Hyperdopaminergic mutant mice have higher "wanting" but not "liking" for sweet rewards
Open accessAbstract
What is the role of dopamine in natural rewards? A genetic mutant approach was taken to examine the consequences of elevated synaptic dopamine on (1) spontaneous food and water intake, (2) incentive motivation and learning to obtain a palatable sweet reward in a runway task, and (3) affective "liking" reactions elicited by the taste of sucrose. A dopamine transporter (DAT) knockdown mutation that preserves only 10% of normal DAT, and therefore causes mutant mice to have 70% elevated levels of synaptic dopamine, was used to identify dopamine effects on food intake and reward. We found that hyperdopaminergic DAT knockdown mutant mice have higher food and water intake. In a runway task, they demonstrated enhanced acquisition and greater incentive performance for a sweet reward. Hyperdopaminergic mutant mice leave the start box more quickly than wild-type mice, require fewer trials to learn, pause less often in the runway, resist distractions better, and proceed more directly to the goal. Those observations suggest that hyperdopaminergic mutant mice attribute greater incentive salience ("wanting") to a sweet reward in the runway test. But sucrose taste fails to elicit higher orofacial "liking" reactions from mutant mice in an affective taste reactivity test. These results indicate that chronically elevated extracellular dopamine facilitates "wanting" and learning of an incentive motivation task for a sweet reward, but elevated dopamine does not increase "liking" reactions to the hedonic impact of sweet tastes.
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Dopamine from the nucleus accumbens is important for rewarding cues to acquire incentive salience and elicit instrumental behavior.
“dopamine from the nucleus accumbens is important for the ability of rewarding cues to gain incentive salience and elicit instrumental behavior (Peciña et al., 2003; Wyvell and Berridge, 2000).”
From The effects of early life stress on reward processing (2018) · cites this paper as Peciña et al., 2003
Dopamine is not the neurotransmitter responsible for pleasure; it instead modulates 'wanting'.
“Although it was long believed that dopamine was the neurotransmitter responsible for pleasure, this has long been disproved, and a large body of evidence suggests that it instead modulates ‘wanting’ (Berridge & Valenstein, 1991; Peciña, Cagniard, Berridge, Aldridge, & Zhuang, 2003; Tindell, Berridge, Zhang, Peciña, & Aldridge, 2005; Wyvell & Berridge, 2000).”
From Cued for Risk: Evidence for an Incentive Sensitization Framework to Explain the Interplay between Stress and Anxiety, Substance Abuse, and Reward Uncertainty in Disordered Gambling Behavior (2019) · cites this paper as Peciña, Cagniard, Berridge, Aldridge, & Zhuang, 2003
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“In addition, dopamine from the nucleus accumbens is important for the ability of rewarding cues to gain incentive salience and elicit instrumental behavior (Peciña et al., 2003; Wyvell and Berridge, 2000).”
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- Authors
- Peciña, S., Cagniard, B., Berridge, K. C., Aldridge, J. W., & Zhuang, X.
- Affiliations
- University of Michigan (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-10-15
- Volume
- 23
- Issue
- 28
- Pages
- 9395-9402
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6740586
- OpenAlex
- W2151211427
- Cited by
- 551
- References
- 68
- Citations by year
- 2026: 4 · 2025: 18 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 24 · 2020: 53 · 2019: 57 · 2018: 20 · 2017: 23 · 2016: 27 · 2015: 37 · 2014: 27 · 2013: 30 · 2012: 27
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0091661)
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health (MH-63649, R01MH063649)
- National Institute on Drug Abuse (DA015188, R01DA015188)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- dopamine, hyperdopaminergic state, synaptic dopamine, reward, incentive motivation, incentive salience, wanting, liking, sucrose taste, dietary intake, runway task, reward learning
- MeSH terms
- Animals, Appetitive Behavior, Behavior, Animal, Body Weight, Dopamine, Drinking, Eating, Exploratory Behavior, Facial Expression, Learning, Male, Membrane Glycoproteins, Mice, Neurologic Mutants, Mutation, Nerve Tissue Proteins, Reward, Stimulation, Chemical, Sucrose, Synapses, Taste, Membrane Transport Proteins, Extracellular Fluid, Dopamine Plasma Membrane Transport Proteins, Mice
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