Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?

Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain

Picciotto, M. R., Zoli, M., Léna, C., Bessis, A., Lallemand, Y., LeNovère, N., Vincent, P., Pich, E. M., Brûlet, P., & Changeux, J.-P. (1995) · Nature · doi:10.1038/374065a0 · Cited by 668 · see citing works

Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

Aiba, A. (1994) · Cell · doi:10.1016/0092-8674(94)90204-6 · Cited by 614 · see citing works

Neural consequences of enviromental enrichment

van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045 · see citing works

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.

Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · see citing works

Genetics of Mouse Behavior: Interactions with Laboratory Environment

Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666 · see citing works

Adenosine Receptors as Therapeutic Targets

Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431 · see citing works

Measuring normal and pathological anxiety-like behaviour in mice: a review

Belzung, C., & Griebel, G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00291-1 · Cited by 912 · see citing works

Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception

Mogil, J. S., Wilson, S. G., Bon, K., Eun Lee, S., Chung, K., Raber, P., Pieper, J. O., Hain, H. S., Belknap, J. K., Hubert, L., et al. (1999) · Pain · doi:10.1016/s0304-3959(98)00197-3 · Cited by 656 · see citing works

Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

Silva, A. J., Simpson, E. M., Takahashi, J. S., Lipp, H.-P., Nakanishi, S., Wehner, J. M., Giese, K. P., Tully, T., Abel, T., Chapman, P. F., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80958-7 · Cited by 479 · see citing works

Parkin-deficient mice are not a robust model of parkinsonism

Perez, F. A., & Palmiter, R. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409598102 · Cited by 477 · see citing works

Learning deficit in BDNF mutant mice.

Linnarsson, S., Björklund, A., & Ernfors, P. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01687.x · Cited by 471 · see citing works

Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice

Marsch, R., Foeller, E., Rammes, G., Bunck, M., Kössl, M., Holsboer, F., Zieglgänsberger, W., Landgraf, R., Lutz, B., & Wotjak, C. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3303-06.2007 · Cited by 359 · see citing works

Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse

Winslow, J. T., Hearn, E. F., Ferguson, J., Young, L. J., Matzuk, M. M., & Insel, T. R. (2000) · Hormones and Behavior · doi:10.1006/hbeh.1999.1566 · Cited by 348 · see citing works

Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses

Owen, E. H., Logue, S. F., Rasmussen, D. L., & Wehner, J. M. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00165-6 · Cited by 347 · see citing works

Modeling madness in mice: one piece at a time

Arguello, P. A., & Gogos, J. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.023 · Cited by 309 · see citing works

Molecular control of vertebrate iron homeostasis by iron regulatory proteins

Wallander, M. L., Leibold, E. A., & Eisenstein, R. S. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.004 · Cited by 287 · see citing works

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies

Blednov, Y. A., Ponomarev, I., Geil, C., Bergeson, S., Koob, G. F., & Harris, R. A. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00284.x · Cited by 251 · see citing works

Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists

Caine, S. B., Negus, S. S., Mello, N. K., Patel, S., Bristow, L., Kulagowski, J., Vallone, D., Saiardi, A., & Borrelli, E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02977.2002 · Cited by 234 · see citing works

A phenotypic and molecular characterization of the <i>fmr1‐tm1Cgr</i> Fragile X mouse

Yan, Q. J., Asafo‐Adjei, P. K., Arnold, H. M., Brown, R. E., & Bauchwitz, R. P. (2004) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2004.00087.x · Cited by 213 · see citing works

Parvalbumin deficiency affects network properties resulting in increased susceptibility to epileptic seizures

Schwaller, B., Tetko, I. V., Tandon, P., Silveira, D. C., Vreugdenhil, M., Henzi, T., Potier, M.-C., Celio, M. R., & Villa, A. E. P. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.12.006 · Cited by 169 · see citing works

Impaired Cerebellar Long-Term Potentiation in Type I Adenylyl Cyclase Mutant Mice

Storm, D. R., Hansel, C., Hacker, B., Parent, A., & Linden, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80500-0 · Cited by 159 · see citing works

Behavior and mutagenesis screens: The importance of baseline analysis of inbred strains

Tarantino, L. M., Gould, T. J., Druhan, J. P., & Bucan, M. (2000) · Mammalian Genome · doi:10.1007/s003350010107 · Cited by 158 · see citing works

Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol

BLEDNOV, Y., BERGESON, S., WALKER, D., FERREIRA, V, KUZIEL, W., & HARRIS, R. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.06.026 · Cited by 149 · see citing works

Maternal behavior and developmental psychopathology

Leckman, J. F., & Herman, A. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01277-x · Cited by 139 · see citing works

Comprehensive analysis of the 16p11.2 deletion and null Cntnap2 mouse models of autism spectrum disorder

Brunner, D., Kabitzke, P., He, D., Cox, K., Thiede, L., Hanania, T., Sabath, E., Alexandrov, V., Saxe, M., Peles, E., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0134572 · Cited by 111 · see citing works

A model of global cerebral ischemia in C57 BL/6 mice

Yonekura, I., Kawahara, N., Nakatomi, H., Furuya, K., & Kirino, T. (2004) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1097/01.wcb.0000096063.84070.c1 · Cited by 93 · see citing works

Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1β receptor 1 and tumor necrosis factor-α receptor 1

Baracchi, F., & Opp, M. R. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.02.001 · Cited by 88 · see citing works

Colony formation of C57BL/6J mice in visible burrow system: identification of eusocial behaviors in a background strain for genetic animal models of autism

ARAKAWA, H., BLANCHARD, D., & BLANCHARD, R. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.027 · Cited by 86 · see citing works

CA1 Long-Term Potentiation Is Diminished but Present in Hippocampal Slices from α-CaMKII Mutant Mice

Hinds, H. L., Tonegawa, S., & Malinow, R. (1998) · Learning &amp; Memory · doi:10.1101/lm.5.4.344 · Cited by 86 · see citing works

Mouse strain modestly influences minimum alveolar anesthetic concentration and convulsivity of inhaled compounds

Sonner, J. M., Gong, D., Li, J., Eger, E. I., & Laster, M. J. (1999) · Anesthesia &amp; Analgesia · doi:10.1213/00000539-199910000-00039 · Cited by 100 · see citing works

Design, Synthesis, and Qualitative Structure–Activity Evaluations of Novel β-Secretase Inhibitors as Potential Alzheimer’s Drug Leads

Al-Tel, T. H., Semreen, M. H., Al-Qawasmeh, R. A., Schmidt, M. F., El-Awadi, R., Ardah, M., Zaarour, R., Rao, S. N., & El-Agnaf, O. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm201181f · Cited by 53 · see citing works

A Flanking Gene Problem Leads to the Discovery of a Gprc5b Splice Variant Predominantly Expressed in C57Bl/6J Mouse Brain and in Maturing Neurons

Cool, B. H., Chan, G. C.-K., Lee, L., Oshima, J., Martin, G. M., & Hu, Q. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010351 · Cited by 18 · see citing works