Long-term potentiation in cultures of single hippocampal granule cells: a presynaptic form of plasticity
Open accessAbstract
We have explored the mechanisms of mossy fiber long-term potentiation (LTP) at autapses in single-cell cultures of guinea pig hippocampal dentate granule cells. L-AP4-sensitive, but not insensitive, cells responded to a brief tetanus with a sustained potentiation in the synaptic responses. The induction of this LTP appeared identical to that observed in hippocampal mossy fiber synapses in situ, in that it required a rise in presynaptic Ca2+ and activation of protein kinase A. Its expression also appeared to be presynaptic and was due, at least in part, to events that occurred after the entry of Ca2+ and to the switching on of previously silent release sites.
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High-frequency stimulation induces several cAMP-dependent forms of presynaptic plasticity.
“For example, high-frequency stimulation (HFS) induces several cyclic adenosine monophosphate (cAMP)-dependent forms of presynaptic plasticity [21,28–33].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [30]
Forskolin is a widely used adenylyl cyclase activator.
“To maximally activate the cAMP pathway, we applied forskolin, a widely used AC activator [28–31,33,48].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [30]
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“…for identifying dentate granule cells. expression are presynaptic (for review, see Nicoll and Malenka, 1995), contradictory views exist (Derrick and Using this cell culture system, we have confirmed and extended many of the findings originally made in slice Martinez, 1994; Johnston et al., 1992).”
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- Authors
- Tong, G., Malenka, R. C., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Nicoll, Roger A
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 16
- Issue
- 6
- Pages
- 1147-1157
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2166291087
- Cited by
- 147
- References
- 3
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 5 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 7
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Center for Neuroscience Research
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, mossy fiber synapses, autapses, presynaptic plasticity, L-AP4, tetanic potentiation, presynaptic calcium, protein kinase A, synaptic transmission
- MeSH terms
- Animals, Cells, Cultured, Guinea Pigs, Hippocampus, Neuronal Plasticity, Time Factors, N-Methylaspartate, Dizocilpine Maleate, Long-Term Potentiation
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