Cited by 1,085Pain Mechanisms and TreatmentsSex and Gender in HealthcarePain Management and Placebo Effect

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Sex differences in the perception of noxious experimental stimuli: a meta-analysis

Riley, Joseph L, Robinson, Michael E, Wise, Emily A, Myers, Cynthia D, Fillingim, Roger B·1998·Pain

Open this paper in CoChat — free account

Abstract

Fillingim and Maixner (Fillingim, R.B. and Maixner, W., Pain Forum, 4(4) (1995) 209-221) recently reviewed the body of literature examining possible sex differences in responses to experimentally induced noxious stimulation. Using a 'box score' methodology, they concluded the literature supports sex differences in response to noxious stimuli, with females displaying greater sensitivity. However, Berkley (Berkley, K.J., Pain Forum, 4(4) (1995) 225-227) suggested the failure of a number of studies to reach statistical significance suggests the effect may be small and of little practical significance. This study used meta-analytic methodology to provide quantitative evidence to address the question of the magnitude of these sex differences in response to experimentally induced pain. We found the effect size to range from large to moderate, depending on whether threshold or tolerance were measured and which method of stimulus administration was used. The values for pressure pain and electrical stimulation, for both threshold and tolerance measures, were the largest. For studies employing a threshold measure, the effect for thermal pain was smaller and more variable. The failures to reject the null hypothesis in a number of these studies appear to have been a function of lack of power from an insufficient number of subjects. Given the estimated effect size of 0.55 threshold or 0.57 for tolerance, 41 subjects per group are necessary to provide adequate power (0.70) to test for this difference. Of the 34 studies reviewed by Fillingim and Maixner, only seven were conducted with groups of this magnitude. The results of this study compels to caution authors to obtain adequate sample sizes and hope that this meta-analytic review can aid in the determination of sample size for future studies.

Integrity signals

Registry

Crossref · 10.1016/s0304-3959(97)00199-1

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Book Reviews: Statistical Methods for Meta-Analysis Larry V. Hedges and Ingram Olkin New York: Academic Press, 1985. xxii + 369 pp
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,361
A power primer.
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771
Distribution Theory for Glass's Estimator of Effect Size and Related Estimators
Hedges, L. V. (1981) · Journal of Educational Statistics · doi:10.2307/1164588 · Cited by 5,695
Gender variations in clinical pain experience
Unruh, A. M. (1996) · Pain · doi:10.1016/0304-3959(95)00214-6 · Cited by 1,550
Estimation of effect size from a series of independent experiments.
Hedges, L. (1982) · Psychological Bulletin · doi:10.1037/0033-2909.92.2.490 · Cited by 1,030
Pressure algometry over normal muscles. Standard values, validity and reproducibility of pressure threshold
Fischer, A. A. (1987) · Pain · doi:10.1016/0304-3959(87)90089-3 · Cited by 960
The science and politics of comparing women and men.
Eagly, A. H. (1995) · American Psychologist · doi:10.1037/0003-066x.50.3.145 · Cited by 606
Gender differences in the responses to noxious stimuli
Fillingim, R. B., & Maixner, W. D. (1995) · Pain Forum · doi:10.1016/s1082-3174(11)80022-x · Cited by 475
Pain Tolerance: Differences According to Age, Sex and Race
Woodrow, K. M., FRIEDMAN, G. D., SIEGELAUB, A. B., & Collen, M. F. (1972) · Psychosomatic Medicine · doi:10.1097/00006842-197211000-00007 · Cited by 436
Gender differences in Pain
Rollman, G. B. (1995) · Pain Forum · doi:10.1016/s1082-3174(11)80026-7 · Cited by 399

Show all 44 references

Research works printed but not linked: 3

Coulthard, 1993, Anxiety during induced experimental pain. Anesth., Pain Control Dentis, 2, 150
Fillingim, 1996, The influence of gender and psychological factors on pain perception. J., Gender Culture Health, 1, 21
Procacci, 1970, The cutaneous pricking threshold in old age. Clin., Gerontol, 12, 213

