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Cited by 76Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and TherapyDietary Effects on Health

The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction

Cavallini, G., Donati, A., Gori, Z., Pollera, M., Bergamini, E.·2001·Experimental Gerontology
DOI 10.1016/s0531-5565(00)00224-2
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Abstract

Restricting caloric intake (CR) well below that of ad libitum (AL) fed animals retards and/or delays many characteristics of ageing and the occurrence and progression of age-associated diseases, efficacy depending on duration. The hypothesis that the anti-ageing effect of CR might involve stimulation of the cell-repair mechanism autophagy was tested. The effects of ageing and duration of anti-ageing CR on liver autophagic proteolysis (AP) were explored in male AL Sprague-Dawley rats aged 2-, 6-, 12- and 24-months; and 24-month-old rats on a CR diet initiated at 2-, 6- and 12-month of age or initiated at age 2-months and interrupted at age 18 months. The age-related changes in the regulation of AP were studied by monitoring the rate of valine release in the incubation medium from isolated liver cells by an HPLC procedure. Results show that the maximum attainable rate and the regulation of AP decline with increasing age; that changes are prevented by anti-ageing CR initiated at young age, that the protective effects of CR change with the duration of diet. It is concluded that the data are compatible with the hypothesis that AP and improved membrane maintenance might be involved in the antiageing mechanism of CR.

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  • Caloric restriction and treatment with lipogenic agents are able to prevent the dysregulation of macroautophagy in old rodents, although the mechanisms are still under investigation.

    “Caloric restriction and treatment with lipogenic agents are able to prevent the dysregulation of macroautophagy in old rodents, although the mechanisms by which they exert their action is still subject of investigation (Cavallini et al., 2001; Donati et al., 2004).”

    From Protein Homeostasis and Aging: the importance of exquisite quality control (2011) · cites this paper as Cavallini et al., 2001

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Authors
Cavallini, G., Donati, A., Gori, Z., Pollera, M., & Bergamini, E.
Affiliations
University of Pisa (IT)
Corresponding author
Bergamini, E.
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2001-03
Volume
36
Issue
3
Pages
497-506
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/s0531-5565(00)00224-2
OpenAlex
W1979931199
Cited by
76
References
1
Citations by year
2026: 1 · 2025: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 1 · 2013: 4 · 2012: 1
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
caloric restriction, autophagy, liver, aging, age-related decline, membrane maintenance, Sprague-Dawley rats
MeSH terms
Adenine, Aging, Amino Acids, Animals, Autophagy, Cycloheximide, Diet, Food Deprivation, Liver, Male, Rats, Sprague-Dawley, Hepatocytes, Rats

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