Cited by 199Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

Modulation of Both the Early and the Late Phase of Mossy Fiber LTP by the Activation of β-Adrenergic Receptors

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Huang, Yan-You, Kandel, Eric R·1996·Neuron

Abstract

cAMP and the cAMP-dependent protein kinase (PKA) are required in the mossy fiber pathway for both the early and the late phase of long-term potentiation (LTP). Since the CA3 region, which is the target of the mossy fibers, receives extensive noradrenergic innervation, we examined the role of beta-adrenergic receptors in mossy fiber LTP. We found that we could induce an early phase of LTP by pairing isoproterenol, a beta-adrenergic receptor agonist, with a weak train, subthreshold for LTP. This LTP was specific to the mossy fiber pathway, was blocked by inhibitors of PKA, and occluded paired-pulse facilitation, suggesting that isoproterenol was acting presynaptically. When isoproterenol was paired with a train that induced only the early phase of LTP, it gave rise to a protein synthesis-dependent late phase. Consistent with these findings, beta-adrenergic antagonists blocked both the late and the early phase of LTP induced by mossy fiber stimulation. Thus, beta-adrenergic receptor modulation is important for both phases of mossy fiber LTP.

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Crossref · 10.1016/s0896-6273(00)80080-x

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Authors
Huang, Y.-Y., & Kandel, E. R.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Kandel, Eric R
Venue
Neuron
Publisher
Elsevier BV
Published
1996-03
Volume
16
Issue
3
Pages
611-617
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2003106844
Cited by
199
References
28
Citations by year
2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 3 · 2016: 5 · 2015: 4 · 2014: 9 · 2013: 4 · 2012: 3
FWCI
5.13
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01gm032099-14)
  • National Institute of General Medical Sciences (GM 32099)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
beta-adrenergic receptors, isoproterenol, cyclic AMP, protein kinase A, CA3, noradrenergic innervation, presynaptic modulation, paired-pulse facilitation, hippocampus
MeSH terms
Animals, Isoproterenol, Models, Neurological, Nerve Fibers, Protein Kinases, Receptors, Adrenergic, beta, Time Factors, Timolol, Rats, Sprague-Dawley, Long-Term Potentiation, Rats

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