Micronutrients and cancer risk

Willett, WC

doi:10.1093/ajcn/59.5.1162s

Cited by 143Nutritional Studies and DietAntioxidant Activity and Oxidative StressPhytochemicals and Antioxidant Activities

Micronutrients and cancer risk

Willett, WC·1994·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/59.5.1162s

Open this paper in CoChat — free account

Abstract

An abundance of epidemiologic evidence, based on numerous and remarkably consistent observations that persons who consume high intakes of fruits and vegetables have reduced risks of most human cancers, supports the concept that micronutrients may play important roles in the prevention of human cancers. Many studies suggest that carotenoid compounds in fruits and vegetables may be important in reducing risk of lung cancer. At least some forms of fiber may contribute to reduced risk of colon cancer, but recent analyses of colonic polyps suggest that folic acid may also play a protective role. Evidence for breast cancer is more limited but protective associations with vitamin A from both carotenoid and preformed sources have been seen in several studies. Although we cannot be certain which compounds are responsible, the evidence is overwhelming that an abundant intake of fruits and vegetables can play an important role in reducing cancer incidence.

Integrity signals

Registry

Crossref · 10.1093/ajcn/59.5.1162s

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Populations with diets high in vegetables and fruits and low in animal fat, meat, and/or calories have a reduced risk of some of the most common types of cancer.
“epidemiological studies also have shown that populations with diets high in vegetables and fruits and low in animal fat, meat, and/or calories have a reduced risk of some of the most common types of cancer.[97][98][99][100]”
From Preventing Cancer, Cardiovascular Disease, and Diabetes: A Common Agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association (2004) · cites this paper as [97]

Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence.
Block, G., Patterson, B. H., & Subar, A. (1992) · Nutrition and Cancer · doi:10.1080/01635589209514201 · Cited by 3,321 · see citing works
Can dietary beta-carotene materially reduce human cancer rates?
Peto, R., Doll, R., Buckley, J. D., & Sporn, M. B. (1981) · Nature · doi:10.1038/290201a0 · Cited by 1,563 · see citing works
Vegetables, fruit, and cancer. I. Epidemiology
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00051672 · Cited by 1,118 · see citing works
Nutritional epidemiology
(1990) · Choice Reviews Online · doi:10.5860/choice.27-5795 · Cited by 1,049 · see citing works
THE USE OF A SELF-ADMINISTERED QUESTIONNAIRE TO ASSESS DIET FOUR YEARS IN THE PAST
Willett, W. C., SAMPSON, L., Browne, M. L., Stampfer, M. J., ROSNER, B. A., Hennekens, C. H., & Speizer, F. E. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114780 · Cited by 801 · see citing works
Self-citation
Role of retinoids in differentiation and carcinogenesis.
Sporn, M. B., & Roberts, A. B. (1983) · PubMed · Cited by 786 · see citing works
Folate, Methionine, and Alcohol Intake and Risk of Colorectal Adenoma
Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Rimm, E. B., Trichopoulos, D., ROSNER, B. A., Speizer, F. E., & Willett, W. C. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.11.875 · Cited by 705 · see citing works
Self-citation
Dietary Fiber, Vegetables, and Colon Cancer: Critical Review and Meta-analyses of the Epidemiologic Evidence
Trock, B. J., Lanza, E., & Greenwald, P. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.8.650 · Cited by 558 · see citing works
Serum Beta-Carotene, Vitamins a and E, Selenium, and the Risk of Lung Cancer
Menkes, M., Comstock, G. W., Vuilleumier, J. P., Helsing, K. J., Rider, A. A., & Brookmeyer, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611133152003 · Cited by 537 · see citing works
DIETARY VITAMIN A AND RISK OF CANCER IN THE WESTERN ELECTRIC STUDY
Shekelle, R. B., Liu, S., RAYNOR, W. J., Lepper, M. H., Maliza, C., Rossof, A., Paul, O., Shryock, A. M., & Stamler, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)91435-5 · Cited by 480 · see citing works
The search for the causes of breast and colon cancer
Willett, W. C. (1989) · Nature · doi:10.1038/338389a0 · Cited by 466 · see citing works
Self-citation
Dietary Fat and Fiber in Relation to Risk of Breast Cancer
Willett, W. C. (1992) · JAMA · doi:10.1001/jama.1992.03490150089030 · Cited by 403 · see citing works
Self-citation
Dietary vitamin a and human lung cancer
Bjelke, E. (1975) · International Journal of Cancer · doi:10.1002/ijc.2910150405 · Cited by 397 · see citing works
Relationship of Diet to Risk of Colorectal Adenoma in Men
Giovannucci, E. L., Stampfer, M. J., Colditz, G. A., Rimm, E. B., & Willett, W. C. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.2.91 · Cited by 341 · see citing works
Self-citation
A Prospective Study of the Intake of Vitamins C, E, and A and the Risk of Breast Cancer
Hunter, D. J., Manson, J. E., Colditz, G. A., Stampfer, M. J., ROSNER, B. A., Hennekens, C. H., Speizer, F. E., & Willett, W. C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199307223290403 · Cited by 307 · see citing works
Self-citation
Dietary habits and lung cancer risk
Kvåle, G., Bjelke, E., & Gart, J. J. (1983) · International Journal of Cancer · doi:10.1002/ijc.2910310402 · Cited by 296 · see citing works
Vegetable Consumption and Lung Cancer Risk: A Population-Based Case-Control Study in Hawaii
Marchand, L. L., YOSHIZAWA, C. N., Kolonel, L. N., Hankin, J. H., & Goodman, M. T. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.15.1158 · Cited by 275 · see citing works
Serum vitamin levels and the risk of cancer of specific sites in men of Japanese ancestry in Hawaii.
Nomura, A. M. Y., Stemmermann, G. N., Heilbrun, L. K., Salkeld, R., & Vuilleumier, J. P. (1985) · PubMed · Cited by 256 · see citing works
SERUM VITAMIN E AND RISK OF CANCER AMONG FINNISH MEN DURING A 10-YEAR FOLLOW-UP
Knekt, P., Aromaa, A., Maatela, J., Aaran, R., Nikkari, T., Hakama, M., Hakulinen, T. R., Peto, R., Saxén, E., & Teppo, L. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114788 · Cited by 233 · see citing works
Modem Nutrition in Health and Disease
FELDMAN, E. B. (1989) · Journal of the American College of Nutrition · doi:10.1080/07315724.1989.10738120 · Cited by 220 · see citing works
Dietary Antioxidants and the Risk of Lung Cancer
Knekt, P., Jarvinen, R., Seppänen, R., Rissanen, A., Aromaa, A., Heinonen, O. P., Albanes, D., Heinonen, M., Pukkala, ., & Teppo, L. (1991) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116118 · Cited by 192 · see citing works
Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked
Koo, L. C. (1988) · Nutrition and Cancer · doi:10.1080/01635588809513983 · Cited by 176 · see citing works
DIETARY VITAMIN A, CAROTENE, VITAMIN C AND RISK OF LUNG CANCER IN HAWAII
Hinds, M. W., Kolonel, L. N., Hankin, J. H., & LEE, J. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113741 · Cited by 174 · see citing works
Cancer, Vitamins, and Plasma Lipids: Prospective Basel Study 1 2
Stähelin, H. B., Rösel, F., Buess, E., & Brubacher, G. (1984) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/73.6.1463 · Cited by 157 · see citing works
Essential micronutrients in relation to carcinogenesis
Kromhout, D. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/45.5.1361 · Cited by 117 · see citing works
Trace elements in health and disease
Aitio, A., Aro, A., Järvisalo, J. O., & Vainio, H. (1991) · Royal Society of Chemistry eBooks · Cited by 114 · see citing works
Smoking and other risk factors for lung cancer in women
(1985) · Lung Cancer · doi:10.1016/s0169-5002(85)80009-x · Cited by 113 · see citing works
Dietary factors and risk of lung cancer: Results from a case‐control study, toronto, 1981–1985
Jain, M., Burch, J. D., Howe, G. R., Risch, H. A., & Miller, A. B. (1990) · International Journal of Cancer · doi:10.1002/ijc.2910450214 · Cited by 112 · see citing works
Vitamin A and lung cancer.
Tms, A. (1980) · Europe PMC (PubMed Central) · Cited by 90 · see citing works
Comparison of dietary histories in lung cancer cases and controls with special reference to vitamin A
Gregor, A., Lee, P. N., Roe, F. J. C., Wilson, M., & Melton, A. (1980) · Nutrition and Cancer · doi:10.1080/01635588009513664 · Cited by 84 · see citing works
DIETARY VITAMIN A AND LUNG CANCER RISK: AN ANALYSIS BY HISTOLOGIC SUBTYPES
Byers, T., Vena, J. E., Mettlin, C. J., Swanson, M. K., & Graham, S. (1984) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113945 · Cited by 82 · see citing works
Lung cancer risk and vitamin A consumption in New Mexico.
Samet, J. M., SKIPPER, B. J., Humble, C. G., & Pathak, D. R. (1985) · PubMed · doi:10.1164/arrd.1985.131.2.198 · Cited by 79 · see citing works
A case‐control study of dietary carotene in men with lung cancer and in men with other epithelial cancers
Harris, R. W., Key, T. J., Silcocks, P., Bull, D., & Wald, N. (1991) · Nutrition and Cancer · doi:10.1080/01635589109514113 · Cited by 68 · see citing works
Paraneoplastic limbic encephalopathy with testicular carcinoma: A reversible neurologic syndrome
Burton, G. V., Bullard, D. E., Walther, P. J., & Burger, P. C. (1988) · Cancer · doi:10.1002/1097-0142(19881115)62:10 · Cited by 56 · see citing works
Vitamin C Status and Cancer
Block, G. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb17107.x · Cited by 56 · see citing works
Vitamin A and female lung cancer: A case‐control study on plasma and diet
Pastorino, U., Pisani, P., Berrino, F., Andreoli, C., Barbieri, A., Costa, A., Mazzoleni, C., Gramegna, G., & Marubini, E. (1987) · Nutrition and Cancer · doi:10.1080/01635588709513955 · Cited by 49 · see citing works
Dietary carotene and vitamin A and risk of lung cancer among white men in New Jersey
(1986) · Lung Cancer · doi:10.1016/s0169-5002(86)80006-x · Cited by 48 · see citing works
Dietary vitamin A, beta carotene and risk of epidermoid lung cancer in South-Western France
Dartigues, J. F., Dabis, F., Gros, N., Moise, A., Bois, G., Salamon, R., Dilhuydy, J.-M., & Courty, G. (1990) · European Journal of Epidemiology · doi:10.1007/bf00150430 · Cited by 34 · see citing works
Lung cancer risk and vitamin a consumption in New Mexico
(1985) · Lung Cancer · doi:10.1016/s0169-5002(85)80148-3 · Cited by 29 · see citing works
Dietary vitamin A, beta-carotene and risk of epidermoid lung cancer among Chinese males.
Ho, S. C., Donnan, S. P. B., Martin, C., & Tsao, S. Y. (1988) · PubMed · Cited by 5 · see citing works
Untitled work
Venkatesh (1989) · doi:10.1002/1097-0142(19890801)64:3

Flagged first, then by citations

Sorted by citations

Nutrition and physical activity guidelines for cancer survivors
Rock, C. L., Doyle, C., Demark‐Wahnefried, W., Meyerhardt, J., Courneya, K. S., Schwartz, A. L., Bandera, E. V., Hamilton, K. K., Grant, B., McCullough, M., et al. (2012) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21142 · Cited by 1,995 · see citing works
American Cancer Society guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity
Kushi, L. H., Byers, T., Doyle, C., Bandera, E. V., McCullough, M., Gansler, T., Andrews, K. S., Thun, M. J., & The American Cancer Society 2006 Nutrition and Physical Activity Guidelines Advisory Committee (2006) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.56.5.254 · Cited by 1,901 · see citing works
Total Antioxidant Capacity of Fruits
Wang, H., Cao, G., & Prior, R. L. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf950579y · Cited by 1,686 · see citing works
Total Antioxidant Capacity of Plant Foods, Beverages and Oils Consumed in Italy Assessed by Three Different In Vitro Assays
Pellegrini, N., Colombi, B., Rio, D. D., Salvatore, S., Bianchi, M. A., Brighenti, F., & Serafini, M. (2003) · Journal of Nutrition · doi:10.1093/jn/133.9.2812 · Cited by 1,488 · see citing works
Breakfast Habits, Nutritional Status, Body Weight, and Academic Performance in Children and Adolescents
Rampersaud, G. C., Pereira, M. A., Girard, B. L., Adams, J., & Metzl, J. D. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2005.02.007 · Cited by 1,333 · see citing works
American Cancer Society guidelines on nutrition and physical activity for cancer prevention
Kushi, L. H., Doyle, C., McCullough, M. L., Rock, C. L., Demark‐Wahnefried, W., Bandera, E. V., Gapstur, S. M., Patel, A. V., Andrews, K. S., & Gansler, T. S. (2012) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20140 · Cited by 1,331 · see citing works
Antioxidant Capacity of Tea and Common Vegetables
Cao, G., Sofic, E., & Prior, R. L. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9602535 · Cited by 1,297 · see citing works
Anti-oxidant activity and total phenolic content of some Asian vegetables
Kaur, C., & Kapoor, H. C. (2002) · International Journal of Food Science & Technology · doi:10.1046/j.1365-2621.2002.00552.x · Cited by 1,158 · see citing works
Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation
Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Bielinski, D., Martin, A., McEwen, J. J., & Bickford, P. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08114.1999 · Cited by 980 · see citing works
Nutrition and physical activity during and after cancer treatment: An American Cancer Society guide for informed choices
Doyle, C., Kushi, L. H., Byers, T., Courneya, K. S., Demark-Wahnefried, W., Grant, B., McTiernan, A., Rock, C. L., Thompson, C., Gansler, T., et al. (2006) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.56.6.323 · Cited by 950 · see citing works
Evaluation of antioxidant capacity and total phenolic content of different fractions of selected microalgae
LI, H., CHENG, K., WONG, C., FAN, K., CHEN, F., & JIANG, Y. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2006.06.022 · Cited by 790 · see citing works
Antioxidant Phytochemicals in Fruits and Vegetables: Diet and Health Implications
Prior, R. L., & Cao, G. (2000) · HortScience · doi:10.21273/hortsci.35.4.588 · Cited by 559 · see citing works
Preventing Cancer, Cardiovascular Disease, and Diabetes: A Common Agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association
Eyre, H., Kahn, R., Robertson, R. M., the ACS/ADA/AHA Collaborative Writing Committee, ACS/ADA/AHA Collaborative Writing Committee Members, Clark, N. G., Doyle, C., Hong, Y., Gansler, T., Glynn, T., et al. (2004) · Circulation · doi:10.1161/01.cir.0000133321.00456.00 · Cited by 542 · see citing works
Walnuts (Juglans regia L): proximate composition, protein solubility, protein amino acid composition and proteinin vitro digestibility
Sze‐Tao, K. W. C., & Sathe, S. K. (2000) · Journal of the Science of Food and Agriculture · doi:10.1002/1097-0010(200007)80:9 · Cited by 266 · see citing works
Long-Term Dietary Strawberry, Spinach, or Vitamin E Supplementation Retards the Onset of Age-Related Neuronal Signal-Transduction and Cognitive Behavioral Deficits
Joseph, J. A., Shukitt‐Hale, B., Denisova, N. A., Prior, R. L., Cao, G., Martín, A., Taglialatela, G., & Bickford, P. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08047.1998 · Cited by 432 · see citing works
Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables
Cao, G., Booth, S. L., Sadowski, J. A., & Prior, R. L. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.5.1081 · Cited by 403 · see citing works
Intestinal absorption and tissue distribution of carotenoids
Furr, H. C., & Clark, R. M. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)00060-0 · Cited by 364 · see citing works
The use of cyclic voltammetry for the evaluation of antioxidant capacity
Chevion, S., Roberts, M., & Chevion, M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00178-7 · Cited by 342 · see citing works
American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention: Reducing the Risk of Cancer with Healthy Food Choices and Physical Activity
Byers, T., Nestle, M., McTiernan, A., Doyle, C., Currie-Williams, A., Gansler, T., & Thun, M. (2002) · CA: A Cancer Journal for Clinicians · doi:10.3322/canjclin.52.2.92 · Cited by 336 · see citing works