Sorted by citations

Items 301–400 of 1,000

Sex Differences in Thermal Pain Sensitivity and Sympathetic Reactivity for Two Strains of Rat
Vierck, C. J., Acosta-Rua, A. J., Rossi, H. L., & Neubert, J. K. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.03.008 · Cited by 62
Psychosocial Influences on Exercise-Induced Hypoalgesia
Brellenthin, A. G., Crombie, K. M., Cook, D. B., Sehgal, N., & Koltyn, K. F. (2016) · Pain Medicine · doi:10.1093/pm/pnw275 · Cited by 75
A comparison of the clinical manifestation and pathophysiology of myofascial pain syndrome and fibromyalgia: implications for differential diagnosis and management.
Bourgaize, S., Newton, G. S., Kumbhare, D. A., & Srbely, J. Z. (2018) · Europe PMC (PubMed Central) · Cited by 61
Is Lethality Different between Males and Females? Clinical and Gender Differences in Inpatient Suicide Attempters
Berardelli, I., Rogante, E., Sarubbi, S., Erbuto, D., Cifrodelli, M., Concolato, C., Pasquini, M., Lester, D., Innamorati, M., & Pompili, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192013309 · Cited by 69
Exposure to movement in chronic back pain: Evidence of successful generalization across a reaching task
Trost, Z., France, C. R., & Thomas, J. S. (2007) · Pain · doi:10.1016/j.pain.2007.08.005 · Cited by 64
Effect of gender and obesity on electrical current thresholds
Maffiuletti, N. A., Morelli, A., Martin, A., Duclay, J., Billot, M., Jubeau, M., Agosti, F., & Sartório, A. (2011) · Muscle & Nerve · doi:10.1002/mus.22050 · Cited by 61
Gender differences in pressure pain threshold in a repeated measures assessment
Garcia, E., Godoy‐Izquierdo, D., Godoy, J. F., Perez, M., & López‐Chicheri, I. (2007) · Psychology Health & Medicine · doi:10.1080/13548500701203433 · Cited by 61
Pain Sensitivity in Sleepy Pain-Free Normals
Chhangani, B. S., Roehrs, T., Harris, B. E. J., Hyde‐Nolan, M. E., Drake, C. L., Hudgel, D. W., & Roth, T. G. (2009) · SLEEP · doi:10.1093/sleep/32.8.1011 · Cited by 61
Sex differences in experimental and clinical pain sensitivity for patients with shoulder pain
Kindlerl, L. L., Valencial, C., Fillingim, R. B., & George, S. Z. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.06.001 · Cited by 60
Effects of temperature on heat pain adaptation and habituation in men and women
Hashmi, J. A., & Davis, K. D. (2010) · Pain · doi:10.1016/j.pain.2010.08.046 · Cited by 60
The Relationship Between Maternal Chronic Pain and Child Adjustment: The Role of Parenting as a Mediator
Evans, S., Shipton, E. A., & Keenan, T. (2006) · Journal of Pain · doi:10.1016/j.jpain.2005.10.010 · Cited by 60
Daily Variations in Objective Nighttime Sleep and Subjective Morning Pain in Older Adults with Insomnia: Evidence of Covariation over Time
Dzierzewski, J. M., Williams, J. M., Roditi, D., Marsiske, M., McCoy, K. J. M., McNamara, J. P. H., Dautovich, N. D., Robinson, M. E., & McCrae, C. S. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02803.x · Cited by 59
The bothersomeness of sciatica: patients’ self-report of paresthesia, weakness and leg pain
Grøvle, L., Haugen, A. J., Keller, A., Natvig, B., Brox, J. I., & Grotle, M. (2009) · European Spine Journal · doi:10.1007/s00586-009-1042-5 · Cited by 59
Sex and Emotion in the Acquired Capability for Suicide
Anestis, M. D., Bender, T. W., Selby, E. A., Ribeiro, J. D., & Joiner, T. E. (2011) · Archives of Suicide Research · doi:10.1080/13811118.2011.566058 · Cited by 61
Pain and its relation to cognitive function and depressive symptoms: A Swedish population study of 70-year-old men and women
