Environmental stress and psychiatric illness
Abstract
It has long been recognized that environmental stress plays a pivotal role in the pathogenesis of psychiatric disorders. The relationship is complex and the neurobiological mechanisms that mediate the contribution of stressful experiences to the manifestation of illness are not well understood. In considering this relationship, it is important to differentiate between the role of environmental stressors as vulnerability factors that predispose the individual to psychiatric illness and may be temporally distant from its clinical onset, and their role as direct precipitants of the illness. Furthermore, environmental stressors must be considered in the context of constitutional vulnerability factors, such as genetic predisposition, with which such stressors may interact. Genetic predisposition may influence not only vulnerability to illness but also the nature of the individual's response to stress and the likelihood of exposure to stressful events. In this paper, we focus on two areas that illustrate the complexity of the field and the important findings that have emerged--the role of early parental loss (EPL) in adult psychopathology, particularly major depression, and the relationship between recent significant life events and depressive episodes. We conclude with a preliminary conceptual framework for considering the relationship between genetic susceptibility and environmental stress in the pathogenesis of psychiatric illness.
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Family stability in the first 5 years of life may play a role in subsequent development of depression.
“Family stability in the first 5 years of life may play a role in subsequent development of depression.33”
From A structured approach to hypotheses involving continuous exposures over the life course (2016) · cites this paper as [33]
Cites
Freud, S. (1922) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-192211000-00066 · Cited by 5,444 · see citing works
A parental bonding instrument.
Parker, G., Tupling, H., & Brown, L. B. (1979) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1979.tb02487.x · Cited by 3,788 · see citing works
Causal Relationship Between Stressful Life Events and the Onset of Major Depression
Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,486 · see citing works
Measures of perceived social support from friends and from family: Three validation studies
Procidano, M. E., & Heller, K. (1983) · American Journal of Community Psychology · doi:10.1007/bf00898416 · Cited by 2,247 · see citing works
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · see citing works
Derogatis, L. R. (1982) · PsycTESTS Dataset · doi:10.1037/t00789-000 · Cited by 863 · see citing works
Childhood Maltreatment Increases Risk for Personality Disorders During Early Adulthood
Johnson, J. G., Cohen, P., Brown, J., Smailes, E. M., & Bernstein, D. P. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.7.600 · Cited by 839 · see citing works
Coplan, J. D., Andrews, M. W., Rosenblum, L. A., Owens, M. J., Friedman, S., Gorman, J. M., & Nemeroff, C. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1619 · Cited by 649 · see citing works
Agid, O., Shapira, B., Zislin, J., Ritsner, M., Hanin, B., Murad, H., Troudart, T., Bloch, M., Heresco‐Levy, U., & Lerer, B. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000473 · Cited by 568 · see citing works
Self-citationCraddock, N. J., & Jones, I. R. (1999) · Journal of Medical Genetics · doi:10.1136/jmg.36.8.585 · Cited by 523 · see citing works
Selected Papers on Psychoanalysis
BOWMAN, K. M., Abraham, K., Bryan, D., & Strachey, A. (1929) · The American Journal of Psychology · doi:10.2307/1415147 · Cited by 401 · see citing works
Life Events and Depressive Disorder Reviewed
Lloyd, C. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780180055005 · Cited by 396 · see citing works
Childhood Parental Loss and Adult Psychopathology in Women
Kendler, K. S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820020029004 · Cited by 394 · see citing works
Suicide Attempts and Recent Life Events
Paykel, E. S. (1975) · Archives of General Psychiatry · doi:10.1001/archpsyc.1975.01760210061003 · Cited by 386 · see citing works
Brown, G. W., Harris, T., & Copeland, J. J. (1977) · The British Journal of Psychiatry · doi:10.1192/bjp.130.1.1 · Cited by 342 · see citing works
Stressful Life Events and Schizophrenia
Norman, R. M. G., & MALLA, A. K. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.162.2.161 · Cited by 328 · see citing works
Relationship of childhood maltreatment to the onset and course of major depression in adulthood
Bernet, C. Z., & Stein, M. B. (1999) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1999)9:4 · Cited by 289 · see citing works
Self-citationTHE ADOLF MEYER LECTURE CHILDHOOD MOURNING AND ITS IMPLICATIONS FOR PSYCHIATRY
Bowlby, J. (1961) · American Journal of Psychiatry · doi:10.1176/ajp.118.6.481 · Cited by 246 · see citing works
Life Events and Depressive Disorder Reviewed
Lloyd, C. (1980) · Archives of General Psychiatry · doi:10.1001/archpsyc.1980.01780180043004 · Cited by 246 · see citing works
Tennant, C. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800350079012 · Cited by 219 · see citing works
Depression and Childhood Bereavement
Brown, F. (1961) · Journal of Mental Science · doi:10.1192/bjp.107.449.754 · Cited by 209 · see citing works
Heim, C. C., Owens, M. J., Plotsky, P. M., & Nemeroff, C. B. (1997) · PubMed · Cited by 206 · see citing works
Childhood Bereavement and Psychiatric Illness
Dennehy, C. M. (1966) · The British Journal of Psychiatry · doi:10.1192/bjp.112.491.1049 · Cited by 188 · see citing works
McGuffin, P., Katz, R., & Bebbington, P. (1988) · The British Journal of Psychiatry · doi:10.1192/bjp.152.6.775 · Cited by 178 · see citing works
Life events, depressive relapse and maintenance treatment
Paykel, E. S., & Tanner, J. (1976) · Psychological Medicine · doi:10.1017/s0033291700015920 · Cited by 176 · see citing works
Parental death during childhood and adult depression: A critical review of the literature.
Crook, T. H., & Eliot, J. F. (1980) · Psychological Bulletin · doi:10.1037/0033-2909.87.2.252 · Cited by 160 · see citing works
Vulnerability Factors and Depression in Men
Roy, A. (1981) · The British Journal of Psychiatry · doi:10.1192/bjp.138.1.75 · Cited by 159 · see citing works
Environmental Stress in Primary Depressive Illness
Thomson, K. C. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750200034007 · Cited by 150 · see citing works
Goodyer, I. M., Herbert, J., Tamplin, A., SECHER, S. M., & PEARSON, J. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199704000-00009 · Cited by 139 · see citing works
WILLIAMSON, D. E., BIRMAHER, B., ANDERSON, B. P., AL-SHABBOUT, M., & RYAN, N. D. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199505000-00011 · Cited by 123 · see citing works
Vulnerability Factors and Depression in Women
Roy, A. (1978) · The British Journal of Psychiatry · doi:10.1192/bjp.133.2.106 · Cited by 118 · see citing works
STUDIES OF PARENTAL DEPRIVATION IN PSYCHIATRIC PATIENTS
Gregory, I. (1958) · American Journal of Psychiatry · doi:10.1176/ajp.115.5.432 · Cited by 104 · see citing works
Early Parental Separation and Adult Depression
Roy, A. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790330067008 · Cited by 89 · see citing works
Some Psychiatric Non-Sequelae of Childhood Bereavement
Munro, A., & Griffiths, A. (1969) · The British Journal of Psychiatry · doi:10.1192/bjp.115.520.305 · Cited by 84 · see citing works
Nature of Life Events and Difficulties in Depressed Adolescents
Williamson, D. E., Birmaher, B. B., Frank, E., Anderson, B. P., MATTY, M. K., & Kupfer, D. J. (1998) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199810000-00015 · Cited by 84 · see citing works
Childhood Bereavement and Subsequent Psychiatric Disorder
Brown, F. (1966) · The British Journal of Psychiatry · doi:10.1192/bjp.112.491.1035 · Cited by 77 · see citing works
Ravindran, A. V., Griffiths, J., Waddell, C., & Anisman, H. (1995) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(95)00108-8 · Cited by 75 · see citing works
Depressive Disease: Life Events and Onset of Illness
Cadoret, R. J. (1972) · Archives of General Psychiatry · doi:10.1001/archpsyc.1972.01750200037008 · Cited by 75 · see citing works
Stressful Life Events and Schizophrenia II: Conceptual and Methodological Issues
Norman, R. M. G., & MALLA, A. K. (1993) · The British Journal of Psychiatry · doi:10.1192/bjp.162.2.166 · Cited by 74 · see citing works
Early Life Events and Affective Disorder Revisited
Faravelli, C., Sacchetti, E., Ambonetti, A., Conte, G., Pallanti, S., & Vita, A. (1986) · The British Journal of Psychiatry · doi:10.1192/bjp.148.3.288 · Cited by 63 · see citing works
Psychosocial factors and episode number in depression
Ezquiaga, E., Gutiérrez, J. L., & López, A. G. (1987) · Journal of Affective Disorders · doi:10.1016/0165-0327(87)90005-x · Cited by 61 · see citing works
Does Depression Generate Negative Life Events?
Cui, X. J., & Vaillant, G. E. (1997) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199703000-00003 · Cited by 61 · see citing works
Canetti, L., Bachar, E., Bonne, O. B., Agid, O., Lerer, B., De‐Nour, A. K., & Shalev, A. Y. (2000) · Comprehensive Psychiatry · doi:10.1053/comp.2000.9002 · Cited by 56 · see citing works
Self-citationClosing in on Genes for Manic-Depressive Illness and Schizophrenia
Gershon, E. S. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00145-0 · Cited by 50 · see citing works
Disruptions in Childhood Parental Care as Risk Factors for Major Depression in Adult Women
Browne, M. A. O., Joyce, P. R., Wells, J. E., Bushnell, J., & Hornblow, A. R. (1995) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679509064952 · Cited by 49 · see citing works
Hällström, T. (1987) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1987.tb02777.x · Cited by 47 · see citing works
McNaughton, M. E., Patterson, T. L., Irwin, M. R., & Grant, I. (1992) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199208000-00003 · Cited by 42 · see citing works
Psychiatric genetics: progress, problems, and potential
Owen, M. J., & Cardno, A. G. (1999) · The Lancet · doi:10.1016/s0140-6736(99)90242-8 · Cited by 32 · see citing works
Early parental death and adult depression
Roy, A. (1983) · Psychological Medicine · doi:10.1017/s0033291700051588 · Cited by 30 · see citing works
Early parental loss and depressive disorder in Japan
Kunugi, H., Sugawara, N., Aoki, H., Nanko, S., Hirose, T., & Kazamatsuri, H. (1995) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02190737 · Cited by 29 · see citing works
The Triggering Hypothesis of the Role of Life Events in Schizophrenia
Hirsch, S. R., Cramer, P., & Bowen, J. (1992) · The British Journal of Psychiatry · doi:10.1192/s0007125000297092 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works
Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
Belforte, J. E., Zsiros, V., Sklar, E. R., Jiang, Z., Yu, G., Li, Y., Quinlan, E. M., & Nakazawa, K. (2010) · Nature Neuroscience · doi:10.1038/nn.2447 · Cited by 752 · see citing works
Heim, C., Plotsky, P. M., & Nemeroff, C. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300397 · Cited by 514 · see citing works
Depression, Neuroimaging and Connectomics: A Selective Overview
Gong, Q., & Yong He, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.009 · Cited by 496 · see citing works
Neuroendocrine aspects of the response to stress
Miller, D. B., & O'Callaghan, J. P. (2002) · Metabolism · doi:10.1053/meta.2002.33184 · Cited by 496 · see citing works
Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378 · see citing works
The recent progress in animal models of depression
Wang, Q., Timberlake, M. A., Prall, K., & Dwivedi, Y. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.008 · Cited by 370 · see citing works
Heim, C., Mletzko, T., Purselle, D., Musselman, D. L., & Nemeroff, C. B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.002 · Cited by 353 · see citing works
Hellemans, K. G. C., Sliwowska, J. H., Verma, P., & Weinberg, J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.06.004 · Cited by 344 · see citing works
The journal of developmental processes
Disorders, L., & Milton (2006) · Medical Entomology and Zoology · Cited by 325 · see citing works
Riepenhausen, A., Wackerhagen, C., Reppmann, Z. C., Deter, H., Kalisch, R., Veer, I. M., & Walter, H. (2022) · Emotion Review · doi:10.1177/17540739221114642 · Cited by 314 · see citing works
Association of childhood trauma with cognitive function in healthy adults: a pilot study
Majer, M., Nater, U. M., Lin, J.-M. S., Capuron, L., & Reeves, W. C. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-61 · Cited by 281 · see citing works
Prior Stressor Exposure Sensitizes LPS-Induced Cytokine Production
Johnson, J. D., O'Connor, K. A., Deak, T., Stark, M., Watkins, L. R., & Maier, S. F. (2002) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2001.0638 · Cited by 270 · see citing works
Pryce, C., Azzinnari, D., Spinelli, S., Seifritz, E., Tegethoff, M., & Meinlschmidt, G. (2011) · Pharmacology and Therapeutics · doi:10.1016/j.pharmthera.2011.06.006 · Cited by 227 · see citing works
Social conflict models: Can they inform us about human psychopathology?
Huhman, K. L. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.022 · Cited by 243 · see citing works
The serotonergic system in mood disorders and suicidal behaviour
Mann, J. J. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0537 · Cited by 235 · see citing works
Lukkes, J. L. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.018.2009 · Cited by 235 · see citing works
Stress, Hypothalamic-Pituitary-Adrenal Axis and Eating Disorders
Lo Sauro, C., Ravaldi, C., Cabras, P. L., Faravelli, C., & Ricca, V. (2008) · Neuropsychobiology · doi:10.1159/000138912 · Cited by 215 · see citing works
Sensitivity to Intranasal Oxytocin in Adult Men with Early Parental Separation
Meinlschmidt, G., & Heim, C. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.007 · Cited by 210 · see citing works
Martins‐de‐Souza, D., Guest, P. C., Harris, L. W., Vanattou‐Saïfoudine, N., Webster, M. J., Rahmoune, H., & Bahn, S. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.13 · Cited by 202 · see citing works
Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
Kapczinski, F., Frey, B. N., Kauer-Sant’Anna, M., & Grassi-Oliveira, R. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.7.1101 · Cited by 181 · see citing works
Duman, C. H. (2010) · Vitamins and hormones · doi:10.1016/s0083-6729(10)82001-1 · Cited by 160 · see citing works
Davenport, M. D., Lutz, C. K., Tiefenbacher, S., Novak, M. A., & Meyer, J. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.025 · Cited by 160 · see citing works
Decreased cortisol awakening response after early loss experience
Meinlschmidt, G., & Heim, C. C. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.01.006 · Cited by 160 · see citing works
Chronic Stress- and Sex-Specific Neuromorphological and Functional Changes in Limbic Structures
McLaughlin, K. J., Baran, S. E., & Conrad, C. D. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8079-7 · Cited by 152 · see citing works
Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology
Kauer‐Sant’Anna, M., Tramontina, J., Andreazza, A. C., Ceresér, K. M. M., da Costa, S. C., Santin, A. M. P., Yatham, L. N., & Kapczinski, F. P. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00478.x · Cited by 148 · see citing works
Perinatal programming of emotional brain circuits: an integrative view from systems to molecules
Bock, J., Rether, K., Gröger, N., Xie, L., & Braun, K. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00011 · Cited by 143 · see citing works
Sex difference in brain CB1 receptor availability in man
Laurikainen, H., Tuominen, L. J., Tikka, M., Merisaari, H., Armio, R.-L., Sormunen, E., Borgan, F., Veronese, M., Howes, O. D., Haaparanta‐Solin, M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.10.013 · Cited by 118 · see citing works
Prior stressor exposure primes the HPA axis
Johnson, J. D., O'Connor, K. A., Deak, T., Spencer, R. L., Watkins, L. R., & Maier, S. F. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00057-9 · Cited by 110 · see citing works
Toledo‐Rodriguez, M., & Sandi, C. (2007) · Neural Plasticity · doi:10.1155/2007/71203 · Cited by 106 · see citing works
DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons
Jovanova, O., Nedeljkovic, I., Spieler, D., Walker, R. M., Liu, C., Luciano, M., Bressler, J., Brody, J. A., Drake, A. J., Evans, K. L., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.1725 · Cited by 108 · see citing works
Tracking biocultural pathways in population health: The value of biomarkers
Worthman, C. M., & Costello, E. J. (2009) · Annals of Human Biology · doi:10.1080/03014460902832934 · Cited by 103 · see citing works
The central corticotropin releasing factor system during development and adulthood
Korosi, A., & Baram, T. Z. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.066 · Cited by 102 · see citing works
Hoppen, T. H., & Chalder, T. (2018) · Clinical Psychology Review · doi:10.1016/j.cpr.2018.08.002 · Cited by 110 · see citing works
Modeling depression: social dominance–submission gene expression patterns in rat neocortex
Kroes, R. A., Panksepp, J., Burgdorf, J. S., Otto, N. J., & Moskal, J. R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.076 · Cited by 101 · see citing works
Jacobson‐Pick, S., & Richter‐Levin, G. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.05.036 · Cited by 98 · see citing works
