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Cited by 282Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsGenetic Associations and Epidemiology

The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index.

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

Rose, G, Dato, S, Altomare, K, Bellizzi, D, Garasto, S, Greco, V, Passarino, G, Feraco, E, Mari, V, Barbi, C, BonaFe, M, Franceschi, C, Tan, Q, Boiko, S, Yashin, A.I, De Benedictis, G·2003·Experimental Gerontology
DOI 10.1016/s0531-5565(03)00209-2
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Abstract

The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.

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Research works printed but not linked: 2

  1. Bellizzi, 2002, The SIRT3 and the PSMD13 genes are linked head-to-head and share a bidirectional promoter, Proceedings of the Cold Spring Harbor Laboratory ‘Molecular genetics of aging’, October 2–6, 2002, Cold Spring Harbor, NY, USA
  2. Yashin, 2000, Genes and longevity: lessons from centenarian studies, J. Gerontol.: Biol. Sci., 55A, B1

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Metadata

Authors
Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V, Passarino, G., Feraco, E., Mari, V, Barbi, C., BonaFe, M., Franceschi, C., Tan, Q., Boiko, S., Yashin, A. I., & De Benedictis, G.
Affiliations
  • University of Calabria (IT)
  • Istituto Nazionale di Riposo e Cura per Anziani (IT)
  • University of Bologna (IT)
  • University of Southern Denmark (DK)
  • Max Planck Institute for Demographic Research (DE)
ORCID
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2003-10
Volume
38
Issue
10
Pages
1065-1070
ISSN
0531-5565 (ISSN-L)
DOI
10.1016/s0531-5565(03)00209-2
OpenAlex
W2077864684
Cited by
282
References
27
Citations by year
2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 17 · 2020: 9 · 2019: 8 · 2018: 12 · 2017: 5 · 2016: 16 · 2015: 18 · 2014: 15 · 2013: 29 · 2012: 16
FWCI
4.27
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Experimental Gerontology (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
SIRT3, sirtuins, genetic variation, human longevity, linkage disequilibrium, 11p15.5, HRAS1, insulin-like growth factor II, proinsulin, tyrosine hydroxylase, mitochondrial deacetylase, lifespan
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Chromosomes, Human, Pair 11, Female, Genotype, Haplotypes, Histone Deacetylases, Humans, Longevity, Male, Middle Aged, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Linkage Disequilibrium, Survival Rate, Mitochondrial Proteins, Sirtuins, Sirtuin 3

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