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CaMKIIβ Functions As an F-Actin Targeting Module that Localizes CaMKIIα/β Heterooligomers to Dendritic Spines
Open accessAbstract
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine protein kinase that regulates long-term potentiation and other forms of neuronal plasticity. Functional differences between the neuronal CaMKIIalpha and CaMKIIbeta isoforms are not yet known. Here, we use green fluorescent protein-tagged (GFP-tagged) CaMKII isoforms and show that CaMKIIbeta is bound to F-actin in dendritic spines and cell cortex while CaMKIIalpha is largely a cytosolic enzyme. When expressed together, the two isoforms form large heterooligomers, and a small fraction of CaMKIIbeta is sufficient to dock the predominant CaMKIIalpha to the actin cytoskeleton. Thus, CaMKIIbeta functions as a targeting module that localizes a much larger number of CaMKIIalpha isozymes to synaptic and cytoskeletal sites of action.
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“A second difference is the specific high-affinity binding of the inactive β, but not α, to F-actin (167–170).”
From Synaptic memory and CaMKII (2023) · cites this paper as [168]
Citations
Cites
Control of memory formation through regulated expression of a CaMKII transgene
Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Sensitivity of CaM Kinase II to the Frequency of Ca 2+ Oscillations
De Koninck, P., & Schulman, H. (1998) · Science · doi:10.1126/science.279.5348.227 · Cited by 1,269
Autophosphorylation at Thr 286 of the α Calcium-Calmodulin Kinase II in LTP and Learning
Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation
Barria, A., Muller, D., Derkach, V., Griffith, L. C., & Soderling, T. R. (1997) · Science · doi:10.1126/science.276.5321.2042 · Cited by 1,049
Rapid Actin-Based Plasticity in Dendritic Spines
Fischer, M., Kaech, S., Knutti, D., & Matus, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80467-5 · Cited by 905
Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation
Ziv, N. E., & Smith, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80283-4 · Cited by 882
Miller, S. (1986) · Cell · doi:10.1016/0092-8674(86)90008-5 · Cited by 864
Contrasting properties of two forms of long-term potentiation in the hippocampus
Nicoll, R. A., & Malenka, R. C. (1995) · Nature · doi:10.1038/377115a0 · Cited by 861
The Multifunctional Calcium/Calmodulin-Dependent Protein Kinase: From Form to Function
Braun, A. P., & Schulman, H. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.002221 · Cited by 820
Conjugative Transfer by the Virulence System of Legionella pneumophila
Vogel, J. P., Andrews, H. L., Wong, S. K., & Isberg, R. R. (1998) · Science · doi:10.1126/science.279.5352.873 · Cited by 721
Calmodulin Trapping by Calcium-Calmodulin-Dependent Protein Kinase
Meyer, T., Hanson, P. I., Stryer, L., & Schulman, H. (1992) · Science · doi:10.1126/science.256.5060.1199 · Cited by 637
Self-citationCompetitive binding of α-actinin and calmodulin to the NMDA receptor
Wyszynski, M., Lin, J., Rao, A., Nigh, E., Beggs, A. H., Craig, A. M., & Sheng, M. (1997) · Nature · doi:10.1038/385439a0 · Cited by 596
A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II
Chen, H.-J., Rojas-Soto, M., Oguni, A., & Kennedy, M. B. (1998) · Neuron · doi:10.1016/s0896-6273(00)80471-7 · Cited by 590
Spector, I., Shochet, N. R., Blasberger, D., & Kashman, Y. (1989) · Cell Motility · doi:10.1002/cm.970130302 · Cited by 580
Burgin, K., Waxham, M., Rickling, S., Westgate, S., Mobley, W. C., & Kelly, P. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-06-01788.1990 · Cited by 564
Mayford, M., Wang, J., Kandel, E., & O'Dell, T. (1995) · Cell · doi:10.1016/0092-8674(95)90009-8 · Cited by 552
Hanson, P. I., Meyer, T., Stryer, L., & Schulman, H. (1994) · Neuron · doi:10.1016/0896-6273(94)90306-9 · Cited by 500
Self-citationBennett, M. K., Erondu, N. E., & Kennedy, M. B. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44239-6 · Cited by 481
McGlade‐McCulloh, E., Yamamoto, H., Tan, S.-E., Brickey, D. A., & Soderling, T. R. (1993) · Nature · doi:10.1038/362640a0 · Cited by 456
