Cited by 1,085Pain Mechanisms and TreatmentsSex and Gender in HealthcarePain Management and Placebo Effect

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Sex differences in the perception of noxious experimental stimuli: a meta-analysis

Riley, Joseph L, Robinson, Michael E, Wise, Emily A, Myers, Cynthia D, Fillingim, Roger B·1998·Pain

Open this paper in CoChat — free account

Abstract

Fillingim and Maixner (Fillingim, R.B. and Maixner, W., Pain Forum, 4(4) (1995) 209-221) recently reviewed the body of literature examining possible sex differences in responses to experimentally induced noxious stimulation. Using a 'box score' methodology, they concluded the literature supports sex differences in response to noxious stimuli, with females displaying greater sensitivity. However, Berkley (Berkley, K.J., Pain Forum, 4(4) (1995) 225-227) suggested the failure of a number of studies to reach statistical significance suggests the effect may be small and of little practical significance. This study used meta-analytic methodology to provide quantitative evidence to address the question of the magnitude of these sex differences in response to experimentally induced pain. We found the effect size to range from large to moderate, depending on whether threshold or tolerance were measured and which method of stimulus administration was used. The values for pressure pain and electrical stimulation, for both threshold and tolerance measures, were the largest. For studies employing a threshold measure, the effect for thermal pain was smaller and more variable. The failures to reject the null hypothesis in a number of these studies appear to have been a function of lack of power from an insufficient number of subjects. Given the estimated effect size of 0.55 threshold or 0.57 for tolerance, 41 subjects per group are necessary to provide adequate power (0.70) to test for this difference. Of the 34 studies reviewed by Fillingim and Maixner, only seven were conducted with groups of this magnitude. The results of this study compels to caution authors to obtain adequate sample sizes and hope that this meta-analytic review can aid in the determination of sample size for future studies.

Integrity signals

Registry

Crossref · 10.1016/s0304-3959(97)00199-1

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Book Reviews: Statistical Methods for Meta-Analysis Larry V. Hedges and Ingram Olkin New York: Academic Press, 1985. xxii + 369 pp
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,361
A power primer.
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771
Distribution Theory for Glass's Estimator of Effect Size and Related Estimators
Hedges, L. V. (1981) · Journal of Educational Statistics · doi:10.2307/1164588 · Cited by 5,695
Gender variations in clinical pain experience
Unruh, A. M. (1996) · Pain · doi:10.1016/0304-3959(95)00214-6 · Cited by 1,550
Estimation of effect size from a series of independent experiments.
Hedges, L. (1982) · Psychological Bulletin · doi:10.1037/0033-2909.92.2.490 · Cited by 1,030
Pressure algometry over normal muscles. Standard values, validity and reproducibility of pressure threshold
Fischer, A. A. (1987) · Pain · doi:10.1016/0304-3959(87)90089-3 · Cited by 960
The science and politics of comparing women and men.
Eagly, A. H. (1995) · American Psychologist · doi:10.1037/0003-066x.50.3.145 · Cited by 606
Gender differences in the responses to noxious stimuli
Fillingim, R. B., & Maixner, W. D. (1995) · Pain Forum · doi:10.1016/s1082-3174(11)80022-x · Cited by 475
Pain Tolerance: Differences According to Age, Sex and Race
Woodrow, K. M., FRIEDMAN, G. D., SIEGELAUB, A. B., & Collen, M. F. (1972) · Psychosomatic Medicine · doi:10.1097/00006842-197211000-00007 · Cited by 436
Gender differences in Pain
Rollman, G. B. (1995) · Pain Forum · doi:10.1016/s1082-3174(11)80026-7 · Cited by 399

Show all 44 references

Research works printed but not linked: 3

Coulthard, 1993, Anxiety during induced experimental pain. Anesth., Pain Control Dentis, 2, 150
Fillingim, 1996, The influence of gender and psychological factors on pain perception. J., Gender Culture Health, 1, 21
Procacci, 1970, The cutaneous pricking threshold in old age. Clin., Gerontol, 12, 213

