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Cited by 113Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

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A brain motivated to play: insights into the neurobiology of playfulness

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Siviy, Stephen M.·2016·Behaviour
DOI 10.1163/1568539x-00003349PMC PMC5646690
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Abstract

Play is an important part of normal childhood development and is seen in varied forms among many mammals. While not indispensable to normal development, playful social experiences as juveniles may provide an opportunity to develop flexible behavioural strategies when novel and uncertain situations arise as an adult. To understand the neurobiological mechanisms responsible for play and how the functions of play may relate to these neural substrates, the rat has become the model of choice. Play in the rat is easily quantified, tightly regulated, and can be modulated by genetic factors and postnatal experiences. Brain areas most likely to be involved in the modulation of play include regions within the prefrontal cortex, dorsal and ventral striatum, some regions of the amygdala, and habenula. This paper discusses what we currently know about the neurobiological substrates of play and how this can help illuminate functional questions about the putative benefits of play.

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  • Play is itself a social behavior and involves the activity of many regions in the social circuitry, such as the medial amygdala, lateral septum, and hypothalamus.

    “given play is itself a social behavior and involves the activity of many regions in the social circuitry, such as the medial amygdala, lateral septum, and hypothalamus (summarized in Siviy, 2016 and VanRyzin et al., 2020a).”

    From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Siviy, 2016

    The Introduction describes social rough-and-tumble play in rats, while noting that human play can also be solitary. The Subcortical involvement section links play to activity in the medial amygdala and hypothalamus, and reports that a lateral septal infusion changes play in rats; it does not establish play-related neural activity in the lateral septum. The claim therefore overgeneralizes both the social nature of play and the evidence for activity in every listed region (page numbers unavailable). (LLM, conf=0.85)

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  • Laboratory rats have been an important model species for studying the neurobiology of rough-and-tumble play.

    “Laboratory rats have been an important model species with which to study the neurobiology of RTP (Siviy and Panksepp, 2011; Siviy, 2016; Vanderschuren et al., 2016).”

    From The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain (2022) · cites this paper as Siviy, 2016

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Metadata

Authors
Siviy, S. M.
Affiliations
Gettysburg College (US)
Corresponding author
Siviy, Stephen M.
ORCID
Siviy, Stephen M.
Venue
Behaviour
Publisher
Walter de Gruyter GmbH
Published
2016
Volume
153
Issue
6-7
Pages
819-844
ISSN
  • 0005-7959 (ISSN-L)
  • 1568-539X
DOI
10.1163/1568539x-00003349
PMC
PMC5646690
OpenAlex
W2334239925
Cited by
113
References
20
Citations by year
2026: 11 · 2025: 9 · 2024: 13 · 2023: 26 · 2022: 12 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 6 · 2016: 1
FWCI
12.58
Type
journal article
Language
en
Open access
Locations
  • Behaviour (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • The Cupola: Scholarship at Gettysburg College (Gettysburg College) (submittedVersion)
Funders
National Institute of Mental Health (R15MH100585)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
playfulness, play behavior, prefrontal cortex, striatum, amygdala, habenula, behavioral flexibility, postnatal experience, genetic factors, child development

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