Cited by 882Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 105 of the 105 references it cites were found in a registry or an index.

Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

Open access

Mirnics, Károly, Middleton, Frank A., Marquez, Adriana, Lewis, David A., Levitt, Pat·2000·Neuron

DOI 10.1016/s0896-6273(00)00085-4

Open this paper in CoChat — free account Open PDF

Abstract

Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and control subjects and hierarchical data analysis revealed that transcripts encoding proteins involved in the regulation of presynaptic function (PSYN) were decreased in all subjects with schizophrenia. Genes of the PSYN group showed a different combination of decreased expression across subjects. Over 250 other gene groups did not show altered expression. Selected PSYN microarray observations were verified by in situ hybridization. Two of the most consistently changed transcripts in the PSYN functional gene group, N-ethylmaleimide sensitive factor and synapsin II, were decreased in ten of ten and nine of ten subjects with schizophrenia, respectively. The combined data suggest that subjects with schizophrenia share a common abnormality in presynaptic function. We set forth a predictive, testable model.

Integrity signals

Registry

Crossref · 10.1016/s0896-6273(00)00085-4

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925
Self-citation
Synaptic density in human frontal cortex —Developmental changes and effects of aging
Peter R., H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90349-4 · Cited by 2,645
Exploring the new world of the genome with DNA microarrays
Brown, P. O., & Botstein, D. (1999) · Nature Genetics · doi:10.1038/4462 · Cited by 2,430
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,025
The synaptic vesicle cycle: a cascade of protein–protein interactions
Südhof, T. C. (1995) · Nature · doi:10.1038/375645a0 · Cited by 1,991
Searching for genetic determinants in the new millennium
Risch, N. J. (2000) · Nature · doi:10.1038/35015718 · Cited by 1,839
The neuropathology of schizophrenia
Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677
Expression profiling using cDNA microarrays
Duggan, D. J., Bittner, M. L., Chen, Y., Meltzer, P. S., & Trent, J. M. (1999) · Nature Genetics · doi:10.1038/4434 · Cited by 1,660
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636
Self-citation

Show all 105 references

Research works printed but not linked: 3

Lewis, 2000, Catching up with schizophrenia, Neuron, in press
Volk, 2000, Decreased GAD67 mRNA expression in a subset of prefrontal cortical GABA neurons in schizophrenia, Arch. Gen. Psychiatry, in press
Weinberger, 1999, Schizophrenia, Biol. Psychiatry, 46, 3