Sorted by citations

Items 401–500 of 1,000

Concept priming and pain: an experimental approach to understanding gender roles in sex-related pain differences
Fowler, S. L., Rasinski, H. M., Geers, A. L., Helfer, S. G., & France, C. R. (2010) · Journal of Behavioral Medicine · doi:10.1007/s10865-010-9291-7 · Cited by 42
Increased Pain Sensitivity in Low Blood Pressure
Duschek, S., Schwarzkopf, W., & Schandry, R. (2008) · Journal of Psychophysiology · doi:10.1027/0269-8803.22.1.20 · Cited by 42
Substance P is increased in patients with sickle cell disease and associated with haemolysis and hydroxycarbamide use
Brandow, A. M., Wandersee, N. J., Dasgupta, M., Hoffmann, R. G., Hillery, C. A., Stucky, C. L., & Panepinto, J. A. (2016) · British Journal of Haematology · doi:10.1111/bjh.14300 · Cited by 43
Age Interactions on Pain Sensitization in Patients With Severe Knee Osteoarthritis and Controls
Petersen, K. K., Arendt‐Nielsen, L., Finocchietti, S., Hirata, R. P., Simonsen, O. H., Laursen, M. B., & Graven‐Nielsen, T. (2017) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000495 · Cited by 42
Sex Differences in Brain Regions Modulating Pain Among Older Adults: A Cross-Sectional Resting State Functional Connectivity Study
Monroe, T. B., Fillingim, R. B., Bruehl, S. P., Rogers, B. P., Dietrich, M. S., Gore, J. C., Atalla, S., & Cowan, R. L. (2017) · Pain Medicine · doi:10.1093/pm/pnx084 · Cited by 42
A Pilot Study on Bioactive Constituents and Analgesic Effects of MyrLiq®, a Commiphora myrrha Extract with a High Furanodiene Content
Germanò, A., Occhipinti, A., Barbero, F., & Maffei, M. E. (2017) · BioMed Research International · doi:10.1155/2017/3804356 · Cited by 42
Sex differences in perceptual and cardiovascular responses to pain: the influence of a perceived ability manipulation
Fillingim, R. B., Browning, A. D., Powell, T., & Wright, R. A. (2002) · Journal of Pain · doi:10.1054/jpai.2002.128067 · Cited by 42
Opioid Use in the Management of Diabetic Peripheral Neuropathy (DPN) in a Large Commercially Insured Population
Patil, P. R., Wolfe, J., Said, Q., Thomas, J., & Martin, B. C. (2014) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000124 · Cited by 40
Spatial summation of heat pain in males and females
Lautenbacher, S. (2001) · Somatosensory & Motor Research · doi:10.1080/135578501012006192-1 · Cited by 41
Prevalence and Psychiatric Correlates of Pain Interference Among Men and Women in the General Population
Barry, D. T., Pilver, C., Potenza, M., & Desai, R. A. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.004 · Cited by 42
No evidence for sex differences in the severity and treatment of cancer pain
Edrington, J., Paul, S. M., Dodd, M. J., West, C. M., Facione, N. C., Tripathy, D., Koo, P., Schumacher, K. L., & Miaskowski, C. A. (2004) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2003.12.013 · Cited by 41
Pain of Paying? A Metaphor Gone Literal: Evidence from Neural and Behavioral SciencePreprint
Mažar, N., Plaßmann, H., & Robitaille, N. (2016) · SSRN Electronic Journal · doi:10.2139/ssrn.2901808 · Cited by 43
Sex differences in the transition to chronic pain
Smith, A. F., Plumb, A. N., Berardi, G., & Sluka, K. A. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191931 · Cited by 43
Comparison of operant escape and reflex tests of nociceptive sensitivity
Vierck, C. J., & Yezierski, R. P. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.022 · Cited by 39
Sex Differences in Pain Intensity in Adolescents Suffering From Cancer: Differences in Pain Memories?
Hechler, T., CHALKIADIS, G. A., Hasan, C., Kosfelder, J., Meyerhoff, U., Vocks, S., & Zernikow, B. (2009) · Journal of Pain · doi:10.1016/j.jpain.2008.11.011 · Cited by 40
Effect of oral ketorolac and gender on human cold pressor pain tolerance
Compton, P. A., Charuvastra, V. C., & Ling, W. W. (2003) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2003.03907.x · Cited by 40
Heart rate mediation of sex differences in pain tolerance in children
Lü, Q., Zeltzer, L. K., Tsao, J. C. I., Kim, S. C., Turk, N., & Naliboff, B. D. (2005) · Pain · doi:10.1016/j.pain.2005.08.008 · Cited by 42