Colbran, R. J., Schworer, C. M., Hashimoto, Y., Fong, Y. L., Rich, D. P., Smith, M. K., & Soderling, T. R. (1989) · Biochemical Journal · doi:10.1042/bj2580313 · Cited by 406
Stabilization of Dendritic Arbor Structure in Vivo by CaMKII
Wu, G., & Cline, H. T. (1998) · Science · doi:10.1126/science.279.5348.222 · Cited by 377
Oancea, E., Teruel, M. N., Quest, A. F. G., & Meyer, T. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.3.485 · Cited by 323
Self-citationLlinas, R. H., Gruner, J. A., Sugimori, M., McGuinness, T. L., & Greengard, P. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018549 · Cited by 317
Miller, S. G., & Kennedy, M. B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39454-1 · Cited by 304
Omkumar, R. V., Kiely, M. J., Rosenstein, A. J., Min, K.-T., & Kennedy, M. B. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31670 · Cited by 304
Benfenati, F., Valtorta, F., Rubenstein, J. L., Gorelick, F. S., Greengard, P., & Czernik, A. J. (1992) · Nature · doi:10.1038/359417a0 · Cited by 304
Strack, S., Choi, S., Lovinger, D. M., & Colbran, R. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13467 · Cited by 293
Lai, Y., Nairn, A. C., & Greengard, P. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4253 · Cited by 292
Vesicle pool mobilization during action potential firing at hippocampal synapses
Ryan, T. A., & Smith, S. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90336-4 · Cited by 282
Schworer, C. M., Colbran, R. J., & Soderling, T. R. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84416-2 · Cited by 269
Srinivasan, M., Edman, C. E., & Schulman, H. (1994) · Journal of Cell Biology · doi:10.1083/jcb.126.4.839 · Cited by 264
Cytoplasmic organization in cerebellar dendritic spines.
Landis, D. M. D., & Reese, T. S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.4.1169 · Cited by 220
Hanson, P. I., & Schulman, H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41915-1 · Cited by 216
In Situ Hybridization Histochemistry
Young, W. S. (1989) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-10726-1_1 · Cited by 213
Lou, L. L., Lloyd, S. J., & Schulman, H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9497 · Cited by 206
Cáceres, A., Payne, M. R., Binder, L. I., & Steward, O. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1738 · Cited by 204
Spatial dynamics of GFP-tagged proteins investigated by local fluorescence enhancement
Yokoe, H., & Meyer, T. (1996) · Nature Biotechnology · doi:10.1038/nbt1096-1252 · Cited by 194
Self-citationStructural features of Ca2+/calmodulin-dependent protein kinase II revealed by electron microscopy
Kanaseki, T., Ikeuchi, Y., Sugiura, H., & Yamauchi, T. (1991) · Journal of Cell Biology · doi:10.1083/jcb.115.4.1049 · Cited by 184
Brocke, L., Srinivasan, M., & Schulman, H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-10-06797.1995 · Cited by 167
Colbran, R. J., & Soderling, T. R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38578-3 · Cited by 153
Requirement for α-CaMKII in Experience-Dependent Plasticity of the Barrel Cortex
Glazewski, S., Chen, C.-M., Silva, A. J., & Fox, K. (1996) · Science · doi:10.1126/science.272.5260.421 · Cited by 142
The α-Ca2+/calmodulin kinase II: A bidirectional modulator of presynaptic plasticity
Chapman, P., Frenguelli, B., Smith, A., Chen, C.-M., & Silva, A. J. (1995) · Neuron · doi:10.1016/0896-6273(95)90315-1 · Cited by 123
Mukherji, S., & Soderling, T. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36708-x · Cited by 114
Teruel, M. N., & Meyer, T. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78209-2 · Cited by 114
Self-citationGordon, J. A., Cioffi, D., Silva, A. J., & Stryker, M. P. (1996) · Neuron · doi:10.1016/s0896-6273(00)80181-6 · Cited by 111
Kelly, P. T., Shields, S. M., Conway, K., Yip, R. K., & Burgin, K. E. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb02456.x · Cited by 111
Calcium/calmodulin-dependent protein kinase II: role in learning and memory
Soderling, T. R. (1993) · Molecular and Cellular Biochemistry · doi:10.1007/bf01076760 · Cited by 103
Calcium Signaling: Up, Down, Up, Down.... What's the Point?
Putney, J. W. (1998) · Science · doi:10.1126/science.279.5348.191 · Cited by 102
Changes in the subcellular distribution of calmodulin-kinase II during brain development
Kelly, P. T., & Vernon, P. J. (1985) · Developmental Brain Research · doi:10.1016/0165-3806(85)90265-2 · Cited by 95
Scholz, W., Baitinger, C., Schulman, H., & Kelly, P. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-01039.1988 · Cited by 91
Egelhoff, T. T., Brown, S. S., & Spudich, J. A. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.112.4.677 · Cited by 89
McNeill, R. B., & Colbran, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.10043 · Cited by 86
Yamauchi, T., Ohsako, S., & Deguchi, T. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47274-8 · Cited by 84
Bayer, K. U., Löhler, J., & Harbers, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.29 · Cited by 59
Vallano, M. L., Goldenring, J. R., Lasher, R. S., & DeLorenzo, R. J. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb38406.x · Cited by 56
Shen, K., & Meyer, T. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70010096.x · Cited by 43
Self-citationNomura, T., Kumatoriya, K., Yoshimura, Y., & Yamauchi, T. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00535-0 · Cited by 30
Guptaroy, B., & Griffith, L. C. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66031282.x · Cited by 22
Sugai, R., Takeuchi, M., Okuno, S., & Fujisawa, H. (1996) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021478 · Cited by 13
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Zhou, Z., Hong, E. J., Cohen, S., Zhao, W.-N., Ho, H.-Y. H., Schmidt, L., Chen, W. G., Lin, Y., Savner, E., Griffith, E. C., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.037 · Cited by 877
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Metadata
- Authors
- Shen, K., Teruel, M. N., Subramanian, K., & Meyer, T.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- Meyer, Tobias
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 21
- Issue
- 3
- Pages
- 593-606
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2146831587
- Cited by
- 350
- References
- 61
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 6 · 2020: 20 · 2019: 14 · 2018: 18 · 2017: 10 · 2016: 7 · 2015: 12 · 2014: 9 · 2013: 21 · 2012: 14
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01gm051457-04)
- National Institute of General Medical Sciences (GM-48113, GM 51457)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- CaMKIIβ, CaMKIIα, CaMKII isoforms, hetero-oligomers, F-actin binding, dendritic spines, actin cytoskeleton, protein localization, synaptic plasticity, long-term potentiation, neuroplasticity
- MeSH terms
- Actins, Animals, Cloning, Molecular, Cytoskeleton, Dendrites, Isoenzymes, Luminescent Proteins, Nerve Fibers, Neurons, Phosphorylation, Recombinant Fusion Proteins, Synapses, Transcription, Genetic, Protein Biosynthesis, Tumor Cells, Cultured, 3T3 Cells, Calcium-Calmodulin-Dependent Protein Kinases, Macromolecular Substances, Green Fluorescent Proteins, Mice, Rats, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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