Sorted by citations

Items 101–200 of 880

Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia
Weickert, C. S., Ligons, D. L., Romanczyk, T. B., Ungaro, G., Hyde, T. M., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001678 · Cited by 199
Patterns of gene expression in the limbic system of suicides with and without major depression
Sequeira, A., Klempan, T. A., Canetti, L., ffrench-Mullen, J. M. H., Benkelfat, C., Rouleau, G. A., & Turecki, G. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001969 · Cited by 200
Dendritic Spine Hypoplasticity and Downregulation of Reelin and GABAergic Tone in Schizophrenia Vulnerability
Costa, E., Davis, J. M., Grayson, D. R., Guidotti, A., Pappas, G. D., & Pesold, C. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0436 · Cited by 197
The GABA-glutamate connection in schizophrenia: which is the proximate cause?
Coyle, J. T. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.07.034 · Cited by 194
Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia
Hwang, Y., Kim, J., Shin, J.-Y., Kim, J.-I., Seo, J.-S., Webster, M. J., Lee, D., & Kim, S. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.94 · Cited by 189
Reduction of synapsin in the hippocampus of patients with bipolar disorder and schizophrenia
Vawter, M. P., Thatcher, L. N., Usen, N., Hyde, T. M., Kleinman, J. E., & Freed, W. J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001158 · Cited by 188
Genetic factors influencing alcohol dependence
Mayfield, R. D., Harris, R. A., & Schuckit, M. A. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.88 · Cited by 186
GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer’s disease
Jiménez-Baladó, J., & Eich, T. S. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.01.005 · Cited by 194
Developmental vitamin D deficiency alters brain protein expression in the adult rat: Implications for neuropsychiatric disorders
Alméras, L., Eyles, D. W., Benech, P. D., Laffite, D., Villard, C., Patatian, A., Boucraut, J., Mackay‐Sim, A., McGrath, J. J., & Feron, F. P. (2007) · PROTEOMICS · doi:10.1002/pmic.200600392 · Cited by 186
Protein Quantification at the Single Vesicle Level Reveals That a Subset of Synaptic Vesicle Proteins Are Trafficked with High Precision
Mutch, S. A., Kensel-Hammes, P., Gadd, J. C., Fujimoto, B. S., Allen, R. W., Schiro, P. G., Lorenz, R. M., Kuyper, C. L., Kuo, J. S., Bajjalieh, S. M., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3805-10.2011 · Cited by 185
Decreased glutamic acid decarboxylase67 mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders
Thompson, M., Weickert, C. S., Wyatt, E. J., & Webster, M. J. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.02.005 · Cited by 193
GABAergic Mechanisms in Schizophrenia: Linking Postmortem and In Vivo Studies
de Jonge, J. C., Vinkers, C. H., Pol, H. E. H., & Marsman, A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00118 · Cited by 203
Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain
Eyles, D. W., Alméras, L., Benech, P. D., Patatian, A., Mackay‐Sim, A., McGrath, J. J., & Feron, F. P. (2006) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2006.12.096 · Cited by 179
Extracellular matrix abnormalities in schizophrenia
Berretta, S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.010 · Cited by 179
Immune System Disturbances in Schizophrenia
Horváth, S., & Mirnics, K. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.06.010 · Cited by 181
Self-citation
Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia
Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Maccarrone, G., Hunyadi‐Gulyás, É., Eberlin, M. N., Souza, G. H. M. F., Marangoni, S., Novello, J. C., Turck, C. W., et al. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.11.006 · Cited by 176
Calcium signaling dysfunction in schizophrenia: a unifying approach
Lidow, M. S. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00203-0 · Cited by 174
Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia
Rao, V. L. R., Bowen, K. K., Dhodda, V. K., Song, G., Franklin, J. L., Gavva, N. R., & Dempsey, R. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01208.x · Cited by 173
Microarray reality checks in the context of a complex disease
Miklos, G. L. G., & Maleszka, R. (2004) · Nature Biotechnology · doi:10.1038/nbt965 · Cited by 176
Functional genomics to new drug targets
Kramer, R. S., & Cohen, D. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1552 · Cited by 169
Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility
Murray, A., Wołoszynowska-Fraser, M. U., Ansel-Bollepalli, L., Marshall-Phelps, K. L., Foggetti, A., Crouch, B., Riedel, G., & Wulff, P. (2015) · Scientific Reports · doi:10.1038/srep16778 · Cited by 173
The Synaptic Hypothesis of Schizophrenia
Frankle, W. G., Lerma, J., & Laruelle, M. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00423-9 · Cited by 172
An evolutionary theory of schizophrenia: Cortical connectivity, metarepresentation, and the social brain
Burns, J. K. (2004) · Behavioral and Brain Sciences · doi:10.1017/s0140525x04000196 · Cited by 171
Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders
Ray, M. T., Shannon Weickert, C., & Webster, M. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.26 · Cited by 161
Tau haplotypes regulate transcription and are associated with Parkinson's disease
Kwok, J. B., Teber, E., Loy, C. T., Hallupp, M., Nicholson, G. A., Mellick, G. D., Buchanan, D. D., Silburn, P. A., & Schofield, P. R. (2004) · Annals of Neurology · doi:10.1002/ana.10826 · Cited by 159