Thermoreception and nociception of the skin: a classic paper of Bessou and Perl and analyses of thermal sensitivity during a student laboratory exercise
Kuhtz-Buschbeck, J. P., Andresen, W., Göbel, S., Gilster, R., & Stick, C. (2010) · AJP Advances in Physiology Education · doi:10.1152/advan.00002.2010 · Cited by 40
Sex differences in nociceptive withdrawal reflex and pain perception
Mylius, V., Miriam Kunz, A., Schepelmann, K., & Lautenbacher, S. (2005) · Somatosensory & Motor Research · doi:10.1080/08990220500262414 · Cited by 40
Sex Differences in the Medical Care of VA Patients with Chronic Non-Cancer Pain
Weimer, M. B., Macey, T. A., Nicolaidis, C., Dobscha, S. K., Duckart, J. P., & Morasco, B. J. (2013) · Pain Medicine · doi:10.1111/pme.12177 · Cited by 40
Clinical Interpretation of Quantitative Sensory Testing as a Measure of Pain Sensitivity in Patients With Sickle Cell Disease
Brandow, A. M., & Panepinto, J. A. (2016) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000532 · Cited by 39
Trade-offs between predator avoidance and electric shock avoidance in hermit crabs demonstrate a non-reflexive response to noxious stimuli consistent with prediction of pain
Magee, B., & Elwood, R. W. (2016) · Behavioural Processes · doi:10.1016/j.beproc.2016.06.017 · Cited by 39
Neurosteroids in Pain Management: A New Perspective on an Old Player
Joksimovic, S. L., Covey, D. F., Jevtović‐Todorović, V., & Todorovic, S. M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01127 · Cited by 40
Restrictions in Quality of Life After Intramedullary Nailing of Tibial Shaft Fracture
Larsen, P. F., Lund, H., Læssøe, U., Graven‐Nielsen, T., & Rasmussen, S. (2013) · Journal of Orthopaedic Trauma · doi:10.1097/bot.0000000000000031 · Cited by 39
Indicators for choosing an optimal mix of major working postures
Laperrière, È., Ngomo, S., Thibault, M.-C., & Messing, K. (2005) · Applied Ergonomics · doi:10.1016/j.apergo.2005.06.014 · Cited by 39
Pain in workers with shoulder impingement syndrome: an assessment using the DASH and McGill pain questionnaires
Camargo, P. R., Haik, M. N., Filho, R., Mattiello, S. M., & Salvini, T. F. (2007) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552007000200012 · Cited by 39
Sex and gender determinants following spinal fusion surgery: A systematic review of clinical data
Salamanna, F., Contartese, D., Tschon, M., Borsari, V., Griffoni, C., Gasbarrini, A., & Fini, M. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.983931 · Cited by 38
Pain depression and sleep disorders among methadone maintenance treatment patients
Pud, D., Zlotnick, C., & Lawental, E. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.05.025 · Cited by 38
Gender differences between WOMAC index scores, health-related quality of life and physical performance in an elderly Taiwanese population with knee osteoarthritis
Fang, W., Huang, G., Chang, H.-F., Chen, C.-Y., Kang, C.-Y., Wang, C., Lin, C. S., Yang, J.-H., Su, W., Kao, S., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-008542 · Cited by 38
Gender analysis of musculoskeletal disorders and emotional exhaustion: interactive effects from physical and psychosocial work exposures and engagement in domestic work
Ahlgren, C., Malmgren‐Olsson, E., & Brulin, C. (2012) · Ergonomics · doi:10.1080/00140139.2011.646319 · Cited by 38
An Everyday Phrase May Harm Your Patients
Ott, J., Aust, S., Nouri, K., & Promberger, R. (2011) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182321cc3 · Cited by 38
Effects of sex, phase of the menstrual cycle and gonadal hormones on pain in healthy humans
Ring, C., Zanten, J. V., & Kavussanu, M. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.04.004 · Cited by 37
Influence of the menstrual cycle on the pressure pain threshold of masticatory muscles in patients with masticatory myofascial pain
Lobato, V. V., Vedolin, G. M., de Araújo, C. D. R. P., & Conti, P. C. R. (2008) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2007.08.044 · Cited by 37
Dental fear among transgender individuals ‐ a cross‐sectional survey
Heima, M., Heaton, L. J., Ng, H., & Roccoforte, E. C. (2017) · Special Care in Dentistry · doi:10.1111/scd.12245 · Cited by 37
