Cited by 250Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Animal models of attention-deficit hyperactivity disorder.

Davids, Eugen, Zhang, Kehong, Tarazi, Frank I, Baldessarini, Ross J·2003·Brain Research Reviews

Abstract

Attention-deficit hyperactivity disorder (ADHD) involves clinically heterogeneous dysfunctions of sustained attention, with behavioral overactivity and impulsivity, of juvenile onset. Experimental models, in addition to mimicking syndromal features, should resemble the clinical condition in pathophysiology, and predict potential new treatments. One of the most extensively evaluated animal models of ADHD is the spontaneously hypertensive rat. Other models include additional genetic variants (dopamine transporter gene knock-out mouse, coloboma mouse, Naples hyperexcitable rat, acallosal mouse, hyposexual rat, and population-extreme rodents), neonatal lesioning of dopamine neurons with 6-hydroxydopamine, and exposure to other neurotoxins or hippocampal irradiation. None is fully comparable to clinical ADHD. The pathophysiology involved varies, including both deficient and excessive dopaminergic functioning, and probable involvement of other monoamine neurotransmitters. Improved models as well as further testing of their ability to predict treatment responses are required.

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Crossref · 10.1016/s0165-0173(02)00274-6

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23 of 23 references verified0 citation errors · 0 not checkable

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  • SHR is the most widely accepted rodent model of ADHD.

    “The spontaneously hypertensive rat strain (SHR), a rat model bred from progenitor Wistar–Kyoto rats (WKY; Okamoto and Aoki, 1963), is the most widely accepted rodent model of ADHD (Sagvolden et al., 1993; Sagvolden, 2000; Davids et al., 2003).”

    From The Effects of Methylphenidate on Goal-directed Behavior in a Rat Model of ADHD (2015) · cites this paper as Davids et al., 2003

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Authors
Davids, E., Zhang, K., Tarazi, F. I., & Baldessarini, R. J.
Affiliations
Harvard University (US)
Corresponding author
Baldessarini, Ross J
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2003-04
Volume
42
Issue
1
Pages
1-21
ISSN
0165-0173 (ISSN-L)
OpenAlex
W2008226573
Cited by
250
References
23
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 16 · 2013: 8 · 2012: 15
FWCI
3.23
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (K05MH047370, R01MH034006, MH-34006, MH47370)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
attention deficit hyperactivity disorder, animal models, spontaneously hypertensive rats, sustained attention, impulsivity, dopaminergic dysfunction, monoamines, treatment prediction
MeSH terms
Animals, Attention Deficit Disorder with Hyperactivity, Disease Models, Animal, Dopamine, Models, Genetic, Neurotoxins, Rats, Inbred SHR, Genetic Variation, Oxidopamine, Models, Animal, Mice, Rats

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