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Modulation of Both the Early and the Late Phase of Mossy Fiber LTP by the Activation of β-Adrenergic Receptors
Open accessAbstract
cAMP and the cAMP-dependent protein kinase (PKA) are required in the mossy fiber pathway for both the early and the late phase of long-term potentiation (LTP). Since the CA3 region, which is the target of the mossy fibers, receives extensive noradrenergic innervation, we examined the role of beta-adrenergic receptors in mossy fiber LTP. We found that we could induce an early phase of LTP by pairing isoproterenol, a beta-adrenergic receptor agonist, with a weak train, subthreshold for LTP. This LTP was specific to the mossy fiber pathway, was blocked by inhibitors of PKA, and occluded paired-pulse facilitation, suggesting that isoproterenol was acting presynaptically. When isoproterenol was paired with a train that induced only the early phase of LTP, it gave rise to a protein synthesis-dependent late phase. Consistent with these findings, beta-adrenergic antagonists blocked both the late and the early phase of LTP induced by mossy fiber stimulation. Thus, beta-adrenergic receptor modulation is important for both phases of mossy fiber LTP.
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“Moreover, neuromodulators can change the induction rules and time course of mossy fiber plasticity [101,102].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [102]
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Cites
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
Frey, U., Huang, Y.-Y., & Kandel, E. R. (1993) · Science · doi:10.1126/science.8389057 · Cited by 1,218
Self-citationMoore, R. Y., & Bloom, F. E. (1979) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.02.030179.000553 · Cited by 1,118
Comparison of Two Forms of Long-Term Potentiation in Single Hippocampal Neurons
Zalutsky, R. A., & Nicoll, R. A. (1990) · Science · doi:10.1126/science.2114039 · Cited by 759
Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP
Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A., & Nicoll, R. A. (1994) · Science · doi:10.1126/science.7916482 · Cited by 618
Huang, Y.-Y., & Kandel, E. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2446 · Cited by 544
Self-citationHuang, Y.-Y., Li, X.-C., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90401-4 · Cited by 490
Self-citationHuang, Y.-Y., & Kandel, E. R. (1994) · Learning & Memory · doi:10.1101/lm.1.1.74 · Cited by 477
Self-citationNoradrenergic innervation of the adult rat hippocampal formation
Loy, R., Koziell, D. A., Lindsey, J. D., & Moore, R. Y. (1980) · Journal of Comparative Neurology · doi:10.1002/cne.901890406 · Cited by 443
Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus
Hopkins, W. F., & Johnston, D. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.2.667 · Cited by 310
Chavez-Noriega, L., & Stevens, C. F. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-01-00310.1994 · Cited by 309
Changes in the statistics of transmitter release during facilitation
Zucker, R. S. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010167 · Cited by 306
NMDA-Receptor-Independent Long-Term Potentiation
Johnston, D., Williams, S., Jaffe, D., & Gray, R. (1992) · Annual Review of Physiology · doi:10.1146/annurev.ph.54.030192.002421 · Cited by 300
Castillo, P. E., Weisskopf, M. G., & Nicoll, R. A. (1994) · Neuron · doi:10.1016/0896-6273(94)90269-0 · Cited by 298
Huang, Y.-Y., Kandel, E. R., Varshavsky, L., Brandont, E. P., Qi, M., Idzerda, R. L., Stanley McKnight, G., & Bourtchouladz, R. (1995) · Cell · doi:10.1016/0092-8674(95)90146-9 · Cited by 267
Self-citationSquire, L. R., Shimamura, A. P., & Amaral, D. G. (1989) · Elsevier eBooks · doi:10.1016/b978-0-12-148955-7.50016-3 · Cited by 224
Nicholas, A. P., Pieribone, V. A., & Hökfelt, T. G. M. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90148-9 · Cited by 210
Mueller, A. L., Hoffer, B. J., & Dunwiddie, T. V. (1981) · Brain Research · doi:10.1016/0006-8993(81)90442-x · Cited by 194
Gold, P. E., & van Buskirk, R. (1978) · Behavioral Biology · doi:10.1016/s0091-6773(78)91614-0 · Cited by 191
Quantified distribution of the noradrenaline innervation in the hippocampus of adult rat
Oleskevich, S., Descarries, L., & Lacaille, J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-11-03803.1989 · Cited by 134
Stanton, P. K., & Sarvey, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90981-3 · Cited by 127
Winder, D. G., & Conn, P. J. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-01-00038.1993 · Cited by 111
Crow, T. J., & Wendlandt, S. (1976) · Nature · doi:10.1038/259042b0 · Cited by 97
Castellano, C., Cestari, V., Cabib, S., & Puglisi‐Allegra, S. (1991) · Behavioral and Neural Biology · doi:10.1016/0163-1047(91)90439-w · Cited by 80
Presynaptic enhancement of excitatory synaptic transmission by beta-adrenergic receptor activation
Gereau, R. W., & Conn, P. J. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.3.1438 · Cited by 75
Gereau, R., & Conn, P. J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03310.1994 · Cited by 56
Parfitt, K. D., Doze, V. A., Madison, D. V., & Browning, M. D. (1992) · Hippocampus · doi:10.1002/hipo.450020108 · Cited by 38
Integrating information at single synaptic connections.
Montague, P. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2424 · Cited by 5
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Izquierdo, I., & Medina, J. H. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3799 · Cited by 959
Vecsey, C. G., Hawk, J. D., Lattal, K. M., Stein, J. M., Fabian, S., Attner, M. A., Cabrera, S. M., McDonough, C. B., Brindle, P. K., Abel, T. G., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0296-07.2007 · Cited by 854
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Metadata
- Authors
- Huang, Y.-Y., & Kandel, E. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kandel, Eric R
- ORCID
- Kandel, Eric R
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 16
- Issue
- 3
- Pages
- 611-617
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2003106844
- Cited by
- 199
- References
- 28
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 3
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01gm032099-14)
- National Institute of General Medical Sciences (GM 32099)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- beta-adrenergic receptors, isoproterenol, cyclic AMP, protein kinase A, CA3, noradrenergic innervation, presynaptic modulation, paired-pulse facilitation, hippocampus
- MeSH terms
- Animals, Isoproterenol, Models, Neurological, Nerve Fibers, Protein Kinases, Receptors, Adrenergic, beta, Time Factors, Timolol, Rats, Sprague-Dawley, Long-Term Potentiation, Rats
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