Cited by 110Stress Responses and CortisolAdrenal Hormones and DisordersMemory and Neural Mechanisms

Prior stressor exposure primes the HPA axis

Johnson, John D., O'Connor, Kevin A., Deak, Terrence, Spencer, Robert L., Watkins, Linda R., Maier, Steven F.·2002·Psychoneuroendocrinology

Abstract

Exposure to stressors often alters the subsequent responsiveness of many systems. The present study tested whether prior exposure to inescapable tailshock (IS) alters the corticosterone (CORT) or adrenocorticotropin hormone (ACTH) response to either an injection of bacterial endotoxin (lipopolysaccharide; LPS) or subsequent placement on a pedestal. Rats were exposed to IS or remained as home cage controls (HCC). 1, 4, 10, or 21 days later animals were injected i.p. with either 10 microg/kg LPS or equivolume sterile saline. Prior IS significantly increased plasma CORT 1 h, but not 2 or 5 h after LPS, compared to controls 1, 4, and 10 days, but not 21 days after IS. Exposure to IS 24 h earlier also significantly increased plasma ACTH 1 h after LPS. Additional animals were placed on a pedestal 24 h after IS, and plasma CORT was measured 15, 30, and 60 min later. IS significantly increased plasma CORT 15 min after pedestal exposure, but not after 30 or 60 min. These results suggest that exposure to IS sensitizes the CORT and ACTH response to subsequent HPA activation.

Integrity signals

Registry

Crossref · 10.1016/s0306-4530(01)00057-9

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Johnson, J. D., O'Connor, K. A., Deak, T., Spencer, R. L., Watkins, L. R., & Maier, S. F.
Affiliations
University of Colorado Boulder (US)
Corresponding author
Johnson, John D.
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2002-04
Volume
27
Issue
3
Pages
353-365
ISSN
0306-4530 (ISSN-L)
OpenAlex
W2109019278
Cited by
110
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 12 · 2014: 7 · 2013: 4 · 2012: 5
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH4505, MH-0314, MH-1558)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
hypothalamic-pituitary-adrenal axis, corticosterone, ACTH, lipopolysaccharide, stress sensitization, rats
MeSH terms
Adrenocorticotropic Hormone, Animals, Arousal, Corticosterone, Electroshock, Endotoxins, Escherichia coli, Hypothalamo-Hypophyseal System, Lipopolysaccharides, Male, Pituitary-Adrenal System, Psychoneuroimmunology, Restraint, Physical, Cytokines, Rats, Sprague-Dawley, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review