Cited by 882Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

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Mirnics, Károly, Middleton, Frank A., Marquez, Adriana, Lewis, David A., Levitt, Pat·2000·Neuron

DOI 10.1016/s0896-6273(00)00085-4

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Abstract

Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and control subjects and hierarchical data analysis revealed that transcripts encoding proteins involved in the regulation of presynaptic function (PSYN) were decreased in all subjects with schizophrenia. Genes of the PSYN group showed a different combination of decreased expression across subjects. Over 250 other gene groups did not show altered expression. Selected PSYN microarray observations were verified by in situ hybridization. Two of the most consistently changed transcripts in the PSYN functional gene group, N-ethylmaleimide sensitive factor and synapsin II, were decreased in ten of ten and nine of ten subjects with schizophrenia, respectively. The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model.

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Characterizing the cognitive, behavioural, and mechanistic actions of novel allosteric modulator PAOPA for the treatment of schizophrenia
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Authors: Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P.
Affiliations: University of Pittsburgh (US)
Corresponding author: Mirnics, Károly
ORCID: Mirnics, Károly
Middleton, Frank A.
Lewis, David A.
Levitt, Pat
Venue: Neuron
Publisher: Elsevier BV
Published: 2000-10
Volume: 28
Issue: 1
Pages: 53-67
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)00085-4
OpenAlex: W2032208151
Cited by: 882
References: 105
Citations by year: 2026: 5 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 16 · 2017: 14 · 2016: 19 · 2015: 32 · 2014: 19 · 2013: 29 · 2012: 37
FWCI: 48.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4672 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (T32 MH18273, MH 45156, T32MH018273, P50MH045156)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, prefrontal cortex, gene expression profiling, presynaptic function, N-ethylmaleimide-sensitive factor, synapsin II, transcriptome
MeSH terms: Animals, Carrier Proteins, Female, Humans, Macaca fascicularis, Male, Middle Aged, Synaptic Transmission, RNA, Messenger, Schizophrenia, Synapses, Antipsychotic Agents, Genetic Variation, Gene Expression, Confounding Factors, Epidemiologic, Synapsins, Prefrontal Cortex, In Situ Hybridization, Presynaptic Terminals, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Vesicular Transport Proteins, N-Ethylmaleimide-Sensitive Proteins

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Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

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