Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons
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Abstract
Synaptic plasticity is a cellular model for learning and memory. However, the expression mechanisms underlying presynaptic forms of plasticity are not well understood. Here, we investigate functional and structural correlates of presynaptic potentiation at large hippocampal mossy fiber boutons induced by the adenylyl cyclase activator forskolin. We performed 2-photon imaging of the genetically encoded glutamate sensor iGluu that revealed an increase in the surface area used for glutamate release at potentiated terminals. Time-gated stimulated emission depletion microscopy revealed no change in the coupling distance between P/Q-type calcium channels and release sites mapped by Munc13-1 cluster position. Finally, by high-pressure freezing and transmission electron microscopy analysis, we found a fast remodeling of synaptic ultrastructure at potentiated boutons: Synaptic vesicles dispersed in the terminal and accumulated at the active zones, while active zone density and synaptic complexity increased. We suggest that these rapid and early structural rearrangements might enable long-term increase in synaptic strength.
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Previous studies reported a lack of change in coupling distance between CaV2.1 and Munc13-1.
“However, previous studies reported a lack of change in coupling distance between CaV2.1 and Munc13-1 [46,47].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [46]
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- Authors
- Orlando, M., Dvorzhak, A., Bruentgens, F., Maglione, M., Rost, B. R., Sigrist, S. J., Breustedt, J., & Schmitz, D.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- NeuroCure Cluster of Excellence (DE)
- German Center for Neurodegenerative Diseases (DE)
- Max Delbrück Center (DE)
- Corresponding author
- Schmitz, Dietmar
- ORCID
- Venue
- PLOS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2021-06-21
- Volume
- 19
- Issue
- 6
- Pages
- e3001149
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC8216508
- OpenAlex
- W3173499376
- Cited by
- 30
- References
- 68
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 6
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Biology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (390688087, 327654276, 184695641, 431572356, 273915538, 365082554)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- presynaptic potentiation, hippocampus, synaptic plasticity, forskolin, adenylate cyclase, P/Q-type calcium channels, Munc13-1, synaptic vesicles, active zone, synaptic ultrastructure, glutamate release
- MeSH terms
- Animals, Colforsin, Male, Mice, Inbred C57BL, Synaptic Vesicles, Presynaptic Terminals, Neurotransmitter Agents, Glutamic Acid, Mossy Fibers, Hippocampal, Microscopy, Fluorescence, Multiphoton, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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