Preventing Cancer, Cardiovascular Disease, and Diabetes: A Common Agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association
Eyre, H. J., Kahn, R., Robertson, R. M., Clark, N. G., Doyle, C., Gansler, T. S., Glynn, T., Hong, Y., Smith, R. A., Taubert, K. A., et al. (2004) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.54.4.190 · Cited by 328 · see citing works
Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction
Eiserich, J. P., van der Vliet, A., Handelman, G., Halliwell, B. B., & Cross, C. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1490s · Cited by 306 · see citing works
Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats
Bickford, P. C., Gould, T., Briederick, L., Chadman, K., Pollock, A., Young, D., Shukitt-Hale, B., & Joseph, J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02280-0 · Cited by 298 · see citing works
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin
Tanaka, T. (1997) · Carcinogenesis · doi:10.1093/carcin/18.5.957 · Cited by 298 · see citing works
Molecular Epidemiology: Insights Into Cancer Susceptibility, Risk Assessment, and Prevention
Perera, F. P. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.8.496 · Cited by 295 · see citing works
Detection and Quantification of the Antioxidant Melatonin in Montmorency and Balaton Tart Cherries (Prunus cerasus)
Burkhardt, S., Tan, D. X., Manchester, L. C., Hardeland, R., & Reiter, R. J. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010321+ · Cited by 242 · see citing works
Neurobehavioral aspects of antioxidants in aging
Cantuti‐Castelvetri, I., Shukitt‐Hale, B., & Joseph, J. A. (2000) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(00)00008-3 · Cited by 233 · see citing works
Population Attributable Risk for Breast Cancer: Diet, Nutrition, and Physical Exercise
Maura, M., Boyle, P., Vecchia, C. L., Decarli, A., Talamini, R., & Franceschi, S. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.5.389 · Cited by 213 · see citing works
Serum concentrations of β-carotene and α-tocopherol are associated with diet, smoking, and general and central adiposity
Wallström, P., Wirfält, E., Lahmann, P. H., Gullberg, B., Janzon, L., & Berglund, G. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.4.777 · Cited by 186 · see citing works
Relationship between vitamin and calcium supplement use and colon cancer.
White, E., Shannon, J., & Patterson, R. E. (1997) · PubMed · Cited by 176 · see citing works
Vitamin supplements and cancer risk: the epidemiologic evidence
Patterson, R. E., White, E., Kristal, A. R., Neuhouser, M. L., & Potter, J. D. (1997) · Cancer Causes & Control · doi:10.1023/a:1018443724293 · Cited by 176 · see citing works
Comparison of the antioxidant content of fruits, vegetables and teas measured as vitamin C equivalents
du Toit, R., Volsteedt, Y., & Apostolides, Z. (2001) · Toxicology · doi:10.1016/s0300-483x(01)00446-2 · Cited by 175 · see citing works
High-Performance Liquid Chromatography Coupled with Coulometric Array Detection of Electroactive Components in Fruits and Vegetables: Relationship to Oxygen Radical Absorbance Capacity
Guo, C., Cao, G., Sofic, E., & Prior, R. L. (1997) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf960786d · Cited by 171 · see citing works
Contribution of genetic and nutritional factors to DNA damage in heavy smokers
Mooney, L. A. (1997) · Carcinogenesis · doi:10.1093/carcin/18.3.503 · Cited by 152 · see citing works
Wnt signalling and prostate cancer
Yardy, G., & Brewster, S. (2005) · Prostate Cancer and Prostatic Diseases · doi:10.1038/sj.pcan.4500794 · Cited by 151 · see citing works
Guidelines on diet, nutrition, and cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. The American Cancer Society 1996 Advisory Committee on Diet, Nutrition, and Cancer Prevention
The American Cancer Society 1996 Advisory Committee on Diet, N. (1996) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.46.6.325 · Cited by 145 · see citing works
Preventing Cancer, Cardiovascular Disease, and Diabetes
Eyre, H. J., Kahn, R., & Robertson, R. M. (2004) · Stroke · doi:10.1161/01.str.0000133321.00456.00 · Cited by 136 · see citing works
Preventing Cancer, Cardiovascular Disease, and Diabetes
Eyre, H. J., Kahn, R., & Robertson, R. M. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1812 · Cited by 133 · see citing works
Evaluation of antioxidant capacity of some fruit and vegetable foods: efficiency of extraction of a sequence of solvents
Pellegrini, N., Colombi, B., Salvatore, S., Brenna, O. V., Galaverna, G., Rio, D. D., Bianchi, M. A., Bennett, R. N., & Brighenti, F. (2006) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2682 · Cited by 126 · see citing works
Correlation of DNA adducts in blood mononuclear cells with tobacco carcinogen-induced damage in human lung
Wiencke, J. K., Kelsey, K. T., Várkonyi, A., Semey, K., Wain, J. C., Mark, E. J., & Christiani, D. C. (1996) · Lung Cancer · doi:10.1016/0169-5002(96)87745-2 · Cited by 126 · see citing works
Estimation of carotenoid bioavailability from fresh stir-fried vegetables using an in vitro digestion/Caco-2 cell culture model
Garrett, D., Failla, M. L., & Sarama, R. J. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(00)00122-4 · Cited by 114 · see citing works
Development and Validation of a Food Frequency Questionnaire for the Assessment of Dietary Total Antioxidant Capacity ,2
Pellegrini, N., Salvatore, S., Valtueña, S., Bedogni, G., Porrini, M., Pala, V. M., Rio, D. D., Sieri, S., Miglio, C., Krogh, V., et al. (2007) · Journal of Nutrition · doi:10.1093/jn/137.1.93 · Cited by 108 · see citing works
Effects of aging on cerebellar noradrenergic function and motor learning: nutritional interventions
Bickford, P. C., Shukitt‐Hale, B., & Joseph, J. A. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00063-9 · Cited by 89 · see citing works
Antioxidant and chemoprotective properties of Momordica charantia L. (bitter melon) fruit extract
Semiz, A., & Şen, A. (2007) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb06.730 · Cited by 87 · see citing works
Green Leafy Vegetables: A Health Promoting Source
Randhawa, M. A., Khan, A. A., Javed, M. S., & Sajid, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800872-0.00018-4 · Cited by 82 · see citing works
AGE-RELATED NEURODEGENERATION AND OXIDATIVE STRESS
Joseph, J. A., Denisova, N., Fisher, D., Shukitt‐Hale, B., Bickford, P. C., Prior, R. L., & Cao, G. (1998) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70092-x · Cited by 79 · see citing works
Changes in Carotenoid Intake in the United States
Nebeling, L. C., Forman, M. R., Graubard, B. I., & SNYDER, R. A. (1997) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(97)00239-3 · Cited by 75 · see citing works
Suppression of Pulmonary Tumor Promotion and Induction of Apoptosis by Crocus sativus L. Extraction
Samarghandian, S., Afshari, J. T., & Davoodi, S. (2010) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-010-9130-x · Cited by 72 · see citing works
Antioxidants, its role in preventing free radicals and infectious diseases in human body
Suleman, M. (2018) · Pure and Applied Biology · doi:10.19045/bspab.2018.700197 · Cited by 68 · see citing works
Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer
Kubatka, P., Kapinová, A., Kello, M., Kružliak, P., Kajo, K., Výbohová, D., Mahmood, S., Murín, R., Tischlerová, V., Mojžíš, J., et al. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0910-5 · Cited by 65 · see citing works
A Review of Sustainable Use of Biogenic Nanoscale Agro-Materials to Enhance Stress Tolerance and Nutritional Value of Plants
Giri, V. P., Shukla, P., Tripathi, A., Verma, P., Kumar, N., Pandey, S., Dimkpa, C. O., & Mishra, A. (2023) · Plants · doi:10.3390/plants12040815 · Cited by 67 · see citing works
Proportion of colon cancer attributable to lifestyle in a cohort of US women
Erdrich, J., Zhang, X., Giovannucci, E. L., & Willett, W. C. (2015) · Cancer Causes & Control · doi:10.1007/s10552-015-0619-z · Cited by 62 · see citing works
Self-citation
Epithelial cell folate depletion occurs in neoplastic but not adjacent normal colon mucosa
Meenan, J. K., O'Hallinan, E., Scott, J. M., & Weir, D. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70127-6 · Cited by 62 · see citing works
Oxidative DNA Damage Levels in Blood from Women at High Risk for Breast Cancer are Associated with Dietary intakes of Meats, Vegetables, and Fruits
Djurić, Z., Depper, J. B., Uhley, V. E., Smith, D. W., Lababidi, S., Martino, S., & Heilbrun, L. K. (1998) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(98)00119-9 · Cited by 57 · see citing works
Folic acid inhibition of EGFR-mediated proliferation in human colon cancer cell lines
Jaszewski, R., Khan, A., Sarkar, F. H., Küçük, Ö., Tobi, M., Zagnoon, A., Dhar, R., Kinzie, J. L., & Majumdar, A. P. N. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.6.c1142 · Cited by 57 · see citing works
Antioxidant Status and Human Health: Use of Cyclic Voltammetry for the Evaluation of the Antioxidant Capacity of Plasma and of Edible Plants
Chevion, S., & Chevion, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06196.x · Cited by 56 · see citing works
Antioxidative activity of selected fruits and vegetables
Žitňanová, I., Ranostajová, S., Sobotová, H., Demelová, D., Pecháň, I., & Ďuračková, Z. (2006) · Biologia · doi:10.2478/s11756-006-0051-7 · Cited by 53 · see citing works
Annurca apple-rich diet restores long-term potentiation and induces behavioral modifications in aged rats
Viggiano, A., Viggiano, A., Monda, M., Turco, I., Incarnato, L., Vinno, V., Viggiano, E., Baccari, M. E., & Luca, B. D. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.001 · Cited by 50 · see citing works
Diet, Aging, and Cancer
Goodwin, J. S., & Brodwick, M. S. (1995) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30258-1 · Cited by 49 · see citing works
Hyperoxia-induced changes in antioxidant capacity and the effect of dietary antioxidants
Cao, G., Shukitt‐Hale, B., Bickford, P. C., Joseph, J. A., McEwen, J. J., & Prior, R. L. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.86.6.1817 · Cited by 49 · see citing works
Electrochemical Determination of the Antioxidant Potential of Some Less Common Fruit Species
Gazdík, Z., KRŠKA, B., Adam, V., Šaloun, J., Pokorna, T., Řezníček, V., Horna, A., & Kizek, R. (2008) · Sensors · doi:10.3390/s8127564 · Cited by 46 · see citing works
Antioxidant status in long-term adherents to a strict uncooked vegan diet
Rauma, A.-L., Törrönen, R., Hänninen, O., Verhagen, H., & Mykkänen, H. M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1221 · Cited by 46 · see citing works
pS2 expression induced by American ginseng in MCF-7 breast cancer cells
Duda, R. B., Taback, B., Kessel, B., Dooley, D. D., Yang, H., Marchiori, J. M., Slomovic, B., & Álvarez, J. G. (1996) · Annals of Surgical Oncology · doi:10.1007/bf02306082 · Cited by 46 · see citing works
Total antioxidant potential of juices, beverages and hot drinks consumed in Egypt screened by DPPH in vitro assay
Ramadan, M. F. (2008) · Grasas y Aceites · doi:10.3989/gya.2008.v59.i3.516 · Cited by 44 · see citing works
Effects of soaking conditions on the antioxidant potentials of oolong tea
Su, X., Duan, J., Jiang, Y., Shi, J., & Kakuda, Y. (2006) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2005.02.005 · Cited by 43 · see citing works
Effect of vegetables on human phenolsulfotransferases in relation to their antioxidant activity and total phenolics
Yeh, C., & Yen, G. (2005) · Free Radical Research · doi:10.1080/10715760500150424 · Cited by 44 · see citing works
Antioxidants and Carcinogenesis
Rautalahti, M. T., & Huttunen, J. K. (1994) · Annals of Medicine · doi:10.3109/07853899409148366 · Cited by 43 · see citing works
Anthocyanin Determination in Black Raspberry ( Rubus occidentalis ) and Biological Specimens Using Liquid Chromatography‐Electrospray Ionization Tandem Mass Spectrometry
Tian, Q., Aziz, R. M., Stoner, G. D., & Schwartz, S. J. (2005) · Journal of Food Science · doi:10.1111/j.1365-2621.2005.tb09018.x · Cited by 36 · see citing works
Nutraceuticals and functional foods: I. Current trend in phytochemical antioxidant research
Tsao, R., & Akhtar, M. (2005) · Cited by 34 · see citing works
A biosensing method with enzyme-immobilized eggshell membranes for determination of total glucosinolates in vegetables
Choi, M. M. F., Liang, M. M. K., & Lee, A. W. M. (2004) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2004.06.009 · Cited by 32 · see citing works
The role of nutrition in the development of esophageal cancer what do we know
Berretta, M. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/382 · Cited by 28 · see citing works
THE INFLUENCE OF ASCORBIC ACID AND HONEY ADDITION ON THE ANTI-OXIDANT PROPERTIES OF FRUIT TEA INFUSIONS: ANTIOXIDANTS IN FRUIT TEA INFUSIONS
Belščak, A., Bukovac, N., & Piljac‐Žegarac, J. (2010) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2010.00375.x · Cited by 28 · see citing works
African Medicinal Spices of Genus Piper
Oyemitan, I. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809286-6.00027-3 · Cited by 28 · see citing works
Phytochemicals Ingested in Traditional Diets and Medicines as Modulators of Energy Metabolism
Johns, T., & Chapman, L. (1995) · Springer eBooks · doi:10.1007/978-1-4899-1778-2_8 · Cited by 26 · see citing works
Variability in PAH‐DNA Adduct Measurements in Peripheral Mononuclear Cells: Implications for Quantitative Cancer Risk Assessment
Dickey, C., Santella, R. M., Hattis, D. B., Tang, D. L., Hsu, Y., Cooper, T. B., Young, T., & Perera, F. P. (1997) · Risk Analysis · doi:10.1111/j.1539-6924.1997.tb00905.x · Cited by 28 · see citing works
From Tiny Microalgae to Huge Biorefineries
(2014) · Oceanography Open Access · doi:10.4172/2332-2632.1000120 · Cited by 25 · see citing works
Environmental Epidemiology of Cancer in South Asian Population: Risk Assessment Against Exposure to Polycyclic Aromatic Hydrocarbons and Volatile Organic Compounds
Manzoor, M., Khan, A. H. A., Ullah, R., Khan, M. Z., & Ahmad, I. (2016) · Arabian Journal for Science and Engineering · doi:10.1007/s13369-016-2139-x · Cited by 24 · see citing works
Effects of omega-3 fatty acids on cancer.
Maclean, C. H., Newberry, S. J., Mojica, W., Issa, A. M., Khanna, P. P., Lim, Y., Morton, S. C., Suttorp, M. J., Tu, W., Hilton, L., et al. (2005) · PubMed Central · Cited by 24 · see citing works
Folic acid mediated attenuation of loss of heterozygosity of DCC tumor suppressor gene in the colonic mucosa of patients with colorectal adenomas
Nagothu, K. K., Jaszewski, R., Moragoda, L., Rishi, A. K., Finkenauer, R., Tobi, M., Naumoff, J. A., Dhar, R., Ehrinpreis, M. N., Küçük, Ö., et al. (2003) · Cancer Detection and Prevention · doi:10.1016/s0361-090x(03)00100-4 · Cited by 24 · see citing works
Insights on the safety of carotenogenic Chlorella vulgaris in rodents
de Mello-Sampayo, C., Corvo, M. L., Mendes, R. O., Duarte, D., Lucas, J., Pinto, R. M. A., Batista, A. P., Raymundo, A., Lima, B. S., Bandarra, N. M., et al. (2013) · Algal Research · doi:10.1016/j.algal.2013.07.005 · Cited by 23 · see citing works
Antioxidant potentials in sprouts vs. seeds of Vigna radiata and Macrotyloma uniflorum
Ramesh, C. K., Rehman, A., Prabhakar, B. T., Vijay, A. B. R., & Rao, S. J. A. (2011) · Journal of Applied Pharmaceutical Science · Cited by 23 · see citing works
Spousal Similarities in Fruit and Vegetable Consumption
Macario, E., & Sorensen, G. (1998) · American Journal of Health Promotion · doi:10.4278/0890-1171-12.6.369 · Cited by 23 · see citing works
Dietary and nutritional patterns in an elderly rural population in Northern and Southern Italy: (II). Nutritional profiles associated with food behaviours
Leite, M. L. C., Nicolosi, A., Cristina, S., Hauser, W. A., Pugliese, P., & Nappi, G. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601720 · Cited by 23 · see citing works
In Vitro Antioxidant Activity of Black Tea and Mediterranean Herb Infusions Toward Iron Under Simulated Gastrointestinal Conditions
Matsingou, T. C., Kapsokefalou, M., & Salifoglou, A. (2000) · Journal of Food Science · doi:10.1111/j.1365-2621.2000.tb09418.x · Cited by 23 · see citing works
Folic acid-mediated inhibition of serum-induced activation of EGFR promoter in colon cancer cells
Nagothu, K. K., Rishi, A. K., Jaszewski, R., Küçük, Ö., & Majumdar, A. P. N. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00365.2003 · Cited by 23 · see citing works
Folate status of gastrointestinal epithelial cells is not predicted by serum and red cell folate values in replete subjects.
Meenan, J. K., O'Hallinan, E., Lynch, S., Molloy, A. M., McPartlan, J., Scott, J. M., & Weir, D. G. (1996) · Gut · doi:10.1136/gut.38.3.410 · Cited by 22 · see citing works
Genetics of serum carotenoid concentrations and their correlation with obesity-related traits in Mexican American children
Farook, V. S., Reddivari, L., Mummidi, S., Puppala, S., Arya, R., López-Alvarenga, J. C., Fowler, S. P., Chittoor, G., Resendez, R. G., Kumar, B. M., et al. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.144006 · Cited by 21 · see citing works
Quercetin Prevents UV‐lnduced Local Immunosuppression, but Does Not Affect UV‐lnduced Tumor Growth in SKH‐1 Hairless Mice
Steerenberg, P. A., Dortant, J. G. V. P., van de Vliet, H., Geerse, L., Verlaan, A. P. J., Goettsch, W., Sontag, Y., Norval, M., Gibbs, N. K., Bueno-de-Mesquita, H. B., et al. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb01918.x · Cited by 19 · see citing works
Vitamin Supplements and Cancer Risk
Patterson, R. E., Kristal, A. R., & Neuhouser, M. L. (2001) · Humana Press eBooks · doi:10.1007/978-1-59259-039-1_2 · Cited by 21 · see citing works
Micronutrients and Breast Cancer Progression: A Systematic Review
Cuenca-Micó, O., & Aceves, C. (2020) · Nutrients · doi:10.3390/nu12123613 · Cited by 20 · see citing works
Microalgal biorefineries
Ferreira, A., & Gouveia, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818536-0.00028-2 · Cited by 20 · see citing works
Comparison of Anti-Oxidant Activities and Exhaustive Extraction Yields between Wild and Cultivated Cyclamen persicum, Malva sylvestris and Urtica pilulifera Leaves
Jaradat, N. A., Abualhasan, M., & Ali, I. (2015) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2015.50417 · Cited by 20 · see citing works
THE USE OF CYCLIC VOLTAMMETRY FOR THE EVALUATION OF ANTIOXIDANT CAPACITY
Chevion, S., ROBERTS, M. A., & Chevion, M. (2001) · Elsevier eBooks · doi:10.1016/b978-0-444-50957-4.50021-1 · Cited by 20 · see citing works
Folic acid reduces nuclear translocation of β-catenin in rectal mucosal crypts of patients with colorectal adenomas
Jaszewski, R., Millar, B., Hatfield, J. S., Nogothu, K., Finkenauer, R., Rishi, A. K., Naumoff, J. A., Küçük, Ö., Axelrod, B. N., & Majumdar, A. P. N. (2004) · Cancer Letters · doi:10.1016/j.canlet.2003.10.027 · Cited by 19 · see citing works
An Evaluation of Plasma Antioxidant Levels and the Risk of Breast Cancer: A Pilot Case Control Study
Simon, M. S., Djurić, Z., Dunn, B. P., Stephens, D., Lababidi, S., & Heilbrun, L. K. (2000) · The Breast Journal · doi:10.1046/j.1524-4741.2000.20067.x · Cited by 19 · see citing works
The U.S. EPA Conference on Preventable Causes of Cancer in Children: a research agenda.
Carroquino, M. J., Galson, S. K., Licht, J. D., Amler, R. W., Perera, F. P., Claxton, L. D., & Landrigan, P. J. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.98106867 · Cited by 19 · see citing works
Diet and Cancer: Future Etiologic Research
Schatzkin, A. G., Dorgan, J. F., Swanson, C., & Potischman, N. A. (1995) · Environmental Health Perspectives · doi:10.1289/ehp.95103s8171 · Cited by 18 · see citing works
Autoantibody against oxidized low-density lipoproteins may be enhanced by cigarette smoking
Liu, C.-S., Lii, C., Ou, C., Tsai, C., Wei, Y., & Chen, H. (2000) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(00)00173-3 · Cited by 17 · see citing works
Dietary change as a strategy for preventing cancer
Schatzkin, A. G. (1997) · Cancer and Metastasis Reviews · doi:10.1023/a:1005812514155 · Cited by 17 · see citing works
Embracing cancer immunotherapy with vital micronutrients
Yuen, R. C.-F., & Tsao, S. Y. (2021) · World Journal of Clinical Oncology · doi:10.5306/wjco.v12.i9.712 · Cited by 16 · see citing works
Optimization of Groundnut Meal and Capsicum Juice for Protein and Antioxidant Rich Pasta
Mridula, D., GUPTA, R. K., Bhadwal, S., & Khaira, H. (2016) · Agricultural Research · doi:10.1007/s40003-016-0216-8 · Cited by 13 · see citing works

Authors: Willett, W.
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 1994-05
Volume: 59
Issue: 5
Pages: 1162S-1165S
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/59.5.1162s
OpenAlex: W2234755759
Cited by: 143
References: 41
Citations by year: 2026: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 4 · 2012: 5
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords: micronutrients, cancer risk, cancer prevention, fruits and vegetables, carotenoids, lung cancer, dietary fiber, colon cancer, colonic polyps, folic acid, breast cancer, vitamin A
MeSH terms: Diet, Female, Fruit, Humans, Male, Neoplasms, Risk Factors, Vegetables, Vitamin A, Vitamins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Micronutrients and cancer risk

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks