citing works

Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease

Austad, S. N., Ballinger, S. W., Buford, T. W., Carter, C. S., Smith, D. L., Darley-Usmar, V. M., & Zhang, J. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.06.014 · Cited by 94 · see citing works

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease

Maria Jose Perez, J., Ponce, D. P., Aránguiz, A., Behrens, M. I., & Quintanilla, R. A. (2018) · Redox Biology · doi:10.1016/j.redox.2018.09.001 · Cited by 90 · see citing works

Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes

Mosconi, L., Berti, V., Swerdlow, R. H., Pupi, A., Duara, R., & de Leon, M. (2010) · Human Genomics · doi:10.1186/1479-7364-4-3-170 · Cited by 85 · see citing works

The mitochondrial hypothesis: Dysfunction, bioenergetic defects, and the metabolic link to Alzheimer's disease

Swerdlow, R. H. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.01.008 · Cited by 88 · see citing works

Respiration in Adipocytes is Inhibited by Reactive Oxygen Species

Wang, T., Si, Y., Shirihai, O. S., Si, H., Schultz, V., Corkey, R. F., Hu, L., Deeney, J. T., Guo, W., & Corkey, B. E. (2009) · Obesity · doi:10.1038/oby.2009.456 · Cited by 85 · see citing works

Treating neurodegeneration by modifying mitochondria: potential solutions to a “complex” problem

Swerdlow, R. H. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1676 · Cited by 81 · see citing works

Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection

Arnold, S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3573-0_13 · Cited by 75 · see citing works

Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients

Uberti, D. L., Carsana, T., Bernardi, E., Rodella, L. F., Grigolato, P., Lanni, C., Racchi, M., Govoni, S. M., & Memo, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.15.3131 · Cited by 75 · see citing works

Oxidative Stress Mediated-Alterations of the MicroRNA Expression Profile in Mouse Hippocampal Neurons

Xu, S., Zhang, R., Niu, J., Cui, D., Xie, B., Zhang, B., Lu, K., Yu, W., Wang, X., & Zhang, Q. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms131216945 · Cited by 73 · see citing works

The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders

Olesen, M. A., Villavicencio-Tejo, F., & Quintanilla, R. A. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00308-y · Cited by 71 · see citing works

Mitochondrial Abnormalities in Alzheimer’s Disease

Silva, D. F., Selfridge, J. E., Lu, J., E, L., Cardoso, S. M., & Swerdlow, R. H. (2012) · Advances in Pharmacology · doi:10.1016/b978-0-12-394816-8.00003-9 · Cited by 86 · see citing works

Mitophagy and the Brain

Swerdlow, N., & Wilkins, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249661 · Cited by 65 · see citing works

Alzheimer’s Disease Pathologic Cascades: Who Comes First, What Drives What

Swerdlow, R. H. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9272-9 · Cited by 66 · see citing works

Metabolic stress is a primary pathogenic event in transgenic Caenorhabditis elegans expressing pan-neuronal human amyloid beta

Teo, E., Ravi, S., Barardo, D., Kim, H.-S., Fong, S., Cazenave-Gassiot, A., Tan, T. Y., Ching, J., Kovalik, J.-P., Wenk, M. R., et al. (2019) · eLife · doi:10.7554/elife.50069 · Cited by 72 · see citing works

The pharmacology of amyloid precursor protein processing

Racchi, M. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00158-4 · Cited by 62 · see citing works

Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype

Ramamoorthy, M., Sýkora, P., Scheibye‐Knudsen, M., Dunn, C., Kasmer, C., Zhang, Y., Becker, K. G., Croteau, D. L., & Bohr, V. A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.018 · Cited by 55 · see citing works

Mitochondrial links between brain aging and Alzheimer’s disease

Wilkins, H., & Swerdlow, R. H. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00261-2 · Cited by 53 · see citing works