The problem of neuronal cell types: a physiological genomics approach
Nelson, S. B., Sugino, K., & Hempel, C. M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.05.004 · Cited by 157
A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia
Clark, D., Dedova, I. V., Cordwell, S. J., & Matsumoto, I. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001806 · Cited by 153
A comprehensive analysis of 22q11 gene expression in the developing and adult brain
Maynard, T. M., Haskell, G., Peters, A. Z., Sikich, L., Lieberman, J. A., & LaMantia, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235651100 · Cited by 155
Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala
Pantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153
Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: A potential animal model for schizophrenia and autism
Fatemi, S. H., Pearce, D. A., Brooks, A. I., & Sidwell, R. W. (2005) · Synapse · doi:10.1002/syn.20162 · Cited by 151
Progress in the use of microarray technology to study the neurobiology of disease
Mirnics, K., & Pevsner, J. (2004) · Nature Neuroscience · doi:10.1038/nn1230 · Cited by 150
Self-citation
Abnormalities of SNARE Mechanism Proteins in Anterior Frontal Cortex in Severe Mental Illness
Honer, W. G. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.349 · Cited by 149
Gene expression profiling of acute spinal cord injury reveals spreading inflammatory signals and neuron loss
CARMEL, J. B., GALANTE, A., SOTEROPOULOS, P., TOLIAS, P., RECCE, M., YOUNG, W., & HART, R. P. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.00074.2001 · Cited by 121
GeneChip ® analysis after acute spinal cord injury in rat
Song, G., Cechvala, C., Resnick, D. K., Dempsey, R. J., & Rao, V. L. R. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00626.x · Cited by 147
Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis
Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Rewerts, C., Marangoni, S., Novello, J. C., Maccarrone, G., Turck, C. W., & Dias‐Neto, E. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0156-y · Cited by 146
Glutamate Dysfunction in Hippocampus: Relevance of Dentate Gyrus and CA3 Signaling
Tamminga, C. A., Southcott, S. A., Sacco, C., Wagner, A. D., & Ghose, S. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs062 · Cited by 152
Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation
Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Novello, J. C., Marangoni, S., Turck, C. W., & Dias‐Neto, E. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-17 · Cited by 144
Overlapping Microarray Profiles of Dentate Gyrus Gene Expression during Development- and Epilepsy-Associated Neurogenesis and Axon Outgrowth
Elliott, R. C., Miles, M. F., & Lowenstein, D. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02218.2003 · Cited by 143
The axonal chemorepellant semaphorin 3A is increased in the cerebellum in schizophrenia and may contribute to its synaptic pathology
Eastwood, S. L., Law, A. J., Everall, I., & Harrison, P. J. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001233 · Cited by 145
Gene regulation by hypoxia and the neurodevelopmental origin of schizophrenia
Schmidt‐Kastner, R., van Os, J., Steinbusch, H. W. M., & Schmitz, C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.02.022 · Cited by 146
Target Identification for CNS Diseases by Transcriptional Profiling
Altar, C. A., Vawter, M. P., & Ginsberg, S. D. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.172 · Cited by 139
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion
Littleton, J. T., Barnard, R. J. O., Titus, S. A., Slind, J., Chapman, E. R., & Ganetzky, B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221450198 · Cited by 140
Chromatin Alterations Associated With Down-regulated Metabolic Gene Expression in the Prefrontal Cortex of Subjects With Schizophrenia
Akbarian, S., Ruehl, M. G., Bliven, E. E., Luiz, L. A., Peranelli, A. C., Baker, S. P., Roberts, R. C., Bunney, W. E., Conley, R. C., Jones, E. G., et al. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.8.829 · Cited by 140
Critical Appraisal of DNA Microarrays in Psychiatric Genomics
Mirnics, K., Levitt, P. R., & Lewis, D. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.003 · Cited by 139
Self-citation
Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders
Tang, B., Dean, B., & Thomas, E. A. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.61 · Cited by 137
Review of Pathological Hallmarks of Schizophrenia: Comparison of Genetic Models With Patients and Nongenetic Models
Jaaro-Peled, H., Ayhan, Y., Pletnikov, M. V., & Sawa, A. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp133 · Cited by 144
Neuronal and non-neuronal functions of the AP-3 sorting machinery
Litwa, K., Seong, E., Burmeister, M., & Faúndez, V. (2007) · Journal of Cell Science · doi:10.1242/jcs.03365 · Cited by 137
Molecular biology of cannabinoid receptors
Lutz, B. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0342 · Cited by 138
Variations in differential gene expression patterns across multiple brain regions in schizophrenia
Katsel, P., Davis, K. L., Gorman, J. M., & Haroutunian, V. H. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.03.020 · Cited by 135
Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia
Petryshen, T. L., Middleton, F. A., Tahl, A. R., Rockwell, G. N., Purcell, S., Aldinger, K. A., Kirby, A. W., Morley, C. P., McGann, L., Gentile, K. L., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001739 · Cited by 132