Bergh, I., Steen, G., Wærn, M., Johansson, B. E. A., Odén, A., Sjöström, B., & Steen, B. C. (2003) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(03)00329-4 · Cited by 59
Peripheral Mechanisms of Ischemic Myalgia
Queme, L. F., Ross, J. L., & Jankowski, M. P. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00419 · Cited by 57
Clinical Pain Perception and Hormone Replacement Therapy in Postmenopausal Women Experiencing Orofacial Pain
Wise, E. A., Riley, J. L., & Robinson, M. E. (2000) · Clinical Journal of Pain · doi:10.1097/00002508-200006000-00005 · Cited by 59
Ethnic differences in physical pain sensitivity: Role of acculturation
Chan, M. Y. P., Hamamura, T., & Janschewitz, K. (2012) · Pain · doi:10.1016/j.pain.2012.09.015 · Cited by 60
Relationships among Self-Rated Tanner Staging, Hormones, and Psychosocial Factors in Healthy Female Adolescents
Rapkin, A. J., Tsao, J. C. I., Turk, N., Anderson, M. M., & Zeltzer, L. K. (2006) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2006.02.004 · Cited by 59
Chest Pain in Patients With Cardiac and Noncardiac Disease
Sheps, D. S., Creed, F. H., & Clouse, R. E. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000146330.80895.77 · Cited by 56
Sex differences in response to cutaneous anesthesia: a double blind randomized study
Robinson, M. E., Riley, J. L., Brown, F. F., & Gremillion, H. A. (1998) · Pain · doi:10.1016/s0304-3959(98)00088-8 · Cited by 58
Sex differences in perceived pain are affected by an anxious brain
Goffaux, P., Michaud, K., Gaudreau, J., Chalaye, P., Rainville, P., & Marchand, S. (2011) · Pain · doi:10.1016/j.pain.2011.05.002 · Cited by 57
Gender Differences in the Prevalence of Chronic Pain and Leisure Time Physical Activity Among US Adults: A NHANES Study
Umeda, M., & Kim, Y. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16060988 · Cited by 58
Sex Differences and Incentive Effects on Perceptual and Cardiovascular Responses to Cold Pressor Pain
Lowery, D., Fillingim, R. B., & Wright, R. A. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000033127.11561.78 · Cited by 57
Differential Relationships Between Anxiety and Treatment-Associated Pain Reduction Among Male and Female Chronic Pain Patients
Edwards, R. R., Augustson, E. M., & Fillingim, R. B. (2003) · Clinical Journal of Pain · doi:10.1097/00002508-200307000-00003 · Cited by 55
Choice and placebo expectation effects in the context of pain analgesia
Rose, J. P., Geers, A. L., Rasinski, H. M., & Fowler, S. L. (2011) · Journal of Behavioral Medicine · doi:10.1007/s10865-011-9374-0 · Cited by 59
Sex-related differences of patient-controlled epidural analgesia for postoperative pain
Schnabel, A., Poepping, D. M., Gerß, J., Zahn, P. K., & Pogatzki-Zahn, E. M. (2011) · Pain · doi:10.1016/j.pain.2011.10.022 · Cited by 56
Nature and Nurture of Human Pain
Belfer, I. (2013) · Scientifica · doi:10.1155/2013/415279 · Cited by 60
Gender Differences in Acute and Chronic Pain in the Emergency Department: Results of the 2014 Academic Emergency Medicine Consensus Conference Pain Section
Musey, P. I., Linnstaedt, S. D., Platts-Mills, T. F., Miner, J. R., Bortsov, A. V., Safdar, B., Bijur, P., Rosenau, A., Tsze, D. S., Chang, A. K., et al. (2014) · Academic Emergency Medicine · doi:10.1111/acem.12529 · Cited by 55
Self-citation
Sex differences in primary muscle afferent sensitization following ischemia and reperfusion injury
Ross, J. L., Queme, L. F., Lamb, J. E., Green, K. J., & Jankowski, M. P. (2018) · Biology of Sex Differences · doi:10.1186/s13293-017-0163-5 · Cited by 55
Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): Implication in burning mouth syndrome