Mitochondrial function and Aβ in Alzheimer's disease postmortem brain

Troutwine, B. R., Strope, T. A., Franczak, E., Lysaker, C. R., Hamid, L., Mansel, C., Stopperan, J. A., Gouvion, C. M., Haeri, M., Swerdlow, R. H., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105781 · Cited by 51 · see citing works

Cerebrometabolic abnormalities in Alzheimer's disease

Blass, J. P. (2003) · Neurological Research · doi:10.1179/016164103101201995 · Cited by 49 · see citing works

Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer’s Disease

Afsar, A., Castro, M. D. C. C., Soladogun, A. S., & Li, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087258 · Cited by 42 · see citing works

Glucose/mitochondria in neurological conditions

Blass, J. P. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)51010-2 · Cited by 40 · see citing works

Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts

Swerdlow, R. H., Hui, D., Chalise, P., Sharma, P., Wang, X., Andrews, S. J., Pa, J., Mahnken, J. D., Morris, J. K., Wilkins, H., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12119 · Cited by 39 · see citing works

Mitochondrial Membrane Potential Influences Amyloid-β Protein Precursor Localization and Amyloid-β Secretion

Wilkins, H., Troutwine, B., Menta, B. W., Manley, S., Strope, T., Lysaker, C., & Swerdlow, R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215280 · Cited by 36 · see citing works

Alzheimer’s disease: roles for mitochondrial damage, the hydroxyl radical, and cerebrospinal fluid deficiency of melatonin

MAURIZI, C. P. (2001) · Medical Hypotheses · doi:10.1054/mehy.2001.1324 · Cited by 35 · see citing works

Uridine Prodrug Improves Memory in Tg2576 and TAPP Mice and Reduces Pathological Factors associated with Alzheimer's Disease in Related Models

Saydoff, J. A., Olariu, A., Sheng, J. G., Hu, Z., Li, Q., Garcia, R. A. G., Pei, J., Sun, G. Y., & von Borstel, R. W. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130059 · Cited by 34 · see citing works

Increasing hexokinase 1 expression improves mitochondrial and glycolytic functional deficits seen in sporadic Alzheimer’s disease astrocytes

Bell, S., Wareing, H. E., Capriglia, F., Hughes, R. M., Barnes, K., Hamshaw, A., Adair, L. D., Shaw, A. C., Olejnik, A., De, S., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02746-8 · Cited by 34 · see citing works

Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts

Gasparini, L., Benussi, L., Bianchetti, A., Binetti, G. G., Curti, D., Govoni, S. M., Moraschi, S., Racchi, M., & Trabucchi, M. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00155-x · Cited by 29 · see citing works

Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway

Shi, C., Wu, F., Xu, J., & Zou, J. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.03.028 · Cited by 28 · see citing works

Mitochondrial dysfunction and Alzheimer's disease: New developments

Mancuso, M., Siciliano, G., Filosto, M., & Murri, L. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9203 · Cited by 27 · see citing works

Mitochondria as a target for neuroprotection: implications for Alzheimer´s disease

Cardoso, S., Seiça, R. M. F., & Moreira, P. I. (2016) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2016.1205488 · Cited by 27 · see citing works

Human Dermal Fibroblast: A Promising Cellular Model to Study Biological Mechanisms of Major Depression and Antidepressant Drug Response

Mesdom, P., Colle, R., Lebigot, É., Trabado, S., Deflesselle, É., Fève, B., Becquemont, L., Corruble, E., & Verstuyft, C. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191021141057 · Cited by 24 · see citing works

Selenomethionine Improves Mitochondrial Function by Upregulating Mitochondrial Selenoprotein in a Model of Alzheimer’s Disease

Chen, C., Chen, Y., Zhang, Z.-H., Jia, S.-Z., Chen, Y., Huang, S. L., Xu, X.-W., & Song, G.-L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.750921 · Cited by 24 · see citing works