Pain Detection with fNIRS-Measured Brain Signals: A Personalized Machine Learning Approach Using the Wavelet Transform and Bayesian Hierarchical Modeling with Dirichlet Process Priors
Lopez-Martinez, D., Peng, K., Lee, A. M., Borsook, D., & Picard, R. W. (2019) · International Conference on Affective Computing and Intelligent Interaction Workshops and Demos (ACIIW) · doi:10.1109/aciiw.2019.8925076 · Cited by 36
Gender Influences Radicular Pain Perception in Patients with Lumbar Disc Herniation
Tschugg, A., Löscher, W. N., Hartmann, S., Neururer, S. B., Wildauer, M., & Thomé, C. (2015) · Journal of Women s Health · doi:10.1089/jwh.2014.5108 · Cited by 36
Children and adolescents with sickle cell disease have worse cold and mechanical hypersensitivity during acute painful events
Brandow, A. M., Hansen, K., Nugent, M., Pan, A. Y., Panepinto, J. A., & Stucky, C. L. (2018) · Pain · doi:10.1097/j.pain.0000000000001407 · Cited by 36
Blood pressure-related hypoalgesia: a systematic review and meta-analysis
Makovac, E., Porciello, G., Palomba, D., Basile, B., & Ottaviani, C. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002427 · Cited by 36
Gender and Age Differences in Medications Dispensed from a National Chain Drugstore
Anthony, M., Lee, K. Y., Bertram, C. T., Abarca, J., Rehfeld, R. A., Malone, D. C., Freeman, M. P., & Woosley, R. L. (2008) · Journal of Women s Health · doi:10.1089/jwh.2007.0731 · Cited by 36
Estrogen-dependent changes in visceral afferent sensitivity
Sanoja, R., & Cerveró, F. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.07.001 · Cited by 36
Effect of pulsed magnetic field therapy on pain reported by human volunteers in a laboratory model of acute pain †
Fernandez, M. I., Watson, P., & Rowbotham, D. J. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem129 · Cited by 36
Gender Biases in Adult Ratings of Pediatric Pain
Cohen, L. L., Cobb, J. E., & Martin, S. R. (2013) · Children s Health Care · doi:10.1080/02739615.2014.849918 · Cited by 36
A Statistical Model to Determine Biomechanical Limits for Physically Safe Interactions With Collaborative Robots
Behrens, R., Pliske, G., Umbreit, M., Piatek, S., Walcher, F., & Elkmann, N. (2022) · Frontiers in Robotics and AI · doi:10.3389/frobt.2021.667818 · Cited by 35
Sex differences in pain anchors revisited: further investigation of “most intense” and common pain events⋆
Robinson, M. E., George, S. Z., Dannecker, E. A., Jump, R. L., Hirsh, A. T., Gagnon, C. M., & Brown, J. L. (2003) · European Journal of Pain · doi:10.1016/j.ejpain.2003.10.003 · Cited by 35
Sex Differences in the Adequacy of Pain Management Among Patients Referred to a Multidisciplinary Cancer Pain Clinic
Donovan, K. A., Taliaferro, L. A., Brock, C. W., & Bazargan, S. (2008) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2007.09.013 · Cited by 35
Hormonal replacement therapy does not affect self-estimated pain or experimental pain responses in post-menopausal women suffering from fibromyalgia: a double-blind, randomized, placebo-controlled trial
Stening, K., Eriksson, O., Henriksson, K. G., Brynhildsen, J., Lindh‐Åstrand, L., Berg, G. E., Hammar, M. L., Amandusson, Å., & Blomqvist, A. G. (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq348 · Cited by 35
Pupillometry: The Influence of Gender and Anxiety on the Pain Response
Garcia, J. B. S. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/e257 · Cited by 35
Sex Differences in Predictors of Outcome in Selected Physical Therapy Interventions for Acute Low Back Pain
George, S. Z., Fritz, J. M., Childs, J. D., & Brennan, G. P. (2006) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.2006.2270 · Cited by 35
The influence of athletic status and gender on experimental pain responses
Manning, E. L., & Fillingim, R. B. (2002) · Journal of Pain · doi:10.1054/jpai.2002.128068 · Cited by 34
Women Have the Same Desflurane Minimum Alveolar Concentration as Men
Wadhwa, A. N., Durrani, J., Sengupta, P., Doufas, A. G., & Sessler, D. I. (2003) · Anesthesiology · doi:10.1097/00000542-200311000-00010 · Cited by 34
Efficacy of a Psychosocial Pain Management Intervention for Men and Women With Substance Use Disorders and Chronic Pain: A Randomized Clinical Trial
