The enzyme indoleamine 2,3-dioxygenase is induced in the mouse brain in response to peripheral administration of lipopolysaccharide and superantigen

Psychopharmacology: The Fourth Generation of Progress

Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985 · see citing works

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

Taylor, M. W., & Feng, G. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.11.1907934 · Cited by 1,060 · see citing works

Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels

Fernstrom, J. D., & Wurtman, R. J. (1971) · Science · doi:10.1126/science.173.3992.149 · Cited by 1,017 · see citing works

Cytokine-induced sickness behavior: where do we stand?

Dantzer, R. (2001) · Brain, Behavior, and Immunity · doi:10.1006/brbi.2000.0613 · Cited by 862 · see citing works

Brain Serotonin Content: Increase Following Ingestion of Carbohydrate Diet

Fernstrom, J. D., & Wurtman, R. J. (1971) · Science · doi:10.1126/science.174.4013.1023 · Cited by 734 · see citing works

Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy

Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473 · see citing works

Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity.

Takikawa, O., Kuroiwa, T., Yamazaki, F., & Kido, R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77982-4 · Cited by 472 · see citing works

The role of IFN-gamma in the pathology of experimental endotoxemia.

Heinzel, F. P. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.9.2920 · Cited by 256 · see citing works

Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon.

Jupin, C., Anderson, S., Damais, C., ALOUF, J. E., & Parant, M. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.3.752 · Cited by 218 · see citing works

Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes.

Thomas, S. R., Mohr, D., & Stocker, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36645-0 · Cited by 211 · see citing works

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.

Saito, K., Markey, S., & Heyes, M. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90467-g · Cited by 196 · see citing works

A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.

Saito, K., Crowley, J. S., Markey, S., & Heyes, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82284-0 · Cited by 194 · see citing works

Induction of Tryptophan Degradation In Vitro and In Vivo : A γ-Interferon-Stimulated Activity

Byrne, G. I., LEHMANN, L. K., KIRSCHBAUM, J. G., Borden, E. C., Lee, C. M., & Brown, R. R. (1986) · Journal of Interferon Research · doi:10.1089/jir.1986.6.389 · Cited by 183 · see citing works

Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.

Sanni, L. A., Thomas, S. R., Tattam, B. N., Moore, D. E., Chaudhri, G., Stocker, R., & Hunt, N. H. (1998) · Europe PMC (PubMed Central) · Cited by 178 · see citing works

IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-alpha, IFN-gamma, and IL-12 production

Muchamuel, T., Menon, S., Pisacane, P. I., Howard, M., & Cockayne, D. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.6.2898 · Cited by 158 · see citing works

Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells

WEISS, G., Murr, C., Zoller, H., HAUN, M., Widner, B., Ludescher, C., & Fuchs, D. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00910.x · Cited by 139 · see citing works

Regulation by interferons of the local inflammatory response to bacterial lipopolysaccharide.

Heremans, H., Dijkmans, R., Sobis, H., Vandekerckhove, F., & Billiau, A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.12.4175 · Cited by 138 · see citing works

Kynurenine Pathway Enzymes in Brain: Responses to Ischemic Brain Injury Versus Systemic Immune Activation

Saito, K., Nowak, T. S., Suyama, K., Quearry, B. J., Saito, M., Crowley, J. S., Markey, S. P., & Heyes, M. P. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb07443.x · Cited by 116 · see citing works

Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography

HOLMES, E. W. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90478-2 · Cited by 113 · see citing works

Hepatic injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B

Nagaki, M., Muto, Y., Ohnishi, H., Yasuda, S., Sano, K., Naito, T., Maeda, T., Yamada, T., & Moriwaki, H. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90604-1 · Cited by 104 · see citing works

Species Heterogeneity Between Gerbils and Rats: Quinolinate Production by Microglia and Astrocytes and Accumulations in Response to Ischemic Brain Injury and Systemic Immune Activation

Heyes, M. P., Saito, K., Chen, C. Y., Proescholdt, M. G., Nowak, T. S., Li, J., Beagles, K. E., Proescholdt, M. A., Zito, M. A., Kawai, K., et al. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041519.x · Cited by 82 · see citing works

Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

Saito, K., Markey, S. P., & Heyes, M. P. (1991) · Brain Research · doi:10.1016/0006-8993(91)91171-v · Cited by 81 · see citing works

Species Differences inl-Tryptophan–Kynurenine Pathway Metabolism: Quantification of Anthranilic Acid and Its Related Enzymes

Fujigaki, S., Saito, K., Takemura, M., Fujii, H., Wada, H., Noma, A., & Seishima, M. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0861 · Cited by 80 · see citing works

The Roles of Superoxide Anion and Methylene Blue in the Reductive Activation of Indoleamine 2,3-Dioxygenase by Ascorbic Acid or by Xanthine Oxidase-Hypoxanthine

Sono, M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94231-6 · Cited by 75 · see citing works

Systemic endotoxin increasesl-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex

Heyes, M. P., Quearry, B. J., & Markey, S. P. (1989) · Brain Research · doi:10.1016/0006-8993(89)90101-7 · Cited by 75 · see citing works

Passive immunization of mice against D factor blocks lethality and cytokine release during endotoxemia.

Block, M. I., van den Berg, M. J. W., McNamara, M. J., Norton, J. A., Fraker, D. L., & Alexander, H. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.1085 · Cited by 53 · see citing works

Endotoxin fails to induce IFN-gamma in endotoxin-tolerant mice: deficiencies in both IL-12 heterodimer production and IL-12 responsiveness.

Balkhy, H. H., & Heinzel, F. P. (1999) · PubMed · Cited by 43 · see citing works

Endotoxin Fails to Induce IFN-γ in Endotoxin-Tolerant Mice: Deficiencies in Both IL-12 Heterodimer Production and IL-12 Responsiveness

Balkhy, H. H., & Heinzel, F. P. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3633 · Cited by 39 · see citing works

“PERFEXT”: a direct method for quantitative assessment of cytokine production in vivo at the local level

Villavedra, M., Carol, H., Hjulström, M., Holmgren, J. R., & Czerkinsky, C. C. (1997) · Research in Immunology · doi:10.1016/s0923-2494(97)80867-x · Cited by 38 · see citing works

Synergism of Pseudomonas aeruginosa exotoxin A with endotoxin, superantigen, or TNF results in TNFR1- and TNFR2-dependent liver toxicity in mice

Schümann, J., Bluethmann, H., & Tiegs, G. (2000) · Immunology Letters · doi:10.1016/s0165-2478(00)00240-6 · Cited by 36 · see citing works

Tryptophan metabolism through the kynurenine pathway in rat brain and liver slices

Dale, W. E., Dang, Y., & Brown, O. R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00341-5 · Cited by 25 · see citing works

Streptococcal Erythrogenic Toxins Induce Tryptophan Degradation in Human Peripheral Blood Mononuclear Cells

Murr, C., Widner, B., Gerlach, D., Werner‐Felmayer, G., Dierich, M. P., WACHTER, H., & Fuchs, D. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000237672 · Cited by 9 · see citing works

Quantification of Anthranilic Acid and its Related Enzyme Activity in Several Different Species

Fujigaki, S., Saito, K., Fujii, H., Wada, H., & Seishima, M. (1999) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4709-9_79 · Cited by 3 · see citing works

Untitled work

(2001) · doi:10.1002/1521-4141(200108)31:8

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 396 · see citing works

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works

Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications

Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works

The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression

Maes, M., Yirmyia, R., Noraberg, J., Brene, S., Hibbeln, J., Perini, G., Kubera, M., Bob, P., Lerer, B., & Maj, M. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-008-9118-1 · Cited by 894 · see citing works

Cytokine, Sickness Behavior, and Depression

Dantzer, R. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.002 · Cited by 789 · see citing works

Inflammation-associated depression: From serotonin to kynurenine

Dantzer, R., O’Connor, J. C., Lawson, M. A., & Kelley, K. W. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.09.012 · Cited by 726 · see citing works

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 670 · see citing works

Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression

Maes, M. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.014 · Cited by 544 · see citing works

Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior

Frenois, F., Moreau, M., O’Connor, J., Lawson, M., Micon, C., Lestage, J., Kelley, K. W., Dantzer, R., & Castanon, N. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.03.005 · Cited by 438 · see citing works

Kynurenines in CNS disease: regulation by inflammatory cytokines.

Campbell, B. M., Charych, E., Lee, A. W., & Möller, T. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00012 · Cited by 409 · see citing works

Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation

Riazi, K., Galic, M. A., Kuzmiski, J. B., Ho, W., Sharkey, K. A., & Pittman, Q. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806682105 · Cited by 400 · see citing works

Cytokine effects on the basal ganglia and dopamine function: The subcortical source of inflammatory malaise

Felger, J. C., & Miller, A. H. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.09.003 · Cited by 394 · see citing works

Review: Systemic inflammation and<scp>A</scp>lzheimer's disease

Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356 · see citing works

Cytokine, sickness behavior, and depression

Dantzer, R. (2006) · Neurologic Clinics · doi:10.1016/j.ncl.2006.03.003 · Cited by 340 · see citing works

Depression in cancer: new developments regarding diagnosis and treatment

Raison, C. L., & Miller, A. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00413-x · Cited by 333 · see citing works

Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System

Godbout, J. P., Moreau, M., Lestage, J., Chen, J., Sparkman, N. L., Connor, J. O., Castanon, N., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301649 · Cited by 299 · see citing works

Induction of IDO by Bacille Calmette-Guérin Is Responsible for Development of Murine Depressive-Like Behavior

O'Connor, J., Lawson, M., André, C., Briley, E. M., Szegedi, S., Lestage, J., Castanon, N., Herkenham, M., Dantzer, R., & Kelley, K. (2009) · Journal of Immunology · doi:10.4049/jimmunol.0802722 · Cited by 305 · see citing works

Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan

Castro-Portuguez, R., & Sutphin, G. L. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110841 · Cited by 282 · see citing works

Cytokines and depression: The need for a new paradigm

Capuron, L., & Dantzer, R. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00078-8 · Cited by 280 · see citing works

Melatonin, a potent agent in antioxidative defense: Actions as a natural food constituent, gastrointestinal factor, drug and prodrug

Hardeland, R., & Pandi-Perumal, S. R. (2005) · Nutrition & Metabolism · doi:10.1186/1743-7075-2-22 · Cited by 263 · see citing works

IL-6 knockout mice exhibit resistance to stress-induced development of depression-like behaviors

Chourbaji, S., Urani, A., Inta, I., Sanchis-Segura, C., Brandwein, C., Zink, M., Schwaninger, M., & Gass, P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.05.001 · Cited by 241 · see citing works

Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches

Dantzer, R. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_6 · Cited by 248 · see citing works

Diet-induced obesity progressively alters cognition, anxiety-like behavior and lipopolysaccharide-induced depressive-like behavior: focus on brain indoleamine 2,3-dioxygenase activation

André, C., Dinel, A.-L., Ferreira, G., Layé, S., & Castanon, N. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.03.012 · Cited by 241 · see citing works

Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: A role for IFN-γ?

Connor, T. J., Starr, N., O’Sullivan, J. B., & Harkin, A. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.06.007 · Cited by 213 · see citing works

Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

Corona, A. W., Huang, Y., O’Connor, J. C., Dantzer, R., Kelley, K. W., Popovich, P. G., & Godbout, J. P. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-93 · Cited by 200 · see citing works

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity

Castanon, N., Luheshi, G. N., & Layé, S. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00229 · Cited by 179 · see citing works

Common Biological Pathways Underlying the Psychoneurological Symptom Cluster in Cancer Patients

Kim, H., Barsevick, A. M., Fang, C. Y., & Miaskowski, C. A. (2012) · Cancer Nursing · doi:10.1097/ncc.0b013e318233a811 · Cited by 181 · see citing works

The biology of depression in cancer and the relationship between depression and cancer progression

Sotelo, J. L., Musselman, D. L., & Nemeroff, C. B. (2014) · International Review of Psychiatry · doi:10.3109/09540261.2013.875891 · Cited by 180 · see citing works

Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: A meta-analysis

Na, K., Lee, K. J., Lee, J. S., Cho, Y. S., & Jung, H. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.09.006 · Cited by 178 · see citing works

Inoculation of Bacillus Calmette-Guerin to mice induces an acute episode of sickness behavior followed by chronic depressive-like behavior

Moreau, M. M., André, C., O’Connor, J. C., Dumich, S. A., Woods, J. A., Kelley, K. W., Dantzer, R., Lestage, J., & Castanon, N. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.04.001 · Cited by 168 · see citing works

Inflammation Models of Depression in Rodents: Relevance to Psychotropic Drug Discovery

Remus, J. L., & Dantzer, R. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw028 · Cited by 166 · see citing works

Therapeutic Strategies for Treatment of Inflammation-related Depression

Adžić, M., Brkic, Z., Mitić, M., Francija, E., Jovicic, M. J., Radulović, J., & Marić, N. P. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170828163048 · Cited by 156 · see citing works

Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis

Lovelace, M. D., Varney, B., Sundaram, G., Franco, N. F., Ng, M. L., Pai, S., Lim, C. K., Guillemin, G. J., & Brew, B. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00246 · Cited by 154 · see citing works

Alcoholism and inflammation: Neuroimmunology of behavioral and mood disorders

Kelley, K. W., & Dantzer, R. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.013 · Cited by 143 · see citing works

Central Administration of Lipopolysaccharide Induces Depressive-like Behavior in Vivo and Activates Brain Indoleamine 2,3 Dioxygenase In Murine Organotypic Hippocampal Slice Cultures

Fu, X., Zunich, S. M., O’Connor, J. C., Kavelaars, A., Dantzer, R., & Kelley, K. W. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-43 · Cited by 130 · see citing works

The role of neuroinflammation on pathogenesis of affective disorders

Rhie, S. J., Jung, E.-Y., & Shim, I. (2020) · Journal of Exercise Rehabilitation · doi:10.12965/jer.2040016.008 · Cited by 126 · see citing works

The Role of Indoleamine 2,3-Dioxygenase in a Mouse Model of Neuroinflammation-Induced Depression

Dobos, N., de Vries, E. F. J., Kema, I. P., Patas, K., Prins, M., Nijholt, I. M., Dierckx, R., Korf, J., den Boer, J. A., Luiten, P. G. M., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111097 · Cited by 119 · see citing works

Peripheral and cerebral metabolic abnormalities of the tryptophan–kynurenine pathway in a murine model of major depression

Laugeray, A., Launay, J., Callebert, J., Surget, A., Belzung, C., & Barone, P. R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.02.014 · Cited by 113 · see citing works

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration

André, C., O’Connor, J. C., Kelley, K. W., Lestage, J., Dantzer, R., & Castanon, N. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.011 · Cited by 111 · see citing works

Tryptophan degradation in autoimmune diseases

Opitz, C. A., Wick, W., Steinman, L., & Platten, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7140-9 · Cited by 100 · see citing works

Bacille Calmette‐Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3‐Dioxygenase in Mice

Moreau, M. M., Lestage, J., Verrier, D., Mormède, C., Kelley, K. W., Dantzer, R., & Castanon, N. (2005) · The Journal of Infectious Diseases · doi:10.1086/431603 · Cited by 104 · see citing works

Identification and treatment of symptoms associated with inflammation in medically ill patients

Dantzer, R., Capuron, L., Irwin, M. R., Miller, A. H., Ollat, H., Perry, V. H., Rousey, S., & Yirmiya, R. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.008 · Cited by 96 · see citing works

Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms

Vancassel, S., Capuron, L., & Castanon, N. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00499 · Cited by 95 · see citing works

An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways

Maes, M. H. J. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.06.023 · Cited by 93 · see citing works

LPS-induced indoleamine 2,3-dioxygenase is regulated in an interferon-γ-independent manner by a JNK signaling pathway in primary murine microglia

Wang, Y., Lawson, M. A., Dantzer, R., & Kelley, K. W. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.06.152 · Cited by 88 · see citing works

The protective effects of resveratrol on social stress-induced cytokine release and depressive-like behavior

