Stress-induced visceral hypersensitivity in female rats is estrogen-dependent and involves tachykinin NK1 receptors
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Hormonal cycling may be related to a higher incidence of pain syndrome in female. As tachykinins are pivotal in stress-induced colonic dysfunction, we investigated whether ovarian steroids influence stress-induced visceral hypersensitivity to rectal distension (RD) in female rats and further, whether this influence involves NK1 receptors. Female Wistar rats, either intact or ovariectomized (OVX), were equipped for abdominal muscle electromyography and submitted to 2-h partial restraint stress (PRS) or sham-PRS. First, the effect of PRS was evaluated in intact rats. Second, abdominal response to RD was recorded in OVX rats treated with either, progesterone, 17beta-estradiol, 17beta-estradiol-plus-progesterone, or vehicle, in both basal and PRS conditions. Third, the NK1 receptor-antagonist, SR140333, was tested in PRS-intact and PRS-OVX rats under 17beta-estradiol or 17beta-estradiol-plus-progesterone treatment. PRS induced visceral hypersensitivity to RD and this effect was prevented by ovariectomy. OVX rats treated with 17beta-estradiol or 17beta-estradiol-plus-progesterone, but not progesterone alone, exhibited visceral hypersensitivity after PRS similar to that of intact rats. Both stress-induced visceral hypersensitivity in intact rats and the hormonally-restored visceral hyper-responsiveness of OVX rats were antagonized by SR140333. It is concluded, therefore, that stress-induced visceral hypersensitivity in female rats is estrogens-dependent and mediated through NK1 receptor activation.
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NK1R antagonism can mitigate alterations in the brain induced by chronic psychological stress, which is associated with visceral hypersensitivity and spinal NK1R up-regulation in female rodents and possibly in mice with induced endometriosis.
“Aside from delaying fibrogenesis, NK1R antagonism can also mitigate alterations in the brain induced by chronic psychological stress99–101, which is associated with visceral hypersensitivity and spinal NK1R up-regulation in female rodents102,103 and possibly in mouse with induced endometriosis as well104–106.”
From Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis (2019) · cites this paper as [102]
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NK-1 receptor is involved in the decreased movement in a rat chronic acid reflux oesophagitis model
Oshima, T., Koseki, J., Sakùrai, J., Watari, J., Matsumoto, T., & Miwa, H. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01450.x · Cited by 7 · see citing works
Pillidge, K., Heal, D. J., & Stanford, S. C. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116658992 · Cited by 6 · see citing works
Distinctive Clinical and Biological Characteristics of Visceral Pain
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Distinctive Clinical and Biological Characteristics of Visceral Pain
Ness, T. J. (2006) · CRC Press eBooks · doi:10.3109/9781420004434-2 · Cited by 1 · see citing works
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Posibilidades farmacológicas de modulación de la percepción visceral
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- Authors
- Bradesi, S., Eutamene, H., Garcia-Villar, R., Fioramonti, J., & Bueno, L.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Corresponding author
- Bueno, Lionel
- Venue
- Pain
- Published
- 2003-04
- Volume
- 102
- Issue
- 3
- Pages
- 227-234
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2023884230
- Cited by
- 54
- References
- 54
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2019: 2 · 2018: 1 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 2
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- green
- hal.inrae.fr
- Licence
- cc-by-sa
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- visceral pain, estrogen dependence, tachykinin NK1 receptor, ovarian steroids, estradiol, progesterone, ovariectomy, rectal distension, SR140333, female rats
- MeSH terms
- Abdominal Muscles, Animals, Estrogens, Female, Ovariectomy, Pain Measurement, Physical Stimulation, Restraint, Physical, Stress, Physiological, Rats, Wistar, Visceral Afferents, Receptors, Neurokinin-1, Rats, Neurokinin-1 Receptor Antagonists
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