The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Neurobehavioral aspects of antioxidants in aging
Abstract
Both aging and age‐associated neurodegenerative diseases are associated with various degrees of behavioral impairments, and among the prime candidates responsible for producing the neuronal changes mediating these behavioral deficits appear to be free radicals and the oxidative stress they generate. Therefore, there have been a number of studies which have examined the putative positive benefits of antioxidants in altering, reversing, or forestalling these neuronal/behavioral decrements, with varying degrees of success. Additional experiments have examined the effects of diets rich in fruits and vegetables or herbal extracts in reducing certain types of cancer and cardiovascular diseases, and evidence emerging from such experiments suggests that these kinds of dietary modifications may be beneficial in altering neuronal/behavioral deficits in aging, as well. These kinds of diets are particularly rich in antioxidants such as vitamins A, C, E, and bioflavonoids (such as flavones, tannins, and anthocyanins), and thus, there may be synergistic effects among them. The present paper will review studies concerning the influence of dietary and synthetic antioxidants on normal, pathological age‐related, and reactive oxygen species‐induced behavioral changes in human and animal subjects. The antioxidants reviewed are vitamin E, α‐lipoic acid, and the phytochemicals contained in herbals, fruits and vegetables.
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Cites
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Cited by
Free radicals, antioxidants and functional foods: impact on human health
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Interaction between flavonoids and the blood–brain barrier: in vitro studies
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Metadata
- Authors
- Cantuti‐Castelvetri, I., Shukitt‐Hale, B., & Joseph, J. A.
- Venue
- International Journal of Developmental Neuroscience
- Publisher
- Wiley
- Published
- 2000-05-15
- Volume
- 18
- Issue
- 4-5
- Pages
- 367-381
- ISSN
- 0736-5748 (ISSN-L)
- 1873-474X
- OpenAlex
- W2072683060
- Cited by
- 231
- References
- 8
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
