Cited by 282Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model OrganismsGenetic Associations and Epidemiology

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Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

Rose, G, Dato, S, Altomare, K, Bellizzi, D, Garasto, S, Greco, V, Passarino, G, Feraco, E, Mari, V, Barbi, C, BonaFe, M, Franceschi, C, Tan, Q, Boiko, S, Yashin, A.I, De Benedictis, G·2003·Experimental Gerontology

DOI 10.1016/s0531-5565(03)00209-2

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Abstract

The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins. Studies in model organisms have demonstrated that SIR2 genes control lifespan, while no data are available regarding a possible role of SIRT3 in human longevity. By analysing the genotype-specific survival function relevant to the G477T marker of SIRT3, we found that in males the TT genotype increases (p=0.0272), while the GT genotype decreases (p=0.0391) survival in the elderly. Since SIRT3 lies in a chromosomal region (11p15.5) where four genes potentially associated with longevity are located (HRAS1, Insulin-like Growth Factor 2, Proinsulin, and Tyrosine Hydroxylase) we tested for linkage-disequilibrium between G477T alleles and alleles of the above genes. The disequilibrium was not significant in any case, thus suggesting that SIRT3 itself, or a gene strictly linked to SIRT3, may have a role in human longevity.

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Authors: Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V, Passarino, G., Feraco, E., Mari, V, Barbi, C., BonaFe, M., Franceschi, C., Tan, Q., Boiko, S., Yashin, A. I., & De Benedictis, G.
Affiliations: University of Calabria (IT)
Istituto Nazionale di Riposo e Cura per Anziani (IT)
University of Bologna (IT)
University of Southern Denmark (DK)
Max Planck Institute for Demographic Research (DE)
ORCID: Rose, G
Dato, S
Bellizzi, D
Garasto, S
Passarino, G
Franceschi, C
Tan, Q
Boiko, S
Venue: Experimental Gerontology
Publisher: Elsevier BV
Published: 2003-10
Volume: 38
Issue: 10
Pages: 1065-1070
ISSN: 0531-5565 (ISSN-L)
DOI: 10.1016/s0531-5565(03)00209-2
OpenAlex: W2077864684
Cited by: 282
References: 27
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 17 · 2020: 9 · 2019: 8 · 2018: 12 · 2017: 5 · 2016: 16 · 2015: 18 · 2014: 15 · 2013: 29 · 2012: 16
FWCI: 4.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Gerontology (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: SIRT3, sirtuins, genetic variation, human longevity, linkage disequilibrium, 11p15.5, HRAS1, insulin-like growth factor II, proinsulin, tyrosine hydroxylase, mitochondrial deacetylase, lifespan
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Chromosomes, Human, Pair 11, Female, Genotype, Haplotypes, Histone Deacetylases, Humans, Longevity, Male, Middle Aged, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Linkage Disequilibrium, Survival Rate, Mitochondrial Proteins, Sirtuins, Sirtuin 3

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Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

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