Seol, S.-H., & Chung, G. (2021) · Journal of Dental Sciences · doi:10.1016/j.jds.2021.06.007 · Cited by 55
Aerobic exercise with blood flow restriction causes local and systemic hypoalgesia and increases circulating opioid and endocannabinoid levels
Hughes, L., Grant, I., & Patterson, S. D. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00543.2021 · Cited by 56
Hypoalgesia in the Referred Pain Areas After Bilateral Injections of Hypertonic Saline Into the Trapezius Muscles of Men and Women: A Potential Experimental Model of Gender-Specific Differences
Ge, H., Madeleine, P., Cairns, B. E., & Arendt‐Nielsen, L. (2005) · Clinical Journal of Pain · doi:10.1097/01.ajp.0000149799.01123.38 · Cited by 55
Sex differences in analgesic responses: evidence from experimental pain models
Fillingim, R. B. (2002) · European Journal of Anaesthesiology · doi:10.1097/00003643-200219261-00004 · Cited by 55
Gender Differences in Pain Severity, Disability, Depression, and Widespread Pressure Pain Sensitivity in Patients with Fibromyalgia Syndrome Without Comorbid Conditions
Castro-Sánchez, A. M., Matarán-Peñarrocha, G. A., López-Rodríguez, M. M., Lara-Palomo, I. C., Arendt-Nielsen, L., & Fernández-de-las-Peñas, C. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2012.01523.x · Cited by 69
A Fracture Pain Model in the Rat
Freeman, K. T., Koewler, N. J., Jiménez‐Andrade, J. M., Buus, R. J., Herrera, M. B., Martin, C. D., Ghilardi, J. R., Kuskowski, M. A., & Mantyh, P. W. (2008) · Anesthesiology · doi:10.1097/aln.0b013e3181649351 · Cited by 54
Intraexaminer and Interexaminer Reliability of Manual Palpation and Pressure Algometry of the Lower Limb Nerves in Asymptomatic Subjects
Fingleton, C., Dempsey, L., Smart, K. M., & Doody, C. (2014) · Journal of Manipulative and Physiological Therapeutics · doi:10.1016/j.jmpt.2013.12.006 · Cited by 54
Sex Differences and Hormonal Influences on Response to Mechanical Pressure Pain in Humans
Kowalczyk, W. J., Sullivan, M. A., Evans, S. M., Bisaga, A. M., Vosburg, S. K., & Comer, S. D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.08.004 · Cited by 52
Assessment of Trigeminal Nerve Functions by Quantitative Sensory Testing in Patients and Healthy Volunteers
Yekta, S. S., Smeets, R., Stein, J. M., & Ellrich, J. (2010) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2009.12.013 · Cited by 53
Gorillas in Our Midst? Human Sexual Dimorphism and Contest Competition in Men
Hill, A. K., Bailey, D. H., & Puts, D. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-420190-3.00015-6 · Cited by 53
Sex differences in common pain events: Expectations and anchors
Robinson, M. E., Gagnon, C. M., Dannecker, E. A., Brown, J. L., Jump, R. L., & Price, D. D. (2003) · Journal of Pain · doi:10.1054/jpai.2003.4 · Cited by 53
A Practical Guide and Perspectives on the Use of Experimental Pain Modalities with Children and Adolescents
Birnie, K. A., Caes, L., Wilson, A. C., Williams, S. E., & Chambers, C. T. (2014) · Pain Management · doi:10.2217/pmt.13.72 · Cited by 52
Estrogen receptors beta and alpha have specific pro- and anti-nociceptive actions.
Coulombe, M., Spooner, M., Gaumond, I., Carrier, J. C., & Marchand, S. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.057 · Cited by 53
Sex-related influences on pain: A review of mechanisms and clinical implications.
Fillingim, R. B. (2003) · Rehabilitation Psychology · doi:10.1037/0090-5550.48.3.165 · Cited by 52
Effect of Age, Sex and Gender on Pain Sensitivity: A Narrative Review
Eltumi, H. G., & Tashani, O. A. (2017) · The Open Pain Journal · doi:10.2174/1876386301710010044 · Cited by 52