Self-citation
Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes
Straub, R. E., MacLean, C. J., Ma, Y., Webb, B. T., Myakishev, M. V., Harris-Kerr, C., Wormley, B., Sadek, H., Kadambi, B., O’Neill, F. A., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001051 · Cited by 133
Neurodevelopment, neuroplasticity, and new genes for schizophrenia
Arnold, S. E., Talbot, K., & Hahn, C.-G. (2004) · Progress in brain research · doi:10.1016/s0079-6123(04)47023-x · Cited by 135
Microarray Technology: A Review of New Strategies to Discover Candidate Vulnerability Genes in Psychiatric Disorders
Bunney, W. E., Bunney, B. G., Vawter, M. P., Tomita, H., Li, J. Z., Evans, S. J., Choudary, P. V., Myers, R., Jones, E. G., Watson, S. J., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.657 · Cited by 130
Microarray screening of lymphocyte gene expression differences in a multiplex schizophrenia pedigree
Vawter, M. P. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00151-8 · Cited by 132
Distinctive Profiles of Gene Expression in the Human Nucleus Accumbens Associated with Cocaine and Heroin Abuse
Albertson, D. N., Schmidt, C. J., Kapatos, G., & Bannon, M. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301089 · Cited by 128
Synaptic changes in the brain of subjects with schizophrenia
Faludi, G., & Mirnics, K. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.02.013 · Cited by 131
Self-citation
Neuropathological, neurogenetic and neuroimaging evidence for white matter pathology in schizophrenia
Walterfang, M., Wood, S. J., Velakoulis, D., & Pantelis, C. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.02.001 · Cited by 131
BLOC-1 Complex Deficiency Alters the Targeting of Adaptor Protein Complex-3 Cargoes
Salazar, G., Craige, B., Styers, M. L., Litwa, K., Doucette, M. M., Wainer, B. H., Falcón‐Pérez, J. M., Dell’Angelica, E. C., Peden, A. A., Werner, E., et al. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0103 · Cited by 131
Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility
Dutton, S. B., Makinson, C. D., Papale, L. A., Shankar, A., Balakrishnan, B., Nakazawa, K., & Escayg, A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.08.012 · Cited by 128
Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss
Bennett, M. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.003 · Cited by 129
The structure of the tau haplotype in controls and in progressive supranuclear palsy
Pittman, A. M. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh138 · Cited by 127
Repeated variable prenatal stress alters pre‐ and postsynaptic gene expression in the rat frontal pole
Kinnunen, A., Koenig, J. I., & Bilbe, G. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01873.x · Cited by 127
Correlation analysis between genome-wide expression profiles and cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders
Kim, S., & Webster, M. J. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.99 · Cited by 102
GABAA receptors and their associated proteins: Implications in the etiology and treatment of schizophrenia and related disorders
Charych, E. I., Liu, F., Moss, S. J., & Brandon, N. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.027 · Cited by 130
Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain
Liu, J., Lewohl, J. M., Dodd, P. R., Randall, P. K., Harris, R. A., & Mayfield, R. D. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02570.x · Cited by 127
The proteome of schizophrenia
Nascimento, J. M., & Martins‐de‐Souza, D. (2015) · Schizophrenia · doi:10.1038/npjschz.2014.3 · Cited by 125
Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability
Carter, C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.05.023 · Cited by 127
Expression of GABAA α2-, β1- and ɛ-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder
Fatemi, S. H., Folsom, T. D., Rooney, R. J., & THURAS, P. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.64 · Cited by 125
Presynaptic proteins in the prefrontal cortex of patients with schizophrenia and rats with abnormal prefrontal development
Halim, N. D., Weickert, C. S., McClintock, B. W., Hyde, T. M., Weinberger, D. R., Kleinman, J. E., & Lipska, B. K. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001319 · Cited by 124
Gene Expression Profiling of Depression and Suicide in Human Prefrontal Cortex
Sibille, E. L., Arango, V., Galfalvy, H., Pavlidis, P., Erraji-Benchekroun, L., Ellis, S., & Mann, J. J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300335 · Cited by 126
Animal models of obstetric complications in relation to schizophrenia
Boksa, P. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.01.001 · Cited by 125
The Role of Synapsins in Neurological Disorders
Mirza, F. J., & Zahid, S. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0201-7 · Cited by 127
SNAP-25 reduction in the hippocampus of patients with schizophrenia
Thompson, P. M., Egbufoama, S., & Vawter, M. P. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00027-7 · Cited by 122
Developmental history of the subplate zone, subplate neurons and interstitial white matter neurons: relevance for schizophrenia
Kostović, I., Judáš, M., & Sedmak, G. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.09.005 · Cited by 122
Differential Gene Expression Patterns Revealed by Oligonucleotide Versus Long cDNA Arrays
Li, J. (2002) · Toxicological Sciences · doi:10.1093/toxsci/69.2.383 · Cited by 121