Ilgen, M. A., Coughlin, L. N., Bohnert, A. S. B., Chermack, S., Price, A., Kim, H. M., Jannausch, M., & Blow, F. C. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.2369 · Cited by 33
Clinical profile in relation to age and gender of patients with temporomandibular disorders: a retrospective study
Qin, H., Guo, S., Chen, X., Liu, Y., Lu, L., Zhang, M., Zhang, H., Zhang, J., & Yu, S. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04736-2 · Cited by 33
The Use of Neuropathic Pain Drugs in Children With Sickle Cell Disease Is Associated With Older Age, Female Sex, and Longer Length of Hospital Stay
Brandow, A. M., Farley, R. A., Dasgupta, M., Hoffmann, R. G., & Panepinto, J. A. (2014) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0000000000000265 · Cited by 33
Sex differences in kappa opioid receptor inhibition of latent postoperative pain sensitization in dorsal horn
Custodio-Patsey, L., Donahue, R. R., Fu, W., Lambert, J., Smith, B. N., & Taylor, B. K. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107726 · Cited by 33
Interactions Among Sex, Ethnicity, Religion, and Gender Role Expectations of Pain
Defrin, R., Eli, I., & Pud, D. (2011) · Gender Medicine · doi:10.1016/j.genm.2011.04.001 · Cited by 33
The Role of Mood States Underlying Sex Differences in the Perception and Tolerance of Pain
Garofalo, J. P., Lawler, C., Robinson, R., Morgan, M. M., & Kenworthy‐Heinige, T. (2006) · Pain Practice · doi:10.1111/j.1533-2500.2006.00084.x · Cited by 33
Dor dentária e fatores associados em adolescentes brasileiros: a Pesquisa Nacional de Saúde do Escolar (PeNSE), Brasil, 2009
Freire, M. D. C. M., Leles, C. R., Sardinha, L. M. V., Paludetto, M., Malta, D. C., & Peres, M. A. (2012) · Cadernos de Saúde Pública · doi:10.1590/s0102-311x2012001300014 · Cited by 33
Sex Differences in Pain
Keogh, E. (2008) · Reviews in Pain · doi:10.1177/204946370800200203 · Cited by 36
The Human Pain System
Lenz, F. A., Casey, K. L., Jones, E. G., & Willis, W. D. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770579 · Cited by 51
Perception of Electrocutaneous Stimuli in Irritable Bowel Syndrome
Iovino, P., Tremolaterra, F., Consalvo, D., Sabbatini, F., Mazzacca, G., & Ciacci, C. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00414.x · Cited by 33
Sex differences in the effects of amiloride on formalin test nociception in mice
Chanda, M. L., & Mogil, J. S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00902.2005 · Cited by 33
Modulation of imidazoline I 2binding sites by CR 4056 relieves postoperative hyperalgesia in male and female rats
Lanza, M., Ferrari, F., Menghetti, I., Tremolada, D., & Caselli, G. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12728 · Cited by 32
Pain sensitivity in major depression and its relationship to central serotoninergic function as reflected by the neuroendocrine response to clomipramine
Kundermann, B., Hemmeter-Spernal, J., Strate, P., Gebhardt, S., Huber, M., Krieg, J.-C., & Lautenbacher, S. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.04.012 · Cited by 32
Modulation of Itch by Conditioning Itch and Pain Stimulation in Healthy Humans
Andersen, H. H., van Laarhoven, A. I. M., Elberling, J., & Arendt‐Nielsen, L. (2017) · Journal of Pain · doi:10.1016/j.jpain.2017.07.002 · Cited by 32
The development and psychometric properties of the Arabic version of the child oral health impact profile-short form (COHIP- SF 19)
Arheiam, A., Baker, S. R., Ballo, L., Elareibi, I., Fakron, S., & Harris, R. V. (2017) · Health and Quality of Life Outcomes · doi:10.1186/s12955-017-0796-4 · Cited by 34
Baseline Risk Factors for Prolonged Opioid Use Following Spine Surgery: Systematic Review and Meta-Analysis
Mohan, S., Lynch, C. P., Cha, E. D. K., Jacob, K. C., Patel, M. R., Geoghegan, C. E., Prabhu, M. C., Vanjani, N. N., Pawlowski, H., & Singh, K. (2021) · World Neurosurgery · doi:10.1016/j.wneu.2021.12.086 · Cited by 32
Personal influencing factors for pressure pain threshold in healthy people: A systematic review and meta-analysis
Vervullens, S., Haenen, V., Meert, L., Meeus, M., Smeets, R., Baert, I. A. C., & Mertens, M. G. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104727 · Cited by 32