Evaluation of Sex Differences in Preclinical Pharmacology Research: How Far Is Left to Go?
Allegra, S., Chiara, F., Grazia, D. D., Gaspari, M., & Francia, S. D. (2023) · Pharmaceuticals · doi:10.3390/ph16060786 · Cited by 54
Exploring sex differences: insights into gene expression, neuroanatomy, neurochemistry, cognition, and pathology
Lafta, M. S., Mwinyi, J., Affatato, O., Rukh, G., Dang, J., Andersson, G., & Schiöth, H. B. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1340108 · Cited by 58
Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences
Klatzkin, R. R., Lindgren, M. E., Forneris, C. A., & Girdler, S. S. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.01.018 · Cited by 54
Changes in the oral health-related quality of life 24 h following insertion of fixed orthodontic appliances
Othman, S. A., Mansor, N., & Saub, R. (2012) · Journal of Orthodontic Science · doi:10.4103/2278-0203.105880 · Cited by 50
Modulation of nociceptive and acoustic startle responses to an unpredictable threat in men and women
Hubbard, C. S., Ornitz, E. M., Gaspar, J. X., Smith, S. E., Amin, J., Labus, J. S., Kilpatrick, L. A., Rhudy, J. L., Mayer, E. A., & Naliboff, B. D. (2011) · Pain · doi:10.1016/j.pain.2011.03.001 · Cited by 50
Psychosocial Factors of Relevance to Sex and Gender Studies in Headache
Smitherman, T., & Ward, T. (2011) · Headache · doi:10.1111/j.1526-4610.2011.01919.x · Cited by 50
Effects of muscle fatigue induced by low-level clenching on experimental muscle pain and resting jaw muscle activity: gender differences
Torisu, T., Wang, K., Svensson, P. J., Laat, A. D., Fujii, H., & Arendt‐Nielsen, L. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0497-4 · Cited by 50
Lack of estrogen increases pain in the trigeminal formalin model: a behavioural and immunocytochemical study of transgenic ArKO mice
Multon, S., Párdutz, Á., Mosen, J., Hua, M.-T., Defays, C., Honda, S.-I., Harada, N., Bohotin, C. R., Franzen, R., & Schoenen, J. E. (2005) · Pain · doi:10.1016/j.pain.2004.12.030 · Cited by 49
Gender differences in electrical pain threshold responses to transcutaneous electrical nerve stimulation (TENS)
Lund, I., Lundeberg, T., Kowalski, J. H., & Svensson, E. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.068 · Cited by 50
Effects of central and peripheral administration of leptin on pain threshold in rats and mice.
Kutlu, S., Canpolat, S., Sandal, S., Özcan, M., Sarsılmaz, M., & Keleştimur, H. (2003) · PubMed · Cited by 50
Sex differences in heat pain thresholds as a function of assessment method and rate of rise
Fillingim, R. B., MADDUX, V., & Shackelford, J. (1999) · Somatosensory & Motor Research · doi:10.1080/08990229970654 · Cited by 50
Comorbid Disorders and Sociodemographic Variables in Temporomandibular Pain in the General Dutch Population
Visscher, C. M., Ligthart, L., Schuller, A. A., Lobbezoo, F., de Jongh, A., van Houtem, C. M. H. H., & Boomsma, D. I. (2015) · Journal of Oral & Facial Pain and Headache · doi:10.11607/ofph.1324 · Cited by 49
Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors
Gintzler, A. R., & Liu, N. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.09.004 · Cited by 49
A Tool for Classifying Individuals with Chronic Back Pain: Using Multivariate Pattern Analysis with Functional Magnetic Resonance Imaging Data
Callan, D. E., Mills, L., Nott, C., England, R. W., & England, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098007 · Cited by 46
Disrupted Sleep Is Associated With Altered Pain Processing by Sex and Ethnicity in Knee Osteoarthritis
