Animal models of attention-deficit hyperactivity disorder.
Abstract
Attention-deficit hyperactivity disorder (ADHD) involves clinically heterogeneous dysfunctions of sustained attention, with behavioral overactivity and impulsivity, of juvenile onset. Experimental models, in addition to mimicking syndromal features, should resemble the clinical condition in pathophysiology, and predict potential new treatments. One of the most extensively evaluated animal models of ADHD is the spontaneously hypertensive rat. Other models include additional genetic variants (dopamine transporter gene knock-out mouse, coloboma mouse, Naples hyperexcitable rat, acallosal mouse, hyposexual rat, and population-extreme rodents), neonatal lesioning of dopamine neurons with 6-hydroxydopamine, and exposure to other neurotoxins or hippocampal irradiation. None is fully comparable to clinical ADHD. The pathophysiology involved varies, including both deficient and excessive dopaminergic functioning, and probable involvement of other monoamine neurotransmitters. Improved models as well as further testing of their ability to predict treatment responses are required.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SHR is the most widely accepted rodent model of ADHD.
“The spontaneously hypertensive rat strain (SHR), a rat model bred from progenitor Wistar–Kyoto rats (WKY; Okamoto and Aoki, 1963), is the most widely accepted rodent model of ADHD (Sagvolden et al., 1993; Sagvolden, 2000; Davids et al., 2003).”
From The Effects of Methylphenidate on Goal-directed Behavior in a Rat Model of ADHD (2015) · cites this paper as Davids et al., 2003
Cites
A cortical network for directed attention and unilateral neglect
Mesulam, M. ‐. (1981) · Annals of Neurology · doi:10.1002/ana.410100402 · Cited by 2,498 · see citing works
Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder
Castellanos, F. X. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830070053009 · Cited by 1,183 · see citing works
Multiple dopamine D4 receptor variants in the human population
Tol, H. H. M. V., Wu, C. M., Guan, H.-C., Ohara, K., Bunzow, J. R., Civelli, O., Kennedy, J., Seeman, P., Niznik, H. B., & Jovanovic, V. (1992) · Nature · doi:10.1038/358149a0 · Cited by 955 · see citing works
Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants
Asghari, V., Sanyal, S., Buchwaldt, S., Paterson, A., Jovanovic, V., & Van Tol, H. H. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031157.x · Cited by 858 · see citing works
Filipek, P. A., Semrud-Clikeman, M., Steingard, R. J., Renshaw, P. F., Kennedy, D. N., & Biederman, J. (1997) · Neurology · doi:10.1212/wnl.48.3.589 · Cited by 732 · see citing works
Barkley, R. A., Grodzinsky, G., & DuPaul, G. J. (1992) · Journal of Abnormal Child Psychology · doi:10.1007/bf00916547 · Cited by 724 · see citing works
Kuczenski, R., & Segal, D. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68052032.x · Cited by 623 · see citing works
Barkley, R. A. (1997) · Psychological Bulletin · doi:10.1037//0033-2909.121.1.65 · Cited by 580 · see citing works
Cerebellum in attention-deficit hyperactivity disorder: A morphometric MRI study
Berquin, P. C., Giedd, J. N., Jacobsen, L. K., Hamburger, S. D., Krain, A. L., Rapoport, J. L., & Castellanos, F. X. (1998) · Neurology · doi:10.1212/wnl.50.4.1087 · Cited by 564 · see citing works
Arnsten, A. F. T., & Goldman-Rakic, P. S. (1985) · Science · doi:10.1126/science.2999977 · Cited by 549 · see citing works
Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum
Heinz, A. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00099-8 · Cited by 538 · see citing works
Frontal lesions and sustained attention
Wilkins, A. J., Shallice, T., & McCarthy, R. (1987) · Neuropsychologia · doi:10.1016/0028-3932(87)90024-8 · Cited by 450 · see citing works
The ecological validity of laboratory and analogue assessment methods of ADHD symptoms
Barkley, R. A. (1991) · Journal of Abnormal Child Psychology · doi:10.1007/bf00909976 · Cited by 419 · see citing works
Validity of the Age-of-Onset Criterion for ADHD: A Report From the DSM-IV Field Trials
APPLEGATE, B., LAHEY, B. B., HART, E. L., BIEDERMAN, J., HYND, G. W., BARKLEY, R. A., OLLENDICK, T., FRICK, P. J., GREENHILI, L., MCBURNETT, K., et al. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199709000-00013 · Cited by 380 · see citing works
Dextroamphetamine: Cognitive and Behavioral Effects in Normal Prepubertal Boys
Rapoport, J. L., Buchsbaum, M. S., Zahn, T. P., Weingartner, H., Ludlow, C., & Mikkelsen, E. J. (1978) · Science · doi:10.1126/science.341313 · Cited by 373 · see citing works
Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder
Sagvolden, T., Aase, H., Zeiner, P., & Berger, D. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00170-8 · Cited by 345 · see citing works
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Franceschi, D., Maynard, L., Ding, Y., Gatley, S. J., Gifford, A., Zhu, W., et al. (2002) · Synapse · doi:10.1002/syn.10038 · Cited by 321 · see citing works
Dresel, S., Krause, J., Krause, K.-H., LaFougere, C., Brinkbäumer, K., Kung, H. F., Hahn, K., & Tatsch, K. (2000) · European Journal of Nuclear Medicine · doi:10.1007/s002590000330 · Cited by 278 · see citing works
Ernst, M., Zametkin, A. J., Matochik, J. A., Pascualvaca, D., Jons, P. H., & Cohen, R. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1209 · Cited by 256 · see citing works
Wilens, T. E., Biederman, J., Spencer, T. J., Bostic, J., Prince, J., Monuteaux, M. C., Soriano, J., Fine, C., Abrams, A., Rater, M., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.12.1931 · Cited by 230 · see citing works
Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter
Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., Missale, C., & Caron, M. G. (1997) · Neuron · doi:10.1016/s0896-6273(00)80353-0 · Cited by 203 · see citing works
Muir, J. L., Page, K. J., Sirinathsinghji, D. J. S., Robbins, T. W., & Everitt, B. J. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90128-d · Cited by 199 · see citing works
Seidman, L. J., Biederman, J., Monuteaux, M. C., Doyle, A. E., & Faraone, S. V. (2001) · Neuropsychology · doi:10.1037/0894-4105.15.4.544 · Cited by 190 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation
Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., Clasen, L., Evans, A., Giedd, J., & Rapoport, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707741104 · Cited by 1,819 · see citing works
sagvolden, T., johansen, E. B., aase, H., & russell, V. A. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000075 · Cited by 1,035 · see citing works
Eagle, D. M., Bari, A., & Robbins, T. W. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1127-6 · Cited by 548 · see citing works
Rodent Models of Attention-Deficit/Hyperactivity Disorder
Sagvolden, T., Russell, V. A., Aase, H., Johansen, E. B., & Farshbaf, M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.002 · Cited by 448 · see citing works
Eagle, D. M., & Robbins, T. W. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1302 · Cited by 252 · see citing works
Hoyle, E., Genn, R. F., Fernandes, C., & Stolerman, I. P. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0549-2 · Cited by 161 · see citing works
Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD
Leo, D., Sorrentino, E., Volpicelli, F., Eyman, M., Greco, D., Viggiano, D., di Porzio, U., & Perrone-Capano, C. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.009 · Cited by 103 · see citing works
Bralten, J., Franke, B., Waldman, I., Rommelse, N., Hartman, C., Asherson, P., Banaschewski, T., Ebstein, R. P., Gill, M., Miranda, A., et al. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.08.020 · Cited by 93 · see citing works
Carlyle, B. C., Duque, A., Kitchen, R. R., Bordner, K. A., Coman, D., Doolittle, E., Papademetris, X., Hyder, F., Taylor, J. R., & Simen, A. A. (2012) · Development and Psychopathology · doi:10.1017/s095457941200079x · Cited by 80 · see citing works
Dopamine selectively potentiates hippocampal mossy fiber to CA3 synaptic transmission
Kobayashi, K., & Suzuki, H. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.08.026 · Cited by 63 · see citing works
Balcioglu, A., Ren, J.-Q., McCarthy, D., Spencer, T. J., Biederman, J., & Bhide, P. G. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.025 · Cited by 60 · see citing works
Johansen, E. B., Killeen, P. R., & Sagvolden, T. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-60 · Cited by 56 · see citing works
Immunologic and neurodevelopmental susceptibilities of autism
Pessah, I. N., Seegal, R. F., Lein, P. J., LaSalle, J., Yee, B. K., Van De Water, J., & Berman, R. F. (2008) · NeuroToxicology · doi:10.1016/j.neuro.2008.02.006 · Cited by 51 · see citing works
Sequence analysis of Drd2, Drd4, and Dat1 in SHR and WKY rat strains
Mill, J., Sagvolden, T., & Asherson, P. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-24 · Cited by 49 · see citing works
Hiraide, S., Ueno, K.-I., Yamaguchi, T., Matsumoto, M., Yanagawa, Y., Yoshioka, M., & Togashi, H. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.01.009 · Cited by 24 · see citing works
The Effects of Methylphenidate on Goal-directed Behavior in a Rat Model of ADHD
Natsheh, J. Y., & Shiflett, M. W. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00326 · Cited by 21 · see citing works
- Authors
- Davids, E., Zhang, K., Tarazi, F. I., & Baldessarini, R. J.
- Affiliations
- Harvard University (US)
- Corresponding author
- Baldessarini, Ross J
- Venue
- Brain Research Reviews
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 42
- Issue
- 1
- Pages
- 1-21
- ISSN
- 0165-0173 (ISSN-L)
- OpenAlex
- W2008226573
- Cited by
- 250
- References
- 23
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 5 · 2018: 6 · 2017: 9 · 2016: 7 · 2015: 9 · 2014: 16 · 2013: 8 · 2012: 15
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (K05MH047370, R01MH034006, MH-34006, MH47370)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- attention deficit hyperactivity disorder, animal models, spontaneously hypertensive rats, sustained attention, impulsivity, dopaminergic dysfunction, monoamines, treatment prediction
- MeSH terms
- Animals, Attention Deficit Disorder with Hyperactivity, Disease Models, Animal, Dopamine, Models, Genetic, Neurotoxins, Rats, Inbred SHR, Genetic Variation, Oxidopamine, Models, Animal, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review