Sex differences in responses to epidural steroid injection for low back pain
Inman, S. L., Faut-Callahan, M., Swanson, B. A., & Fillingim, R. B. (2004) · Journal of Pain · doi:10.1016/j.jpain.2004.07.004 · Cited by 32
Oxycodone: A Current Perspective on Its Pharmacology, Abuse, and Pharmacotherapeutic Developments
Barrett, J. E., Shekarabi, A., & Inan, S. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000506 · Cited by 35
Sex, pain, and the microbiome: The relationship between baseline gut microbiota composition, gender and somatic pain in healthy individuals
Caputi, V., Bastiaanssen, T. F. S., Peterson, V. L., Sajjad, J., Murphy, A., Stanton, C., McNamara, B., Shorten, G., Cryan, J. F., & O’Mahony, S. M. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.06.002 · Cited by 33
Is use of exogenous estrogen associated with temporomandibular signs and symptoms?
Hatch, J. P., Rugh, J. D., Sakai, S., & Saunders, M. J. (2001) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2001.0174 · Cited by 31
Comparison of the Cold Pressor Test and Contact Thermode-Delivered Cold Stimuli for the Assessment of Cold Pain Sensitivity
Ruscheweyh, R., Stumpenhorst, F., Knecht, S., & Marziniak, M. (2010) · Journal of Pain · doi:10.1016/j.jpain.2009.10.016 · Cited by 31
Immediate changes in pressure pain threshold in the iliotibial band using a myofascial (foam) roller
Vaughan, B., McLaughlin, P. A., & Lepley, A. S. (2014) · International Journal of Therapy and Rehabilitation · doi:10.12968/ijtr.2014.21.12.569 · Cited by 31
Sex-specific effects of gender identification on pain study recruitment
Mattos Feijó, L., Tarman, G. Z., Fontaine, C., Harrison, R., Johnstone, T., & Salomons, T. (2018) · The Journal of Pain · doi:10.1016/j.jpain.2017.09.009 · Cited by 29
Pain profiles and variability in temporal summation of pain and conditioned pain modulation in pain‐free individuals and patients with low back pain, osteoarthritis, and fibromyalgia
Petersen, K. K., O’Neill, S. F. D., Blichfeldt‐Eckhardt, M. R., Nim, C. G., Arendt‐Nielsen, L., & Vægter, H. B. (2024) · European Journal of Pain · doi:10.1002/ejp.4741 · Cited by 29
Do sex hormones influence emotional modulation of pain and nociception in healthy women?
Rhudy, J. L., Bartley, E. J., Palit, S., Kerr, K. L., Kuhn, B. L., Martin, S. L., DelVentura, J. L., & Terry, E. L. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.10.003 · Cited by 30
Symptoms of Fibromyalgia According to the 2016 Revised Fibromyalgia Criteria in Chronic Pain Patients Referred to Multidisciplinary Pain Rehabilitation: Influence on Clinical and Experimental Pain Sensitivity
Bruun, K. D., & Vægter, H. B. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.02.009 · Cited by 31
Muscle alterations in the development and progression of cancer-induced muscle atrophy: a review
Rosa‐Caldwell, M. E., Fix, D. K., Washington, T. A., & Greene, N. P. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00622.2019 · Cited by 30
Somatosensory function following painful repetitive electrical stimulation of the human temporomandibular joint and skin
Ayesh, E., Jensen, T. S., & Svensson, P. J. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0801-3 · Cited by 30
Effects of chewing gum on responses to routine painful procedures in children
Lewkowski, M. D., Barr, R. G., Sherrard, A., Lessard, J., Harris, A., & Young, S. N. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00098-2 · Cited by 30
Fear of Severe Pain Mediates Sex Differences in Pain Sensitivity Responses to Thermal Stimuli
Horn, M. E., Alappattu, M. J., Gay, C. W., & Bishop, M. D. (2014) · Pain Research and Treatment · doi:10.1155/2014/897953 · Cited by 30
Effects of Intramuscular Anesthesia on the Expression of Primary and Referred Pain Induced by Intramuscular Injection of Hypertonic Saline
Rubin, T. K., Gandevia, S. C., Henderson, L. A., & Macefield, V. G. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.01.327 · Cited by 30
No pain, no social gains: A social-signaling perspective of human pain behaviors
Vigil, J. M. (2014) · World Journal of Anesthesiology · doi:10.5313/wja.v3.i1.18 · Cited by 30
Reproducibility of quantitative sensory testing applied to musculoskeletal orofacial region: Site and sex differences
