Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia
Open accessAbstract
The laminar cortical distribution of the [125I]alpha-bungarotoxin, [3H]cytisine and [3H]epibatidine nicotinic acetylcholine receptor ligands was investigated by quantitative autoradiography in autopsy tissue from the cingulate, orbitofrontal and temporal cortices of control and schizophrenia subjects matched for age and smoking history. Different laminar binding patterns were observed for the various nicotinic ligands both in schizophrenic and control brains. [125I]alpha-Bungarotoxin binding was distributed homogeneously across all cortical layers in all three brain regions, with highest binding densities in the cingulate cortex. [3H]Cytisine and [3H]epibatidine binding varied across the cortical ribbon, with high binding in layers I, III, V and VI, within the three cortical regions. A significantly reduced [125I] alpha-bungarotoxin binding (-54%) was observed in the cingulate cortex of schizophrenia subjects, in comparison with normal individuals who smoked tobacco. In the same brain region also a significantly higher [3H]cytisine binding (48-77%) was observed in nearly all layers, except for layer I of the schizophrenia subjects, when compared to normal individuals with a history of tobacco use. No significant changes in [3H]epibatidine binding was observed within the individual cortical layers between control subjects and patients with schizophrenia, but when calculated as a whole region (i.e. measurements performed across the whole cortical ribbon), the temporal cortex showed a significant increase in [3H]epibatidine binding in schizophrenia subjects compared to control subjects. The results suggest opposite changes of the alpha4beta2 and alpha7 nicotinic receptor subtypes in the cingulate cortex of patients with schizophrenia which might reflect involvement of two different nicotinic receptor mechanisms in schizophrenia brain.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Anomalies in the availability or expression of specific nAChR subunits have been implicated in depression and schizophrenia patients.
“Notably, anomalies in the availability or expression of specific nAChR subunits have been implicated in depression [104] and schizophrenia patients [105, 106].”
From Adolescent nicotine exposure and persistent neurocircuitry changes: unveiling lifelong psychiatric risks (2025) · cites this paper as [106]
Cites
Implications of Normal Brain Development for the Pathogenesis of Schizophrenia
Weinberger, D. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800190080012 · Cited by 3,724 · see citing works
Progress in experimental personality research
Maher, W. B., & Maher, B. A. (1964) · Academic Press eBooks · Cited by 2,347 · see citing works
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471 · see citing works
Prevalence of smoking among psychiatric outpatients
(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.8.993 · Cited by 1,058 · see citing works
Clarke, P. B. S., Schwartz, R., Paul, S. M., Cb, P., & Pert, A. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-05-01307.1985 · Cited by 1,037 · see citing works
Physiological Diversity of Nicotinic Acetylcholine Receptors Expressed by Vertebrate Neurons
McGehee, D. S., & Role, L. W. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002513 · Cited by 1,022 · see citing works
A functional neuroanatomy of hallucinations in schizophrenia
Silbersweig, D. A., Stern, E., Frith, C., Cahill, C., Holmes, A., Grootoonk, S., Seaward, J., McKenna, P., Chua, S. E., Schnorr, L., et al. (1995) · Nature · doi:10.1038/378176a0 · Cited by 906 · see citing works
Adler, L. E., Pachtman, E., Franks, R. D., Pecevich, M., Waldo, M. C., & Freedman, R. (1982) · PubMed · Cited by 896 · see citing works
Neuronal nicotinic receptors in the human brain
Paterson, D., & Nordberg, A. K. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00045-3 · Cited by 782 · see citing works
Self-citationInformation Processing and Attention Dysfunctions in Schizophrenia
Braff, D. L. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.2.233 · Cited by 738 · see citing works
Schizophrenia, sensory gating, and nicotinic receptors
Adler, L. E., Olincy, A., Waldo, M., Harris, J. G., Griffith, J., Stevens, K., Flach, K., Nagamoto, H., Bickford, P., Leonard, S., et al. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033320 · Cited by 690 · see citing works
Normalization of auditory physiology by cigarette smoking in schizophrenic patients
Adler, L. E., Hoffer, L., Wiser, A., & Freedman, R. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1856 · Cited by 679 · see citing works
Freedman, R., Hall, M., Adler, L. E., & Leonard, S. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00252-x · Cited by 678 · see citing works
Nicotinic systems and cognitive function
Levin, E. D. (1992) · Psychopharmacology · doi:10.1007/bf02247415 · Cited by 511 · see citing works
Nicotine Dependence in Schizophrenia: Clinical Phenomena and Laboratory Findings
Dalack, G. W., Healy, D. J., & Meador‐Woodruff, J. H. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.11.1490 · Cited by 498 · see citing works
Nicotinic acetylcholine binding sites in Alzheimer's disease
Whitehouse, P. J., Martino, A. M., Antuono, P., Lowenstein, P. R., Coyle, J. T., Price, D. L., & Kellar, K. J. (1986) · Brain Research · doi:10.1016/0006-8993(86)90819-x · Cited by 485 · see citing works
INPUT DYSFUNCTION IN SCHIZOPHRENIA.
Ph, V. (1964) · PubMed · Cited by 473 · see citing works
Schizophrenia and smoking: an epidemiological survey in a state hospital
de León, J., Dadvand, M., Canuso, C. M., Odom-White, A., Stanilla, J. K., & Simpson, G. M. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.453 · Cited by 417 · see citing works
Human neuronal nicotinic receptors
Gotti, C., Fornasari, D., & Clementi, F. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00034-8 · Cited by 413 · see citing works
Effect of smoking history on [3H]nicotine binding in human postmortem brain
Breese, C. R., Marks, M. J., Logel, J., Adams, C. E., Sullivan, B., Collins, A. C., & Leonard, S. (1997) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36798-9 · Cited by 396 · see citing works
Bertrand, D., Galzi, J., Devillers‐Thiéry, A., Bertrand, S., & Changeux, J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.6971 · Cited by 390 · see citing works
Abnormal Regulation of High Affinity Nicotinic Receptors in Subjects with Schizophrenia
Breese, C. R. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00121-4 · Cited by 343 · see citing works
Lohr, J. B., & FLYNN, K. (1992) · Schizophrenia Research · doi:10.1016/0920-9964(92)90024-y · Cited by 340 · see citing works
Guan, Z., Zhang, X., Blennow, K., & Nordberg, A. K. (1999) · Neuroreport · doi:10.1097/00001756-199906030-00028 · Cited by 286 · see citing works
Self-citationNicotinic Receptor Function in Schizophrenia
Leonard, S. S., Adams, C., Breese, C. R., Adler, L. E., Bickford, P. C., Byerley, W., Coon, H. H., Griffith, J. M., Miller, C., Myles‐Worsley, M., et al. (1996) · Schizophrenia Bulletin · doi:10.1093/schbul/22.3.431 · Cited by 263 · see citing works
Sensory gating deficits in schizophrenia: new results
Judd, L. L., McAdams, L. A., Budnick, B., & BRAFF, D. L. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.4.488 · Cited by 263 · see citing works
Whiting, P. J., & Lindström, J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-09-03395.1988 · Cited by 262 · see citing works
Neuronal Nicotinic Receptors in Dementia with Lewy Bodies and Schizophrenia
COURT, J. A., Spurden, D., Lloyd, S. R., McKeith, I. G., Ballard, C. G., Cairns, N. J., Kerwin, R. W., Perry, R., & Perry, E. K. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731590.x · Cited by 252 · see citing works
Self-citationCortical Development and Thalamic Pathology in Schizophrenia
Jones, E. G. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.3.483 · Cited by 223 · see citing works
Kaiser, S., & Wonnacott, S. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.2.312 · Cited by 218 · see citing works
Gerzanich, V., Anand, R., & Lindstrom, J. M. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09916-x · Cited by 218 · see citing works
Schizophrenia and Nicotinic Receptors
Freedman, R., Adler, L. E., Bickford, P. C., Byerley, W., Coon, H. H., Cullum, C. M., Griffith, J. M., Harris, J. G., Leonard, S. S., Miller, C. L., et al. (1994) · Harvard Review of Psychiatry · doi:10.3109/10673229409017136 · Cited by 217 · see citing works
Recent advances in defining the neuropathology of schizophrenia
Arnold, S. E., & Trojanowski, J. Q. (1996) · Acta Neuropathologica · doi:10.1007/s004010050512 · Cited by 205 · see citing works
Houghtling, R. A., Dávila‐García, M. I., & Kellar, K. J. (1995) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10246-0 · Cited by 200 · see citing works
Allosteric modulations of the nicotinic acetylcholine receptor
Léna, C., & Changeux, J. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90150-k · Cited by 181 · see citing works
Biological perspectives of schizophrenia
Venables, P. H. (1987) · Biological Psychology · doi:10.1016/0301-0511(87)90052-4 · Cited by 166 · see citing works
[3H]epibatidine labels nicotinic receptors in rat brain: an autoradiographic study.
Perry, D. C., & Kellar, K. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12091-0 · Cited by 163 · see citing works
Presynaptic ionotropic receptors
McGehee, D. S., & Role, L. W. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80118-8 · Cited by 157 · see citing works
COURT, J. A., Piggott, M. A., Lloyd, S. R., Cookson, N., Ballard, C. G., McKeith, I. G., Perry, R. H., & Perry, E. K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00071-3 · Cited by 156 · see citing works
Self-citationCOURT, J. A., Lloyd, S. R., Johnson, M. H., Griffiths, M., Birdsall, N. J. M., Piggott, M. A., Oakley, A. E., Ince, P. G., Perry, E. K., & Perry, R. H. (1997) · Developmental Brain Research · doi:10.1016/s0165-3806(97)00052-7 · Cited by 146 · see citing works
Self-citationNicotinic acetylcholine receptor subtypes in human frontal cortex: Changes in Alzheimer's disease
Sugaya, K., Giacobini, E., & Chiappinelli, V. A. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490270314 · Cited by 144 · see citing works
Improvement in Smooth Pursuit Eye Movements after Cigarette Smoking in Schizophrenic Patients
D, A. O. M. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00095-x · Cited by 136 · see citing works
Court, J. A., Lloyd, S., Thomas, N., Piggott, M. A., Marshall, E. F., Morris, C. M., Lamb, H., Perry, R. H., Johnson, M., & Perry, E. K. (1998) · Neuroscience · doi:10.1016/s0306-4522(98)00088-8 · Cited by 135 · see citing works
Self-citationPresynaptic Nicotinic Receptors and the Modulation of Transmitter Release
Wonnacott, S., Drasdo, A. L., Sanderson, E. M., & Rowell, P. P. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513965.ch6 · Cited by 128 · see citing works
Lang, W., & Henke, H. (1983) · Brain Research · doi:10.1016/0006-8993(83)90879-x · Cited by 124 · see citing works
Adler, L. E., Waldo, M. C., & Freedman, R. (1985) · Biological Psychiatry · doi:10.1016/0006-3223(85)90113-1 · Cited by 120 · see citing works
Regional neuropathology in schizophrenia: Where are we? Where are we going?
Shapiro, R. M. (1993) · Schizophrenia Research · doi:10.1016/0920-9964(93)90057-p · Cited by 119 · see citing works
Durany, N., Zöchling, R., Boissl, K. W., Paulus, W., Ransmayr, G. N., Tatschner, T., Danielczyk, W., Jellinger, K. A., Deckert, J., & Riederer, P. F. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01144-7 · Cited by 112 · see citing works
Chini, B., Raimond, E., Elgoyhen, A. B., Moralli, D., Balzaretti, M., & Heinemann, S. (1994) · Genomics · doi:10.1006/geno.1994.1075 · Cited by 99 · see citing works
Marutle, A., Berglund, U. W., Bogdanović, N., & Nordberg, A. K. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00558-7 · Cited by 96 · see citing works
Self-citationBiological perspectives of schizophrenia
Helmchen, H., & Henn, F. A. (1987) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 87 · see citing works
Happe, H. K., Peters, J. L., Bergman, D. A., & Murrin, L. C. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90484-7 · Cited by 82 · see citing works
Wevers, A., Jeske, A., Lobron, C., Birtsch, C., Heinemann, S., Maelicke, A., Schröder, R., & Schröder, H. C. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90286-0 · Cited by 72 · see citing works
The Neuropathology of Schizophrenia
Powers, R. E. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199907000-00001 · Cited by 71 · see citing works
Characterization of [3H]cytisine binding to human brain membrane preparations
Hall, M., Zerbe, L., Leonard, S., & Freedman, R. (1993) · Brain Research · doi:10.1016/0006-8993(93)90410-o · Cited by 64 · see citing works
Distribution of neuronal nicotinic receptor subunits in human brain
Rubboli, F., COURT, J. A., Sala, C., Morris, C. M., Perry, E. K., & Clementi, F. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90055-8 · Cited by 62 · see citing works
Self-citationNicotinic Receptors, Smoking and Schizophrenia
Leonard, S. S., Gault, J., Adams, C. E., Breese, C. R., Rollins, Y. D., Adler, L. E., D, A. O. M., & Freedman, R. (1998) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-1998-00036 · Cited by 60 · see citing works
Cannon, T. D. (1996) · Annals of Medicine · doi:10.3109/07853899608999117 · Cited by 60 · see citing works
Sihver, W., Gillberg, P., & Nordberg, A. K. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00652-0 · Cited by 57 · see citing works
Self-citationSihver, W., Gillberg, P.-G., Svensson, A., & Nordberg, A. K. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00295-x · Cited by 53 · see citing works
Self-citationEffects of smoking on drug action
Miller, R. R. (1977) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1977225part2749 · Cited by 52 · see citing works
Perry, E. K., COURT, J. A., Johnson, M., Piggott, M. A., & Perry, R. H. (1992) · Journal of Chemical Neuroanatomy · doi:10.1016/0891-0618(92)90056-v · Cited by 47 · see citing works
Self-citationWevers, A., Sullivan, J. P., Giordano, T., Birtsch, C., Monteggia, L. M., Nowacki, S., Arnerić, S. P., & Schröder, H. C. (1995) · Drug Development Research · doi:10.1002/ddr.430360205 · Cited by 18 · see citing works
Freedman, R. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00271-6 · Cited by 9 · see citing works
Vocal acoustic correlates of flat affect: Differences with other negative signs and with depression
Alpert, M., Welkowitz, J., Sobin, C. A., Rosen, A. D., Teti, D., & Borod, J. C. (1989) · Schizophrenia Research · doi:10.1016/0920-9964(89)90129-1 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 66 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
Neurophysiological Endophenotypes of Schizophrenia: The Viability of Selected Candidate Measures
Turetsky, B. I., Calkins, M. E., Light, G. A., D, A. O. M., Radant, A. D., & Swerdlow, N. R. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl060 · Cited by 563 · see citing works
Nicotinic acetylcholine receptors: From basic science to therapeutics
Hurst, R. S., Rollema, H., & Bertrand, D. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.08.012 · Cited by 525 · see citing works
Hurst, R. S., Hajós, M., Raggenbass, M., Wall, T. M., Higdon, N. R., Lawson, J. A., Rutherford-Root, K. L., Berkenpas, M. B., Hoffmann, W. E., Piotrowski, D. W., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5269-04.2005 · Cited by 447 · see citing works
Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia
Martin, L., Kem, W., & Freedman, R. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1750-1 · Cited by 340 · see citing works
Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection
Egea, J., Buendía, I., Parada, E., Navarro, E., Leon, R. M., & López, M. G. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.032 · Cited by 298 · see citing works
Effects of Nicotine on Cognitive Deficits in Schizophrenia
Harris, J. G., Kongs, S., Allensworth, D., Martín, L., Tregellas, J. R., Sullivan, B. F., Zerbe, G. O., & Freedman, R. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300450 · Cited by 235 · see citing works
Jones, C. K., Byun, N. E., & Bubser, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.199 · Cited by 228 · see citing works
Smoking, nicotine and neuropsychiatric disorders
Döme, P., Lazáry, J., Kalapos, M. P., & Rihmer, Z. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.013 · Cited by 215 · see citing works
Schizophrenia and the α7 Nicotinic Acetylcholine Receptor
Martin, L. F., & Freedman, R. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78008-4 · Cited by 213 · see citing works
Brain Imaging of Nicotinic Receptors in Alzheimer's Disease
Wu, J., Ishikawa, M., Zhang, J., & Hashimoto, K. (2010) · International Journal of Alzheimer s Disease · doi:10.4061/2010/548913 · Cited by 209 · see citing works
The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function
Sinkus, M. L., Graw, S. L., Freedman, R., Ross, R. G., Lester, H. A., & Leonard, S. S. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.006 · Cited by 186 · see citing works
Neuromodulation by acetylcholine: examples from schizophrenia and depression
Higley, M. J., & Picciotto, M. R. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.06.004 · Cited by 184 · see citing works
Modulatory effects of α7 nAChRs on the immune system and its relevance for CNS disorders
Kalkman, H. O., & Feuerbach, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2175-4 · Cited by 182 · see citing works
Prenatal Exposure to Maternal Cigarette Smoking and the Adolescent Cerebral Cortex
Toro, R., Leonard, G. T., Lerner, J. V., Lerner, R. M., Perron, M., Pike, G. B., Richer, L., Veillette, S., Pausová, Z., & Paus, T. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301484 · Cited by 166 · see citing works
Hoyle, E., Genn, R. F., Fernandes, C., & Stolerman, I. P. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0549-2 · Cited by 161 · see citing works
Wischhof, L., Irrsack, E., Osorio, C., & Koch, M. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.10.004 · Cited by 158 · see citing works
Hong, L. E. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.83 · Cited by 150 · see citing works
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
Bertrand, D., Lee, C., Flood, D. G., Marger, F., & Donnelly‐Roberts, D. L. (2015) · Pharmacological Reviews · doi:10.1124/pr.113.008581 · Cited by 139 · see citing works
Treating schizophrenia symptoms with an α7 nicotinic agonist, from mice to men
D, A. O. M., & Stevens, K. E. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.015 · Cited by 131 · see citing works
Genetics of Chromosome 15q13-q14 in Schizophrenia
Leonard, S. S., & Freedman, R. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.054 · Cited by 130 · see citing works
Nicotine reduces Aβ in the brain and cerebral vessels of APPsw mice
Hellström‐Lindahl, E., COURT, J. A., Keverne, J., Svedberg, M. M., Lee, M., Marutle, A., Thomas, A. J., Perry, E. K., Bednar, I., & Nordberg, A. K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03377.x · Cited by 127 · see citing works
Self-citationThe genetics of sensory gating deficits in schizophrenia
Freedman, R., Olincy, A., Ross, R. G., Waldo, M. C., Stevens, K. E., Adler, L. E., & Leonard, S. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0032-2 · Cited by 153 · see citing works
Young, J. W., & Geyer, M. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.06.031 · Cited by 123 · see citing works
Genetics of Smoking and Schizophrenia
Leonard, S. S., Mexal, S., & Freedman, R. (2007) · Journal of Dual Diagnosis · doi:10.1300/j374v03n03_05 · Cited by 124 · see citing works
McCluskey, S. P., Plisson, C., Rabiner, E. A., & Howes, O. D. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04488-0 · Cited by 121 · see citing works
Araud, T., Graw, S. L., Berger, R., Lee, M., Neveu, E., Bertrand, D., & Leonard, S. S. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.06.018 · Cited by 122 · see citing works
Brunzell, D. H., & McIntosh, J. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.299 · Cited by 114 · see citing works
Shim, J.-C., Jung, D.-U., Jung, S. S., Seo, Y.-S., Cho, D.-M., Lee, J.-H., Lee, S.-W., Kong, B.-G., Kang, J.-W., Oh, M., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.238 · Cited by 112 · see citing works
Developmental Excitation of Corticothalamic Neurons by Nicotinic Acetylcholine Receptors
Kassam, S. M., Herman, P. M., Goodfellow, N. M., Alves, N. C., & Lambe, E. K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2645-08.2008 · Cited by 100 · see citing works
Toyohara, J., & Hashimoto, K. (2010) · The Open Medicinal Chemistry Journal · doi:10.2174/1874104501004010037 · Cited by 109 · see citing works
Nicotinic receptors and schizophrenia
Ripoll, N., Grall‐Bronnec, M., & Bourin, M. (2004) · Current Medical Research and Opinion · doi:10.1185/030079904125004060 · Cited by 106 · see citing works
Lyon, L., Saksida, L. M., & Bussey, T. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2536-5 · Cited by 105 · see citing works
Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia
Martin-Ruiz, C. M., Haroutunian, V. H., Long, P., Young, A. H., Davis, K. L., Perry, E. K., & Court, J. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00348-2 · Cited by 100 · see citing works
Self-citationDifferential Regulation of α7 Nicotinic Receptor Gene (CHRNA7) Expression in Schizophrenic Smokers
Mexal, S., Berger, R., Logel, J., Ross, R. G., Freedman, R., & Leonard, S. S. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9233-4 · Cited by 100 · see citing works
Stephens, S. H., Logel, J., Barton, A., Franks, A. L., Finlay-Schultz, J., Short, M., Dickenson, J., James, B., Fingerlin, T. E., Wagner, B. D., et al. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.12.017 · Cited by 97 · see citing works
Molecular substrates of schizophrenia: homeostatic signaling to connectivity
Landek‐Salgado, M. A., Faust, T. E., & Sawa, A. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.141 · Cited by 93 · see citing works
Castner, S. A., Smagin, G. N., Piser, T. M., Wang, Y., Smith, J. S., Christian, E. P., Mrzljak, L., & Williams, G. V. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.006 · Cited by 90 · see citing works
Sinkus, M. L., Lee, M. J., Gault, J., Logel, J., Short, M., Freedman, R., Christian, S. L., Lyon, J., & Leonard, S. S. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.041 · Cited by 88 · see citing works
The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease
Fontana, I. C., Kumar, A., & Nordberg, A. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00792-4 · Cited by 86 · see citing works
Self-citationThe Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7
Wang, Y., Xiao, C., Indersmitten, T., Freedman, R., Leonard, S. S., & Lester, H. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.582858 · Cited by 85 · see citing works
Tietje, K. R., Anderson, D. J., Bitner, R. S., Blomme, E. A. G., Brackemeyer, P. J., Briggs, C. A., Browman, K. E., Bury, D., Curzon, P., Drescher, K. U., et al. (2008) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1527-3458.2008.00037.x · Cited by 85 · see citing works
Sarter, M. F., Lustig, C., & Taylor, S. F. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.001 · Cited by 82 · see citing works
Synaptic Dysfunction in Schizophrenia
Yin, D., Chen, Y., Sathyamurthy, A., Xiong, W., & Mei, L. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_22 · Cited by 81 · see citing works
Nicotinic Mechanisms in the Treatment of Psychotic Disorders: A Focus on the α7 Nicotinic Receptor
D, A. O. M., & Freedman, R. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25758-2_8 · Cited by 80 · see citing works
Nicotinic acetylcholine receptors: an overview on drug discovery
D’hoedt, D., & Bertrand, D. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902841045 · Cited by 79 · see citing works
Dinklo, T., Shaban, H., Thuring, J. W., Lavreysen, H., Stevens, K. E., Zheng, L., Mackie, C. E., Grantham, C., Vandenberk, I., Meulders, G., et al. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.173245 · Cited by 79 · see citing works
Toyohara, J., Sakata, M., Wu, J., Ishikawa, M., Oda, K., Ishii, K., Iyo, M., Hashimoto, K., & Ishiwata, K. (2009) · Annals of Nuclear Medicine · doi:10.1007/s12149-009-0240-x · Cited by 79 · see citing works
Lewis, A. S., van Schalkwyk, G. I., & Bloch, M. H. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.01.001 · Cited by 80 · see citing works
Thomsen, M. S., Christensen, D. Z., Hansen, H. H., Redrobe, J. P., & Mikkelsen, J. D. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.02.003 · Cited by 78 · see citing works
Timofeeva, O. A., & Levin, E. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.038 · Cited by 74 · see citing works
Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia
Coyle, J. T., Balu, D. T., Benneyworth, M. A., Basu, A. C., & Roseman, A. S. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.3/jcoyle · Cited by 75 · see citing works
Targeting α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia
Hajós, M., & Rogers, B. N. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361434 · Cited by 73 · see citing works
Cyto- and receptor architectonic mapping of the human brain
Palomero‐Gallagher, N., & Zilles, K. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00024-4 · Cited by 74 · see citing works
Wong, D. F., Kuwabara, H., Pomper, M. G., Holt, D. P., Brašić, J. R., George, N., Фролов, Б. А., Willis, W. D., Gao, Y., Valentine, H., et al. (2014) · Molecular Imaging and Biology · doi:10.1007/s11307-014-0779-3 · Cited by 73 · see citing works
Guan, Z., Nordberg, A. K., Mousavi, M. T., Rinne, J. O., & Hellström‐Lindahl, E. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03571-0 · Cited by 68 · see citing works
Self-citationZuelli, F. M. D. G. C., Brognara, F., Quirino, G. F. S., Hiroki, C. H., Fais, R. S., Del‐Ben, C. M., Ulloa, L., Salgado, H. C., Kanashiro, A., & Loureiro, C. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00618 · Cited by 69 · see citing works
Wong, D. F., Kuwabara, H., Horti, A. G., Roberts, J., Nandi, A., Cascella, N. G., Brašić, J. R., Weerts, E. M., Kitzmiller, K., Phan, J.-A., et al. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy021 · Cited by 65 · see citing works
Evidence for a role of nicotinic acetylcholine receptors in schizophrenia
Catherine, E. A. (2007) · Frontiers in bioscience · doi:10.2741/2424 · Cited by 63 · see citing works
Nicotine Effect on Prepulse Inhibition and Prepulse Facilitation in Schizophrenia Patients
Hong, L. E., Wonodi, I., Lewis, J., & Thaker, G. K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301601 · Cited by 63 · see citing works
Mathew, S., Law, A. J., Lipska, B. K., Dávila‐García, M. I., Zamora, E. D., Mitkus, S. N., Vakkalanka, R., Straub, R. E., Weinberger, D. R., Kleinman, J. E., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm253 · Cited by 63 · see citing works
Gao, Y., Kellar, K. J., Yasuda, R. P., Tran, T. P., Xiao, Y., Dannals, R. F., & Horti, A. G. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401184f · Cited by 63 · see citing works
Acker, B. A., Jacobsen, E. J., Rogers, B. N., Wishka, D. G., Reitz, S. C., Piotrowski, D. W., Myers, J. K., Wolfe, M. L., Groppi, V. E., Thornburgh, B. A., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.04.070 · Cited by 61 · see citing works
Nicotinic receptors and Alzheimer's disease
Bourin, M., Ripoll, N., & Dailly, É. (2003) · Current Medical Research and Opinion · doi:10.1185/030079903125001631 · Cited by 61 · see citing works
Proulx, É., Piva, M., Tian, M. K., Bailey, C. D. C., & Lambe, E. K. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1481-3 · Cited by 57 · see citing works
Hashimoto, K., Nishiyama, S., Ohba, H., Matsuo, M., Kobashi, T., Takahagi, M., Iyo, M., Kitashoji, T., & Tsukada, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003231 · Cited by 59 · see citing works
Hashimoto, K. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150605111345 · Cited by 53 · see citing works
Novel α7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia
Severance, E. G., & Yolken, R. H. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00323.x · Cited by 51 · see citing works
Cognitive performance and smoking in first-episode psychosis: the self-medication hypothesis
Segarra, R., Zabala, A., Eguíluz, J. I., Ojeda, N., Elizagárate, E., Sánchez, P., Ballesteros, J., & Gutiérrez, M. (2010) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-010-0146-6 · Cited by 50 · see citing works
The role of alpha-7 nicotinic receptors in food intake behaviors
Legget, K. T., Cornier, M., & Tregellas, J. R. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00553 · Cited by 49 · see citing works
Thomsen, M. S., Weyn, A., & Mikkelsen, J. D. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00961.x · Cited by 46 · see citing works
Knott, V., Fisher, D. J., & Millar, A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.012 · Cited by 44 · see citing works
Brunzell, D. H., McIntosh, J. M., & Papke, R. L. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12421 · Cited by 40 · see citing works
Espeseth, T., Endestad, T., Rootwelt, H., & Reinvang, I. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.027 · Cited by 41 · see citing works
Hansen, H. H., Timmermann, D. B., Peters, D., Walters, C. L., Damaj, M. I., & Mikkelsen, J. D. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21293 · Cited by 40 · see citing works
Duffy, Á., Zhou, P., Milner, T. A., & Pickel, V. M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.04.024 · Cited by 40 · see citing works
Mastropaolo, J. P., Rosse, R. B., & Deutsch, S. I. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.12.023 · Cited by 39 · see citing works
Lewis, A. S., & Picciotto, M. R. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3126-5 · Cited by 38 · see citing works
Pharmacological Strategies for Enhancing Cognition in Schizophrenia
Barch, D. M. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_39 · Cited by 38 · see citing works
Synthesis and analgesic activity of new pyridine-based heterocyclic derivatives
Nigade, G. B., Chavan, P., & Deodhar, M. N. (2010) · Medicinal Chemistry Research · doi:10.1007/s00044-010-9489-9 · Cited by 38 · see citing works
Horti, A. G. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.030 · Cited by 37 · see citing works
Coughlin, J. M., Du, Y., Rosenthal, H. B., Slania, S., Koo, S. M., Park, A., Solomon, G., Vranešić, M., Antonsdottir, I. M., Speck, C. L., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.10.009 · Cited by 37 · see citing works
Autism - A Neurodevelopmental Journey from Genes to Behaviour
Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36 · see citing works
Knott, V., de la Salle, S., Smith, D., Phillipe, T., Dort, H., Choueiry, J., & Impey, D. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113490449 · Cited by 35 · see citing works
Transmitter Receptor Distribution in the Human Brain
Palomero‐Gallagher, N., Amunts, K., & Zilles, K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397025-1.00221-9 · Cited by 35 · see citing works
Lascio, S. D., Fornasari, D., & Benfante, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073463 · Cited by 35 · see citing works
Georgiou, R., Lamnisos, D., & Giannakou, K. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.779607 · Cited by 34 · see citing works
Cannon, C. E., Puri, V., Vivian, J. A., Egbertson, M. S., Eddins, D. M., & Uslaner, J. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.003 · Cited by 34 · see citing works
Toyohara, J., Ishiwata, K., Sakata, M., Wu, J., Nishiyama, S., Tsukada, H., & Hashimoto, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008961 · Cited by 34 · see citing works
Jones, K. M., Mcdonald, I. M., Bourin, C., Olson, R., Bristow, L., & Easton, A. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3275-6 · Cited by 33 · see citing works
Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia
Stephens, S. H., Franks, A. L., Berger, R., Palionyte, M., Fingerlin, T. E., Wagner, B. D., Logel, J., D, A. O. M., Ross, R. G., Freedman, R., et al. (2011) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32834c0c33 · Cited by 30 · see citing works
Rötering, S., Scheunemann, M., Fischer, S., Hiller, A., Peters, D., Deuther‐Conrad, W., & Brust, P. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.02.018 · Cited by 30 · see citing works
Cholinergic system in schizophrenia: A systematic review and meta-analysis
Saint-Georges, Z., MacDonald, J., Al-Khalili, R., Hamati, R., Solmi, M., Keshavan, M. S., Tuominen, L. J., & Guimond, S. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03023-y · Cited by 30 · see citing works
Thomsen, M. S., Mikkelsen, J. D., Timmermann, D. B., Peters, D., Hay‐Schmidt, A., Martens, H., & Hansen, H. H. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.083 · Cited by 28 · see citing works
Ishikawa, M., Sakata, M., Toyohara, J., Oda, K., Ishii, K., Wu, J., Yoshida, T., Iyo, M., Ishiwata, K., & Hashimoto, K. (2011) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2011.9.3.111 · Cited by 28 · see citing works
Tanibuchi, Y., Wu, J., Toyohara, J., Fujita, Y., Iyo, M., & Hashimoto, K. (2010) · Brain Research · doi:10.1016/j.brainres.2010.06.008 · Cited by 27 · see citing works
Boggs, D. L., Carlson, J., Cortes-Briones, J., Krystal, J. H., & D’Souza, D. C. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612819666131216121019 · Cited by 26 · see citing works
Hellier, J. L., Arevalo, N. L., Blatner, M. J., Dang, A. K., Clevenger, A. C., Adams, C. E., & Restrepo, D. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.027 · Cited by 26 · see citing works
Metabolism and Disposition of a Selective α7 Nicotinic Acetylcholine Receptor Agonist in Humans
Shaffer, C. L., Gunduz, M., Scialis, R. J., & Fang, A. F. (2007) · Drug Metabolism and Disposition · doi:10.1124/dmd.106.014449 · Cited by 26 · see citing works
Severance, E. G., & Yolken, R. H. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.008 · Cited by 25 · see citing works
- Authors
- Marutle, A., Zhang, X., Court, J., Piggott, M., Johnson, M., Perry, R., Perry, E., & Nordberg, A.
- Affiliations
- Karolinska Institutet (SE)
- Medical Research Council (GB)
- Corresponding author
- Nordberg, Agneta
- Venue
- Journal of Chemical Neuroanatomy
- Publisher
- Elsevier BV
- Published
- 2001-07
- Volume
- 22
- Issue
- 1-2
- Pages
- 115-126
- ISSN
- 0891-0618 (ISSN-L)
- OpenAlex
- W2019990977
- Cited by
- 175
- References
- 66
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 4 · 2015: 11 · 2014: 10 · 2013: 12 · 2012: 10
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Journal of Chemical Neuroanatomy (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- schizophrenia, nicotinic acetylcholine receptors, alpha4beta2 nicotinic receptor, alpha7 nicotinic acetylcholine receptor, laminar distribution, cingulate cortex, orbitofrontal cortex, temporal cortex, alpha-bungarotoxin binding, epibatidine binding, smoking, cortical layers
- MeSH terms
- Acetylcholine, Aged, Binding Sites, Brain Chemistry, Bungarotoxins, Cerebral Cortex, Cystine, Female, Humans, Iodine Radioisotopes, Ligands, Male, Middle Aged, Neurons, Pyridines, Radioligand Assay, Receptors, Nicotinic, Schizophrenia, Tobacco Use Disorder, Tritium, Nicotinic Agonists, Bridged Bicyclo Compounds, Heterocyclic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