Petrov, M. E. R., Goodin, B. R., Cruz‐Almeida, Y., King, C., Glover, T. L., Bulls, H. W., Herbert, M. S., Sibille, K. T., Bartley, E. J., Fessler, B. J., et al. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.02.004 · Cited by 49
The effects of age and sex on pain sensitivity in young lambs
Guesgen, M. J., Beausoleil, N. J., Minot, E. O., Stewart, M., Jones, G., & Stafford, K. J. (2011) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2011.09.008 · Cited by 49
Evaluation of variations in sensory and pain threshold assessments by electrocutaneous stimulation
Lund, I., Lundeberg, T., Kowalski, J. H., Sandberg, L., Budh, C. N., & Svensson, E. (2005) · Physiotherapy Theory and Practice · doi:10.1080/09593980590922307 · Cited by 49
Sex Differences in Delayed Onset Muscle Pain
Dannecker, E. A., Hausenblas, H. A., Kaminski, T. W., & Robinson, M. E. (2005) · Clinical Journal of Pain · doi:10.1097/00002508-200503000-00002 · Cited by 49
Sex and gender differences in pain and its relief
Holdcroft, A., & Berkley, K. J. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50080-1 · Cited by 50
Temporal summation of heat pain modulated by isometric exercise
Koltyn, K. F., Knauf, M. T., & Brellenthin, A. G. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00264.x · Cited by 48
The effect of situation–evoked anxiety and gender on pain report using the cold pressor test
Jones, A., Spindler, H., Jørgensen, M. M., & Zachariae, R. H. (2002) · Scandinavian Journal of Psychology · doi:10.1111/1467-9450.00299 · Cited by 48
Possible involvement of ghrelin on pain threshold in obesity
Güneli, E., Gümüştekin, M., & Ateş, M. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.10.006 · Cited by 48
Characterization of a novel model of tonic heat pain stimulation in healthy volunteers
Naert, A., Kehlet, H., & Kupers, R. C. (2008) · Pain · doi:10.1016/j.pain.2007.11.018 · Cited by 47
Assessment of conditioned pain modulation in healthy participants and patients with chronic pain: manifestations and implications for pain progression
Petersen, K. K., McPhee, M. E., Hoegh, M., & Graven‐Nielsen, T. (2019) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000419 · Cited by 47
Identification of Molecular Fingerprints in Human Heat Pain Thresholds by Use of an Interactive Mixture Model R Toolbox (AdaptGauss)
Ultsch, A., Thrun, M. C., Hansen-Goos, O., & Lötsch, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025897 · Cited by 47
Prediction of pain sensitivity in healthy volunteers
Ravn, P., Werner, M. U., Fredriksen, Skovsen, A. P., & Christrup, L. L. (2012) · Journal of Pain Research · doi:10.2147/jpr.s33925 · Cited by 47
Endogenous pain modulation during the formalin test in estrogen receptor beta knockout mice
Spooner, M.-F., Robichaud, P., Carrier, J. C., & Marchand, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.037 · Cited by 47
Performance, Tolerability, and Symptoms Related to Prolonged pH Monitoring Using the Bravo System in Mexico
Remes-Troche, J. M., Ibarra-Palomino, J., Carmona-Sánchez, R., & Valdovinos, M. A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00292.x · Cited by 47
In Vivo and in Vitro Comparison of Female and Male Nociceptors
Hendrich, J., Álvarez, P., Joseph, E. K., Ferrari, L. F., Chen, X., & Levine, J. D. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.09.009 · Cited by 46
Does In Vivo Catastrophizing Engage Descending Modulation of Spinal Nociception?
Rhudy, J. L., Maynard, L. J., & Russell, J. L. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.10.003 · Cited by 46
Gender-differences in risk factors for suicidal behaviour identified by perceived burdensomeness, thwarted belongingness and acquired capability: cross-sectional analysis from a longitudinal cohort study