Costa, Y. M., de Araújo-Júnior, E. N. S., Fiedler, L. S., de Souza, P. R. J., Silva, L. L. C. P., Ferreira, D. M. A. O., Conti, P. C. R., & Bonjardim, L. R. (2018) · European Journal of Pain · doi:10.1002/ejp.1287 · Cited by 30
Sex Differences in Clinical Outcomes Following Surgical Treatment of Femoroacetabular Impingement
Maerz, T., Nepple, J. J., Bedi, A., Zaltz, I., Belzile, É. L., Beaulé, P. E., Sink, E. L., the ANCHOR Group, & Clohisy, J. C. (2021) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.20.00394 · Cited by 29
Risk factors for new chronic opioid use after hip fracture surgery: a Danish nationwide cohort study from 2005 to 2016 using the Danish multidisciplinary hip fracture registry
Edwards, N. M., Varnum, C., Overgaard, S., Nikolajsen, L., Christiansen, C. F., & Pedersen, A. B. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-039238 · Cited by 31
Variation of pain and vasomotor responses evoked by intramuscular infusion of hypertonic saline in human subjects: Influence of gender and its potential neural mechanisms
Lei, J., & You, H. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.003 · Cited by 29
A machine-learned knowledge discovery method for associating complex phenotypes with complex genotypes. Application to pain
Lötsch, J., & Ultsch, A. (2013) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2013.07.010 · Cited by 29
Designing and conducting proof-of-concept chronic pain analgesic clinical trials
Campbell, C. M., Gilron, I., Doshi, T. L., & Raja, S. N. (2018) · PAIN Reports · doi:10.1097/pr9.0000000000000697 · Cited by 32
Muscle pain in myophosphorylase deficiency (McArdle’s disease): The role of gender, genotype, and pain-related coping
Rommel, O., Kley, R. A., Dekomien, G., Epplen, J. T., Vorgerd, M., & Hasenbring, M. I. (2006) · Pain · doi:10.1016/j.pain.2006.04.017 · Cited by 29
The biosocial female choice theory of social stratification*
Ellis, L. (2001) · Biodemography and Social Biology · doi:10.1080/19485565.2001.9989040 · Cited by 29
The effects of a cold-water stimulus on butorphanol effects in males and females
Zacny, J. P., & Beckman, N. J. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.01.021 · Cited by 29
Gender Differences in Pain and Biomechanical Responses After Acid Sensitization of the Human Esophagus
Reddy, H., Arendt‐Nielsen, L., Staahl, C., Pedersen, J., Funch-Jensen, P. M., Gregersen, H. N., & Drewes, A. M. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-3006-x · Cited by 29
Sex Differences in Task Distribution and Task Exposures among Danish House Painters: An Observational Study Combining Questionnaire Data with Biomechanical Measurements
Heilskov-Hansen, T., Svendsen, S. W., Thomsen, J. F., Mikkelsen, S., & Hansson, G.-Å. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110899 · Cited by 28
Single-Point but Not Tonic Cuff Pressure Pain Sensitivity Is Associated with Level of Physical Fitness – A Study of Non-Athletic Healthy Subjects
Lemming, D., Börsbo, B., Sjörs, A., Lind, E.-B., Arendt‐Nielsen, L., Graven‐Nielsen, T., & Gerdle, B. U. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125432 · Cited by 28
Efficacy of cold application on pain during chest tube removal
Hsieh, L., Chen, Y., & Lu, M. (2017) · Medicine · doi:10.1097/md.0000000000008642 · Cited by 28
Functional near-infrared spectroscopy study on tonic pain activation by cold pressor test
Barati, Z., Zakeri, I., & Pourrezaei, K. (2017) · Neurophotonics · doi:10.1117/1.nph.4.1.015004 · Cited by 29
Somatic focus/awareness: Relationship to negative affect and pain in chronic pain patients
O’Brien, E. M., Atchison, J. W., Gremillion, H. A., Waxenberg, L. B., & Robinson, M. E. (2007) · European Journal of Pain · doi:10.1016/j.ejpain.2007.04.001 · Cited by 28
Does gender affect the relation between blood pressure and pain sensitivity?
Helfer, S. G., & McCubbin, J. A. (2001) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0803_4 · Cited by 28
Aspects of Pain, Its Assessment and Evaluation from An Acupuncture Perspective
Lund, I., & Lundeberg, T. (2006) · Acupuncture in Medicine · doi:10.1136/aim.24.3.109 · Cited by 28

Authors: Riley, J. L., Robinson, M. E., Wise, E. A., Myers, C. D., & Fillingim, R. B.
Affiliations: University of Florida Health (US)
University of Alabama at Birmingham (US)
Corresponding author: Riley, Joseph L
ORCID: Riley, Joseph L
Robinson, Michael E
Fillingim, Roger B
Venue: Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1998-01
Volume: 74
Issue: 2
Pages: 181-187
ISSN: 0304-3959 (ISSN-L)
DOI: 10.1016/s0304-3959(97)00199-1
OpenAlex: W2018901856
Cited by: 1,085
References: 44
Citations by year: 2026: 16 · 2025: 29 · 2024: 25 · 2023: 44 · 2022: 31 · 2021: 43 · 2020: 27 · 2019: 41 · 2018: 36 · 2017: 42 · 2016: 46 · 2015: 46 · 2014: 51 · 2013: 49 · 2012: 55
FWCI: 3.52
Type: journal article
Language: en
Open access: closed
Locations: Pain (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Dental and Craniofacial Research (DE-07283)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Keywords: sex differences, pain perception, noxious stimuli, pain threshold, pain tolerance, pressure pain, electrical stimulation, thermal pain, sample size, statistical power, effect size
MeSH terms: Female, Humans, Male, Noxae, Sex Characteristics, Pain Threshold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sex differences in the perception of noxious experimental stimuli: a meta-analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks