Brain interleukin-1β and tumor necrosis factor-α are involved in lipopolysaccharide-induced delayed rectal allodynia in awake rats

Coelho, Anne-Marie; Fioramonti, Jean; Bueno, Lionel

doi:10.1016/s0361-9230(00)00269-0

Cited by 31Pain Mechanisms and TreatmentsGastrointestinal motility and disordersVagus Nerve Stimulation Research

Brain interleukin-1β and tumor necrosis factor-α are involved in lipopolysaccharide-induced delayed rectal allodynia in awake rats

Coelho, Anne-Marie, Fioramonti, Jean, Bueno, Lionel·2000·Brain Research Bulletin

DOI 10.1016/s0361-9230(00)00269-0

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Abstract

Recently, we have developed a model of delayed (12 h) increase in sensitivity (allodynia) to rectal distension (RD) induced by intraperitoneal lipopolysaccharide (LPS) in awake rats. Thus, we examined whether central interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are involved in LPS response. Abdominal contractions (criterion of visceral pain) were recorded in rats equipped with intramuscular electrodes. RDs were performed at various times after pharmacological treatments. RD induced abdominal contractions from a threshold volume of distension of 0.8 ml. At lowest volume (0.4 ml), this number was significantly increased 12 h after LPS. Intracerebroventricular (i.c.v.) injection of IL-1 receptor antagonist, IL-1beta converting enzyme inhibitor or recombinant human TNF-alpha soluble receptor reduced LPS-induced increase of abdominal contractions at 0.4 ml volume of distension. When injected i.c.v., recombinant human IL-1beta and recombinant bovine TNF-alpha reproduced LPS response at 9 and 12 h and at 6 and 9 h, respectively. These data suggest that IL-1beta and TNF-alpha act centrally to induce delayed rectal hypersensitivity and that central release of these cytokines is responsible of LPS-induced delayed (12 h) rectal allodynia.

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Authors: Coelho, A.-M., Fioramonti, J., & Bueno, L.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Corresponding author: Bueno, Lionel
Venue: Brain Research Bulletin
Publisher: Elsevier BV
Published: 2000-06
Volume: 52
Issue: 3
Pages: 223-228
ISSN: 0361-9230 (ISSN-L)
DOI: 10.1016/s0361-9230(00)00269-0
OpenAlex: W2070025133
Cited by: 31
References: 46
Citations by year: 2026: 1 · 2022: 1 · 2020: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 1
FWCI: 1.65
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords: lipopolysaccharide, IL-1β, TNF-α, visceral pain, rectal distension, central sensitization, intracerebroventricular administration, interleukin-1 receptor antagonist, abdominal contractions, cytokines
MeSH terms: Animals, Brain, Consciousness, Electromyography, Hyperalgesia, Injections, Intraventricular, Interleukin-1, Lipopolysaccharides, Male, Nociceptors, Pain Measurement, Recombinant Proteins, Rectum, Tumor Necrosis Factor-alpha, Viral Proteins, Serpins, Cysteine Proteinase Inhibitors, Rats, Wistar, Rats

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Brain interleukin-1β and tumor necrosis factor-α are involved in lipopolysaccharide-induced delayed rectal allodynia in awake rats

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