Lamina-Specific Alterations in Cortical GABAA Receptor Subunit Expression in Schizophrenia
Beneyto, M., Abbott, A., Hashimoto, T., & Lewis, D. A. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq169 · Cited by 121
Self-citation
Schizophrenia: New Pathological Insights and Therapies
Jarskog, L. F., Miyamoto, S., & Lieberman, J. A. (2007) · Annual Review of Medicine · doi:10.1146/annurev.med.58.060904.084114 · Cited by 119
Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling
Mash, D. C., ffrench‐Mullen, J. M. H., Adi, N., Qin, Y., Buck, A., & Pablo, J. P. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001187 · Cited by 119
A new hypothesis of drug refractory epilepsy: Neural network hypothesis
Fang, M., Xi, Z., Wu, Y. F., & Wang, X. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.02.039 · Cited by 118
Genomic Convergence Analysis of Schizophrenia: mRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum
Mudge, J., Miller, N., Khrebtukova, I., Lindquist, I. E., May, G. D., Huntley, J. J., Luo, S. J., Zhang, L., van Velkinburgh, J. C., Farmer, A. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003625 · Cited by 120
Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches
Middleton, F. A., Pato, C. N., Gentile, K. L., McGann, L., Brown, A. M., Trauzzi, M., Diab, H. I., Morley, C. P., Medeiros, H., Macedo, A., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30171 · Cited by 116
Self-citation
Evaluation of Affymetrix Gene Chip sensitivity in rat hippocampal tissue using SAGE analysis*
Evans, S. J., Datson, N. A., Kabbaj, M., Thompson, R. C., Vreugdenhil, E., de Kloet, E. R., Watson, S. J., & Akil, H. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02097.x · Cited by 116
Prefrontal Abnormality of Schizophrenia Revealed by DNA Microarray: Impact on Glial and Neurotrophic Gene Expression
Sugai, T., Kawamura, M., Iritani, S., Araki, K., Makifuchi, T., Imai, C., Nakamura, R., Kakita, A., Takahashi, H., & Nawa, H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.011 · Cited by 115
Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia
Mohammadi, A., Rashidi, E., & Amooeian, V. G. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.036 · Cited by 119
Hippocampal Complexin Proteins and Cognitive Dysfunction in Schizophrenia
Sawada, K., Barr, A. M., Nakamura, M., Arima, K., Young, C. E., Dwork, A. J., Falkai, P., Phillips, A. G., & Honer, W. G. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.3.263 · Cited by 115
Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia
Beneyto, M., & Meador‐Woodruff, J. H. (2006) · Synapse · doi:10.1002/syn.20329 · Cited by 113
A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene
Zhu, Y., Kalbfleisch, T., Brennan, M. D., & Li, Y. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.01.022 · Cited by 114
A microarray study of post-mortem mRNA degradation in mouse brain tissue
Catts, V. S., Catts, S. V., Fernandez, H. R., Taylor, J. M., Coulson, E. J., & Lutze-Mann, L. H. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.04.017 · Cited by 113
Altered Cortical Glutamate Neurotransmission in Schizophrenia
Lewis, D. A., Glantz, L. A., Pierri, J. N., & Sweet, R. A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.007 · Cited by 113
Self-citation
Postmortem Brain: An Underutilized Substrate for Studying Severe Mental Illness
McCullumsmith, R. E., Hammond, J. H., Shan, D., & Meador‐Woodruff, J. H. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.239 · Cited by 115
Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment
Corradi, A. M., Zanardi, A., Giacomini, C., Onofri, F., Valtorta, F., Zoli, M., & Benfenati, F. (2008) · Journal of Cell Science · doi:10.1242/jcs.035063 · Cited by 113
Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia
Pasinetti, G. M. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1176 · Cited by 111
Predicting Drug Efficacy for Cognitive Deficits in Schizophrenia
Hagan, J. J. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi058 · Cited by 111
The limitations of simple gene set enrichment analysis assuming gene independence
Tamayo, P., Steinhardt, G., Liberzon, A., & Mesirov, J. P. (2012) · Statistical Methods in Medical Research · doi:10.1177/0962280212460441 · Cited by 109
Theranostic Biomarkers for Schizophrenia
Perković, M. N., Erjavec, G. N., Štrac, D. Š., Uzun, S., Kozumplik, O., & Pivac, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040733 · Cited by 113
Prefrontal Cortical Circuits in Schizophrenia
Volk, D. W., & Lewis, D. A. (2010) · Current topics in behavioral neurosciences · doi:10.1007/7854_2010_44 · Cited by 107
Self-citation
Longitudinal Brain Changes in Early-Onset Psychosis
Arango, C., Moreno, C., Martı́nez, S., Parellada, M., Desco, M., Moreno, D. M., Fraguas, D., Gogtay, N., James, A. C., & Rapoport, J. L. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm157 · Cited by 110
Cortical Oscillations in Health and Disease
Traub, R. D., & Whittington, M. A. (2010) · doi:10.1093/acprof:oso/9780195342796.001.0001 · Cited by 108
Gene Expression Profiling with DNA Microarrays: Advancing Our Understanding of Psychiatric Disorders
Pongrac, J. L., Middleton, F. A., Lewis, D. A., Levitt, P. R., & Mirnics, K. (2002) · Neurochemical Research · doi:10.1023/a:1020904821237 · Cited by 107
Self-citation
Defects in Bioenergetic Coupling in Schizophrenia
Sullivan, C. R., O'Donovan, S. M., McCullumsmith, R. E., & Ramsey, A. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.014 · Cited by 108

Authors: Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P.
Affiliations: University of Pittsburgh (US)
Corresponding author: Mirnics, Károly
ORCID: Mirnics, Károly
Middleton, Frank A.
Lewis, David A.
Levitt, Pat
Venue: Neuron
Publisher: Elsevier BV
Published: 2000-10
Volume: 28
Issue: 1
Pages: 53-67
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(00)00085-4
OpenAlex: W2032208151
Cited by: 882
References: 105
Citations by year: 2026: 5 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 16 · 2017: 14 · 2016: 19 · 2015: 32 · 2014: 19 · 2013: 29 · 2012: 37
FWCI: 48.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4672 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (T32 MH18273, MH 45156, T32MH018273, P50MH045156)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, prefrontal cortex, gene expression profiling, presynaptic function, N-ethylmaleimide-sensitive factor, synapsin II, transcriptome
MeSH terms: Animals, Carrier Proteins, Female, Humans, Macaca fascicularis, Male, Middle Aged, Synaptic Transmission, RNA, Messenger, Schizophrenia, Synapses, Antipsychotic Agents, Genetic Variation, Gene Expression, Confounding Factors, Epidemiologic, Synapsins, Prefrontal Cortex, In Situ Hybridization, Presynaptic Terminals, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Vesicular Transport Proteins, N-Ethylmaleimide-Sensitive Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks