The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Effects of insufficient sleep on blood pressure in hypertensive patients: a 24-h study
Abstract
The influence of acute sleep deprivation during the first part of the night on 24-h blood pressure monitoring (ABPM) was studied in 36 never-treated mild to moderate hypertensive patients. According to a crossover design, they were randomized to have either sleep deprivation or a full night's sleep 1 week apart, during which they were monitored with ABPM. Urine samples for analysis of nocturnal urinary excretion of norepinephrine were collected. During the sleep-deprivation day, both mean 24-h blood pressure and mean 24-h heart rate were higher in comparison with those recorded during the routine workday, the difference being more pronounced during the nighttime (P < .01). Urinary excretion of norepinephrine showed a significant increase at night during sleep deprivation (P < .05). Blood pressure and heart rate significantly increased in the morning after a sleep-insufficient night (P < .05). These data suggest that lack of sleep in hypertensive patients may increase sympathetic nervous activity during the night and the following morning, leading to increased blood pressure and heart rate. This situation might represent an increased risk for both target organ damage and acute cardiovascular diseases.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“when sleep was restricted to the second half of the night for only a week, elevated diastolic and systolic blood pressure were present, compared to the week prior where a typical night of sleep was observed with no alterations(70).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [70]
In the citing paper
“Sympathetic activity is also increased in sleep deprivation, restless leg syndrome, and OSA.252–254”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [253]
In the citing paper
“The mechanism of poor sleep quality contributing to elevated BP and paroxysmal bouts of very high BP relates to activation of both the sympathetic nervous system and the renin-angiotensin-aldosterone system.252–255”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [253]
In the citing paper
“SBP, diastolic BP, and heart rate increase the day after a sleep-deprived night compared with the day after a normal sleep; urinary excretion of norepinephrine is also increased.56,253–256”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [253]
Citations
Cites
Sympathetic-Nerve Activity during Sleep in Normal Subjects
Somers, V. K., Dyken, M. E., Mark, A. L., & Abboud, F. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280502 · Cited by 1,574
Circadian variation and triggers of onset of acute cardiovascular disease.
Muller, J. E., Tofler, G. H., & Stone, P. H. (1989) · Circulation · doi:10.1161/01.cir.79.4.733 · Cited by 1,426
Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension.
Verdecchia, P., Schillaci, G., Guerrieri, M., Gatteschi, C., Benemio, G., Boldrini, F., & Porcellati, C. (1990) · Circulation · doi:10.1161/01.cir.81.2.528 · Cited by 1,225
O'Brien, E. T., Sheridan, J., & O'MALLEY, K. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92867-x · Cited by 1,032
Short and Long Sleep and Sleeping Pills: Is Increased Mortality Associated?
Kripke, D. F. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780010109014 · Cited by 660
Willich, S. N., Levy, D., Rocco, M. B., Tofler, G. H., Stone, P. H., & Muller, J. E. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)91027-7 · Cited by 653
Effects of Insufficient Sleep on Blood Pressure Monitored by a New Multibiomedical Recorder
Tochikubo, O., Ikeda, A., Miyajima, E., & Ishii, M. (1996) · Hypertension · doi:10.1161/01.hyp.27.6.1318 · Cited by 470
Sleep problems in the community elderly as predictors of death and nursing home placement
Pollak, C. P., PERLICK, D. A., Linsner, J. P., Wenston, J., & Hsieh, F. (1990) · Journal of Community Health · doi:10.1007/bf01321316 · Cited by 350
Verdecchia, P., Schillaci, G., Gatteschi, C., Zampi, I., Battistelli, M., Bartoccini, C., & Porcellati, C. (1993) · Circulation · doi:10.1161/01.cir.88.3.986 · Cited by 276
Dodt, C., Breckling, U., Derad, I., Fehm, H. L., & Jan Born, A. (1997) · Hypertension · doi:10.1161/01.hyp.30.1.71 · Cited by 252
Quantitative analysis of the 24-hour blood pressure and heart rate patterns in young men.
Degaute, J. P., van de Borne, P., Linkowski, P., & Van Cauter, E. (1991) · Hypertension · doi:10.1161/01.hyp.18.2.199 · Cited by 243
Autonomic Modulation of the Cardiovascular System during Sleep
Mancia, G. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280511 · Cited by 240
A MULTIVARIATE ANALYSIS OF HEALTH-RELATED PRACTICES
Wingard, D. L., Berkman, L. F., & Brand, R. (1982) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113466 · Cited by 219
Clark, L. A., Denby, L., Pregibon, D., Harshfield, G. A., Pickering, T. G., Blank, S., & Laragh, J. H. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90103-2 · Cited by 200
Lusardi, P. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00389-4 · Cited by 183
Circadian Variation in Onset of Acute Ischemic Stroke
Marsh, E. E., Biller, J., Adams, H. P., Marler, J. R., Hulbert, J. R., Love, B. B., & Gordon, D. L. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530110032012 · Cited by 160
Rapid reversal of circadian blood pressure rhythm in shift workers
Sundberg, S., Kohvakka, A., & Gordin, A. (1988) · Journal of Hypertension · doi:10.1097/00004872-198805000-00009 · Cited by 149
Twenty-four-hour ambulatory blood pressure in shift workers.
Chau, N. P., Mallion, J. M., Gaudemaris, R. D., Ruche, E., Siche, J. P., Pelen, O., & Mathern, G. W. (1989) · Circulation · doi:10.1161/01.cir.80.2.341 · Cited by 140
Effects of sleep disturbances on subsequent physical performance
Mougin, F., Simon-Rigaud, M.-L., Davenne, D., Renaud, A., Garnier, A., Kantelip, J., & Magnin, P. (1991) · European Journal of Applied Physiology · doi:10.1007/bf00235173 · Cited by 121
Twenty-four-hour blood pressure is not dependent on endogenous circadian rhythm
Baumgart, P., Walger, P., Fuchs, G., Dorst, K., Vettert, H., & Rahn, K. H. (1989) · Journal of Hypertension · doi:10.1097/00004872-198904000-00014 · Cited by 117
Sleep Disorders in Relation to Coronary Heart Disease
Partinen, M., Putkonen, P. T. S., Kaprio, J. A., Koskenvuo, M., & Hilakivi, I. T. (1982) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1982.tb00362.x · Cited by 117
Determinants and Consequences of the Diurnal Rhythm of Blood Pressure
Pickering, T. G., & James, G. D. (1993) · American Journal of Hypertension · doi:10.1093/ajh/6.6.166s · Cited by 111
Siesta and Ambulatory Blood Pressure Monitoring Comparability of the Afternoon Nap and Night Sleep
Bursztyn, M., Mekler, J., Wachtel, N., & Ben‐Ishay, D. (1994) · American Journal of Hypertension · doi:10.1093/ajh/7.3.217 · Cited by 108
The influence of daily activity on ambulatory blood pressure
Pickering, T. G. (1988) · American Heart Journal · doi:10.1016/0002-8703(88)90178-0 · Cited by 79
Factors Influencing the Urinary Excretion of Free Catecholamines in Man
Townshend, M. M., & Smith, A. J. (1973) · Clinical Science · doi:10.1042/cs0440253 · Cited by 72
Waking up exhausted as risk indicator of myocardial infarction
Appels, A., & Schouten, E. G. W. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90839-d · Cited by 65
Habitual sleep durations and health in a 50?65 year old population
Bliwise, D. L. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90031-0 · Cited by 59
Determinants of Short-term Blood Pressure Variability
van den Meiracker, A. H., Veld, A. J. M. I. '., van Eck, H. J. R., Wenting, G. J., & Schalekamp, M. A. D. H. (1988) · American Journal of Hypertension · doi:10.1093/ajh/1.1.22 · Cited by 35
Lusardi, P. (1995) · American Journal of Hypertension · doi:10.1016/0895-7061(95)97699-r · Cited by 17
Essential hypertension in the elderly: circadian variation of arterial pressure
Kobrin, I., Dunn, F. G., Oigman, W., Kumar, A., Ventura, H. O., Messerli, F. H., & Frohlich, E. D. (1984) · Steinkopff eBooks · doi:10.1007/978-3-662-05685-1_23 · Cited by 11
Fogari, R., Lusardi, P., Zoppi, A., Pasotti, M., & Corradi, L. (1997) · Journal of Hypertension · doi:10.1097/00004872-199715020-00004 · Cited by 5
Palatini, P., Mormino, P., Martina, S., Businaro, R., Penzo, M., Racioppa, A., Guzzardi, G., Anaclerio, M., & Ac, P. (1990) · PubMed · Cited by 2
Cited by
Sorted by citations
Gangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2006) · Hypertension · doi:10.1161/01.hyp.0000217362.34748.e0 · Cited by 1,284
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195
Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153
Spiegel, K., Leproult, R., L’Hermite-Balériaux, M., Copinschi, G., Penev, P. D., & Van Cauter, E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1003 · Cited by 1,006
Luyster, F. S., Strollo, P. J., Zee, P. C., & Walsh, J. K. (2012) · SLEEP · doi:10.5665/sleep.1846 · Cited by 927
Metadata
- Authors
- Lusardi, P.
- Affiliations
- University of Pavia (IT)
- Corresponding author
- Lusardi, P
- Venue
- American Journal of Hypertension
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01
- Volume
- 12
- Issue
- 1
- Pages
- 63-68
- ISSN
- 0895-7061 (ISSN-L)
- OpenAlex
- W2045209949
- Cited by
- 331
- References
- 32
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 14 · 2023: 20 · 2022: 18 · 2021: 13 · 2020: 15 · 2019: 19 · 2018: 12 · 2017: 17 · 2016: 22 · 2015: 17 · 2014: 23 · 2013: 14 · 2012: 17
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep deprivation, insufficient sleep, hypertension, blood pressure, heart rate, urinary norepinephrine, sympathetic activity, 24-hour ambulatory blood pressure monitoring, nocturnal blood pressure, morning blood pressure surge, target organ damage, cardiovascular risk
- MeSH terms
- Adult, Aged, Blood Pressure, Circadian Rhythm, Creatinine, Female, Follow-Up Studies, Heart Rate, Humans, Hypertension, Male, Middle Aged, Norepinephrine, Prognosis, Risk Factors, Sleep Deprivation, Sympathetic Nervous System, Cross-Over Studies, Blood Pressure Monitoring, Ambulatory
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