Donker, T., Batterham, P. J., Orden, K. A. V., & Christensen, H. M. (2014) · BMC Psychology · doi:10.1186/2050-7283-2-20 · Cited by 50
Sex, gender, coping, and self‐efficacy: Mediation of sex differences in pain perception in children and adolescents
Vierhausl, M., Lohaus, A., & Schmitz, A. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.11.003 · Cited by 46
Integrating the Dimensions of Sex and Gender into Basic Life Sciences Research: Methodologic and Ethical Issues
Holdcroft, A. (2007) · Gender Medicine · doi:10.1016/s1550-8579(07)80048-9 · Cited by 46
‘Women get this’: gendered meanings of chronic pelvic pain
Grace, V. M., & MacBride‐Stewart, S. (2006) · Health An Interdisciplinary Journal for the Social Study of Health Illness and Medicine · doi:10.1177/1363459307070803 · Cited by 46
Effects of Gender and Acute Dental Pain on Thermal Pain Responses
Edwards, R. R., Fillingim, R. B., Yamauchi, S., Sigurðsson, Á., Bunting, S., Mohorn, S., & Maixner, W. D. (1999) · Clinical Journal of Pain · doi:10.1097/00002508-199909000-00011 · Cited by 46
Behavioural and neural correlates of visceral pain sensitivity in healthy men and women: Does sex matter?
Benson, S., Kotsis, V., Rosenberger, C., Bingel, U., Forsting, M., Schedlowski, M., Gizewski, E. R., & Elsenbruch, S. (2011) · European Journal of Pain · doi:10.1002/j.1532-2149.2011.00027.x · Cited by 45
Cold pressor pain responses in healthy libyans: Effect of sex/gender, anxiety, and body size
Tashani, O. A., Alabas, O., & Johnson, M. I. (2010) · Gender Medicine · doi:10.1016/j.genm.2010.07.002 · Cited by 45
Hippocampal subfields differentially correlate with chronic pain in older adults
Ezzati, A., Zimmerman, M. E., Katz, M. J., Sundermann, E. E., Smith, J. L., Lipton, M. L., & Lipton, R. B. (2014) · Brain Research · doi:10.1016/j.brainres.2014.05.025 · Cited by 45
Emotional Intelligence and Acute Pain: The Mediating Effect of Negative Affect
Ruiz-Aranda, D., Salguero, J. M., & Fernández‐Berrocal, P. (2011) · Journal of Pain · doi:10.1016/j.jpain.2011.06.008 · Cited by 45
Vogel conflict test: Sex differences and pharmacological validation of the model
Basso, A. M., Gallagher, K. B., Mikusa, J. P., & Rueter, L. E. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.11.041 · Cited by 45
Effect of gender on pain perception and analgesic consumption in laparoscopic cholecystectomy: An observational study
Khan, F., Hussain, A. M., Ahmed, A., Chawla, T. U., & Azam, S. I. (2013) · Journal of Anaesthesiology Clinical Pharmacology · doi:10.4103/0970-9185.117095 · Cited by 45
Laser Therapy in the Treatment of Paresthesia: A Retrospective Study of 125 Clinical Cases
de Oliveira, R. F., da Silva, A. C., Simões, A., Youssef, M. N., & de Freitas, P. M. (2015) · Photomedicine and Laser Surgery · doi:10.1089/pho.2015.3888 · Cited by 45
Reassessing the Ecology of Medical Care in Japan
Fukui, T., Rahman, M., Ohde, S., Hoshino, E., Kimura, T., Urayama, K. Y., Omata, F., Deshpande, G. A., & Takahashi, O. (2017) · Journal of Community Health · doi:10.1007/s10900-017-0337-4 · Cited by 45
Estrogen modulation of visceral pain
Sun, L., Zhang, W., Xu, Q., Wu, H. B. K., Jiao, C., & Chen, X. (2019) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1800582 · Cited by 45
Menarche in Girls and Headache – A Longitudinal Analysis
Kröner‐Herwig, B., & Vath, N. (2009) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2009.01397.x · Cited by 44
Sex differences in opioid-mediated pain inhibitory mechanisms during the interphase in the formalin test
Gaumond, I., Spooner, M.-F., & Marchand, S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.002 · Cited by 45
Physical Exposures in Work Commonly Done by Women
Messing, K. (2004) · Canadian Journal of Applied Physiology · doi:10.1139/h04-041 · Cited by 45
Are There Sex Differences in Affective Modulation of Spinal Nociception and Pain?
Rhudy, J. L., Bartley, E. J., Williams, A. E., McCabe, K. M., Chandler, M. C., Russell, J. L., & Kerr, K. L. (2010) · Journal of Pain · doi:10.1016/j.jpain.2010.04.003 · Cited by 49
Influence of Pain Sensitivity on Surgical Outcomes After Lumbar Spine Surgery in Patients With Lumbar Spinal Stenosis
Kim, H., Lee, J.-I., Kang, K., Chang, B., Lee, C., Ruscheweyh, R., Kang, S. S., & Yeom, J. S. (2014) · Spine · doi:10.1097/brs.0000000000000699 · Cited by 44
Gender Difference of Symptom Severity in Lumbar Spinal Stenosis: Role of Pain Sensitivity
Yeom, J. S. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/e715 · Cited by 44
Sex-related differences in descending norepinephrine and serotonin controls of spinal withdrawal reflex during intramuscular saline induced muscle nociception in rats
Lei, J., Jin, L., Zhao, Y., Sui, M.-Y., Huang, L., Tan, Y.-X., Chen, Y.-K., & You, H. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.01.004 · Cited by 43
Microscopic Periradicular Surgery: Perioperative Predictors for Postoperative Clinical Outcomes and Quality of Life Assessment
Iqbal, M., Kratchman, S., Guess, G., Karabucak, B., & KIM, S. (2007) · Journal of Endodontics · doi:10.1016/j.joen.2006.11.017 · Cited by 43
Influence of moderate intensity physical activity levels and gender on conditioned pain modulation
Umeda, M., Lee, W., Marino, C. A., & Hilliard, S. C. (2015) · Journal of Sports Sciences · doi:10.1080/02640414.2015.1061199 · Cited by 42
Mid-air tactile stimulation using laser-induced thermoelastic effects: The first study for indirect radiation
Lee, H., Kim, J.-S., Choi, S., Jun, J.-H., Park, J.-R., Kim, A.-H., Oh, H.-B., Kim, H.-S., & Chung, S. (2015) · IEEE World Haptics Conference (WHC) · doi:10.1109/whc.2015.7177741 · Cited by 42
Involvement of the Melanocortin-1 Receptor in Acute Pain and Pain of Inflammatory but Not Neuropathic Origin
Delaney, A., Keighren, M., Fleetwood-Walker, S. M., & Jackson, I. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012498 · Cited by 42

Authors: Riley, J. L., Robinson, M. E., Wise, E. A., Myers, C. D., & Fillingim, R. B.
Affiliations: University of Florida Health (US)
University of Alabama at Birmingham (US)
Corresponding author: Riley, Joseph L
ORCID: Riley, Joseph L
Robinson, Michael E
Fillingim, Roger B
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1998-01
Volume: 74
Issue: 2
Pages: 181-187
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/s0304-3959(97)00199-1
OpenAlex: W2018901856
Cited by: 1,085
References: 44
Citations by year: 2026: 16 · 2025: 29 · 2024: 25 · 2023: 44 · 2022: 31 · 2021: 43 · 2020: 27 · 2019: 41 · 2018: 36 · 2017: 42 · 2016: 46 · 2015: 46 · 2014: 51 · 2013: 49 · 2012: 55
FWCI: 3.52
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Dental and Craniofacial Research (DE-07283)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: sex differences, pain perception, noxious stimuli, pain threshold, pain tolerance, pressure pain, electrical stimulation, thermal pain, sample size, statistical power, effect size
MeSH terms: Female, Humans, Male, Noxae, Sex Characteristics, Pain Threshold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex differences in the perception of noxious experimental stimuli: a meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks