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Cited by 356Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityNeuroscience and Neuropharmacology Research

Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens

Hernandez, Luis, Hoebel, Bartley G.·1988·Physiology & Behavior
DOI 10.1016/0031-9384(88)90324-1
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Abstract

The hypothesis that the dopaminergic system plays a role in feeding behavior was tested in three experiments. First, microdialysis was performed in the nucleus accumbens (NAC) at 20 min intervals during free feeding in rats at 80% of normal body weight. Extracellular concentration of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), and homovanillic acid (HVA) increased significantly during eating indicating an increase in DA turnover. Second, microdialysis samples were collected from the NAC during bar pressing with a) a signal light on and food available, b) the light on but no food available, c) neither light nor food. Only when food was available did extracellular DA, DOPAC and HVA increase significantly. This increase in DA turnover occurred in the accumbens but not in the ventral striatum. Third, electrical stimulation of the perifornical lateral hypothalamus (LH) that was capable of inducing feeding increased extracellular DA, DOPAC and HVA in the NAC. This occurred whether the animal had food to eat or not. The effect of LH stimulation on DA turnover resembled the effects of free feeding and operant feeding in Experiments 1 and 2. Perifornical LH stimulation did not increase dopamine turnover in the ventral striatum. The results show that perifornical LH stimulation activates the mesolimbic dopamine system and that dopamine release in the accumbens is involved in feeding. The increase in dopamine turnover outlasted the consummatory act. This suggests that accumbens dopamine may be related to sensory input, feeding reflexes, food reward or memory processes and not just to the consummatory act itself.

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Crossref · 10.1016/0031-9384(88)90324-1

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  • Increased dopamine release in mesolimbic reward circuitry is associated with approach behaviors that promote survival.

    “Increased dopamine (DA) release in mesolimbic reward circuitry is associated with approach behaviors that promote survival.”

    From Physiological feelings (2019) · cites this paper as Hernandez and Hoebel, 1988

  • The presence of food triggers an increase in extracellular DA in the nucleus accumbens.

    “For example, the presence of food triggers an increase in extracellular DA in the nucleus accumbens (Hernandez and Hoebel, 1988;Yoshida et al., 1992)”

    From Physiological feelings (2019) · cites this paper as Hernandez and Hoebel, 1988

  • When palatable foods such as sucrose are actually consumed, a sustained and sweetness-dependent increase occurs in nucleus accumbens dopamine levels and turnover.

    “In addition, when palatable foods such as sucrose are actually consumed, a sustained and sweetness-dependent increase occurs in nucleus accumbens dopamine levels and turnover ([75](#B75), [80](#B80), [165](#B165)).”

    From Food reward, hyperphagia, and obesity (2011) · cites this paper as [80]

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Authors
Hernandez, L., & Hoebel, B. G.
Affiliations
Princeton University (US)
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
1988-01
Volume
44
Issue
4-5
Pages
599-606
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/0031-9384(88)90324-1
OpenAlex
W2066841804
Cited by
355
References
36
Citations by year
2026: 1 · 2025: 3 · 2023: 3 · 2022: 12 · 2021: 7 · 2020: 49 · 2019: 9 · 2018: 7 · 2017: 6 · 2016: 5 · 2015: 11 · 2014: 11 · 2013: 9 · 2012: 14
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Drug Abuse (DA 03597)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
feeding behavior, dopamine turnover, nucleus accumbens, mesolimbic dopamine system, extracellular dopamine, dihydroxyphenylacetic acid, homovanillic acid, ventral striatum, food reward
MeSH terms
Animals, Body Weight, Corpus Striatum, Dopamine, Eating, Electric Stimulation, Female, Hunger, Hypothalamic Area, Lateral, Male, Neural Pathways, Nucleus Accumbens, Rats, Inbred Strains, Receptors, Dopamine, Septal Nuclei, Rats

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