Cell type and sex specific mitochondrial phenotypes in iPSC derived models of Alzheimer’s disease

Flannagan, K., Stopperan, J. A., Hauger, B. M., Troutwine, B., Lysaker, C. R., Strope, T. A., Csikós, V., Gilmore, C. A., Swerdlow, N., Draper, J. M., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1201015 · Cited by 24 · see citing works

Sodium azide and 2-deoxy-D-glucose-induced cellular stress affects phosphorylation-dependent AβPP processing

Henriques, A. G., Domingues, S. C., Fardilha, M., Silva, E. F. D. C. E., & Silva, O. A. B. D. C. E. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7302 · Cited by 20 · see citing works

Intrinsic aerobic capacity modulates Alzheimer’s disease pathological hallmarks, brain mitochondrial function and proteome during aging

Kugler, B. A., Lysaker, C. R., Franczak, E., Hauger, B. M., Csikós, V., Stopperan, J. A., Allen, J., Stanford, J. A., Koch, L. G., Britton, S. L., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01248-3 · Cited by 17 · see citing works

Cross-species metabolomic analysis of tau- and DDT-related toxicity

Kalia, V., Niedzwiecki, M. M., Bradner, J. M., Lau, F. K., Anderson, F. L., Bucher, M. L., Manz, K. E., Schlotter, A. P., Fuentes, Z. C., Pennell, K. D., et al. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac050 · Cited by 15 · see citing works

Mitochondrial respiratory chain in brain homogenates: activities in different brain areas in patients with Alzheimer’s disease

Casademont, J., Rodríguez‐Santiago, B., Miró, Ò., Beato, A., López, S., Nunes, V., & Cardellach, F. (2005) · Aging Clinical and Experimental Research · doi:10.1007/bf03337713 · Cited by 14 · see citing works

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

Cardoso, S., Santos, R. X., Correia, S. C., Carvalho, C., Zhu, X., Lee, H., Casadesús, G., Smith, M. A., Perry, G. L., & Moreira, P. I. (2009) · Pharmaceuticals · doi:10.3390/ph2030250 · Cited by 9 · see citing works

PET sheds light on Alzheimer's disease genetic risk

Swerdlow, R. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709690104 · Cited by 9 · see citing works

Mitochondria and oxidative damage in amyotrophic lateral sclerosis.

Beal, M. F. (2001) · PubMed · Cited by 7 · see citing works

Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation

Murphy, E. J., Huang, H., Cowburn, R. F., Lannfelt, L., & Gibson, G. E. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.10.012 · Cited by 6 · see citing works

Human skeletal muscle mitochondrial pathways are impacted by a neuropathologic diagnosis of Alzheimer's disease

Johnson, C. N., Evans, M. R., Blankenship, A. E., John, C. S., Rekowski, M. J., Washburn, M. P., Phan, A. V., Gouvion, C. M., Haeri, M., Swerdlow, R. H., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106916 · Cited by 4 · see citing works

Rapid Inhibition by Sodium Azide of the Phosphoinositide-Mediated Calcium Response to Serotonin Stimulation in Human Platelets: Preservation in Alzheimer's Disease

Hedin, H. L. M., Eriksson, S., & Fowler, C. J. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3154 · Cited by 4 · see citing works

Phospholipid composition and levels are not altered in fibroblasts bearing presenilin-1 mutations

Murphy, E. J., Zhang, H., Sorbi, S., Rapoport, S. I., & Gibson, G. E. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00257-4 · Cited by 4 · see citing works

Editorial: Systemic implications of Alzheimer's disease

Cortés, C. J., Thyfault, J. P., & Wilkins, H. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1219987 · Cited by 4 · see citing works

HK1 and HK2 Beyond Glycolysis: Mitochondrial Interactions and Dual Roles in Metabolism and Cell Fate

Pesce, N. A., Seminara, G., Giarrusso, G., & Tomasello, M. F. (2025) · Advanced Biology · doi:10.1002/adbi.202500472 · Cited by 3 · see citing works

