First Evidence of Human Zoonotic Infection by Onchocerca lupi (Spirurida, Onchocercidae)
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In the past decades, cases of canine ocular onchocercosis have been reported worldwide, particularly in the United States and Europe. Onchocerca lupi, originally described from a wolf, has been implicated in some of these cases, and its zoonotic role has been hypothesized on the basis of the reexamination of two cases of human ocular onchocerciasis. In the present study, we describe, for the first time, the occurrence of O. lupi in the subconjunctival region of the human eye in a patient from Turkey. The nematode was identified as O. lupi based on its morphology and molecular phylogenetic analysis of partial cox 1 and 12S ribosomal DNA genes. The results suggest that O. lupi should be considered in the differential diagnosis of other eye parasitic infections in humans. The role of dogs as natural hosts of O. lupi and the vectors of this zoonotic parasite need to be investigated.
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Onchocerca lupi has been unambiguously identified morphologically and molecularly in two patients from Turkey and one from Tunisia who exhibited clinical features similar to those of the infestation in dogs.
“Indeed, O. lupi has only been suspected to act as a causative agent of infestation in humans until recently [92], when this species has been unambiguously identified morphologically and molecularly in two patients from Turkey and one from Tunisia who exhibited clinical features similar to those of the infestation in dogs [92,93].”
From Vector-borne helminths of dogs and humans in Europe (2013) · cites this paper as [92]
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- Authors
- Otranto, D., Sakru, N., Testini, G., Gürlü, V. P., Yakar, K., Lia, R. P., Dantas-Torres, F., & Bain, O.
- Affiliations
- University of Bari Aldo Moro (IT)
- Venue
- The American Society of Tropical Medicine and Hygiene
- Published
- 2011-01-05
- Volume
- 84
- Issue
- 1
- Pages
- 55-58
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- PMC
- PMC3005520
- OpenAlex
- W2100587498
- Cited by
- 110
- References
- 30
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 20 · 2014: 7 · 2013: 7 · 2012: 9
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Trakya University's Institutional Open Access System (Trakya University) (submittedVersion, other-oa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Medicine › Pathology and Forensic Medicine › Parasitic infections in humans and animals
- Keywords
- Onchocerca lupi, zoonoses, mitochondrial COI, 12S rRNA, molecular phylogeny
- MeSH terms
- Adolescent, Animals, Diagnosis, Differential, Disease Reservoirs, Disease Vectors, Dog Diseases, Dogs, Female, Humans, Onchocerca, Phylogeny, Zoonoses, Onchocerciasis, Ocular
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