Finnell, J. E., Lombard, C. M., Melson, M. N., Singh, N. P., Nagarkatti, M., Nagarkatti, P. S., Fadel, J. R., Wood, C. S., & Wood, S. K. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.08.019 · Cited by 86 · see citing works

A final common pathway for depression? Progress toward a general conceptual framework

Stone, E. A., Lin, Y., & Quartermain, D. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.08.007 · Cited by 82 · see citing works

Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice

Souza, L. C., Jessé, C. R., Antunes, M. S., Ruff, J. R., Janner, D. E., Gomes, N. S., Donato, F., Giacomeli, R., & Boeira, S. P. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.002 · Cited by 81 · see citing works

The Kynurenine Pathway in Traumatic Brain Injury: Implications for Psychiatric Outcomes

Meier, T. B., & Savitz, J. B. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.021 · Cited by 77 · see citing works

Immune system and obsessive-compulsive disorder

Marazziti, D., Mucci, F., & Fontenelle, L. F. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.04.013 · Cited by 78 · see citing works

Inflammatory stimuli reduce survival of serotonergic neurons and induce neuronal expression of indoleamine 2,3-dioxygenase in rat dorsal raphe nucleus organotypic brain slices

Hochstrasser, T., Ullrich, C., Sperner‐Unterweger, B., & Humpel, C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.070 · Cited by 76 · see citing works

Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

Brooks, A. K., Lawson, M., Smith, R. A. J., Janda, T. M., Kelley, K., & McCusker, R. H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0563-1 · Cited by 62 · see citing works

Cannabidiol antidepressant-like effect in the lipopolysaccharide model in mice: Modulation of inflammatory pathways

Florensa-Zanuy, E., Garro-Martínez, E., Adell, A., Castro, E., Díaz, Á., Pazos, Á., MacDowell, K. S., Martín‐Hernández, D., & Pilar-Cuéllar, F. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114433 · Cited by 68 · see citing works

Active Immunization with Amyloid-β 1–42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System

Vollmar, P., Kullmann, J. S., Thilo, B., Claussen, M. C., Rothhammer, V., Jacobi, H., Sellner, J., Nessler, S., Korn, T., & Hemmer, B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001765 · Cited by 68 · see citing works

(R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation

Zhang, J., Ma, L., Wan, X., Shan, J., Qu, Y., & Hashimoto, K. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05889-6 · Cited by 67 · see citing works

Systematic Review on the Involvement of the Kynurenine Pathway in Stroke: Pre-clinical and Clinical Evidence

Colpo, G. D., Venna, V. R., McCullough, L. D., & Teixeira, A. L. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00778 · Cited by 68 · see citing works

Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide

Park, S.-E., Lawson, M. A., Dantzer, R., Kelley, K. W., & McCusker, R. H. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-179 · Cited by 65 · see citing works

Cancer-Related Symptom Clusters, Eosinophils, and Survival in Hepatobiliary Cancer: An Exploratory Study

Steel, J. L., Kim, K. H., Dew, M. A., Unruh, M. L., Antoni, M. H., Olek, M. C., Geller, D. A., Carr, B. I., Butterfield, L. H., & Gamblin, T. C. (2010) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2009.09.019 · Cited by 65 · see citing works

A Proposed Role for Pro-Inflammatory Cytokines in Damaging Behavior in Pigs

Nordgreen, J., Edwards, S. A., Boyle, L. A., Bolhuis, J. E., Veit, C., Sayyari, A., Marin, D. E., Dimitrov, I., Janczak, A. M., & Valros, A. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00646 · Cited by 60 · see citing works

The Kynurenine Pathway in the Acute and Chronic Phases of Cerebral Ischemia

Cuartero, M. I., de la Parra, J., García‐Culebras, A., Ballesteros, I., Lizasoaín, I., & Moro, M. Á. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151214125950 · Cited by 60 · see citing works

Pre-treatment effects of peripheral tumors on brain and behavior: Neuroinflammatory mechanisms in humans and rodents

Schrepf, A., Lutgendorf, S. K., & Pyter, L. M. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.010 · Cited by 60 · see citing works

