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Cited by 106Suicide and Self-Harm StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

Postmortem Findings in Suicide Victims. Implications for in Vivo Imaging Studiesa

ARANGO, VICTORIA, UNDERWOOD, MARK D., MANN, J. JOHN·1997·Annals of the New York Academy of Sciences
DOI 10.1111/j.1749-6632.1997.tb52365.x
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Abstract

Abstract Alterations in serotonergic and noradrenergic receptor binding in membrane homogenates from the brain of suicide victims suggest a biological substrate for the vulnerability to commit suicide. We and others have employed high‐resolution quantitative autoradiography of full coronal sections of the prefrontal cortex to map the locus of maximal change in receptor binding. We found alternations in binding to the serotonin transporter, the 5‐HT 1A', and the 5‐HT 2A receptors primarily in the ventral and ventrolateral prefrontal cortex of suicide victims. Importantly, these changes are often modest in magnitude and anatomically restricted to one or two Brodmann areas. Furthermore, we have found that care in case selection is essential, because sex, age, drugs, and comorbid diagnoses contribute to receptor binding. The implications for in vivo imaging are considerable, directing the focus of such studies toward the ventrolateral prefrontal cortex. However, because ligands are limited, as is the resolution of current methods, including PET, automated analyses that produce statistical images, rather than manual selection of individual slices, will likely lack the ability to detect the discrete receptor changes found postmortem. Alternatively, the advantages of examining large numbers of subjects, imaging the entire brain, obtaining detailed clinical information in the living patient, and magnifying the changes with neuropharmacological challenges present a promising outlook for making major advances into the identification of brain abnormalities associated with suicide risk.

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Crossref · 10.1111/j.1749-6632.1997.tb52365.x

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  • Dombrovski and colleagues' finding of deficits in depressed attempters supports the notion that late life suicidal behavior is in some instances associated with impaired decision-making based on impaired ability to access and use prior experience, which may relate to underlying age-related ventral prefrontal pathology.

    “Their finding of deficits in depressed attempters supports the notion that late life suicidal behavior is in some instances associated with impaired decision-making based on impaired ability to access and use prior experience, which in turn may be related to underlying age-related ventral prefrontal pathology (36).”

    From Suicide in older adults (2011) · cites this paper as [36]

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Authors
ARANGO, V., UNDERWOOD, M. D., & MANN, J. J.
Affiliations
New York State Psychiatric Institute (US)
Corresponding author
ARANGO, VICTORIA
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
1997-12
Volume
836
Issue
1
Pages
269-287
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/j.1749-6632.1997.tb52365.x
OpenAlex
W1969768785
Cited by
106
References
77
Citations by year
2025: 1 · 2024: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 5
FWCI
1.34
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3303 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA09004, R01AA009004)
  • National Institute of Mental Health (MH46745, MH-40210, R01MH040210)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
suicide, postmortem brain, serotonin transporter, 5-HT1A receptor, 5-HT2A receptor, ventrolateral prefrontal cortex, suicide vulnerability, in vivo imaging, PET ligands, case selection
MeSH terms
Mental Disorders, Brain, Humans, Serotonin, Suicide, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon, Prefrontal Cortex

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