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Cited by 243Heart Rate Variability and Autonomic ControlCircadian rhythm and melatoninBlood Pressure and Hypertension Studies

Quantitative analysis of the 24-hour blood pressure and heart rate patterns in young men.

Degaute, J P, van de Borne, P, Linkowski, P, Van Cauter, E·1991·Hypertension
DOI 10.1161/01.hyp.18.2.199
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Abstract

To characterize the normal nycterohemeral blood pressure and heart rate profiles and to delineate the relative roles of sleep and circadian rhythmicity, we performed 24-hour ambulatory blood pressure monitoring with simultaneous polygraphic sleep recording in 31 healthy young men investigated in a standardized physical and social environment. Electroencephalographic sleep recordings were performed during 4 consecutive nights. Blood pressure and heart rate were measured every 10 minutes for 24 hours starting in the morning preceding the fourth night of recording. Sleep quality was not significantly altered by ambulatory blood pressure monitoring. A best-fit curve based on the periodogram method was used to quantify changes in blood pressure and heart rate over the 24-hour cycle. The typical blood pressure and heart rate patterns were bimodal with a morning acrophase (around 10:00 AM), a small afternoon nadir (around 3:00 PM), an evening acrophase (around 8:00 PM), and a profound nocturnal nadir (around 3:00 AM). The amplitude of the nycterohemeral variations was largest for heart rate, intermediate for diastolic blood pressure, and smallest for systolic blood pressure (respectively, 19.9%, 14.1%, and 10.9% of the 24-hour mean). Before awakening, a significant increase in blood pressure and heart rate was already present. Recumbency and sleep accounted for 65-75% of the nocturnal decline in blood pressure, but it explained only 50% of the nocturnal decline in heart rate. Thus, the combined effects of postural changes and the wake-sleep transition are the major factors responsible for the 24-hour rhythm in blood pressure. In contrast, the 24-hour rhythm of heart rate may reflect an endogenous circadian rhythm, amplified by the effect of sleep. We conclude that modulatory factors different from those controlling nycterohemeral changes in blood pressure influence the 24-hour variation in heart rate.

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Crossref · 10.1161/01.hyp.18.2.199

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  • Almost all cardiovascular variables assessed at different times of day and night in humans have a day/night pattern, including blood pressure, heart rate, circulating catecholamines, blood coagulation markers, and vascular endothelial function.

    “Almost all cardiovascular (CV) variables that have been assessed at different times of day and night in humans have been found to have a day/night pattern, including blood pressure (BP) (1-3), heart rate (HR) (3), circulating catecholamines (4), blood coagulation markers (5), and vascular endothelial function (6).”

    From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [3]

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Authors
Degaute, J. P., van de Borne, P., Linkowski, P., & Van Cauter, E.
Affiliations
  • Université Libre de Bruxelles (BE)
  • Hypertension Clinic, Hopital Erasme, Universite Libre de Bruxelles, Belgium.
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1991-08
Volume
18
Issue
2
Pages
199-210
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.18.2.199
OpenAlex
W2019606254
Cited by
243
References
23
Citations by year
2026: 6 · 2025: 9 · 2024: 14 · 2023: 16 · 2022: 16 · 2021: 16 · 2020: 15 · 2019: 9 · 2018: 10 · 2017: 9 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 9
FWCI
5.48
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
heart rate variability, circadian rhythm, sleep, nocturnal blood pressure dipping, postural changes, wake-sleep transition, ambulatory blood pressure monitoring, young men, sleep quality
MeSH terms
Adolescent, Adult, Blood Pressure, Circadian Rhythm, Diastole, Heart, Heart Rate, Humans, Male, Regression Analysis, Sleep, Systole, White People

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