Neurodevelopmental Animal Models Reveal the Convergent Role of Neurotransmitter Systems, Inflammation, and Oxidative Stress as Biomarkers of Schizophrenia: Implications for Novel Drug Development

Möller, M., Swanepoel, T., & Harvey, B. H. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn5003368 · Cited by 59 · see citing works

Immune and behavioral consequences of microglial reactivity in the aged brain

Wynne, A. M., Henry, C. J., & Godbout, J. P. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp009 · Cited by 58 · see citing works

Lipopolysaccharide repeated challenge followed by chronic mild stress protocol introduces a combined model of depression in rats: Reversibility by imipramine and pentoxifylline

Elgarf, A. A., Aboul‐Fotouh, S., Abd-Alkhalek, H. A., El‐Tabbal, M., Hassan, A. N. E.-D., Kassim, S. K., Hammouda, G. A., Farrag, K. A. E.-R., & Abdel-Tawab, A. M. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.09.014 · Cited by 57 · see citing works

Association between interleukin 1‐β promoter (−511) polymorphism and depressive symptoms in Alzheimer's disease

McCulley, M., Day, I. N. M., & Holmes, C. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20086 · Cited by 56 · see citing works

An Emerging Cross-Species Marker for Organismal Health: Tryptophan-Kynurenine Pathway

Jamshed, L., Debnath, A., Jamshed, S., Wish, J. V., Raine, J. C., Tomy, G. T., Thomas, P. J., & Holloway, A. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116300 · Cited by 54 · see citing works

Probiotics-Based Treatment as an Integral Approach for Alcohol Use Disorder in Alcoholic Liver Disease

Fuenzalida, C., Dufeu, M. S., Poníachik, J., Roblero, J. P., Valenzuela-Pérez, L., & Beltrán, C. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.729950 · Cited by 48 · see citing works

Ethanol extracts from Hemerocallis citrina attenuate the upregulation of proinflammatory cytokines and indoleamine 2,3-dioxygenase in rats

Liu, X., Luo, L., Bin-bin, L., Li, J., Geng, D., Liu, Q., & Yi, L. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.03.001 · Cited by 48 · see citing works

Induction of depression-related behaviors by reactivation of chronic Toxoplasma gondii infection in mice

Mahmoud, M. E., Ihara, F., Fereig, R. M., Nishimura, M., & Nishikawa, Y. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.005 · Cited by 47 · see citing works

Swimming exercise prevents behavioural disturbances induced by an intracerebroventricular injection of amyloid-β 1-42 peptide through modulation of cytokine/NF-kappaB pathway and indoleamine-2,3-dioxygenase in mouse brain

Souza, L. C., Jessé, C. R., Fabbro, L. D., de Gomes, M. G., Goes, A. T. R., Filho, C. B., Luchese, C., Pereira, A. A. M., & Boeira, S. P. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.024 · Cited by 45 · see citing works

Disgust affects TNF-α, IL-6 and noradrenalin levels in patients with obsessive–compulsive disorder

Fluitman, S. B. A. H. A., Denys, D. A. J. P., Heijnen, C. J., & Westenberg, H. G. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.12.005 · Cited by 44 · see citing works

Interleukin‐12 modulates the immunomodulatory properties of human periodontal ligament cells

Ayuthaya, B. I. N., Satravaha, P., & Pavasant, P. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12421 · Cited by 40 · see citing works

Mahuang-Fuzi-XixinDecoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis

Jing, W., Song, S., Sun, H., Chen, Y., Zhao, Q., Zhang, Y., Dai, G., & Ju, W. (2019) · Neural Plasticity · doi:10.1155/2019/1571392 · Cited by 39 · see citing works

Post-inflammatory behavioural despair in male mice is associated with reduced cortical glutamate-glutamine ratios, and circulating lipid and energy metabolites

Chan, S. Y., Probert, F., Radford‐Smith, D. E., Hebert, J. C., Claridge, T. D. W., Anthony, D. C., & Burnet, P. W. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-74008-w · Cited by 38 · see citing works

RhANP attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota–brain axis

Wu, Y., Zhang, Y., Xie, B., Abdelgawad, A. F., Chen, X., Han, M., Shang, Y., Yuan, S., & Zhang, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02356-z · Cited by 39 · see citing works

Lipopolysaccharide-induced cytokine production in obsessive–compulsive disorder and generalized social anxiety disorder

Fluitman, S. B. A. H. A., Denys, D. A. J. P., Vulink, N. C. C., Schutters, S. I. J., Heijnen, C. J., & Westenberg, H. G. M. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.05.008 · Cited by 38 · see citing works

The associations of high levels of C-reactive protein with depression and myocardial infarction in 9258 women and men from the HUNT population study

Bjerkeset, O. A., Romild, U. K., Smith, G. D., & Hveem, K. (2010) · Psychological Medicine · doi:10.1017/s0033291710000887 · Cited by 38 · see citing works

Association between plasma inflammatory markers and irrational beliefs; the ATTICA epidemiological study

Papageorgiou, C., Panagiotakos, D. B., Pitsavos, C. S., Tsetsekou, E., Kontoangelos, K. A., Stefanadis, C., & Soldatos, C. R. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.05.018 · Cited by 37 · see citing works

Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice

Larsson, M. K., Faka, A., Bhat, M., Imbeault, S., Goiny, M., Orhan, F., Oliveros, A., Ståhl, S., Liu, X. C., Choi, D., et al. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1939-4 · Cited by 35 · see citing works

Differential lipopolysaccharide-induced immune alterations in the hippocampus of two mouse strains: Effects of stress

Browne, C. A., O’Brien, F. E., Connor, T., Dinan, T. G., & Cryan, J. F. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.031 · Cited by 35 · see citing works

Involvement of Host Defense Mechanisms against Toxoplasma gondii Infection in Anhedonic and Despair-Like Behaviors in Mice

Mahmoud, M. E., Fereig, R. M., & Nishikawa, Y. (2017) · Infection and Immunity · doi:10.1128/iai.00007-17 · Cited by 34 · see citing works

Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress

Berkiks, I., Benmhammed, H., Mesfioui, A., Ouichou, A., hasnaoui, A. E., Mouden, S., Touil, T., Bahbiti, Y., Nakache, R., & Hessni, A. E. (2017) · International Journal of Neuroscience · doi:10.1080/00207454.2017.1398156 · Cited by 35 · see citing works

Is tryptophan catabolism increased under indoleamine 2,3 dioxygenase activity during chronic lung inflammation in pigs?

Melchior, D., Mézière, N., Sève, B., & Floc'H, N. L. (2005) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:2005013 · Cited by 33 · see citing works

Glia- and tissue-specific changes in the Kynurenine Pathway after treatment of mice with lipopolysaccharide and dexamethasone

Dostal, C. R., Gamsby, N. S., Lawson, M. A., & McCusker, R. H. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.12.006 · Cited by 32 · see citing works

Obsessive-Compulsive Disorder, PANDAS, and Tourette Syndrome: Immuno-inflammatory Disorders

Marazziti, D., Palermo, S., Arone, A., Massa, L., Parra, E., Simoncini, M., Martucci, L., Beatino, M. F., & Pozza, A. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_13 · Cited by 34 · see citing works

Cytokines, Sickness Behavior, and Depression

Dantzer, R., Bluthé, R.-M., Castanon, N., Kelley, K. W., Konsman, J. P., Layé, S., Lestage, J., & Parnet, P. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50019-8 · Cited by 32 · see citing works

Effects of IDO1 and TDO2 inhibition on cognitive deficits and anxiety following LPS-induced neuroinflammation

Imbeault, S., Goiny, M., Liu, X.-C., & Erhardt, S. (2019) · Acta Neuropsychiatrica · doi:10.1017/neu.2019.44 · Cited by 25 · see citing works

Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors

Li, X., Yin, W., Sarma, P., Zhou, H., Ma, J., & Cook, J. M. (2004) · Tetrahedron Letters · doi:10.1016/j.tetlet.2004.09.113 · Cited by 30 · see citing works

Lipopolysaccharide‐induced indoleamine 2,3‐dioxygenase expression in the periodontal ligament

Moon, J.-H., Cheong, N. R., Yang, S. Y., Kim, I. S., Chung, H., Jeong, Y. W., Park, J. C., Kim, M. S., Kim, S. H., & Ko, H. M. (2013) · Journal of Periodontal Research · doi:10.1111/jre.12063 · Cited by 29 · see citing works

Neuronal localization of indoleamine 2,3-dioxygenase in mice

Roy, E. J., Takikawa, O., Kranz, D. M., Brown, A. R., & Thomas, D. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.07.010 · Cited by 29 · see citing works

Vortioxetine Prevents Lipopolysaccharide-Induced Memory Impairment Without Inhibiting the Initial Inflammatory Cascade

Alboni, S., Benatti, C., Colliva, C., Radighieri, G., Blom, J. M. C., Brunello, N., & Tascedda, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.603979 · Cited by 28 · see citing works

Activation of Brain Indoleamine-2,3-dioxygenase Contributes to Depressive-Like Behavior Induced by an Intracerebroventricular Injection of Streptozotocin in Mice

Souza, L. C., Jessé, C. R., de Gomes, M. G., Fabbro, L. D., Goes, A. T. R., Donato, F., & Boeira, S. P. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2329-2 · Cited by 28 · see citing works

Endogenous antagonists of N‐methyl‐ d ‐aspartate receptor in schizophrenia

Jorratt, P., Höschl, C., & Ovsepian, S. V. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12244 · Cited by 27 · see citing works

T. gondii Infection Acquired during Pregnancy and/or after Birth may be Responsible for Development of both Type 1 and 2 Diabetes Mellitus

Prandota, J. (2013) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.1000241 · Cited by 27 · see citing works

Aging exacerbates cognitive and anxiety alterations induced by an intracerebroventricular injection of amyloid-β1–42 peptide in mice

Souza, L. C., Jessé, C. R., Fabbro, L. D., de Gomes, M. G., Gomes, N. S., Filho, C. B., Goes, A. T. R., Wilhelm, E. A., Luchese, C., Roman, S. S., et al. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.01.005 · Cited by 27 · see citing works

Inhibition of indoleamine 2,3-dioxygenase 1/2 prevented cognitive impairment and energetic metabolism changes in the hippocampus of adult rats subjected to polymicrobial sepsis

Comim, C. M., Freiberger, V., Ventura, L., Mina, F., Ferreira, G. K., Michels, M., Generoso, J. S., STRECK, E. L., Quevedo, J., Barichello, T., et al. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.02.001 · Cited by 26 · see citing works

Cytokine secretion responsiveness of lymphomonocytes following cortisol cell exposure: Sex differences

Pozzo, E. D., Giacomelli, C., Cavallini, C., & Martini, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200924 · Cited by 25 · see citing works

Spatio-temporal differences in the profile of murine brain expression of proinflammatory cytokines and indoleamine 2,3-dioxygenase in response to peripheral lipopolysaccharide administration

André, C., O’Connor, J. C., Kelley, K. W., Lestage, J., Dantzer, R., & Castanon, N. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.06.011 · Cited by 111 · see citing works

Mechanisms of cytokine-induced activation of brain indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing enzyme, involved in behavioral and mood alterations observed in mice models of infection and obesity

Castanon, N., André, C., Dinel, A., Lestage, J., & Dantzer, R. (2006) · HAL

Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

Lawson, M. A., Parrott, J. M., McCusker, R. H., Dantzer, R., Kelley, K. W., & O’Connor, J. C. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-87 · Cited by 159 · see citing works

Bacille Calmette‐Guérin Inoculation Induces Chronic Activation of Peripheral and Brain Indoleamine 2,3‐Dioxygenase in Mice

Moreau, M. M., Lestage, J., Verrier, D., Mormède, C., Kelley, K. W., Dantzer, R., & Castanon, N. (2005) · The Journal of Infectious Diseases · doi:10.1086/431603 · Cited by 104 · see citing works

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

O'Connor, J. C., Lawson, M. A., André, C., Moreau, M., Lestage, J., Castanon, N., Kelley, K. W., & Dantzer, R. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002148 · Cited by 1,278 · see citing works