Mitochondrial Function and Neurodegenerative Diseases

Wilkins, H. M., Weidling, I., Koppel, S., Wang, X., von Schulze, A., & Swerdlow, R. H. (2018) · The Molecular and Cellular Basis of Neurodegenerative Diseases · doi:10.1016/b978-0-12-811304-2.00013-4 · Cited by 2 · see citing works

Mitochondrial Genome Variants and Alzheimer’s Disease

Kozin, M., Kulakova, O., Kiselev, I., Semina, E., Kakotkin, V., Agapov, M., & Favorova, O. O. (2025) · Biochemistry (Moscow) · doi:10.1134/s0006297924603174 · Cited by 2 · see citing works

Multiple System Atrophy : Mitochondria Dysregulation, Reprogramming and Alternative of Neuroprotective AgentsPreprint

Widyarti, S., Wibowo, S., Sabarudin, A., Abhirama, I., & Sumitro, S. B. (2023) · Preprints.org · doi:10.20944/preprints202301.0220.v1 · Cited by 1 · see citing works

Deficits in mitochondrial function and glucose metabolism seen in sporadic and familial Alzheimer’s disease derived Astrocytes are ameliorated by increasing hexokinase 1 expression

Bell, S. M., Wareing, H., Hamshaw, A., De, S., New, E., Shaw, P. J., De Marco, M., Venneri, A., Blackburn, D. J., Ferraiuolo, L., et al. (2023) · doi:10.1101/2023.03.23.534020 · Cited by 1 · see citing works

Efectes de la infecció per VIH i dels fàrmacs antiretrovirals envers el mitocondri: les cèl.lules mononuclears de sang perifèrica com a model d'estudi

Moreno, S. (2005) · TDX (Tesis Doctorals en Xarxa)

The Biological Basis of Dementias

Racchi, M., & Govoni, S. M. (1999) · Springer eBooks · doi:10.1007/978-88-470-2149-5_2

Análise de danos ao DNA e expressão de genes supressores de tumor em tecido post mortem de pacientes com doença de Alzheimer

dos Santos, A. C. F., & dos Santos (2012)

Metabolic evaluation of genetic and environmental contributors to Alzheimer’s disease

Kalia, V. (2021) · doi:10.7916/d8-fj0m-bn64

Brain Hypometabolism, Oxidative Stress, Maternal Transmission, and Risk of Late-Onset Alzheimer’s Disease

Mosconi, L., Murray, J., McHugh, P. F., & de Leon, M. J. (2013) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-62703-598-9_10

Alterations in Metabolic Properties in Fibroblasts in Alzheimer Disease

Sorbi, S., Piacentini, S., Latorraca, S., Piersanti, P., & Amaducci, L. A. (1995) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199509020-00003 · Cited by 21 · see citing works

Alzheimer skin fibroblasts show increased susceptibility to free radicals

Tesco, G., Latorraca, S., Piersanti, P., Piacentini, S., Amaducci, L. A., & Sorbi, S. (1992) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(92)90129-2 · Cited by 17 · see citing works

Chronically increased oxidative stress in fibroblasts from Alzheimer's disease patients causes early senescence and renders resistance to apoptosis by oxidative stress

Naderi, J., Lopez, C., & Pandey, S. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.08.006 · Cited by 54 · see citing works

Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype

Ramamoorthy, M., Sýkora, P., Scheibye‐Knudsen, M., Dunn, C., Kasmer, C., Zhang, Y., Becker, K. G., Croteau, D. L., & Bohr, V. A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.018 · Cited by 55 · see citing works

Free Radical Injury in Skin Cultured Fibroblasts from Alzheimer's Disease Patients

Tesco, G., Latorraca, S., Piersanti, P., Sorbi, S., Piacentini, S., & Amaducci, L. A. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27446.x · Cited by 18 · see citing works