The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Expression of c-fos gene activation during rough and tumble play in juvenile rats
Abstract
Rough and tumble (R&T) play is an intrinsic behavior in most mammals. However, unlike sex and aggression, play has not been well characterized in terms of neuronal circuitry. We employed in situ hybridization to explore the differences of c-fos mRNA activation in juvenile rats that had been allowed R&T play for a total of 30 min before sacrifice contrasted to animals with comparable histories that had received no play. Densitometric estimates of c-fos gene activation revealed that the deep and dorsolateral tectum, inferior colliculus, dorsal periaquaductal gray, ventromedial hypothalamus, dorsal and ventral striatum, and somatosensory cortex were significantly more activated in animals that had played than those that had not. Prior play dominance and amount of social experience had no clear effects on the levels of c-fos gene expression. This provides a variety of new hypotheses concerning the role of various brain areas in the elaboration of R&T play behavior, but the important role of other types of motor arousal in the differential effects were not evaluated in this study.
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“The activation patterns in many of these regions correlated with one another, suggesting that the coordinated activity, rather than individual activation, of specific brain circuits is necessary for proper play behavior.”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Gordon et al., 2002
In the citing paper
“Using this methodology, two leading play research groups demonstrated that play activates several distinct brain regions, including those involved in motivation, reward, sensory, and motor processing (Gordon et al., 2002; van Kerkhof et al., 2014).”
From Developmental origins of sex differences in the neural circuitry of play (2020) · cites this paper as Gordon et al., 2002
In the citing paper
“Social play enhances neuronal activity in a broad network of limbic and corticostriatal structures”
From Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats (2022) · cites this paper as Gordon et al., 2002
Citations
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585
Affective Neuroscience: The Foundations of Human and Animal Emotions
Panksepp, J. (1998) · doi:10.1093/oso/9780195096736.001.0001 · Cited by 4,428
Self-citationIkemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Self-citationThe neurobiology of social play behavior in rats
Vanderschuren, L. J. M. J., Niesink, R. J. M., & Van Pee, J. M. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00020-6 · Cited by 559
Panksepp, J. (1981) · Developmental Psychobiology · doi:10.1002/dev.420140405 · Cited by 537
Self-citationThe psychobiology of play: Theoretical and methodological perspectives
Panksepp, J., Siviy, S., & Normansell, L. (1984) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(84)90005-8 · Cited by 468
Self-citationAnticipation of play elicits high-frequency ultrasonic vocalizations in young rats.
Knutson, B. D., Burgdorf, J. S., & Panksepp, J. (1998) · Journal of comparative psychology · doi:10.1037/0735-7036.112.1.65 · Cited by 456
Self-citation(1998) · Journal of Consciousness Studies · Cited by 332
Self-citationKollack‐Walker, S., & Newman, S. W. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00563-k · Cited by 315
Self-citationPlace conditioning reveals the rewarding aspect of social interaction in juvenile rats
Calcagnetti, D. J., & Schechter, M. D. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90101-7 · Cited by 284
Research works printed but not linked: 1
- Panksepp, 1998, The periconscious substrates of consciousness, J. Consciousness Stud., 5, 566
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Items 101–103 of 103
How social play experience shapes development of higher brain function
Bijlsma, A. (2023) · Utrecht University Repository (Utrecht University) · doi:10.33540/1927
Play behavior: Tickle and play in the periaqueductal gray
Ahmed, I. A., & Froemke, R. C. (2023) · Current Biology · doi:10.1016/j.cub.2023.09.035
Bouamrane, L. (2015) · theses.fr (ABES) · doi:10.70675/00597159za953z4221z95b8z57a6c1d48c8e
Metadata
- Authors
- Gordon, N. S., Kollack-Walker, S., Akil, H., & Panksepp, J.
- Affiliations
- Bowling Green State University (US)
- University of Michigan (US)
- Corresponding author
- Panksepp, Jaak
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2002-03
- Volume
- 57
- Issue
- 5
- Pages
- 651-659
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2078189006
- Cited by
- 103
- References
- 36
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 8 · 2022: 4 · 2021: 2 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 8 · 2012: 2
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- rough-and-tumble play, c-fos gene expression, young rats, neuronal activation, brain regions, tectum, inferior colliculus, hypothalamus, striatum, somatosensory cortex, social experience
- MeSH terms
- Aging, Animals, Arousal, Behavior, Animal, Brain, Brain Stem, Male, Motor Activity, Neurons, Play and Playthings, RNA, Messenger, Social Behavior, Up-Regulation, Proto-Oncogene Proteins c-fos, Rats, Long-Evans, Rats
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