Maes, M. H. J., Mylle, J. J. C., Delmeire, L., & Janca, A. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00325-0 · Cited by 93 · see citing works
Chronic psychosocial stressors in adulthood: Studies in mice, rats and tree shrews
Pryce, C. R., & Fuchs, E. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.10.001 · Cited by 91 · see citing works
Litvin, Y., Murakami, G., & Pfaff, D. W. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.03.007 · Cited by 90 · see citing works
Butler, M., Mörkl, S., Sandhu, K. V., Cryan, J. F., & Dinan, T. G. (2019) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719874168 · Cited by 89 · see citing works
Deficient inhibitory control as an outcome of childhood trauma
Marshall, D., Passarotti, A. M., Ryan, K. A., Kamali, M., Saunders, E. F. H., Pester, B., McInnis, M. G., & Langenecker, S. A. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.12.013 · Cited by 82 · see citing works
Macrı̀, S., & Giovanni Laviola, A. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.02.009 · Cited by 82 · see citing works
Kroes, R. A., Burgdorf, J. S., Otto, N. J., Panksepp, J., & Moskal, J. R. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.03.022 · Cited by 80 · see citing works
Horovitz, O., Tsoory, M., Hall, J., Jacobson‐Pick, S., & Richter‐Levin, G. (2012) · Neuroendocrinology · doi:10.1159/000331393 · Cited by 76 · see citing works
Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters
Partrick, K. A., Chassaing, B., Beach, L. Q., McCann, K. E., Gewirtz, A. T., & Huhman, K. L. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.02.005 · Cited by 83 · see citing works
Father absence and depressive symptoms in adolescence: findings from a UK cohort
Culpin, I., Heron, J., Araya, R., Melotti, R., & Joinson, C. J. (2013) · Psychological Medicine · doi:10.1017/s0033291713000603 · Cited by 74 · see citing works
Morse, T. F., Dussetschleger, J., Warren, N. D., & Cherniack, M. C. (2011) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0b013e3182260e2c · Cited by 66 · see citing works
Warren, N. D. (2001) · Work · doi:10.3233/wor-2001-00191 · Cited by 64 · see citing works
Gröger, N., Matas, E., Gos, T., Lesse, A., Poeggel, G., Braun, K., & Bock, J. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1570-1 · Cited by 61 · see citing works
A structured approach to hypotheses involving continuous exposures over the life course
Smith, A. D. A. C., Hardy, R., Heron, J., Joinson, C. J., Lawlor, D. A., Macdonald-Wallis, C., & Tilling, K. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw164 · Cited by 59 · see citing works
Neurobiology of Early-Life Stress
Heim, C. C., Meinlschmidt, G., & Nemeroff, C. B. (2003) · Psychiatric Annals · doi:10.3928/0048-5713-20030101-05 · Cited by 58 · see citing works
McIntyre, L., Kwok, C., Emery, J. C. H., & Dutton, D. J. (2016) · Canadian Journal of Public Health · doi:10.17269/cjph.107.5372 · Cited by 57 · see citing works
Horovitz, O., Tsoory, M., Yovell, Y., & Richter‐Levin, G. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.745604 · Cited by 56 · see citing works
Current research status on the psychological situation of adults with congenital heart disease
Andonian, C., Beckmann, J., Biber, S., Ewert, P., Freilinger, S., Kaemmerer, H. M., Oberhoffer, R., Pieper, L., & Neidenbach, R. C. (2018) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2018.12.06 · Cited by 57 · see citing works
Partrick, K. A., Rosenhauer, A. M., Auger, J., Arnold, A. R., Ronczkowski, N. M., Jackson, L. M., Lord, M. N., Abdulla, S. M., Chassaing, B., & Huhman, K. L. (2021) · Scientific Reports · doi:10.1038/s41598-021-83284-z · Cited by 54 · see citing works
Braun, K., & Bock, J. (2011) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2011.04056.x · Cited by 54 · see citing works
Cooper, M. A., McIntyre, K. E., & Huhman, K. L. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.06.009 · Cited by 52 · see citing works
Riaz, M. S., Bohlen, M. O., Gunter, B. W., Henry, Q., Stockmeier, C. A., & Paul, I. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.09.005 · Cited by 49 · see citing works
Krause, S., Boeck, C., Gumpp, A. M., Rottler, E., Schury, K., Karabatsiakis, A., Buchheim, A., Gündel, H., Kolassa, I., & Waller, C. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.00173 · Cited by 49 · see citing works
Seifried, C., Boehncke, S., Heinzmann, J., Baudrexel, S., Weise, L. M., Gasser, T., Eggert, K. M., Fogel, W., Baas, H. K. J., Badenhoop, K. W. J., et al. (2012) · Neuroendocrinology · doi:10.1159/000343808 · Cited by 45 · see citing works
Nakama, N., Usui, N., Doi, M., & Shimada, S. (2023) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110783 · Cited by 43 · see citing works
Pryce, C. R., & Seifritz, E. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.05.003 · Cited by 44 · see citing works
Schwartz‐Mette, R. A., Duell, N., Lawrence, H. R., & Balkind, E. G. (2022) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2022.2042697 · Cited by 45 · see citing works
Pauliks, L. B. (2013) · World Journal of Cardiology · doi:10.4330/wjc.v5.i6.186 · Cited by 41 · see citing works
DeSouza, F., Rodrigues, M. L., Tufik, S. B., Nobrega, J., & D’Almeida, V. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.09.008 · Cited by 40 · see citing works
The impact of perinatal stress on the functional maturation of prefronto-cortical synaptic circuits
Bock, J., & Braun, K. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53884-0.00023-3 · Cited by 39 · see citing works
Razzoli, M., Carboni, L., & Arban, R. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.04.018 · Cited by 38 · see citing works
Pallier, P. N., Ferrara, M., Romagnolo, F., Ferretti, M. T., Soreq, H., & Cerase, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102353 · Cited by 35 · see citing works
Ekinci, S., & Kandemır, H. (2014) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2014.981856 · Cited by 36 · see citing works
Marx, M., Young, S. Y., Harvey, J., Rosenstein, D., & Seedat, S. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.02058 · Cited by 36 · see citing works
HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding to FAF1
Gao, X.-J., Liu, W., Huang, L., Zhang, T., Mei, Z., Wang, X.-X., Gong, J., Zhao, Y. M., Xie, F., Ma, J., et al. (2015) · Cell stress & chaperones (Print) · doi:10.1007/s12192-015-0589-9 · Cited by 33 · see citing works
Wincewicz, D., Juchniewicz, A., Waszkiewicz, N., & Braszko, J. J. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.06.010 · Cited by 34 · see citing works
McCann, K. E., & Huhman, K. L. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.09.009 · Cited by 32 · see citing works
A dual-pathway architecture for stress to disrupt agency and promote habit
Giovanniello, J. R., Paredes, N., Wiener, A., Ramírez-Armenta, K., Oragwam, C., Uwadia, H. O., Yu, A. L., Lim, K., Pimenta, J. S., Vilchez, G. E., et al. (2025) · Nature · doi:10.1038/s41586-024-08580-w · Cited by 30 · see citing works
Han, K., Choi, K. W., Kim, A., Kang, W., Kang, Y., Tae, W., Han, M.-R., & Ham, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105768 · Cited by 32 · see citing works
Srivastava, A., Brown, R., Newport, D. J., Rousseau, J. F., Wagner, K. D., Guzick, A. G., Devargas, C., Claassen, C. A., Ugalde, I. T., Garrett, A. S., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.115772 · Cited by 29 · see citing works
The impact of abuse and neglect on the health and mental health of children and young people
Lazenbatt, A. (2010) · Cited by 28 · see citing works
Musculoskeletal Disorder Symptoms in Correction Officers
Warren, N. D., Dussetschleger, J., Punnett, L., & Cherniack, M. G. (2014) · Human Factors The Journal of the Human Factors and Ergonomics Society · doi:10.1177/0018720814547569 · Cited by 28 · see citing works
Zhao, Y., Wu, S., Gao, X., Zhang, Z., Gong, J., Zhan, R., Wang, X., Wang, W., & Qian, L. (2013) · Cell Stress and Chaperones · doi:10.1007/s12192-013-0416-0 · Cited by 28 · see citing works
Pérez, G. A. C., Sierra, G., Sánchez, D. A. M., Torres, Y., Salas, C., & Salazar, J. C. B. (2017) · Biomédica · doi:10.7705/biomedica.v38i0.3890 · Cited by 27 · see citing works
Levinson, D., & Ifrah, A. (2009) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-009-0079-4 · Cited by 26 · see citing works
Liu, X., Stancliffe, D., Lee, S. J., Mathur, S., & Gershenfeld, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.017 · Cited by 26 · see citing works
Culpin, I., Heron, J., Araya, R., & Joinson, C. J. (2014) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-014-9960-z · Cited by 25 · see citing works
Abuse in childhood and mental disorder in adult life
Śpila, B., Makara, M., Kozak, G., & Urbańska, A. (2008) · Child Abuse Review · doi:10.1002/car.1022 · Cited by 24 · see citing works
Novoa, J., Rivero, C. J., Pérez‐Cardona, E. U., Freire, J. A., Zegers, J., Yarur, H. E., Santiago-Marrero, I. G., Agosto, J. L., González‐Pérez, J. L., Gysling, K., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15345 · Cited by 23 · see citing works
The role of the nucleus accumbens in the acquisition and expression of conditioned defeat
Luckett, C., Norvelle, A., & Huhman, K. L. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.012 · Cited by 23 · see citing works
McCann, K. E., Sinkiewicz, D. M., Rosenhauer, A. M., Beach, L. Q., & Huhman, K. L. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1339-7 · Cited by 22 · see citing works
Dai, F., Cai, Y., Chen, M., & Dai, Y. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06697-4 · Cited by 22 · see citing works
Tay, N., Macare, C., Liu, Y., Ruggeri, B., Jia, T., Chu, C., Biondo, F., Ing, A., Luo, Q., Sarkysian, D., et al. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17121360 · Cited by 18 · see citing works
Coplan, J. D., Fulton, S. L., Reiner, W. J., Jackowski, A. P., Panthangi, V., Perera, T. D., Gorman, J. M., Huang, Y., Tang, C. Y., Hof, P. R., et al. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00440 · Cited by 17 · see citing works
Looking Forward in Geriatric Anxiety and Depression: Implications of Basic Science for the Future
Gershenfeld, H. K., Philibert, R. A., & Boehm, G. W. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200512000-00002 · Cited by 16 · see citing works
Histone deacetylase and acetyltransferase inhibitors modulate behavioral responses to social stress
McCann, K. E., Rosenhauer, A. M., Jones, G. M. F., Norvelle, A., Choi, D. C., & Huhman, K. L. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.10.022 · Cited by 15 · see citing works
Psychological Health and Overweight and Obesity Among High Stressed Work Environments
Faghri, P. D. (2015) · Obesity Open Access · doi:10.16966/2380-5528.101 · Cited by 15 · see citing works
Nuclei-specific hypothalamus networks predict a dimensional marker of stress in humans
Jensen, D. E. A., Ebmeier, K. P., Suri, S., Rushworth, M. F. S., & Klein-Flügge, M. C. (2024) · Nature Communications · doi:10.1038/s41467-024-46275-y · Cited by 17 · see citing works
Genetic risk for neuroticism predicts emotional health depending on childhood adversity
Lehto, K., Karlsson, I., Lundholm, C., & Pedersen, N. L. (2018) · Psychological Medicine · doi:10.1017/s0033291718000715 · Cited by 14 · see citing works
Overweight and Obesity in High Stress Workplaces
Faghri, P. D., & Mignano, C. (2013) · Journal of Nutritional Disorders & Therapy · doi:10.4172/2161-0509.1000e110 · Cited by 13 · see citing works
Janković, M., Spasojević, N., Ferizović, H., Stefanović, B., & Dronjak, S. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136363 · Cited by 13 · see citing works
Swim stress inhibits 5-HT2A receptor-mediated head twitch behaviour in mice
Peričić, D. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1357-y · Cited by 13 · see citing works
Developing a monitoring psychological stress index system via photoplethysmography
Abbod, M., Chiou, Y.-R., Yang, S.-H., Fan, S., & Shieh, J.-S. (2011) · Artificial Life and Robotics · doi:10.1007/s10015-011-0976-y · Cited by 12 · see citing works
Lopes, A., Fonseca, I. M., Sousa, A., Rodrigues, C., Branco, M., Coelho, T., Sequeiros, J., & Freitas, P. (2018) · Amyloid · doi:10.1080/13506129.2018.1428795 · Cited by 12 · see citing works
- Authors
- Agid, O., Kohn, Y., & Lerer, B.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Agid, O.
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2000-04
- Volume
- 54
- Issue
- 3
- Pages
- 135-141
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W2157974953
- Cited by
- 169
- References
- 53
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 11 · 2017: 3 · 2016: 9 · 2015: 10 · 2014: 10 · 2013: 8 · 2012: 5
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- environmental stress, mental illness, major depressive disorder, major life events, genetic susceptibility, vulnerability factors, stress response
- MeSH terms
- Animals, Mental Disorders, Depressive Disorder, Environment, Humans, Stress, Psychological
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