Morphologic and genetic characterization of Onchocerca lupi infecting dogs
Abstract
In the past decades, sporadic cases of ocular Onchocerca infection have been reported in canids in US and Europe. The present study was undertaken to provide a detailed description of the morphologic characteristics of adults and microfilariae and to characterize the 5S ribosomal rRNA gene (5S rDNA) spacer sequences of Onchocerca lupi causing canine onchocercosis. The morphology of O. lupi is unique within the genus, and morphology based cluster analysis indicates that O. lupi is not closely related to the members of domestic cattle or horse clades occurring in North America and Europe. Similarly, the signature of the 5S rDNA spacer sequences of O. lupi does not resemble any other Onchocerca 5S rDNA spacer sequences including those of the members of domestic cattle or horse clades. The adult and microfilarial morphology and sequence signature supports the biological arguments that a distinct species, O. lupi and not O. lienalis, is responsible for canine ocular onchocercosis.
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Onchocerca lupi causes canine and human infestation in Europe and overseas.
“The recent finding of Onchocerca lupi causing canine and human infestation in Europe and overseas renders the picture of VBH even more complicated.”
From Vector-borne helminths of dogs and humans in Europe (2013) · cites this paper as [22]
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- Authors
- Egyed, Z., Sréter, T., Széll, Z., Beszteri, B., Oravecz, O., Márialigeti, K., & Varga, I.
- Affiliations
- Magyar Agrár- és Élettudományi Egyetem (HU)
- Eötvös Loránd University (HU)
- Corresponding author
- Sréter, T.
- Venue
- Veterinary Parasitology
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 102
- Issue
- 4
- Pages
- 309-319
- ISSN
- 0304-4017 (ISSN-L)
- OpenAlex
- W2040979566
- Cited by
- 42
- References
- 19
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2021: 4 · 2018: 3 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Helmholtz-Zentrum für Polar-und Meeresforschung (Alfred-Wegener-Institut) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- Onchocerca lupi, microfilariae, adult worm morphology, species delimitation, Onchocerca lienalis, molecular phylogeny, dogs
- MeSH terms
- Animals, Base Sequence, Dog Diseases, Dogs, Eye, Female, Male, Microfilariae, Molecular Sequence Data, Onchocerca, Phylogeny, RNA, Ribosomal, 5S, Sequence Homology, Nucleic Acid, Onchocerciasis, Ocular, Cluster Analysis, Polymerase Chain Reaction, Sequence Alignment
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