CoChat
Sign Up
Cited by 347Memory and Neural MechanismsCognitive Abilities and TestingNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses

Owen, E.H, Logue, S.F, Rasmussen, D.L, J. M. Wehner·1997·Neuroscience
DOI 10.1016/s0306-4522(97)00165-6
Open this paper in CoChat — free account

Abstract

Genetic methods including the creation of transgenic or null mutant models and mapping studies using quantitative trait loci strategies can be used to identify candidate genes in mice that regulate learning processes. Interpretations as to the impact of single gene mutations for polygenic behaviours like learning will depend in part on the genetic background of the animals used for these manipulations. To address the issue of genetic variability, 12 inbred strains and seven different F1 hybrids were tested on multiple behavioural tasks, including two complex learning paradigms: the Morris water task and fear conditioning. Strain differences were found for all variables measured. In the hidden platform version of the Morris task, the albino animals performed poorly while overall the F1 hybrids showed the best selectivity for the trained quadrant as measured in a probe trial. In contrast, almost all genotypes performed well on the contextual fear conditioning task and learned to associate the test context with the pairing of a foot shock and auditory stimulus as demonstrated 24 h after training by increased freezing in the test environment compared to an altered context. Significant genetic correlations were obtained for behavioural measures suggesting that the same genes regulate various aspects of performance on behavioural tasks. Scores from these multiple inbred strains and F1 hybrids provide a baseline level of learning ability for fear conditioning and the Morris water task. The results of the present study confirm the importance of genetic background in the performance of various learning tasks. This variability should be considered when developing new transgenic or null mutant animal models.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0306-4522(97)00165-6

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 39 references

Research works printed but not linked: 1

  1. Plomin R., DeFries J. C. and McClearn G. E. (1990) Quantitative genetic theory. Behavioral Genetics: A Primer. 2nd edn, pp. 207–253. W. H. Freeman and Co., New York.

Cited by

Sorted by citations

Items 301–347 of 347

Related

See all

Metadata

Authors
Owen, E. H., Logue, S. F., Rasmussen, D. L., & Wehner, J. M.
Affiliations
University of Colorado Boulder (US)
Corresponding author
J. M. Wehner
ORCID
J. M. Wehner
Venue
Neuroscience
Publisher
Elsevier BV
Published
1997-08
Volume
80
Issue
4
Pages
1087-1099
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/s0306-4522(97)00165-6
OpenAlex
W2142349181
Cited by
347
References
39
Citations by year
2026: 1 · 2025: 4 · 2024: 7 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 8 · 2014: 15 · 2013: 14 · 2012: 14
FWCI
12.72
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh048663-05)
  • National Institute of Mental Health (MH16880, MH-48663, T32MH016880)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 07289, T32HD007289)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
learning, genetic background, inbred mouse strains, F1 hybrids, Morris water task, fear conditioning, contextual fear, genetic correlation, single-gene mutations, quantitative trait loci, candidate genes, albino mice, behavioral variability
MeSH terms
Acoustic Stimulation, Animals, Conditioning, Operant, Crosses, Genetic, Electroshock, Fear, Female, Genotype, Male, Mice, Inbred Strains, Models, Genetic, Mutation, Species Specificity, Maze Learning, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review