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Cited by 35Parasitic Diseases Research and TreatmentHelminth infection and controlResearch on Leishmaniasis Studies

Molecular genetic comparison of Onchocerca sp. infecting dogs in Europe with other spirurid nematodes including Onchocerca lienalis

Sréter-Lancz, Z., Széll, Z., Sréter, T.·2007·Veterinary Parasitology
DOI 10.1016/j.vetpar.2007.06.021
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Abstract

In the past 15 years, subconjunctival onchocercosis has been reported from 63 dogs in south-western United States (Arizona, California, Utah) and Southern and Central Europe (Germany, Greece, Hungary, Portugal, Switzerland). To reveal the taxonomic status of the parasite responsible for these infections, fragments of the mitochondrial cytochrome oxidase subunit I (COI) and NADH dehydrogenase subunit 5 (ND5) genes of three European strains of canine Onchocerca sp. and the 16S ribosomal RNA (16S rRNA) gene of their Wolbachia endosymbionts were sequenced and compared to the homologous sequences of other spirurid nematodes. The evolutionary divergence between COI and ND5 gene sequences of Greek, Hungarian and Portuguese strains of canine Onchocerca sp. were similar in magnitude to that seen within Thelazia callipaeda or Onchocerca lienalis. The evolutionary divergence between the sequences of canine Onchocerca sp. and other Onchocerca spp. including O. lienalis were similar or higher in magnitude to that seen between other Onchocerca spp. The results of the current and earlier phylogenetic analyses indicate that canine Onchocerca sp. separated from other Onchocerca spp. early in the evolution. Based on the similar clinical pictures, the identical morphology of nematodes and the sequence analyses of COI and ND5 genes of the worms and 16S rRNA gene of their wolbachiae, the Onchocerca worms isolated from European dogs appear to belong to the same species. The results support the earlier biological and morphological arguments that a distinct species, most likely O. lupi originally described from the subconjunctival tissues of a Caucasian wolf is responsible for canine ocular onchocercosis in Europe.

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  • D. immitis has only recently been introduced to Hungary.

    “However, it is more plausible that D. immitis has only recently been introduced to Hungary because neither microfilariae nor adult worms of D. immitis had been found in local dogs (Fok et al. 2007) and red foxes earlier (Sréter et al. 2003).”

    From The current situation of canine dirofilariosis in Hungary (2020) · cites this paper as Sréter et al. 2003

  • Onchocerca lupi causes canine and human infestation in Europe and overseas.

    “The recent finding of Onchocerca lupi causing canine and human infestation in Europe and overseas renders the picture of VBH even more complicated.”

    From Vector-borne helminths of dogs and humans in Europe (2013) · cites this paper as [26]

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Authors
Sréter-Lancz, Z., Széll, Z., & Sréter, T.
Corresponding author
Sréter, T.
ORCID
Sréter, T.
Venue
Veterinary Parasitology
Publisher
Elsevier BV
Published
2007-09
Volume
148
Issue
3-4
Pages
365-370
ISSN
0304-4017 (ISSN-L)
DOI
10.1016/j.vetpar.2007.06.021
OpenAlex
W2007559120
Cited by
35
References
34
Citations by year
2025: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 2 · 2013: 2 · 2012: 3
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Veterinary Parasitology (publishedVersion)
  • PubMed (publishedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
Funders
Magyar Tudományos Akadémia
Topics
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
  • Health Sciences › Veterinary › Small Animals › Helminth infection and control
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
Keywords
Onchocerca lupi, Onchocerca lienalis, spirurid nematodes, Wolbachia endosymbiont, COI, ND5, 16S rRNA, phylogenetic analysis, species delimitation, Thelazia callipaeda, dogs
MeSH terms
Animals, Electron Transport Complex IV, Dog Diseases, Dogs, Europe, Female, Molecular Sequence Data, NADH Dehydrogenase, Onchocerca, Phylogeny, Onchocerciasis, Ocular, Spirurida, Wolbachia

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