Modulation of Both the Early and the Late Phase of Mossy Fiber LTP by the Activation of β-Adrenergic Receptors
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cAMP and the cAMP-dependent protein kinase (PKA) are required in the mossy fiber pathway for both the early and the late phase of long-term potentiation (LTP). Since the CA3 region, which is the target of the mossy fibers, receives extensive noradrenergic innervation, we examined the role of beta-adrenergic receptors in mossy fiber LTP. We found that we could induce an early phase of LTP by pairing isoproterenol, a beta-adrenergic receptor agonist, with a weak train, subthreshold for LTP. This LTP was specific to the mossy fiber pathway, was blocked by inhibitors of PKA, and occluded paired-pulse facilitation, suggesting that isoproterenol was acting presynaptically. When isoproterenol was paired with a train that induced only the early phase of LTP, it gave rise to a protein synthesis-dependent late phase. Consistent with these findings, beta-adrenergic antagonists blocked both the late and the early phase of LTP induced by mossy fiber stimulation. Thus, beta-adrenergic receptor modulation is important for both phases of mossy fiber LTP.
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Neuromodulators can change the induction rules and time course of mossy fiber plasticity.
“Moreover, neuromodulators can change the induction rules and time course of mossy fiber plasticity [101,102].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [102]
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- Authors
- Huang, Y.-Y., & Kandel, E. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kandel, Eric R
- ORCID
- Kandel, Eric R
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 16
- Issue
- 3
- Pages
- 611-617
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2003106844
- Cited by
- 199
- References
- 28
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 3
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01gm032099-14)
- National Institute of General Medical Sciences (GM 32099)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- beta-adrenergic receptors, isoproterenol, cyclic AMP, protein kinase A, CA3, noradrenergic innervation, presynaptic modulation, paired-pulse facilitation, hippocampus
- MeSH terms
- Animals, Isoproterenol, Models, Neurological, Nerve Fibers, Protein Kinases, Receptors, Adrenergic, beta, Time Factors, Timolol, Rats, Sprague-Dawley, Long-Term Potentiation, Rats
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