Cited by 377Circadian rhythm and melatoninCancer, Stress, Anesthesia, and Immune ResponseStress Responses and Cortisol

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Circadian disruption in cancer: a neuroendocrine-immune pathway from stress to disease?

Sephton, Sandra, Spiegel, David·2003·Brain Behavior and Immunity

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Abstract

Psychosocial factors may modulate the course of cancer, but few data have been gathered on the biological mechanisms by which these effects may be mediated. We briefly review evidence of psychosocial effects on cancer progression and discuss one potential pathway that may underlie these effects: the disruption of neuroendocrine and immune circadian rhythms. Circadian system alterations occur in tumor tissue, tumor-bearing animals, and cancer patients with greater disruption seen in more advanced cases. Rhythm alterations include diminished amplitude, phase shifts, period changes, and erratic peaks and troughs in endocrine, metabolic, immunological, and rest- activity cycles. Psychosocial factors can engender dysregulation of circadian function. Cancer-related circadian dysregulation may also be driven by genetic factors, environmental and behavioral influences, and effects of the tumor on host clock regulation. There are several mechanisms by which circadian disruption might hasten tumor growth: via direct effects of altered hormone levels on tumor cells, effects on tumor versus host metabolism, neuroimmune effects resulting in cancer-relevant immunosuppression, or reduced efficacy and tolerability of cancer treatments for which the timing of administration is based upon the assumption of normal circadian rhythms. Emerging data in the human and animal literature suggest that circadian regulation may be an important prerequisite for the maintenance of host defenses against cancer. Thus, stress-related circadian disruption may have negative implications for cancer prognosis. Psychosocial effects on cancer progression may be measured, and possibly mediated, by disruption of circadian function.

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House, J. S., Landis, K. R., & Umberson, D. (1988) · Science · doi:10.1126/science.3399889 · Cited by 7,073
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · cited 3×
“Research illustrating relationships between psychological stress (e.g., depression and unemployment) and alterations of circadian cortisol rhythms (Chrousos and Gold, 1998) support the notion that repeated stress-response activation may result in circadian endocrine disruption (McEwen, 1998) (Fig.”
Background
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo
Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,268
Rotating night shifts and risk of breast cancer in women participating in the nurses׳ health study
Schernhammer, E. S., Laden, F., Speizer, F. E., Willett, W. C., Hunter, D. J., Kawachi, I., & Colditz, G. A. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1563 · Cited by 1,142
Diurnal Cortisol Rhythm as a Predictor of Breast Cancer Survival
Sephton, S. E. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.12.994 · Cited by 1,082
Neuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957
Night Shift Work, Light at Night, and Risk of Breast Cancer
Davis, S., Mirick, D. K., & Stevens, R. G. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.20.1557 · Cited by 930
The hypothalamic–pituitary–adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke
Rosmond, R., & Björntorp, P. A. (2000) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2000.00603.x · Cited by 513
Current status of cortisol findings in post-traumatic stress disorder
Yehuda, R. (2002) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(02)00002-3 · Cited by 511

Show all 37 references

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Antoni, M. H., Lutgendorf, S. K., Cole, S. W., Dhabhar, F. S., Sephton, S. E., McDonald, P. G., Stefanek, M., & Sood, A. K. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1820 · Cited by 981
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Ryff, C. D., Singer, B. H., & Dienberg Love, G. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2004.1521 · Cited by 916
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Adam, E. K., Quinn, M. E., Tavernier, R., McQuillan, M. T., Dahlke, K. A., & Gilbert, K. E. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.05.018 · Cited by 905
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Dhabhar, F. S. (2009) · Neuroimmunomodulation · doi:10.1159/000216188 · Cited by 903
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Carlson, L. E., Speca, M., Faris, P., & Patel, K. D. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.04.002 · Cited by 688
Shift work and chronic disease: the epidemiological evidence
Wang, X.-S., Armstrong, M. E. G., Cairns, B. J., Key, T. J., & Travis, R. C. (2011) · Occupational Medicine · doi:10.1093/occmed/kqr001 · Cited by 670
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Ryan, J. L., Carroll, J. K., Ryan, E. P., Mustian, K. M., Fiscella, K. A., & Morrow, G. R. (2007) · The Oncologist · doi:10.1634/theoncologist.12-s1-22 · Cited by 599
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Moreno‐Smith, M., Lutgendorf, S. K., & Sood, A. K. (2010) · Future Oncology · doi:10.2217/fon.10.142 · Cited by 522
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The impact of psychosocial stress and stress management on immune responses in patients with cancer
Antoni, M. H., & Dhabhar, F. S. (2019) · Cancer · doi:10.1002/cncr.31943 · Cited by 419
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Understanding the interaction between psychosocial stress and immune-related diseases: A stepwise progression
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Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345
Systems Chronotherapeutics
Ballesta, A., Innominato, P. F., Dallmann, R., Rand, D. A. J., & Lévi, F. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013441 · Cited by 348
The short-term stress response – Mother nature’s mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity
Dhabhar, F. S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.004 · Cited by 377
Diurnal cortisol rhythm as a predictor of lung cancer survival
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Abercrombie, H. C., Giese‐Davis, J., Sephton, S. E., Epel, E. S., Turner‐Cobb, J. M., & Spiegel, D. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.11.003 · Cited by 287
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Carlson, L. E., Doll, R., Stephen, J., Faris, P., Tamagawa, R., Drysdale, E., & Speca, M. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.47.5210 · Cited by 282
Psychological distress and cancer mortality
Hamer, M., Chida, Y., & Molloy, G. J. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.11.002 · Cited by 282
Diurnal cortisol rhythm and fatigue in breast cancer survivors
Bower, J. E., Ganz, P. A., Dickerson, S. S., Petersen, L., Aziz, N., & Fahey, J. L. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.06.003 · Cited by 308
Elevated Serum Cytokines Correlated with Altered Behavior, Serum Cortisol Rhythm, and Dampened 24-Hour Rest-Activity Patterns in Patients with Metastatic Colorectal Cancer
Rich, T. A., Innominato, P. F., Boerner, J. L., Mormont, M., Iacobelli, S., Baron, B., Jasmin, C., & Lévi, F. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2000 · Cited by 262
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Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
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Foster, F., & Wulff, K. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1670 · Cited by 255
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Bower, J. E., Ganz, P. A., & Aziz, N. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000155666.55034.c6 · Cited by 236
Residential mobility, well-being, and mortality.
Oishi, S., & Schimmack, U. (2010) · Journal of Personality and Social Psychology · doi:10.1037/a0019389 · Cited by 239
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Slopen, N., McLaughlin, K. A., & Shonkoff, J. P. (2014) · Pediatrics · doi:10.1542/peds.2013-1632 · Cited by 211
Psychological vulnerability and stress: The effects of self-affirmation on sympathetic nervous system responses to naturalistic stressors.
Sherman, D. K., Bunyan, D. P., Creswell, J. D., & Jaremka, L. M. (2009) · Health Psychology · doi:10.1037/a0014663 · Cited by 234
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Banasik, J., Williams, H., Haberman, M., Blank, S. E., & Bendel, R. (2011) · Journal of the American Academy of Nurse Practitioners · doi:10.1111/j.1745-7599.2010.00573.x · Cited by 201
A longitudinal study of depression, pain, and stress as predictors of sleep disturbance among women with metastatic breast cancer
Palesh, O. G., Collie, K., Batiuchok, D., Tilston, J., Koopman, C., Perlis, M. L., Butler, L. D., Carlson, R., & Spiegel, D. (2007) · Biological Psychology · doi:10.1016/j.biopsycho.2006.11.002 · Cited by 183
Sleep Duration and Breast Cancer: A Prospective Cohort Study
Verkasalo, P. K., Lillberg, K., Stevens, R. G., Hublin, C., Partinen, M., Koskenvuo, M. J., & Kaprio, J. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2138 · Cited by 177
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Innominato, P. F., Lévi, F., & Bjarnason, G. A. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.06.002 · Cited by 168
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Hamilton, N. A., Catley, D., & Karlson, C. (2007) · Health Psychology · doi:10.1037/0278-6133.26.3.288 · Cited by 149
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Innominato, P. F., Giacchetti, S., Bjarnason, G. A., Focan, C., Garufi, C., Coudert, B. P., Iacobelli, S., Tampellini, M., Durando, X., Mormont, M., et al. (2012) · International Journal of Cancer · doi:10.1002/ijc.27574 · Cited by 129
Psychological stress and immunoprotection versus immunopathology in the skin
Dhabhar, F. S. (2012) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2011.11.003 · Cited by 128
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Law, R. J., & Clow, A. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.01.001 · Cited by 125
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Giese‐Davis, J., Sephton, S. E., Abercrombie, H. C., Durán, R. E., & Spiegel, D. (2004) · Health Psychology · doi:10.1037/0278-6133.23.6.645 · Cited by 113
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Intraindividual variability in sleep and comorbid medical and mental health conditions
Slavish, D. C., Taylor, D. J., & Lichstein, K. L. (2019) · SLEEP · doi:10.1093/sleep/zsz052 · Cited by 116
Linking Perceived Unfairness to Physical Health: The Perceived Unfairness Model
Jackson, B. M., Kubzansky, L. D., & Wright, R. J. (2006) · Review of General Psychology · doi:10.1037/1089-2680.10.1.21 · Cited by 108
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Goodman, A. O. G., Rogers, L., Pilsworth, S., McAllister, C., Shneerson, J., Morton, A., & Barker, R. A. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-010-0163-x · Cited by 111
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Neikrug, A. B., Rissling, M. B., Trofimenko, V., Liu, L., Natarajan, L., Lawton, S., Parker, B. A., & Ancoli‐Israel, S. (2012) · Behavioral Sleep Medicine · doi:10.1080/15402002.2011.634940 · Cited by 105
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Entrainment of peripheral clock genes by cortisol
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Ah, D. M. V., Kang, D.-H., & Carpenter, J. S. (2007) · Research in Nursing & Health · doi:10.1002/nur.20164 · Cited by 75
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Authors: Sephton, S., & Spiegel, D.
Affiliations: University of Louisville (US)
Stanford Medicine (US)
Corresponding author: Sephton, Sandra
ORCID: Sephton, Sandra
Spiegel, David
Venue: Brain Behavior and Immunity
Publisher: Elsevier BV
Published: 2003-10
Volume: 17
Issue: 5
Pages: 321-328
ISSN: 0889-1591 (ISSN-L)
DOI: 10.1016/s0889-1591(03)00078-3
OpenAlex: W1985105677
Cited by: 377
References: 37
Citations by year: 2026: 11 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 16 · 2021: 18 · 2020: 14 · 2019: 26 · 2018: 18 · 2017: 13 · 2016: 18 · 2015: 11 · 2014: 16 · 2013: 21 · 2012: 21
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Behavior and Immunity (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: circadian rhythm disruption, tumor progression, psychosocial factors, circadian rhythm, stress, tumor immunosuppression, host defense against cancer, circadian clock regulation, cancer prognosis
MeSH terms: Animals, Circadian Rhythm, Humans, Neoplasms, Neurosecretory Systems, Prognosis, Psychology, Neuroimmunomodulation, Disease Progression, Chronobiology Disorders

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